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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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February 2011 Volume 27 Issue 2

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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February 2011 Volume 27 Issue 2

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Article

Lipopolysaccharide promotes adhesion and migration of murine dental papilla-derived MDPC-23 cells via TLR4

  • Authors:
    • Jong-Hwan Park
    • Seong-Min Kwon
    • Hyo-Eun Yoon
    • Soo-A Kim
    • Sang-Gun Ahn
    • Jung-Hoon Yoon

  • View Affiliations / Copyright

    Affiliations: Department of Biochemistry, College of Medicine, Konyang University, Daejeon 302-711, Republic of Korea, Department of Pathology, School of Dentistry, Chosun University, 375 Seoseok-dong, Dong-gu, Gwangju 501-759, Republic of Korea
  • Pages: 277-281
    |
    Published online on: December 1, 2010
       https://doi.org/10.3892/ijmm.2010.568
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Abstract

Odontoblasts and/or dental pulp cells are responsible for tooth repair and dentin formation. Furthermore, adhesion and migration are critical processes for tissue regeneration. This study was performed to clarify whether lipopolysaccharide (LPS) modulates adhesion and migration of the murine odontoblast-like cell line MDPC-23, and whether Toll-like receptor 4 (TLR4) signaling is engaged in this process. TLR4 expression in MDPC-23 cells was examined by RT-PCR. Adhesion assay was performed using type I collagen-coated plates. Migration ability was determined by a commercial assay kit. Phosphorylation of IκB-α, FAK, AKT, and ERK was examined by Western blot analysis. TLR4 was functionally expressed in MDPC-23 cells. LPS treatment enhanced adhesion and migration of MDPC-23 cells in a dose-dependent manner. Blockade of TLR4 using its antibody restored LPS-induced adhesion and migration of MDPC-23 cells. These findings indicate that LPS, an immune activator from Gram-negative bacteria, can promote the adhesion and migration ability of MDPC-23 cells via TLR4.

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Copy and paste a formatted citation
Spandidos Publications style
Park J, Kwon S, Yoon H, Kim S, Ahn S and Yoon J: Lipopolysaccharide promotes adhesion and migration of murine dental papilla-derived MDPC-23 cells via TLR4. Int J Mol Med 27: 277-281, 2011.
APA
Park, J., Kwon, S., Yoon, H., Kim, S., Ahn, S., & Yoon, J. (2011). Lipopolysaccharide promotes adhesion and migration of murine dental papilla-derived MDPC-23 cells via TLR4. International Journal of Molecular Medicine, 27, 277-281. https://doi.org/10.3892/ijmm.2010.568
MLA
Park, J., Kwon, S., Yoon, H., Kim, S., Ahn, S., Yoon, J."Lipopolysaccharide promotes adhesion and migration of murine dental papilla-derived MDPC-23 cells via TLR4". International Journal of Molecular Medicine 27.2 (2011): 277-281.
Chicago
Park, J., Kwon, S., Yoon, H., Kim, S., Ahn, S., Yoon, J."Lipopolysaccharide promotes adhesion and migration of murine dental papilla-derived MDPC-23 cells via TLR4". International Journal of Molecular Medicine 27, no. 2 (2011): 277-281. https://doi.org/10.3892/ijmm.2010.568
Copy and paste a formatted citation
x
Spandidos Publications style
Park J, Kwon S, Yoon H, Kim S, Ahn S and Yoon J: Lipopolysaccharide promotes adhesion and migration of murine dental papilla-derived MDPC-23 cells via TLR4. Int J Mol Med 27: 277-281, 2011.
APA
Park, J., Kwon, S., Yoon, H., Kim, S., Ahn, S., & Yoon, J. (2011). Lipopolysaccharide promotes adhesion and migration of murine dental papilla-derived MDPC-23 cells via TLR4. International Journal of Molecular Medicine, 27, 277-281. https://doi.org/10.3892/ijmm.2010.568
MLA
Park, J., Kwon, S., Yoon, H., Kim, S., Ahn, S., Yoon, J."Lipopolysaccharide promotes adhesion and migration of murine dental papilla-derived MDPC-23 cells via TLR4". International Journal of Molecular Medicine 27.2 (2011): 277-281.
Chicago
Park, J., Kwon, S., Yoon, H., Kim, S., Ahn, S., Yoon, J."Lipopolysaccharide promotes adhesion and migration of murine dental papilla-derived MDPC-23 cells via TLR4". International Journal of Molecular Medicine 27, no. 2 (2011): 277-281. https://doi.org/10.3892/ijmm.2010.568
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