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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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February 2011 Volume 27 Issue 2

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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February 2011 Volume 27 Issue 2

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Article Open Access

Genetically modified macrophages expressing hypoxia regulated cytochrome P450 and P450 reductase for the treatment of cancer

  • Authors:
    • On Kan
    • Debbie Day
    • Sharifah Iqball
    • Frances Burke
    • Matthew J. Grimshaw
    • Stuart Naylor
    • Katie Binley

  • View Affiliations / Copyright

    Affiliations: Oxford BioMedica (UK) Ltd., Medawar Centre, Oxford Science Park, Oxford OX4 4GA, UK
  • Pages: 173-180
    |
    Published online on: December 15, 2010
       https://doi.org/10.3892/ijmm.2010.583
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Abstract

This study describes a combined gene and cell therapy based on the genetic modification of primary human macrophages, as a treatment for cancer. Here, we have utilised the tumour-infiltrating properties of macrophages as vehicles to deliver a gene encoding a prodrug-activating enzyme such as human cytochrome P450 2B6 (CYP2B6) inside tumours followed by killing the tumour cells with the prodrug cyclophosphamide (CPA). Macrophages were transduced with an adenoviral vector that expresses human cytochrome CYP2B6 via a synthetic hypoxia responsive promoter (OBHRE) and with human P450 reductase (P450R), via the CMV promoter. In the presence of CPA, these genetically modified macrophages showed increased cytotoxicity against various tumour cell lines compared to untransduced macrophages or macrophages transduced with CYP2B6 alone. In human ovarian carcinoma xenograft models, the median survival of mice treated with genetically modified macophages plus CPA increased up to two-fold compared to the survival of mice treated with untransduced macrophages and CPA. Genetically modified autologous macrophages may be a feasible therapeutic option for the treatment of some solid tumours, such as ovarian cancer.

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Copy and paste a formatted citation
Spandidos Publications style
Kan O, Day D, Iqball S, Burke F, Grimshaw MJ, Naylor S and Binley K: Genetically modified macrophages expressing hypoxia regulated cytochrome P450 and P450 reductase for the treatment of cancer. Int J Mol Med 27: 173-180, 2011.
APA
Kan, O., Day, D., Iqball, S., Burke, F., Grimshaw, M.J., Naylor, S., & Binley, K. (2011). Genetically modified macrophages expressing hypoxia regulated cytochrome P450 and P450 reductase for the treatment of cancer. International Journal of Molecular Medicine, 27, 173-180. https://doi.org/10.3892/ijmm.2010.583
MLA
Kan, O., Day, D., Iqball, S., Burke, F., Grimshaw, M. J., Naylor, S., Binley, K."Genetically modified macrophages expressing hypoxia regulated cytochrome P450 and P450 reductase for the treatment of cancer". International Journal of Molecular Medicine 27.2 (2011): 173-180.
Chicago
Kan, O., Day, D., Iqball, S., Burke, F., Grimshaw, M. J., Naylor, S., Binley, K."Genetically modified macrophages expressing hypoxia regulated cytochrome P450 and P450 reductase for the treatment of cancer". International Journal of Molecular Medicine 27, no. 2 (2011): 173-180. https://doi.org/10.3892/ijmm.2010.583
Copy and paste a formatted citation
x
Spandidos Publications style
Kan O, Day D, Iqball S, Burke F, Grimshaw MJ, Naylor S and Binley K: Genetically modified macrophages expressing hypoxia regulated cytochrome P450 and P450 reductase for the treatment of cancer. Int J Mol Med 27: 173-180, 2011.
APA
Kan, O., Day, D., Iqball, S., Burke, F., Grimshaw, M.J., Naylor, S., & Binley, K. (2011). Genetically modified macrophages expressing hypoxia regulated cytochrome P450 and P450 reductase for the treatment of cancer. International Journal of Molecular Medicine, 27, 173-180. https://doi.org/10.3892/ijmm.2010.583
MLA
Kan, O., Day, D., Iqball, S., Burke, F., Grimshaw, M. J., Naylor, S., Binley, K."Genetically modified macrophages expressing hypoxia regulated cytochrome P450 and P450 reductase for the treatment of cancer". International Journal of Molecular Medicine 27.2 (2011): 173-180.
Chicago
Kan, O., Day, D., Iqball, S., Burke, F., Grimshaw, M. J., Naylor, S., Binley, K."Genetically modified macrophages expressing hypoxia regulated cytochrome P450 and P450 reductase for the treatment of cancer". International Journal of Molecular Medicine 27, no. 2 (2011): 173-180. https://doi.org/10.3892/ijmm.2010.583
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