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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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March 2011 Volume 27 Issue 3

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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March 2011 Volume 27 Issue 3

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Article

Involvement of Cyr61 in the growth, invasiveness and adhesion of esophageal squamous cell carcinoma cells

  • Authors:
    • Jian-Jun Xie
    • Li-Yan Xu
    • Yang-Min Xie
    • Ze-Peng Du
    • Cai-Hua Feng
    • Hui Dong
    • En-Min Li

  • View Affiliations / Copyright

    Affiliations: Department of Biochemistry and Molecular Biology, Medical College of Shantou University, Shantou 515041, P.R. China
  • Pages: 429-434
    |
    Published online on: January 18, 2011
       https://doi.org/10.3892/ijmm.2011.603
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Abstract

Cysteine-rich 61 (Cyr61), a secreted protein which belongs to the CCN family, has been found to be differentially expressed in many cancers and to be involved in tumor progression. The expression of Cyr61 in esophageal squamous cell carcinoma (ESCC) has only recently been described, but the roles of Cyr61 in ESCC cells still remained unclear. In this study, we have shown that there are high levels of Cyr61 in ESCC cell lines. Furthermore, using RNA interference (RNAi), we stably silenced the expression of Cyr61 in EC109 cells, an ESCC cell line. The colony formation, MTT, cell migration, cell invasiveness and cell adhesion assays were employed to address the roles of Cyr61 in the growth, migration and adhesion of ESCC cells. The results have shown that Cyr61 knockdown by RNAi leads to a significant reduction of colony formation and cell growth. The migration and invasiveness ability of EC109 cells were also suppressed with the Cyr61 down-regulation. Furthermore, the adhesion of the EC109 cells was decreased in the Cyr61 knockdown cells compared to the control cells. Taken together, our data suggest that Cyr61 may play crucial roles in regulating neoplasm progression of ESCC.

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Copy and paste a formatted citation
Spandidos Publications style
Xie J, Xu L, Xie Y, Du Z, Feng C, Dong H and Li E: Involvement of Cyr61 in the growth, invasiveness and adhesion of esophageal squamous cell carcinoma cells. Int J Mol Med 27: 429-434, 2011.
APA
Xie, J., Xu, L., Xie, Y., Du, Z., Feng, C., Dong, H., & Li, E. (2011). Involvement of Cyr61 in the growth, invasiveness and adhesion of esophageal squamous cell carcinoma cells. International Journal of Molecular Medicine, 27, 429-434. https://doi.org/10.3892/ijmm.2011.603
MLA
Xie, J., Xu, L., Xie, Y., Du, Z., Feng, C., Dong, H., Li, E."Involvement of Cyr61 in the growth, invasiveness and adhesion of esophageal squamous cell carcinoma cells". International Journal of Molecular Medicine 27.3 (2011): 429-434.
Chicago
Xie, J., Xu, L., Xie, Y., Du, Z., Feng, C., Dong, H., Li, E."Involvement of Cyr61 in the growth, invasiveness and adhesion of esophageal squamous cell carcinoma cells". International Journal of Molecular Medicine 27, no. 3 (2011): 429-434. https://doi.org/10.3892/ijmm.2011.603
Copy and paste a formatted citation
x
Spandidos Publications style
Xie J, Xu L, Xie Y, Du Z, Feng C, Dong H and Li E: Involvement of Cyr61 in the growth, invasiveness and adhesion of esophageal squamous cell carcinoma cells. Int J Mol Med 27: 429-434, 2011.
APA
Xie, J., Xu, L., Xie, Y., Du, Z., Feng, C., Dong, H., & Li, E. (2011). Involvement of Cyr61 in the growth, invasiveness and adhesion of esophageal squamous cell carcinoma cells. International Journal of Molecular Medicine, 27, 429-434. https://doi.org/10.3892/ijmm.2011.603
MLA
Xie, J., Xu, L., Xie, Y., Du, Z., Feng, C., Dong, H., Li, E."Involvement of Cyr61 in the growth, invasiveness and adhesion of esophageal squamous cell carcinoma cells". International Journal of Molecular Medicine 27.3 (2011): 429-434.
Chicago
Xie, J., Xu, L., Xie, Y., Du, Z., Feng, C., Dong, H., Li, E."Involvement of Cyr61 in the growth, invasiveness and adhesion of esophageal squamous cell carcinoma cells". International Journal of Molecular Medicine 27, no. 3 (2011): 429-434. https://doi.org/10.3892/ijmm.2011.603
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