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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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June 2011 Volume 27 Issue 6

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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June 2011 Volume 27 Issue 6

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Article

Activated protein C inhibits bisphosphonate-induced endothelial cell death via the endothelial protein C receptor and nuclear factor-κB pathways

  • Authors:
    • Jae-Won Seol
    • You-Jin Lee
    • Christopher J. Jackson
    • Philip N. Sambrook
    • Sang-Youel Park

  • View Affiliations / Copyright

    Affiliations: Center for Healthcare Technology Development, Bio-Safety Research Institute, College of Veterinary Medicine, Chonbuk National University, Jeonju, Jeonbuk 561-756, Republic of Korea, College of Veterinary Medicine, Chonbuk National University, Jeonju, Jeonbuk 561-756, Republic of Korea
  • Pages: 835-840
    |
    Published online on: March 17, 2011
       https://doi.org/10.3892/ijmm.2011.649
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Abstract

Bisphosphonates promote apoptosis of cancer cells as well as osteoclasts in bone metastatic sites, but several clinical trials and high concentration treatment have shown that bisphosphonates have side effects that include bone loss and damage to normal cells. The aim of this study was to elucidate the protective effect and the possible mechanism of activated protein C (APC) against bisphosphonate-induced cell damage using primary cultured human umbilical vein endothelial cells (HUVECs). HUVECs were treated with APC (10 μg/ml) for 1 h, and then treated with bisphosphonates including alendronate, zoledronate and pamidronate. Bisphosphonates induced cell death in HUVECs but the cell death was blocked by treatment with APC. Bisphosphonates markedly induced caspase-3 activaion, which was diminished in cells exposed to APC. Matrix metalloproteinase-2 (MMP-2) reduction and nuclear factor-κB (NF-κB) activation induced by bisphosphonates in HUVECs were also blocked by APC treatment. Furthermore, APC highly induced the expression of the endothelial protein c receptor (EPCR) in HUVEC cells. In conclusion, the present study demonstrates that APC inhibits bisphosphonate-induced endothelial cell death via EPCR-induced inactivation of caspase-3 and NF-κB, and also suggests that APC has the potential to be a therapeutic drug in various vascular diseases induced by endothelial cell damage.

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Copy and paste a formatted citation
Spandidos Publications style
Seol J, Lee Y, Jackson CJ, Sambrook PN and Park S: Activated protein C inhibits bisphosphonate-induced endothelial cell death via the endothelial protein C receptor and nuclear factor-κB pathways. Int J Mol Med 27: 835-840, 2011.
APA
Seol, J., Lee, Y., Jackson, C.J., Sambrook, P.N., & Park, S. (2011). Activated protein C inhibits bisphosphonate-induced endothelial cell death via the endothelial protein C receptor and nuclear factor-κB pathways. International Journal of Molecular Medicine, 27, 835-840. https://doi.org/10.3892/ijmm.2011.649
MLA
Seol, J., Lee, Y., Jackson, C. J., Sambrook, P. N., Park, S."Activated protein C inhibits bisphosphonate-induced endothelial cell death via the endothelial protein C receptor and nuclear factor-κB pathways". International Journal of Molecular Medicine 27.6 (2011): 835-840.
Chicago
Seol, J., Lee, Y., Jackson, C. J., Sambrook, P. N., Park, S."Activated protein C inhibits bisphosphonate-induced endothelial cell death via the endothelial protein C receptor and nuclear factor-κB pathways". International Journal of Molecular Medicine 27, no. 6 (2011): 835-840. https://doi.org/10.3892/ijmm.2011.649
Copy and paste a formatted citation
x
Spandidos Publications style
Seol J, Lee Y, Jackson CJ, Sambrook PN and Park S: Activated protein C inhibits bisphosphonate-induced endothelial cell death via the endothelial protein C receptor and nuclear factor-κB pathways. Int J Mol Med 27: 835-840, 2011.
APA
Seol, J., Lee, Y., Jackson, C.J., Sambrook, P.N., & Park, S. (2011). Activated protein C inhibits bisphosphonate-induced endothelial cell death via the endothelial protein C receptor and nuclear factor-κB pathways. International Journal of Molecular Medicine, 27, 835-840. https://doi.org/10.3892/ijmm.2011.649
MLA
Seol, J., Lee, Y., Jackson, C. J., Sambrook, P. N., Park, S."Activated protein C inhibits bisphosphonate-induced endothelial cell death via the endothelial protein C receptor and nuclear factor-κB pathways". International Journal of Molecular Medicine 27.6 (2011): 835-840.
Chicago
Seol, J., Lee, Y., Jackson, C. J., Sambrook, P. N., Park, S."Activated protein C inhibits bisphosphonate-induced endothelial cell death via the endothelial protein C receptor and nuclear factor-κB pathways". International Journal of Molecular Medicine 27, no. 6 (2011): 835-840. https://doi.org/10.3892/ijmm.2011.649
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