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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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August 2011 Volume 28 Issue 2

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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August 2011 Volume 28 Issue 2

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Article

Selective leukemia cell death by activation of the double-stranded RNA-dependent protein kinase PKR

  • Authors:
    • Ya-Juan Li
    • Jian-Ming Zeng
    • Shi-Feng Huang
    • Xiao-Zhong Wang
    • Shi-Qiao Zhao
    • Wei-Jun Bai
    • Wei-Xi Cao
    • Zong-Gan Huang
    • Wen-Li Feng

  • View Affiliations / Copyright

    Affiliations: Department of Clinical Hematology, Key Laboratory of Laboratory Medical Diagnostics, Ministry of Education, Chongqing 400016, P.R. China, Department of Clinical Hematology, Key Laboratory of Laboratory Medical Diagnostics, Ministry of Education, Chongqing Medical University, Chongqing 400016, P.R. China
  • Pages: 215-222
    |
    Published online on: April 4, 2011
       https://doi.org/10.3892/ijmm.2011.666
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Abstract

Deregulated activity of the BCR-ABL tyrosine kinase encoded by the Bcr-Abl oncogene represents an important therapeutic target for all the chronic myelogenous leukemia (CML) phases. In this study, we sought to identify targeted PKR activation by Bcr-Abl AS RNA, an anti-sense RNA complementary to the unique mRNA fragments flanking the fusion point of Bcr-Abl, which can be used as an effective anti-leukemia strategy in K562 cells. Moreover, we observed expression of Bcr-Abl AS RNA in K562 cells which resulted in selective apoptosis induction through specific activation of PKR, leading to phosphorylation of eIF2α, global inhibition of protein synthesis, caspase-8 activation and BAX up-regulation. The targeted PKR activation and induced apoptosis were reversed by the PKR inhibitor 2-aminopurine. Taken together, our results indicate that targeted PKR activation led to selective apoptosis induction in K562 cells, which correlated with caspase-8 activity and enhanced expression of BAX.

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Copy and paste a formatted citation
Spandidos Publications style
Li Y, Zeng J, Huang S, Wang X, Zhao S, Bai W, Cao W, Huang Z and Feng W: Selective leukemia cell death by activation of the double-stranded RNA-dependent protein kinase PKR. Int J Mol Med 28: 215-222, 2011.
APA
Li, Y., Zeng, J., Huang, S., Wang, X., Zhao, S., Bai, W. ... Feng, W. (2011). Selective leukemia cell death by activation of the double-stranded RNA-dependent protein kinase PKR. International Journal of Molecular Medicine, 28, 215-222. https://doi.org/10.3892/ijmm.2011.666
MLA
Li, Y., Zeng, J., Huang, S., Wang, X., Zhao, S., Bai, W., Cao, W., Huang, Z., Feng, W."Selective leukemia cell death by activation of the double-stranded RNA-dependent protein kinase PKR". International Journal of Molecular Medicine 28.2 (2011): 215-222.
Chicago
Li, Y., Zeng, J., Huang, S., Wang, X., Zhao, S., Bai, W., Cao, W., Huang, Z., Feng, W."Selective leukemia cell death by activation of the double-stranded RNA-dependent protein kinase PKR". International Journal of Molecular Medicine 28, no. 2 (2011): 215-222. https://doi.org/10.3892/ijmm.2011.666
Copy and paste a formatted citation
x
Spandidos Publications style
Li Y, Zeng J, Huang S, Wang X, Zhao S, Bai W, Cao W, Huang Z and Feng W: Selective leukemia cell death by activation of the double-stranded RNA-dependent protein kinase PKR. Int J Mol Med 28: 215-222, 2011.
APA
Li, Y., Zeng, J., Huang, S., Wang, X., Zhao, S., Bai, W. ... Feng, W. (2011). Selective leukemia cell death by activation of the double-stranded RNA-dependent protein kinase PKR. International Journal of Molecular Medicine, 28, 215-222. https://doi.org/10.3892/ijmm.2011.666
MLA
Li, Y., Zeng, J., Huang, S., Wang, X., Zhao, S., Bai, W., Cao, W., Huang, Z., Feng, W."Selective leukemia cell death by activation of the double-stranded RNA-dependent protein kinase PKR". International Journal of Molecular Medicine 28.2 (2011): 215-222.
Chicago
Li, Y., Zeng, J., Huang, S., Wang, X., Zhao, S., Bai, W., Cao, W., Huang, Z., Feng, W."Selective leukemia cell death by activation of the double-stranded RNA-dependent protein kinase PKR". International Journal of Molecular Medicine 28, no. 2 (2011): 215-222. https://doi.org/10.3892/ijmm.2011.666
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