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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Journal Cover
August 2011 Volume 28 Issue 2

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Journal Metrics

Impact Factor: 5.8

CiteScore: 13.2

CiteScore Rank: Q1: #23/348 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 1.28

SCImago Journal Rank (SJR): 1.381

Article Open Access

Identification of biological functions and gene networks regulated by heat stress in U937 human lymphoma cells

Yukihiro Furusawa, Yoshiaki Tabuchi, Shigehito Wada, Ichiro Takasaki, Kenzo Ohtsuka, Takashi Kondo
Pages: 143-151
Published online on: 20 May 2011

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Article Open Access

Alteration of the proteome profile of the pancreas in diabetic rats induced by streptozotocin

Yong-Liang Jiang, You Ning, Xiao-Lei Ma, Yan-Yan Liu, Yu Wang, Zeng Zhang, Chun-Xiao Shan, Yu-Dong Xu, Lei-Miao Yin, Yong-Qing Yang
Pages: 153-160
Published online on: 09 May 2011

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Article

Dynamin-related protein 1 is implicated in endoplasmic reticulum stress-induced pancreatic β-cell apoptosis

Liang Peng, Xiuli Men, Wenjian Zhang, Haiyan Wang, Shiqing  Xu, Mei Xu, Yaping Xu, Wenying Yang, Jinning Lou
Pages: 161-169
Published online on: 28 April 2011

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Article

GATA binding protein 3 overexpression and suppression significantly contribute to the regulation of allergic skin inflammation

Chang Jun Bae, Jae Won Lee, Sun Bo Shim, Seung Wan Jee, Su Hae Lee, Jong Min Woo, Chang Kyu Lee, Dae Youn Hwang
Pages: 171-179
Published online on: 28 April 2011

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Article

Role of periostin in cancer progression and metastasis: Inhibition of breast cancer progression and metastasis by anti-periostin antibody in a murine model

Mariko Kyutoku, Yoshiaki Taniyama, Naruto Katsuragi, Hideo Shimizu, Yasuo Kunugiza, Kazuma Iekushi, Nobutaka Koibuchi, Fumihiro Sanada, Yoshihiro Oshita, Ryuichi Morishita
Pages: 181-186
Published online on: 26 May 2011

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Article

Effects of sivelestat on bronchial inflammatory responses after esophagectomy

Keisuke Yamaguchi, Yusuke Sugasawa, Kazuyo Takeuchi, Toyoki Kugimiya, Seiichiro Kumakura, Yoshimi Iwanuma, Yoshiaki Kajiyama, Masahiko Tsurumaru, Isao Nagaoka, Eiichi Inada
Pages: 187-192
Published online on: 06 May 2011

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Article

Fasudil, a Rho-associated protein kinase inhibitor, attenuates retinal ischemia and reperfusion injury in rats Expression of Concern in /10.3892/ijmm.2026.5803

Haishan Song, Dianwen Gao
Pages: 193-198
Published online on: 30 March 2011

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Article

Transcription factor decoy against NFATc1 in human primary osteoblasts

Letizia Penolazzi, Gina Lisignoli, Elisabetta Lambertini, Elena Torreggiani, Cristina Manferdini, Andrea Lolli, Renata Vecchiatini, Francesca Ciardo, Elena Gabusi, Andrea Facchini, Roberto Gambari, Roberta Piva
Pages: 199-206
Published online on: 16 May 2011

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Aging reduces susceptibility of vascular smooth muscle cells to H2O2-induced apoptosis through the down-regulation of Jagged1 expression in endothelial cells

Dehui Qian, Xiaojing Wu, Hong Jiang, Pan Gao, Chunyan Kuang, Kui Wang, Lan Huang
Pages: 207-213
Published online on: 13 April 2011

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Selective leukemia cell death by activation of the double-stranded RNA-dependent protein kinase PKR

Ya-Juan Li, Jian-Ming Zeng, Shi-Feng Huang, Xiao-Zhong Wang, Shi-Qiao Zhao, Wei-Jun Bai, Wei-Xi Cao, Zong-Gan Huang, Wen-Li Feng
Pages: 215-222
Published online on: 04 April 2011

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Aβ-42 deposition significantly increases the insolubility of synaptophysin in the brains of hAPPsw/hPS2m double transgenic mice

Dae Youn Hwang, Seung Wan Jee, Su Hae Lee, Chang Jun Bae, Jun Seo Goo, Jee Eun Kim, So Hee Nam, Sun Il Choi, Hye Ryun Lee, Sun Bo Shim, Mi Hee Park, Jin Tae Hong, Hye Sung Kim
Pages: 223-229
Published online on: 13 April 2011

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Estrogen induces cardioprotection in male C57BL/6J mice after acute myocardial infarction via decreased activity of matrix metalloproteinase-9 and increased Akt-Bcl-2 anti-apoptotic signaling

Jiumei Cao, Tianqi Zhu, Lin Lu, Liang Geng, Lingjie Wang, Qi Zhang, Ke Yang, Haibo Wang, Weifeng Shen
Pages: 231-237
Published online on: 20 April 2011

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Article

Ultraviolet A exposure induces reversible disruption of gap junction intercellular communication in lens epithelial cells

Dayang Wu, Jiangyue Zhao, Di Wu, Jinsong Zhang
Pages: 239-245
Published online on: 31 March 2011

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Article

MMP-2 and MMP-9 are prominent matrix metalloproteinases during atherosclerosis development in the Ldlr-/-Apob100/100 mouse

Dick Wågsäter, Chaoyong Zhu, Johan Björkegren, Josefin Skogsberg, Per Eriksson
Pages: 247-253
Published online on: 06 May 2011

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Up-regulation of Foxo4 mediated by hepatitis B virus X protein confers resistance to oxidative stress-induced cell death

Ratakorn Srisuttee, Sang Seok Koh, Eun Hee Park, Il-Rae Cho, Hye Jin Min, Byung Hak Jhun, Dae-Yeul Yu, Sun Park, Do Yun Park, Mi Ock Lee, Diego H. Castrillon, Randal N. Johnston, Young-Hwa Chung
Pages: 255-260
Published online on: 11 May 2011

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Modulatory activities of Agelanthus dodoneifolius (Loranthaceae) extracts on stimulated equine neutrophils and myeloperoxidase activity

Raïnatou Boly, Stéphanie Dessy, Stephan Kohnen, Félix Kini, Marius Lompo, Ange Mouithys-Mickalad, Innocent Pierre Guissou, Jacques Dubois, Ginette Deby-Dupont, Didier Serteyn, Thierry Franck
Pages: 261-270
Published online on: 09 May 2011

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Article

Single impact trauma in human early-stage osteoarthritic cartilage: Implication of prostaglandin D2 but no additive effect of IL-1β on cell survival

Helga Joos, Cathrin Hogrefe, Lucia Rieger, Lutz Dürselen, Anita Ignatius, Rolf E. Brenner
Pages: 271-277
Published online on: 06 May 2011

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Journal Cover
May-2026 Volume 57 Issue 5

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Journal Metrics

Impact Factor: 5.8

CiteScore: 13.2

CiteScore Rank: Q1: #23/348 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 1.28

SCImago Journal Rank (SJR): 1.381

Article Open Access

Macrophage SH3 domain‑containing GRB2‑like protein B1 is required for Rab7‑mediated mitophagy in inflammation during sea water drowning acute lung injury

Hongjuan Ning, Jingyu Deng, Yongheng Gao, Wei Zhang, Jian Chen, Xian Guo, Faguang Jin
Article Number: 138
Published online on: 24 March 2026

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Deferoxamine mitigates neuronal loss following spinal cord injury via ferroptosis inhibition and Nrf2/HO‑1 pathway activation

Ziqian Ma, Xinwei Zhang, Tao Liu, Yan Zhang, Guanghao Li, Xin Yuan, Benqiang Tang, Hangyi Zhao, Liang Liu, Xueming Chen
Article Number: 137
Published online on: 23 March 2026

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Review Open Access

USP10 deubiquitinase: Physiological function, diseases and therapeutic target (Review)

Linlin Zhang, Huajing Sun, Zifan Wang, Zhimei Wang, Qiang Mu, Yukun Liu
Article Number: 136
Published online on: 23 March 2026

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Siglec‑15 dysregulation and its therapeutic implications in new‑onset type 1 diabetes 

Heming Guo, Yunwen Tao, Sicheng Li, Ying Gu, Yiting Huang, Chen Fang, Ji Hu
Article Number: 135
Published online on: 20 March 2026

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ZEB1 maintains mitochondrial fission and macrophage efferocytosis by restraining MFN2, thereby limiting inflammation and improving tendon‑bone healing

Yan Zhao, Yuankai Zhang, Tian Lei, Shangqing Zhang, Kai Nan, Xin Zhang, Li-Hong Fan
Article Number: 134
Published online on: 19 March 2026

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Targeting pyroptosis in renal fibrosis: From molecular mechanisms to therapeutic horizons (Review)

Yihuai Tian, Quwu Mushuo, Hui Fan, Hongwei Su, Jianchun Li, Qiong Zhang
Article Number: 133
Published online on: 19 March 2026

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Expression of Concern Open Access

[Expression of Concern] Fasudil, a Rho‑associated protein kinase inhibitor, attenuates retinal ischemia and reperfusion injury in rats

Haishan Song, Dianwen Gao
Article Number: 132
Published online on: 18 March 2026

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Epigenetic regulation in a high-sugar environment (Review)

Huili Zhou, Xinhe Lv, Yu Liang, Dehai Yu, Wanning Wang
Article Number: 131
Published online on: 17 March 2026

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The roles and heterogeneity of CD8+ T cells in inflammatory bowel disease: A narrative review of insights from single‑cell transcriptomics (Review)

Rui Zhong, Jing Guo, Wujie Ye, Zhihui Deng, Huangan Wu, Qin Qi, Guona Li, Lu Zhu, Yan Huang, Luyi Wu
Article Number: 130
Published online on: 17 March 2026

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Mechanism of action and clinical application of autophagy in multiple sclerosis (Review)

Dongmei Wang, Qizhi Fu, Ying Zhao, Guangda Li, Yongjie Bai, Yang Yang, Hongna Song, Mingwei Wang, Hua Fan
Article Number: 129
Published online on: 17 March 2026

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Expression of Concern Open Access

[Expression of Concern] Insulin‑dependent diabetes mellitus decreases osteoblastogenesis associated with the inhibition of Wnt signaling through increased expression of Sost and Dkk1 and inhibition of Akt activation

Mamiko Hie, Natsumi Iitsuka, Tomoyo Otsuka, Ikuyo Tsukamoto
Article Number: 128
Published online on: 16 March 2026

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Mechanotransduction and its impact on regenerative medicine in orthopedic rehabilitation (Review)

Baohui Wang, Xueqin Zeng, Huajian Liu, Liang Li, Tao Lei, Yafeng Li, Qing Fang, Yi Cao, Bo Dong
Article Number: 127
Published online on: 13 March 2026

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4‑Acetylantrocamol LT3 suppresses colorectal cancer growth and metastasis via PI3K/AKT and MAPK pathway modulation

Kuen-Tze Lin, Yu-Chieh Hsieh, Pi-Kai Chang, Chih-Wei Lai, Shih-Yu Lee, I-Chuan Yen
Article Number: 126
Published online on: 13 March 2026

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Roles of ubiquitin‑specific peptidase 22 in cellular fate: From embryonic survival to tissue repair, inflammation and metabolism (Review)

Jia-Nan Xiang, Chen-Yang Zhou, Yu-Di Zhao, Xiao Xu, Sun-Bin Ling
Article Number: 125
Published online on: 12 March 2026

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m6A in adipose tissue inflammation: A novel regulator of obesity and metabolic diseases (Review)

Xiaoting Yang, Xiaodan Wang, Haojun Tang, Shuangxi Tu, Kai Yin, Xiao Zhu
Article Number: 124
Published online on: 12 March 2026

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Expression of Concern Open Access

[Expression of Concern] Visfatin/PBEF/Nampt induces EMMPRIN and MMP‑9 production in macrophages via the NAMPT‑MAPK (p38, ERK1/2)‑NF‑κB signaling pathway

Yuqi Fan, Shu Meng, Yue Wang, Jiatian Cao, Changqian Wang
Article Number: 123
Published online on: 12 March 2026

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Article Open Access

IL‑37/IL‑1R8 blocks keratinocyte acantholysis via suppressing ADAM17/EGFR

Fengxia Hu, Wenjing Chen, Qian Wang, Xiaoyu Zhang, Fuyang Xiao, Jinying Zhang, Junqin Liang
Article Number: 122
Published online on: 12 March 2026

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Reactive oxygen species in fetal growth restriction mechanisms and therapeutic directions (Review)

Di Cheng, Songbin Yang, Cuilan Wang, Kefeng Fan, Fengchun Gao, Qian Sun
Article Number: 121
Published online on: 12 March 2026

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Research progress on the molecular mechanisms of tanshinone IIA in the treatment of cardiovascular and cerebrovascular diseases (Review)

Wen Pei, Ping Lu, Chenhuan Ding, Ying Li, Yong Li
Article Number: 120
Published online on: 12 March 2026

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Ferritin in ferroptosis: Implications for neurodegenerative diseases (Review)

Wenjing Chen, Heng Tian, Ran Wei, Xiaomei Chen, Yiwen Jia
Article Number: 119
Published online on: 12 March 2026

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Correction Open Access

[Corrigendum] Ursolic acid protects against cisplatin‑induced ototoxicity by inhibiting oxidative stress and TRPV1‑mediated Ca2+‑signaling  

Yang Di, Tao Xu, Yuan Tian, Tingting Ma, Donghao Qu, Yan Wang, Yuhan Lin, Dongyan Bao, Li Yu, Shuangyue Liu, Aimei Wang
Article Number: 118
Published online on: 09 March 2026

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HELLS inhibits autophagy‑dependent ferroptosis in nasopharyngeal carcinoma by modulating the Nrf2/HO‑1/GPX4 pathway

Chengxun Jin, Jinqiu Li, Siqi Han, Chaoluomeng Bai, Jingpu Yang, Zonggui Wang
Article Number: 117
Published online on: 09 March 2026

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Expression of Concern Open Access

[Expression of Concern] Inhibitory effect of curcumin on angiogenesis in ectopic endometrium of rats with experimental endometriosis

Ying Zhang, Hong Cao, Yue-Yue Hu, Hua Wang, Chang-Jun Zhang
Article Number: 116
Published online on: 09 March 2026

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Article Open Access

Propofol upregulates MFG‑E8 in BV2 cells to inhibit pyroptosis mediated by the NF‑κB/NLRP3 pathway, thereby ameliorating ischemic‑reperfusion neuronal injury

Shewei Guo, Yingwei Zhen, Guosheng Zhou, Zhihua Zhao
Article Number: 115
Published online on: 05 March 2026

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Exosomal circ0000549 promotes MNNG‑induced gastric cancer through miR‑15b‑5p/KIF1B

Zhaofeng Liang, Zihan Gao, Yue Zhang, Jiajia Song, Hui Qian, Xuezhong Xu
Article Number: 114
Published online on: 04 March 2026

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Expression of Concern Open Access

[Expression of Concern] Syringin prevents cardiac hypertrophy induced by pressure overload through the attenuation of autophagy  

Fangfang Li, Ning Zhang, Qingqing Wu, Yuan Yuan, Zheng Yang, Mengqiao Zhou, Jinxiu Zhu, Qizhu Tang
Article Number: 113
Published online on: 04 March 2026

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Treatment of pulmonary fibrosis: From disease mechanisms to future novel therapies (Review)

Sen Lu, Yunfei Liu, Xiaohua Li, Qipeng Yao
Article Number: 112
Published online on: 03 March 2026

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Research progress in single‑cell omics technologies for kidney disease (Review)

Jia Xu, Ziwei Chen, Shengyao Li, Xiaoya Wang, Ming Chen
Article Number: 111
Published online on: 03 March 2026

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CLDN7: Epithelial gatekeeper from physiology to pathology‑roles in cancer and epithelial‑related diseases (Review)

Xiuping Lai, Yan Yan, Lu Sun, Zili Lei, Yanhong Yang
Article Number: 110
Published online on: 03 March 2026

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Dynamic regulation and targeted intervention of neutrophils in hepatic ischemia‑reperfusion injury (Review)

Sen Lu, Jiale Tong, Jing Jiang, Qin Zhang, Youjin Huang
Article Number: 109
Published online on: 03 March 2026

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The dual role of the crosstalk between autophagy and ferroptosis in lung cancer treatment: Advances in mechanisms and therapeutic strategies (Review)

Yingying Zhang, Ruxin Shen
Article Number: 108
Published online on: 02 March 2026

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Mechanistic insights into inflammatory cytokines in adenomyosis‑induced infertility (Review)

Bojiao Yang, Feng Li, Guimao Cao, Mingtu Nuo, Yaxin Shi, Zilu Wang, Jing Jia, Wei Shi, Zhiyong Liu
Article Number: 107
Published online on: 02 March 2026

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Correction Open Access

[Corrigendum] Astragaloside IV promotes the proliferation and migration of osteoblast‑like cells through the hedgehog signaling pathway

Li-Hua Guo, Yu Cao, Run-Tao Zhuang, Yan Han, Jun Li
Article Number: 106
Published online on: 02 March 2026

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Journal Cover
June-2026 Volume 57 Issue 6

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Journal Metrics

Impact Factor: 5.8

CiteScore: 13.2

CiteScore Rank: Q1: #23/348 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 1.28

SCImago Journal Rank (SJR): 1.381

Article Open Access

Astragaloside IV targets TUBB4B to inhibit proliferation and promote apoptosis of pituitary tumor cells via the STMN1/ERK pathway

Jiale Li, Yufei Qu, Wenge Zhang, Zexu Yang, Yangdong Zeng, Jisheng Xu, Kuncen Xie, Qi Liu
Article Number: 151
Published online on: 01 April 2026

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Expression of Concern Open Access

[Expression of Concern] Increased expression of heat shock protein 90 under chemical hypoxic conditions protects cardiomyocytes against injury induced by serum and glucose deprivation

Keng Wu, Wenming Xu, Qiong You, Runmin Guo, Jianqiang Feng, Changran Zhang, Wen Wu
Article Number: 150
Published online on: 01 April 2026

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Animal models accurately representing acute liver failure (Review)

Sang Luo, Fang Wu, Yiran Jin, Xiaofen Huang, Dan Liu, Bingren Tian
Article Number: 149
Published online on: 01 April 2026

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Correction Open Access

[Corrigendum] Influence of aspirin on the CX3CL1/CX3CR1 signaling pathway in acute pulmonary embolism 

Zhirong Zhang, Weiji Yang, Rongbiao Ying, Ying Shi, Huifang Jiang, Danli Cai, Jing Kuang, Ruhui Yang, Lingcong Wang
Article Number: 148
Published online on: 31 March 2026

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Targeting pyroptosis to treat aortic aneurysms: From mechanism to drug discovery (Review)

Jing Mao, Mandi Luo, Lei Ruan, Cuntai Zhang
Article Number: 147
Published online on: 31 March 2026

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Role of aging‑related cytokines in neurodegenerative disease (Review)

Xinke Dai, Xinran Rao, Yuandi Wang, Weijiang Zhao
Article Number: 146
Published online on: 31 March 2026

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Expression of Concern Open Access

[Expression of Concern] DTX3L is upregulated in glioma and is associated with glioma progression

Peng Xu, Xuelei Tao, Chengjin Zhao, Qingfeng Huang, Hao Chang, Na Ban, Yuanqi Bei, Xiaojie Xia, Chaoyan Shen, Kun Wang, Li Xu, Peizhang Wu, Jianbing Ren, Donglin Wang
Article Number: 145
Published online on: 30 March 2026

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Role of itaconate in intestinal disease (Review)

Xin Li, Qian Liu, Jiajia Li, Li Zhang, Shun Yao, Lulu Tang, Bingqi Yang, Yongfeng Wang, Guorong Wen, Jiaxing An, Hai Jin, Biguang Tuo
Article Number: 144
Published online on: 27 March 2026

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Expression of Concern Open Access

[Expression of Concern] Involvement of Cyr61 in the growth, invasiveness and adhesion of esophageal squamous cell carcinoma cells

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