Association analysis of DTD1 gene variations with aspirin-intolerance in asthmatics

Pasaje,Charisse  Flerida A.; Bae,Joon  Seol; Park,Byung-Lae; Jang,An-Soo; Uh,Soo-Taek; Kim,Mi-Kyeong; Koh,In  Song; Kim,Jeong-Hyun; Park,Tae-Joon; Lee,Jin-Sol; Kim,Yongha; Park,Choon-Sik; Shin,Hyoung  Doo

doi:10.3892/ijmm.2011.669

July 2011 Volume 28 Issue 1

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July 2011 Volume 28 Issue 1

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Article

Association analysis of DTD1 gene variations with aspirin-intolerance in asthmatics

Authors:
- Charisse Flerida A. Pasaje
- Joon Seol Bae
- Byung-Lae Park
- An-Soo Jang
- Soo-Taek Uh
- Mi-Kyeong Kim
- In Song Koh
- Jeong-Hyun Kim
- Tae-Joon Park
- Jin-Sol Lee
- Yongha Kim
- Choon-Sik Park
- Hyoung Doo Shin
View Affiliations / Copyright

Affiliations: Department of Life Science, Sogang University, Seoul 121-742, Republic of Korea, Division of Allergy and Respiratory Medicine, Soonchunhyang University Seoul Hospital, Seoul 140-743, Republic of Korea
Pages: 129-137
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Published online on: April 6, 2011

https://doi.org/10.3892/ijmm.2011.669
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Abstract

Aspirin ingestion is a common precipitating factor of life-threatening asthma attacks, requiring some patients to undergo mechanical ventilation. The gene, D-tyrosyl-tRNA deacylase 1 (DTD1), may be a risk factor for aspirin-intolerant asthma (AIA) by catalyzing the hydrolysis of D-tryptophan and interacting with the tyrosyl-tRNA synthetase (tyrRS) enzyme, which promotes a pro-inflammatory phenotype. In order to investigate the association of DTD1 variants with the risk of AIA in an asthma cohort, 38 single nucleotide polymorphisms (SNPs) were genotyped and 5 major haplotypes were obtained in 163 AIA cases and 429 aspirin-tolerant asthma (ATA) controls. Differences in DTD1 SNP and haplotype distributions were analyzed using logistic and multiple regression models and were adjusted for age, gender, smoking status, atopy and body mass index (BMI) as covariates. Subsequent analyses revealed no association between DTD1 variants and the risk of AIA. Although nominal evidence of an association was detected between several DTD1 variants and the rate of decline of the forced expiratory volume in the first second (FEV1) in AIA patients (rs6136444, rs6136469, rs6081338 and DTD1_ht5; P=0.01-0.02), the signals reached the threshold of multiple testing corrections, suggesting that DTD1 variants do not affect the abnormalities of the upper airways in AIA patients.

Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Association analysis of DTD1 gene variations with aspirin-intolerance in asthmatics

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