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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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August 2011 Volume 28 Issue 2

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

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Medicine International

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Article

Aging reduces susceptibility of vascular smooth muscle cells to H2O2-induced apoptosis through the down-regulation of Jagged1 expression in endothelial cells

  • Authors:
    • Dehui Qian
    • Xiaojing Wu
    • Hong Jiang
    • Pan Gao
    • Chunyan Kuang
    • Kui Wang
    • Lan Huang

  • View Affiliations / Copyright

    Affiliations: Institute of Cardiovascular Diseases of PLA, Xinqiao Hospital, Third Military Medical University, Chongqing 400037, P.R. China
  • Pages: 207-213
    |
    Published online on: April 13, 2011
       https://doi.org/10.3892/ijmm.2011.671
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Abstract

In addition to excessive proliferation, reduced apoptosis of vascular smooth muscle cells (VSMCs) plays a key role in aging-exaggerated neointima formation after vascular injury. Our previous studies have shown that impaired expression of Jagged1 in the endothelium may be a key event that leads to enhanced VSMC proliferation in the elderly. Here, we are the first to investigate whether the expression of Jagged1 in endothelial cells (ECs) may regulate apoptosis of VSMCs. We discovered that VSMCs co-cultured with senescent ECs exhibited decreased susceptibility to H2O2-induced apoptosis compared with those co-cultured with young ECs. Senescent ECs also displayed lower Jagged1 expression compared to young ECs, which was more evident after H2O2 stimulation. Overexpression of Jagged1 in senescent ECs significantly promoted H2O2-induced apoptosis in the co-cultured VSMCs, whereas silencing Jagged1 expression in young ECs reduced H2O2-induced apoptosis in the co-cultured VSMCs. Our studies also revealed that Jagged1 expressed in ECs exerted its pro-apoptotic activity by lowering expression of the anti-apoptotic protein Bcl-2. These results demonstrate that aging reduces the susceptibility of co-cultured VSMCs to H2O2-induced apoptosis through impaired Jagged1 expression in ECs.

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Copy and paste a formatted citation
Spandidos Publications style
Qian D, Wu X, Jiang H, Gao P, Kuang C, Wang K and Huang L: Aging reduces susceptibility of vascular smooth muscle cells to H2O2-induced apoptosis through the down-regulation of Jagged1 expression in endothelial cells. Int J Mol Med 28: 207-213, 2011.
APA
Qian, D., Wu, X., Jiang, H., Gao, P., Kuang, C., Wang, K., & Huang, L. (2011). Aging reduces susceptibility of vascular smooth muscle cells to H2O2-induced apoptosis through the down-regulation of Jagged1 expression in endothelial cells. International Journal of Molecular Medicine, 28, 207-213. https://doi.org/10.3892/ijmm.2011.671
MLA
Qian, D., Wu, X., Jiang, H., Gao, P., Kuang, C., Wang, K., Huang, L."Aging reduces susceptibility of vascular smooth muscle cells to H2O2-induced apoptosis through the down-regulation of Jagged1 expression in endothelial cells". International Journal of Molecular Medicine 28.2 (2011): 207-213.
Chicago
Qian, D., Wu, X., Jiang, H., Gao, P., Kuang, C., Wang, K., Huang, L."Aging reduces susceptibility of vascular smooth muscle cells to H2O2-induced apoptosis through the down-regulation of Jagged1 expression in endothelial cells". International Journal of Molecular Medicine 28, no. 2 (2011): 207-213. https://doi.org/10.3892/ijmm.2011.671
Copy and paste a formatted citation
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Spandidos Publications style
Qian D, Wu X, Jiang H, Gao P, Kuang C, Wang K and Huang L: Aging reduces susceptibility of vascular smooth muscle cells to H2O2-induced apoptosis through the down-regulation of Jagged1 expression in endothelial cells. Int J Mol Med 28: 207-213, 2011.
APA
Qian, D., Wu, X., Jiang, H., Gao, P., Kuang, C., Wang, K., & Huang, L. (2011). Aging reduces susceptibility of vascular smooth muscle cells to H2O2-induced apoptosis through the down-regulation of Jagged1 expression in endothelial cells. International Journal of Molecular Medicine, 28, 207-213. https://doi.org/10.3892/ijmm.2011.671
MLA
Qian, D., Wu, X., Jiang, H., Gao, P., Kuang, C., Wang, K., Huang, L."Aging reduces susceptibility of vascular smooth muscle cells to H2O2-induced apoptosis through the down-regulation of Jagged1 expression in endothelial cells". International Journal of Molecular Medicine 28.2 (2011): 207-213.
Chicago
Qian, D., Wu, X., Jiang, H., Gao, P., Kuang, C., Wang, K., Huang, L."Aging reduces susceptibility of vascular smooth muscle cells to H2O2-induced apoptosis through the down-regulation of Jagged1 expression in endothelial cells". International Journal of Molecular Medicine 28, no. 2 (2011): 207-213. https://doi.org/10.3892/ijmm.2011.671
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