DcR3-TL1A signalling inhibits cytokine-induced proliferation of rheumatoid synovial fibroblasts

  • Authors:
    • Masayasu Takahashi
    • Yasushi Miura
    • Shinya Hayashi
    • Koji Tateishi
    • Koji Fukuda
    • Masahiro Kurosaka
  • View Affiliations

  • Published online on: May 2, 2011     https://doi.org/10.3892/ijmm.2011.687
  • Pages: 423-427
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Abstract

Decoy receptor 3 (DcR3), a member of the tumour necrosis factor receptor (TNFR) superfamily, lacks the transmembrane domain of conventional TNFRs in order to be a secreted protein. DcR3 competitively binds and inhibits members of the TNF family, including Fas ligand (FasL), LIGHT and TL1A. We previously reported that TNFα-induced DcR3 overexpression in rheumatoid synovial fibroblasts (RA-FLS) protects the cells from Fas-induced apoptosis and that DcR3 induces VLA-4 expression in THP-1 macrophages to inhibit cycloheximide-induced apoptosis. Meanwhile, recent studies have suggested that DcR3 acting as a ligand directly induces the differentiation of macrophages to osteoclasts. Therefore, in the present study, we analyzed the direct effects of DcR3 as a ligand in RA-FLS. The experiments showed that DcR3 binds to TL1A expressed in RA-FLS resulting in the negative regulation of cell proliferation induced by inflammatory cytokines. DcR3-TL1A signalling may be involved in the pathogenesis of rheumatoid arthritis (RA).

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September 2011
Volume 28 Issue 3

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Spandidos Publications style
Takahashi M, Miura Y, Hayashi S, Tateishi K, Fukuda K and Kurosaka M: DcR3-TL1A signalling inhibits cytokine-induced proliferation of rheumatoid synovial fibroblasts. Int J Mol Med 28: 423-427, 2011
APA
Takahashi, M., Miura, Y., Hayashi, S., Tateishi, K., Fukuda, K., & Kurosaka, M. (2011). DcR3-TL1A signalling inhibits cytokine-induced proliferation of rheumatoid synovial fibroblasts. International Journal of Molecular Medicine, 28, 423-427. https://doi.org/10.3892/ijmm.2011.687
MLA
Takahashi, M., Miura, Y., Hayashi, S., Tateishi, K., Fukuda, K., Kurosaka, M."DcR3-TL1A signalling inhibits cytokine-induced proliferation of rheumatoid synovial fibroblasts". International Journal of Molecular Medicine 28.3 (2011): 423-427.
Chicago
Takahashi, M., Miura, Y., Hayashi, S., Tateishi, K., Fukuda, K., Kurosaka, M."DcR3-TL1A signalling inhibits cytokine-induced proliferation of rheumatoid synovial fibroblasts". International Journal of Molecular Medicine 28, no. 3 (2011): 423-427. https://doi.org/10.3892/ijmm.2011.687