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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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August 2011 Volume 28 Issue 2

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

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International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

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Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

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Article Open Access

Alteration of the proteome profile of the pancreas in diabetic rats induced by streptozotocin

  • Authors:
    • Yong-Liang Jiang
    • You Ning
    • Xiao-Lei Ma
    • Yan-Yan Liu
    • Yu Wang
    • Zeng Zhang
    • Chun-Xiao Shan
    • Yu-Dong Xu
    • Lei-Miao Yin
    • Yong-Qing Yang

  • View Affiliations / Copyright

    Affiliations: Yue Yang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200030, P.R. China, Yue Yang Hospital, Shanghai University of Traditional Chinese Medicine, 650 South Wanping Road, Shanghai 200030, P.R. China
  • Pages: 153-160
    |
    Published online on: May 9, 2011
       https://doi.org/10.3892/ijmm.2011.696
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Abstract

Type 1 diabetes mellitus (T1DM) is receiving increased attention. To obtain a better understanding of the mechanism underlying T1DM, we performed a proteomic study on a rat model induced by streptozotocin. Pancreatic proteins were separated by two-dimensional gel electrophoresis. Eighteen protein spots were differentially expressed (P<0.05) with 2-fold or more increased or decreased intensity in the diabetic rats as compared with controls, of which 11 protein spots were up-regulated and 7 protein spots were down-regulated. These protein spots were successfully identified by liquid chromatography-electrospray ionization tandem mass spectrometry. The 60 kDa heat shock protein, the carbonyl reductase 1 (Cbr1), the hydroxyacyl-CoA dehydrogenase, Δ3,5,Δ2,4-dienoyl-CoA isomerase, the elongation factor 1-δ, the 26S protease regulatory subunit 7 and the transitional endoplasmic reticulum ATPase were up-regulated, while the 78 kDa glucose-regulated protein, peroxiredoxin 4 and plakoglobin were down-regulated. The expression change of Cbr1 which is closely related to diabetic complications was further validated by western blotting. Our results and those of the bioinformatics analysis suggest that oxidative stress, the Wnt pathway, fatty acid degradation and glucose transport may be closely related to T1DM.

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Copy and paste a formatted citation
Spandidos Publications style
Jiang Y, Ning Y, Ma X, Liu Y, Wang Y, Zhang Z, Shan C, Xu Y, Yin L, Yang Y, Yang Y, et al: Alteration of the proteome profile of the pancreas in diabetic rats induced by streptozotocin. Int J Mol Med 28: 153-160, 2011.
APA
Jiang, Y., Ning, Y., Ma, X., Liu, Y., Wang, Y., Zhang, Z. ... Yang, Y. (2011). Alteration of the proteome profile of the pancreas in diabetic rats induced by streptozotocin. International Journal of Molecular Medicine, 28, 153-160. https://doi.org/10.3892/ijmm.2011.696
MLA
Jiang, Y., Ning, Y., Ma, X., Liu, Y., Wang, Y., Zhang, Z., Shan, C., Xu, Y., Yin, L., Yang, Y."Alteration of the proteome profile of the pancreas in diabetic rats induced by streptozotocin". International Journal of Molecular Medicine 28.2 (2011): 153-160.
Chicago
Jiang, Y., Ning, Y., Ma, X., Liu, Y., Wang, Y., Zhang, Z., Shan, C., Xu, Y., Yin, L., Yang, Y."Alteration of the proteome profile of the pancreas in diabetic rats induced by streptozotocin". International Journal of Molecular Medicine 28, no. 2 (2011): 153-160. https://doi.org/10.3892/ijmm.2011.696
Copy and paste a formatted citation
x
Spandidos Publications style
Jiang Y, Ning Y, Ma X, Liu Y, Wang Y, Zhang Z, Shan C, Xu Y, Yin L, Yang Y, Yang Y, et al: Alteration of the proteome profile of the pancreas in diabetic rats induced by streptozotocin. Int J Mol Med 28: 153-160, 2011.
APA
Jiang, Y., Ning, Y., Ma, X., Liu, Y., Wang, Y., Zhang, Z. ... Yang, Y. (2011). Alteration of the proteome profile of the pancreas in diabetic rats induced by streptozotocin. International Journal of Molecular Medicine, 28, 153-160. https://doi.org/10.3892/ijmm.2011.696
MLA
Jiang, Y., Ning, Y., Ma, X., Liu, Y., Wang, Y., Zhang, Z., Shan, C., Xu, Y., Yin, L., Yang, Y."Alteration of the proteome profile of the pancreas in diabetic rats induced by streptozotocin". International Journal of Molecular Medicine 28.2 (2011): 153-160.
Chicago
Jiang, Y., Ning, Y., Ma, X., Liu, Y., Wang, Y., Zhang, Z., Shan, C., Xu, Y., Yin, L., Yang, Y."Alteration of the proteome profile of the pancreas in diabetic rats induced by streptozotocin". International Journal of Molecular Medicine 28, no. 2 (2011): 153-160. https://doi.org/10.3892/ijmm.2011.696
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