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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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November 2011 Volume 28 Issue 5

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

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Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

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International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

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Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

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International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

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International Journal of Epigenetics

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Article

Bee venom phospholipase A2 prevents prion peptide induced-cell death in neuronal cells

  • Authors:
    • Jae-Kyo Jeong
    • Myung-Hee Moon
    • Bum-Chul Bae
    • You-Jin Lee
    • Jae-Won Seol
    • Sang-Youel Park

  • View Affiliations / Copyright

    Affiliations: Center for Healthcare Technology Development, Korea Zoonoses Research Institute, College of Veterinary Medicine, Chonbuk National University, Jeonju 561-756, Republic of Korea, College of Veterinary Medicine, Chonbuk National University, Jeonju, Jeonbuk 561-756, Republic of Korea
  • Pages: 867-873
    |
    Published online on: June 23, 2011
       https://doi.org/10.3892/ijmm.2011.730
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Abstract

Bee venom phospholipase A2 (bvPLA2) is a prototypic group III enzyme which consists of unique N-terminal and C-terminal domains and a central secretory PLA2 (sPLA2) domain. This sPLA2 domain is highly homologous with human group III sPLA2. Current evidence suggests that group III sPLA2 may affect some neuronal functions, such as neuritogenesis, neurotransmitter release and neuronal survival. The prion diseases are neurodegenerative disorders characterized by the conversion of the normal cellular prion (PrPC) to the misfolded isoform scrapie prion protein (PrPSc). PrPSc accumulation in the central nervous system (CNS) leads to neurotoxicity by inhibition of the PI3K/AKT pathway or activation of p38 mitogen-activated protein kinase (MAPK) pathways. In the present study, we found that bvPLA2 inhibited prion protein (PrP) fragment (106-126)-induced neuronal cell death. PrP(106-126)-mediated increase of p-p38 MAPK and cleaved caspases and decrease of p-AKT were blocked by bvPLA2 treatment. These results indicate that increasing PLA2, including the group III sPLA2 is key to regulating PrP(106-126)-mediated neurotoxicity. Taken together, the results of this study suggest that specific modulation of PLA2 appears to prevent neuronal cell death caused by prion peptides.

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Copy and paste a formatted citation
Spandidos Publications style
Jeong J, Moon M, Bae B, Lee Y, Seol J and Park S: Bee venom phospholipase A2 prevents prion peptide induced-cell death in neuronal cells. Int J Mol Med 28: 867-873, 2011.
APA
Jeong, J., Moon, M., Bae, B., Lee, Y., Seol, J., & Park, S. (2011). Bee venom phospholipase A2 prevents prion peptide induced-cell death in neuronal cells. International Journal of Molecular Medicine, 28, 867-873. https://doi.org/10.3892/ijmm.2011.730
MLA
Jeong, J., Moon, M., Bae, B., Lee, Y., Seol, J., Park, S."Bee venom phospholipase A2 prevents prion peptide induced-cell death in neuronal cells". International Journal of Molecular Medicine 28.5 (2011): 867-873.
Chicago
Jeong, J., Moon, M., Bae, B., Lee, Y., Seol, J., Park, S."Bee venom phospholipase A2 prevents prion peptide induced-cell death in neuronal cells". International Journal of Molecular Medicine 28, no. 5 (2011): 867-873. https://doi.org/10.3892/ijmm.2011.730
Copy and paste a formatted citation
x
Spandidos Publications style
Jeong J, Moon M, Bae B, Lee Y, Seol J and Park S: Bee venom phospholipase A2 prevents prion peptide induced-cell death in neuronal cells. Int J Mol Med 28: 867-873, 2011.
APA
Jeong, J., Moon, M., Bae, B., Lee, Y., Seol, J., & Park, S. (2011). Bee venom phospholipase A2 prevents prion peptide induced-cell death in neuronal cells. International Journal of Molecular Medicine, 28, 867-873. https://doi.org/10.3892/ijmm.2011.730
MLA
Jeong, J., Moon, M., Bae, B., Lee, Y., Seol, J., Park, S."Bee venom phospholipase A2 prevents prion peptide induced-cell death in neuronal cells". International Journal of Molecular Medicine 28.5 (2011): 867-873.
Chicago
Jeong, J., Moon, M., Bae, B., Lee, Y., Seol, J., Park, S."Bee venom phospholipase A2 prevents prion peptide induced-cell death in neuronal cells". International Journal of Molecular Medicine 28, no. 5 (2011): 867-873. https://doi.org/10.3892/ijmm.2011.730
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