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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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October 2011 Volume 28 Issue 4

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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October 2011 Volume 28 Issue 4

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Article

Id1 induces tubulogenesis by regulating endothelial cell adhesion and cytoskeletal organization through β1-integrin and Rho-kinase signalling

  • Authors:
    • Juhui Qiu
    • Guixue Wang
    • Qin Peng
    • Jianjun Hu
    • Xiangdong Luo
    • Yiming Zheng
    • Yanqun Teng
    • Chaojun Tang

  • View Affiliations / Copyright

    Affiliations: Key Laboratory of Biorheological Science and Technology, Ministry of Education, Chongqing Engineering Laboratory in Vascular Implants, Bioengineering College of Chongqing University, Chongqing 400044, P.R. China
  • Pages: 543-548
    |
    Published online on: July 4, 2011
       https://doi.org/10.3892/ijmm.2011.741
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Abstract

The inhibitor of differentiation 1 (Id1) protein is required for tubulogenesis, but the molecular signalling pathways remain unclear. Overexpression (Id1-t) or down-regulation (si-Id1) of Id-1 in cell lines, were used to study the function of Id1. The expression of Id1 and β1-integrin was assessed by Western blotting. Up-regulation of Id1 in human umbilical vascular endothelial cells (HUVECs) activated the expression of β1-integrin and promoted cell adhesion and spreading. Conversely, down-regulation of Id1 suppressed β1-integrin expression and inhibited tubulogenesis. By using a β1-integrin antibody to inhibit β1-integrin function, we demonstrated that Id1-induced cell adhesion and tubulogenesis were mediated by β1-integrin. In addition, HUVECs overexpressing Id1 were able to promote capillary tube formation through cytoskeleton reorganization and cell contraction. Finally, the Rho-kinase inhibitor Y27632 inhibited tubulo-genesis induced by Id1. Our findings provide evidence that Id1 regulates tubulogenesis in vitro through β1-integrin and Rho-kinase signalling.

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Copy and paste a formatted citation
Spandidos Publications style
Qiu J, Wang G, Peng Q, Hu J, Luo X, Zheng Y, Teng Y and Tang C: Id1 induces tubulogenesis by regulating endothelial cell adhesion and cytoskeletal organization through β1-integrin and Rho-kinase signalling. Int J Mol Med 28: 543-548, 2011.
APA
Qiu, J., Wang, G., Peng, Q., Hu, J., Luo, X., Zheng, Y. ... Tang, C. (2011). Id1 induces tubulogenesis by regulating endothelial cell adhesion and cytoskeletal organization through β1-integrin and Rho-kinase signalling. International Journal of Molecular Medicine, 28, 543-548. https://doi.org/10.3892/ijmm.2011.741
MLA
Qiu, J., Wang, G., Peng, Q., Hu, J., Luo, X., Zheng, Y., Teng, Y., Tang, C."Id1 induces tubulogenesis by regulating endothelial cell adhesion and cytoskeletal organization through β1-integrin and Rho-kinase signalling". International Journal of Molecular Medicine 28.4 (2011): 543-548.
Chicago
Qiu, J., Wang, G., Peng, Q., Hu, J., Luo, X., Zheng, Y., Teng, Y., Tang, C."Id1 induces tubulogenesis by regulating endothelial cell adhesion and cytoskeletal organization through β1-integrin and Rho-kinase signalling". International Journal of Molecular Medicine 28, no. 4 (2011): 543-548. https://doi.org/10.3892/ijmm.2011.741
Copy and paste a formatted citation
x
Spandidos Publications style
Qiu J, Wang G, Peng Q, Hu J, Luo X, Zheng Y, Teng Y and Tang C: Id1 induces tubulogenesis by regulating endothelial cell adhesion and cytoskeletal organization through β1-integrin and Rho-kinase signalling. Int J Mol Med 28: 543-548, 2011.
APA
Qiu, J., Wang, G., Peng, Q., Hu, J., Luo, X., Zheng, Y. ... Tang, C. (2011). Id1 induces tubulogenesis by regulating endothelial cell adhesion and cytoskeletal organization through β1-integrin and Rho-kinase signalling. International Journal of Molecular Medicine, 28, 543-548. https://doi.org/10.3892/ijmm.2011.741
MLA
Qiu, J., Wang, G., Peng, Q., Hu, J., Luo, X., Zheng, Y., Teng, Y., Tang, C."Id1 induces tubulogenesis by regulating endothelial cell adhesion and cytoskeletal organization through β1-integrin and Rho-kinase signalling". International Journal of Molecular Medicine 28.4 (2011): 543-548.
Chicago
Qiu, J., Wang, G., Peng, Q., Hu, J., Luo, X., Zheng, Y., Teng, Y., Tang, C."Id1 induces tubulogenesis by regulating endothelial cell adhesion and cytoskeletal organization through β1-integrin and Rho-kinase signalling". International Journal of Molecular Medicine 28, no. 4 (2011): 543-548. https://doi.org/10.3892/ijmm.2011.741
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