Open Access

Suppression of Th17 response by Streptococcus thermophilus ST28 through induction of IFN-γ

  • Authors:
    • Tasuku Ogita
    • Yusuke Tanii
    • Hidetoshi Morita
    • Takuya Suzuki
    • Soichi Tanabe
  • View Affiliations

  • Published online on: July 20, 2011     https://doi.org/10.3892/ijmm.2011.755
  • Pages: 817-822
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

The proinflammatory cytokine interleukin (IL)-17 plays important roles in various inflammatory diseases, and IL-17-producing T helper 17 cells (Th17) have received much attention. For therapy of Th17-mediated diseases, some reports have indicated the clinical efficacy of lactic acid bacteria, including Streptococcus thermophilus. In this study, we examined the mechanism for the suppressive effects of S. thermophilus ST28 on the Th17 response in murine splenocytes stimulated with transforming growth factor (TGF)-β plus IL-6. Stimulation with TGF-β plus IL-6 increased mRNA expression of IL-17 and its production in the splenocytes, but ST28 markedly suppressed both. Meanwhile, ST28 increased the mRNA expression of interferon (IFN)-γ as well as its production. Anti-IFN-γ completely cancelled the suppressive effect of ST28 on IL-17 production. From these data, it was concluded that IFN-γ induced by ST28 had an important role on the effect. A genomic DNA (10 µg/ml) from ST28 effectively suppressed IL-17 production, probably via the Toll-like receptor 9. Therefore, modulation of Th1/Th17 balance would be one of the mechanisms under which S. thermophilus ST28 exerts an anti-inflammatory effect.

Related Articles

Journal Cover

November 2011
Volume 28 Issue 5

Print ISSN: 1107-3756
Online ISSN:1791-244X

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Ogita T, Tanii Y, Morita H, Suzuki T and Tanabe S: Suppression of Th17 response by Streptococcus thermophilus ST28 through induction of IFN-γ. Int J Mol Med 28: 817-822, 2011.
APA
Ogita, T., Tanii, Y., Morita, H., Suzuki, T., & Tanabe, S. (2011). Suppression of Th17 response by Streptococcus thermophilus ST28 through induction of IFN-γ. International Journal of Molecular Medicine, 28, 817-822. https://doi.org/10.3892/ijmm.2011.755
MLA
Ogita, T., Tanii, Y., Morita, H., Suzuki, T., Tanabe, S."Suppression of Th17 response by Streptococcus thermophilus ST28 through induction of IFN-γ". International Journal of Molecular Medicine 28.5 (2011): 817-822.
Chicago
Ogita, T., Tanii, Y., Morita, H., Suzuki, T., Tanabe, S."Suppression of Th17 response by Streptococcus thermophilus ST28 through induction of IFN-γ". International Journal of Molecular Medicine 28, no. 5 (2011): 817-822. https://doi.org/10.3892/ijmm.2011.755