Relationship between serum undercarboxylated osteocalcin and hyaluronan levels in patients with bilateral knee osteoarthritis

  • Authors:
    • Kiyohito Naito
    • Taiji Watari
    • Osamu Obayashi
    • Sadanobu Katsube
    • Isao Nagaoka
    • Kazuo Kaneko
  • View Affiliations

  • Published online on: January 26, 2012     https://doi.org/10.3892/ijmm.2012.897
  • Pages: 756-760
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Abstract

Serum undercarboxylated osteocalcin (s-ucOC) is a marker for vitamin K metabolism (deficiency). The aim of this study was to investigate the serum levels of ucOC in patients with bilateral knee osteoarthritis (K-OA), and the correlation between ucOC and other biomarkers for K-OA. A total of 25 patients (22 women, 3 men, mean age 76.0±7.8, range 54-88 years, mean BMI 24.9±4.7) with a Kellgren-Lawrence grade of 3 or 4 for bilateral knee were enrolled in this study. The levels of s-ucOC and other biomarkers were measured. The levels of s-ucOC (5.66±4.70 ng/ml) as well as other cartilage metabolism markers, were elevated in the patients; however, bone metabolism markers were within the normal ranges. Of interest, there was a significant correlation between s-ucOC and serum hyaluronan (a marker for synovitis) (P<0.05). Our findings suggest that vitamin K metabolism may be associated with synovitis in patients with K-OA, and s-ucOC could be a biomarker for K-OA.

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May 2012
Volume 29 Issue 5

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Spandidos Publications style
Naito K, Watari T, Obayashi O, Katsube S, Nagaoka I and Kaneko K: Relationship between serum undercarboxylated osteocalcin and hyaluronan levels in patients with bilateral knee osteoarthritis. Int J Mol Med 29: 756-760, 2012
APA
Naito, K., Watari, T., Obayashi, O., Katsube, S., Nagaoka, I., & Kaneko, K. (2012). Relationship between serum undercarboxylated osteocalcin and hyaluronan levels in patients with bilateral knee osteoarthritis. International Journal of Molecular Medicine, 29, 756-760. https://doi.org/10.3892/ijmm.2012.897
MLA
Naito, K., Watari, T., Obayashi, O., Katsube, S., Nagaoka, I., Kaneko, K."Relationship between serum undercarboxylated osteocalcin and hyaluronan levels in patients with bilateral knee osteoarthritis". International Journal of Molecular Medicine 29.5 (2012): 756-760.
Chicago
Naito, K., Watari, T., Obayashi, O., Katsube, S., Nagaoka, I., Kaneko, K."Relationship between serum undercarboxylated osteocalcin and hyaluronan levels in patients with bilateral knee osteoarthritis". International Journal of Molecular Medicine 29, no. 5 (2012): 756-760. https://doi.org/10.3892/ijmm.2012.897