Relationship between serum undercarboxylated osteocalcin and hyaluronan levels in patients with bilateral knee osteoarthritis

Naito,Kiyohito; Watari,Taiji; Obayashi,Osamu; Katsube,Sadanobu; Nagaoka,Isao; Kaneko,Kazuo

doi:10.3892/ijmm.2012.897

May 2012 Volume 29 Issue 5

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May 2012 Volume 29 Issue 5

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Article

Relationship between serum undercarboxylated osteocalcin and hyaluronan levels in patients with bilateral knee osteoarthritis

Authors:
- Kiyohito Naito
- Taiji Watari
- Osamu Obayashi
- Sadanobu Katsube
- Isao Nagaoka
- Kazuo Kaneko
View Affiliations / Copyright

Affiliations: Department of Orthopaedic Surgery, Juntendo University Shizuoka Hospital, Izunokuni, Shizuoka 410-2295, Japan, Department of Orthopaedic Surgery, Hot Spring of Rehabilitation Nakaizu Hospital, Izu, Shizuoka 410-2502, Japan, Department of Host Defense and Biochemical Research, Juntendo University Graduate School of Medicine, Bunkyo-ku, Tokyo 113-8421, Japan, Department of Orthopaedics, Juntendo University, Bunkyo-ku, Tokyo 113-8421, Japan
Pages: 756-760
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Published online on: January 26, 2012

https://doi.org/10.3892/ijmm.2012.897
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Abstract

Serum undercarboxylated osteocalcin (s-ucOC) is a marker for vitamin K metabolism (deficiency). The aim of this study was to investigate the serum levels of ucOC in patients with bilateral knee osteoarthritis (K-OA), and the correlation between ucOC and other biomarkers for K-OA. A total of 25 patients (22 women, 3 men, mean age 76.0±7.8, range 54-88 years, mean BMI 24.9±4.7) with a Kellgren-Lawrence grade of 3 or 4 for bilateral knee were enrolled in this study. The levels of s-ucOC and other biomarkers were measured. The levels of s-ucOC (5.66±4.70 ng/ml) as well as other cartilage metabolism markers, were elevated in the patients; however, bone metabolism markers were within the normal ranges. Of interest, there was a significant correlation between s-ucOC and serum hyaluronan (a marker for synovitis) (P<0.05). Our findings suggest that vitamin K metabolism may be associated with synovitis in patients with K-OA, and s-ucOC could be a biomarker for K-OA.

Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Relationship between serum undercarboxylated osteocalcin and hyaluronan levels in patients with bilateral knee osteoarthritis

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Abstract

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