Bradykinin prevents the apoptosis of NIT-1 cells induced by TNF-α via the PI3K/Akt and MAPK signaling pathways

  • Authors:
    • Xizhen Xu
    • Ling Tu
    • Wei Jiang
    • Wenjing Feng
    • Chun Xia Zhao
    • Dao Wen Wang
  • View Affiliations

  • Published online on: February 21, 2012     https://doi.org/10.3892/ijmm.2012.922
  • Pages: 891-898
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

The kallikrein-kinin system (KKS) is a complex multi-enzyme system which is composed of circulating and tissue kallikrein and kinin. It is well established that tissue kallikrein and kinin play crucial and diverse roles in cardiovascular and renal homeostasis. Recent data indicate that kallikrein gene delivery reduces insulin resistance in STZ-treated rats suggesting a protective role for kinin in the development of diabetes. This study investigated the effects of exogenous bradykinin (BK) on the apoptosis of NIT-1 cells, a pancreatic β-cell line in vitro. Exogenous BK significantly protected NIT-1 cells from TNF-α-induced apoptosis. These effects were associated with upregulation of Bcl-2 and Bcl-xL protein expression levels as well as with downregulation of Bax expression levels via the activation of the mitogen-activated protein kinase and PI3K/Akt signaling pathways. In conclusion, these data highlight the beneficial roles of BK on pancreatic β-cell function.

Related Articles

Journal Cover

May 2012
Volume 29 Issue 5

Print ISSN: 1107-3756
Online ISSN:1791-244X

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Xu X, Tu L, Jiang W, Feng W, Zhao CX and Wang DW: Bradykinin prevents the apoptosis of NIT-1 cells induced by TNF-α via the PI3K/Akt and MAPK signaling pathways. Int J Mol Med 29: 891-898, 2012
APA
Xu, X., Tu, L., Jiang, W., Feng, W., Zhao, C.X., & Wang, D.W. (2012). Bradykinin prevents the apoptosis of NIT-1 cells induced by TNF-α via the PI3K/Akt and MAPK signaling pathways. International Journal of Molecular Medicine, 29, 891-898. https://doi.org/10.3892/ijmm.2012.922
MLA
Xu, X., Tu, L., Jiang, W., Feng, W., Zhao, C. X., Wang, D. W."Bradykinin prevents the apoptosis of NIT-1 cells induced by TNF-α via the PI3K/Akt and MAPK signaling pathways". International Journal of Molecular Medicine 29.5 (2012): 891-898.
Chicago
Xu, X., Tu, L., Jiang, W., Feng, W., Zhao, C. X., Wang, D. W."Bradykinin prevents the apoptosis of NIT-1 cells induced by TNF-α via the PI3K/Akt and MAPK signaling pathways". International Journal of Molecular Medicine 29, no. 5 (2012): 891-898. https://doi.org/10.3892/ijmm.2012.922