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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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May 2012 Volume 29 Issue 5

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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May 2012 Volume 29 Issue 5

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Article

Bradykinin prevents the apoptosis of NIT-1 cells induced by TNF-α via the PI3K/Akt and MAPK signaling pathways

  • Authors:
    • Xizhen Xu
    • Ling Tu
    • Wei Jiang
    • Wenjing Feng
    • Chun Xia Zhao
    • Dao Wen Wang

  • View Affiliations / Copyright

    Affiliations: Department of Internal Medicine and The Institute of Hypertension, Tongji Hospital, Tongji Medical College of Huazhong University of Science and Technology, Wuhan 430030, P.R. China
  • Pages: 891-898
    |
    Published online on: February 21, 2012
       https://doi.org/10.3892/ijmm.2012.922
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Abstract

The kallikrein-kinin system (KKS) is a complex multi-enzyme system which is composed of circulating and tissue kallikrein and kinin. It is well established that tissue kallikrein and kinin play crucial and diverse roles in cardiovascular and renal homeostasis. Recent data indicate that kallikrein gene delivery reduces insulin resistance in STZ-treated rats suggesting a protective role for kinin in the development of diabetes. This study investigated the effects of exogenous bradykinin (BK) on the apoptosis of NIT-1 cells, a pancreatic β-cell line in vitro. Exogenous BK significantly protected NIT-1 cells from TNF-α-induced apoptosis. These effects were associated with upregulation of Bcl-2 and Bcl-xL protein expression levels as well as with downregulation of Bax expression levels via the activation of the mitogen-activated protein kinase and PI3K/Akt signaling pathways. In conclusion, these data highlight the beneficial roles of BK on pancreatic β-cell function.

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Copy and paste a formatted citation
Spandidos Publications style
Xu X, Tu L, Jiang W, Feng W, Zhao CX and Wang DW: Bradykinin prevents the apoptosis of NIT-1 cells induced by TNF-α via the PI3K/Akt and MAPK signaling pathways. Int J Mol Med 29: 891-898, 2012.
APA
Xu, X., Tu, L., Jiang, W., Feng, W., Zhao, C.X., & Wang, D.W. (2012). Bradykinin prevents the apoptosis of NIT-1 cells induced by TNF-α via the PI3K/Akt and MAPK signaling pathways. International Journal of Molecular Medicine, 29, 891-898. https://doi.org/10.3892/ijmm.2012.922
MLA
Xu, X., Tu, L., Jiang, W., Feng, W., Zhao, C. X., Wang, D. W."Bradykinin prevents the apoptosis of NIT-1 cells induced by TNF-α via the PI3K/Akt and MAPK signaling pathways". International Journal of Molecular Medicine 29.5 (2012): 891-898.
Chicago
Xu, X., Tu, L., Jiang, W., Feng, W., Zhao, C. X., Wang, D. W."Bradykinin prevents the apoptosis of NIT-1 cells induced by TNF-α via the PI3K/Akt and MAPK signaling pathways". International Journal of Molecular Medicine 29, no. 5 (2012): 891-898. https://doi.org/10.3892/ijmm.2012.922
Copy and paste a formatted citation
x
Spandidos Publications style
Xu X, Tu L, Jiang W, Feng W, Zhao CX and Wang DW: Bradykinin prevents the apoptosis of NIT-1 cells induced by TNF-α via the PI3K/Akt and MAPK signaling pathways. Int J Mol Med 29: 891-898, 2012.
APA
Xu, X., Tu, L., Jiang, W., Feng, W., Zhao, C.X., & Wang, D.W. (2012). Bradykinin prevents the apoptosis of NIT-1 cells induced by TNF-α via the PI3K/Akt and MAPK signaling pathways. International Journal of Molecular Medicine, 29, 891-898. https://doi.org/10.3892/ijmm.2012.922
MLA
Xu, X., Tu, L., Jiang, W., Feng, W., Zhao, C. X., Wang, D. W."Bradykinin prevents the apoptosis of NIT-1 cells induced by TNF-α via the PI3K/Akt and MAPK signaling pathways". International Journal of Molecular Medicine 29.5 (2012): 891-898.
Chicago
Xu, X., Tu, L., Jiang, W., Feng, W., Zhao, C. X., Wang, D. W."Bradykinin prevents the apoptosis of NIT-1 cells induced by TNF-α via the PI3K/Akt and MAPK signaling pathways". International Journal of Molecular Medicine 29, no. 5 (2012): 891-898. https://doi.org/10.3892/ijmm.2012.922
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