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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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June 2012 Volume 29 Issue 6

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Article

Emodin inhibits tumor necrosis factor-α-induced migration and inflammatory responses in rat aortic smooth muscle cells

  • Authors:
    • Liang Meng
    • Dongming Yan
    • Weidong Xu
    • Jian Ma
    • Bin Chen
    • Hong  Feng

  • View Affiliations / Copyright

    Affiliations: Department of Circulation, Fengtian Hospital Affiliated to Shenyang Medical College, Shenyang, Liaoning, P.R. China, Division of Human Resources, Shenyang Medical College, Shenyang, Liaoning, P.R. China, Department of Science and Education, Fengtian Hospital Affiliated to Shenyang Medical College, Shenyang, Liaoning, P.R. China, Division of Scientific Research Administration, Shenyang Medical College, Shenyang, Liaoning, P.R. China, Department of Ophthalmology, The Fourth People's Hospital, Shenyang, Liaoning, P.R. China, Department of Obstetrics and Gynaecology, Fengtian Hospital Affiliated to Shenyang Medical College, Shenyang, Liaoning, P.R. China
  • Pages: 999-1006
    |
    Published online on: March 15, 2012
       https://doi.org/10.3892/ijmm.2012.940
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Abstract

Emodin, a naturally occurring anthraquinone derivative in oriental herbal medicine, has been shown to exert a variety of pharmacological activities. The goal of this study was to determine the effects of emodin on the modulation of cell proliferation, migration, inflammatory responses, and matrix metalloproteinase (MMP)-2 and MMP-9 expression in tumor necrosis factor (TNF)-α-induced rat aortic smooth muscle cells (RASMCs). Cell proliferation and migration were measured using the MTT assay and the transwell chamber assay, respectively. Quantitative real-time PCR and western blot analysis were used to detect MMP expression. Gel shift was used for analysis of nuclear factor (NF)-κB activation. In addition, the expression of several inflammatory genes was also analyzed. Treatment of RASMCs with emodin significantly and dose-dependently attenuated TNF-α-induced proliferation, migration, mRNA and protein expression of MMP-2 and MMP-9, and NF-κB activation. Furthermore, emodin significantly inhibited TNF-α-evoked inflammatory responses, as demonstrated by the reduction in the expression of inflammatory genes. These results suggest that emodin inhibits TNF-α-induced proliferation, migration, MMP-2 and MMP-9 expression as well as inflammatory responses in cultured RASMCs, supporting the notion that emodin may have potential application in clinical atherosclerosis disease.

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Copy and paste a formatted citation
Spandidos Publications style
Meng L, Yan D, Xu W, Ma J, Chen B and Feng H: Emodin inhibits tumor necrosis factor-α-induced migration and inflammatory responses in rat aortic smooth muscle cells. Int J Mol Med 29: 999-1006, 2012.
APA
Meng, L., Yan, D., Xu, W., Ma, J., Chen, B., & Feng, H. (2012). Emodin inhibits tumor necrosis factor-α-induced migration and inflammatory responses in rat aortic smooth muscle cells. International Journal of Molecular Medicine, 29, 999-1006. https://doi.org/10.3892/ijmm.2012.940
MLA
Meng, L., Yan, D., Xu, W., Ma, J., Chen, B., Feng, H."Emodin inhibits tumor necrosis factor-α-induced migration and inflammatory responses in rat aortic smooth muscle cells". International Journal of Molecular Medicine 29.6 (2012): 999-1006.
Chicago
Meng, L., Yan, D., Xu, W., Ma, J., Chen, B., Feng, H."Emodin inhibits tumor necrosis factor-α-induced migration and inflammatory responses in rat aortic smooth muscle cells". International Journal of Molecular Medicine 29, no. 6 (2012): 999-1006. https://doi.org/10.3892/ijmm.2012.940
Copy and paste a formatted citation
x
Spandidos Publications style
Meng L, Yan D, Xu W, Ma J, Chen B and Feng H: Emodin inhibits tumor necrosis factor-α-induced migration and inflammatory responses in rat aortic smooth muscle cells. Int J Mol Med 29: 999-1006, 2012.
APA
Meng, L., Yan, D., Xu, W., Ma, J., Chen, B., & Feng, H. (2012). Emodin inhibits tumor necrosis factor-α-induced migration and inflammatory responses in rat aortic smooth muscle cells. International Journal of Molecular Medicine, 29, 999-1006. https://doi.org/10.3892/ijmm.2012.940
MLA
Meng, L., Yan, D., Xu, W., Ma, J., Chen, B., Feng, H."Emodin inhibits tumor necrosis factor-α-induced migration and inflammatory responses in rat aortic smooth muscle cells". International Journal of Molecular Medicine 29.6 (2012): 999-1006.
Chicago
Meng, L., Yan, D., Xu, W., Ma, J., Chen, B., Feng, H."Emodin inhibits tumor necrosis factor-α-induced migration and inflammatory responses in rat aortic smooth muscle cells". International Journal of Molecular Medicine 29, no. 6 (2012): 999-1006. https://doi.org/10.3892/ijmm.2012.940
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