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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Journal Cover
June 2012 Volume 29 Issue 6

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Impact Factor: 8.5

CiteScore: 9.7

CiteScore Rank: Q1: #35/357 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 1.28

SCImago Journal Rank (SJR): 1.381

Review

Functional MRI using robotic MRI compatible devices for monitoring rehabilitation from chronic stroke in the molecular medicine era (Review)

Loukas G. Astrakas, Syed Hassan Naqvi, Babak Kateb, A. Aria Tzika
Pages: 963-973
Published online on: 15 March 2012

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Resveratrol: Antioxidant activity and induction of fetal hemoglobin in erythroid cells from normal donors and β-thalassemia patients

Eitan Fibach, Eugenia Prus, Nicoletta Bianchi, Cristina Zuccato, Giulia Breveglieri, Francesca Salvatori, Alessia Finotti, Michele Lipucci di Paola, Eleonora Brognara, Ilaria Lampronti, Monica Borgatti, Roberto Gambari
Pages: 974-982
Published online on: 28 February 2012

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Evaluation of circulating CD4+CD25+ and liver-infiltrating Foxp3+ cells in HCV-associated liver disease

Alfredo Amoroso, Fabio D'Amico, Maria Consolo, Evangelia Skarmoutsou, Sergio Neri, Umberto Dianzani, Demetrios A. Spandidos, Maria Clorinda Mazzarino
Pages: 983-988
Published online on: 22 March 2012

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Na+/H+-exchanger-1 inhibition counteracts diabetic cataract formation and retinal oxidative-nitrative stress and apoptosis

Sergey Lupachyk, Roman Stavniichuk, Julia I. Komissarenko, Viktor R. Drel, Alexander A. Obrosov, Azza B. El-Remessy , Pal Pacher, Irina G. Obrosova
Pages: 989-998
Published online on: 07 March 2012

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Article

Emodin inhibits tumor necrosis factor-α-induced migration and inflammatory responses in rat aortic smooth muscle cells

Liang Meng, Dongming Yan, Weidong Xu, Jian Ma, Bin Chen, Hong  Feng
Pages: 999-1006
Published online on: 15 March 2012

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Article

Effects of bisphosphonates on osteoclastogenesis in RAW264.7 cells

Keigo Abe, Yoshitaka Yoshimura, Yoshiaki Deyama, Takashi Kikuiri , Tomokazu Hasegawa, Kanchu Tei, Hisashi Shinoda, Kuniaki Suzuki, Yoshimasa Kitagawa
Pages: 1007-1015
Published online on: 23 March 2012

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Μolecular impact of bone morphogenetic protein 7, on lung cancer cells and its clinical significance Corrigendum in /10.3892/ijmm.2025.5585

Yinan Liu, Jinfeng Chen, Yue Yang, Lijian Zhang, Wen G. Jiang
Pages: 1016-1024
Published online on: 23 March 2012

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Apoptosis induced by pneumolysin in human endothelial cells involves mitogen-activated protein kinase phosphorylation

Aie Zhou, Hong Wang, Kai Lan, Xuemei Zhang, Wenchun Xu, Yibing Yin, Dairong Li, Jun Yuan, Yujuan He
Pages: 1025-1030
Published online on: 22 March 2012

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Spatiotemporal behavior of nuclear cyclophilin B indicates a role in RNA transcription

Birger Dieriks, Patrick Van Oostveldt
Pages: 1031-1038
Published online on: 13 March 2012

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Article

Protein kinase CK2 mediates peroxynitrite-induced heme oxygenase-1 expression in articular chondrocytes

Kang Mi Kim, Ju Dong Song, Hun Taeg Chung, Young Chul Park
Pages: 1039-1044
Published online on: 23 March 2012

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Zanthoxylum avicennae extracts inhibit cell proliferation through protein phosphatase 2A activation in HA22T human hepatocellular carcinoma cells in vitro and in vivo

Tran Duc Dung, Hsien-Cheh Chang, Truong Viet Binh, Maw-Rong Lee, Chang-Hai Tsai, Fuu-Jen Tsai, Wei-Wen Kuo, Li-Mien Chen, Chih-Yang Huang
Pages: 1045-1052
Published online on: 13 March 2012

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Potent inhibitory effect of Foeniculum vulgare Miller extract on osteoclast differentiation and ovariectomy-induced bone loss

Tae-Ho Kim, Hyun-Ju Kim, Sang-Han Lee, Shin-Yoon Kim
Pages: 1053-1059
Published online on: 23 March 2012

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Dicer 1, ribonuclease type III modulates a reprogramming effect in colorectal cancer cells

Dyah Laksmi Dewi, Hideshi Ishii, Naotsugu Haraguchi, Shimpei Nishikawa, Yoshihiro Kano, Takahito Fukusumi, Miyuki Ozaki, Toshiyuki Saito, Daisuke Sakai, Taroh Satoh, Yuichiro Doki, Masaki Mori
Pages: 1060-1064
Published online on: 19 March 2012

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A novel GATA6 mutation associated with congenital ventricular septal defect

Gui-Fen Zheng, Dong Wei, Hong Zhao, Ning Zhou, Yi-Qing Yang, Xing-Yuan Liu
Pages: 1065-1071
Published online on: 07 March 2012

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Pretreatment with Mycobacterium avium-derived lipids attenuates the response of murine macrophages to components of Mycobacterium tuberculosis

Daqing Yang, Yuan Liu, Yiguo Chen, Delong Jiao, Xiaorui Hou, Lei Wang, Ning Fu
Pages: 1072-1082
Published online on: 07 March 2012

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Osteogenic response of mesenchymal stem cells to continuous mechanical strain is dependent on ERK1/2-Runx2 signaling

Peng Zhang, Yuqiong Wu, Zonglai Jiang, Lingyong Jiang, Bing Fang
Pages: 1083-1089
Published online on: 08 March 2012

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Astragaloside II induces osteogenic activities of osteoblasts through the bone morphogenetic protein-2/MAPK and Smad1/5/8 pathways

Xiang-He Kong, Yin-Bo Niu, Xiao-Mei Song, Dong-Dong Zhao, Juan Wang, Xiang-Long Wu, Rong Zhang, Qi-Bing Mei
Pages: 1090-1098
Published online on: 15 March 2012

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Proteomic analysis of oxidative modification in endothelial colony-forming cells treated by hydrogen peroxide

Jun Wei, Ying Liu, Ming Chang, Chong-Ling Sun, Da-Wei Li, Zhi-Qiang Liu, Lin-Sen Hu
Pages: 1099-1105
Published online on: 19 March 2012

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IL-6 induction of hepatocyte proliferation through the Tmub1-regulated gene pathway

Menggang Liu, Hongming Liu, Xiaofeng Wang, Ping Chen, Hongxu Chen
Pages: 1106-1112
Published online on: 15 March 2012

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CCM2 gene polymorphisms in Italian sporadic patients with cerebral cavernous malformation: A case-control study

Rosalia D'Angelo, Concetta Scimone, Carmela Rinaldi, Giuseppe Trimarchi, Domenico Italiano, Placido Bramanti, Aldo Amato, Antonina Sidoti
Pages: 1113-1120
Published online on: 28 February 2012

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Perturbation of glycerol metabolism in hepatocytes from n3-PUFA-depleted rats

Laurence Portois, Ying Zhang, Laurence Ladrière, Jason Perret, Karim Louchami, Nathalie Gaspard, Emeline Hupkens, Nargis Bolaky, Valérie Delforge, Renaud Beauwens, Willy J. Malaisse, Abdullah Sener, Yvon A. Carpentier, Christine Delporte
Pages: 1121-1126
Published online on: 16 March 2012

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Estrogen receptor β transcript variants associate with oncogene expression in endometrial cancer

Julia Häring, Maciej Skrzypczak, Anette Stegerer, Claus Lattrich, Florian Weber, Regina Görse, Olaf Ortmann, Oliver Treeck
Pages: 1127-1136
Published online on: 28 February 2012

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Anti-atherogenic activity of wild grape (Vitis thunbergii) extract antagonizing smooth muscle cell proliferation and migration promoted by neighboring macrophages

Sang-Wook Kang, Min Soo Kim, Hyun-Sung Kim, Yong-Jin Lee, Young-Hee Kang
Pages: 1137-1145
Published online on: 07 March 2012

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Article

7,8-Dihydroxyflavone exhibits anti-inflammatory properties by downregulating the NF-κB and MAPK signaling pathways in lipopolysaccharide-treated RAW264.7 cells

Hye Young Park, Gi-Young Kim, Jin Won Hyun, Hye   Jin Hwang, Nam  Deuk Kim, Byung-Woo  Kim, Yung Hyun Choi
Pages: 1146-1152
Published online on: 13 March 2012

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Article

Adenovirally delivered IFN-β exerts antitumor effects through transient T-lymphocyte depletion and Ag-specific T-cell proliferation

Sang-Seok Oh, Chaerin Moon, Dong-Hyeok Kim, Hyunkeun  Song, Saegwang  Park, Yangxin Fu, Kwang Dong Kim
Pages: 1153-1157
Published online on: 13 March 2012

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Characterization of hepatocellular carcinoma cell lines based on cell adhesion molecules

Cheol Woong Jung, Tae-Jin Song, Kun-Ok Lee, Sae Byeol Choi, Wan Bae Kim, Sung Ock Suh, Young Chul Kim, Sang Yong Choi
Pages: 1158-1164
Published online on: 23 March 2012

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Journal Cover
August-2026 Volume 58 Issue 2

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Impact Factor: 8.5

CiteScore: 9.7

CiteScore Rank: Q1: #35/357 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 1.28

SCImago Journal Rank (SJR): 1.381

Review Open Access

Myokines in exercise‑mediated bone homeostasis: Molecular signaling mechanisms and therapeutic implications for bone disorders (Review)

Bin Tian, Xuesong Chen, Jiang Zheng, Xin Kang
Article Number: 231
Published online on: 24 June 2026

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Neutrophil extracellular traps in thrombosis of hematologic malignancies: Underlying mechanisms and therapeutic opportunities (Review)

Kebing Lv, Zijie Ma, Qiuni Chen, Yang Su, Jingjing Ma, Chunling Wang, Liang Yu
Article Number: 230
Published online on: 23 June 2026

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Recombinant myonectin ameliorates sepsis‑induced cardiomyopathy by alleviating mitochondrial dysfunction via the AdipoR1/AMPK pathway

Peipei Li, Rui Chen, Hanmo Zhang, Lihong Li, Huiling Luo, Beibei Du, Ping Yang
Article Number: 229
Published online on: 23 June 2026

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MTA2: Decoding pathogenic mechanisms, clinical implications and therapeutic frontiers across disease landscapes (Review)

Hao Xie, Ling Chen, Jing Gou, Xuehong Long, Ya Yang, Hai Hu, Ping Wu, Qibing Yan, Yongkang Wu
Article Number: 228
Published online on: 22 June 2026

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Mitochondria‑endoplasmic reticulum contact site nexus: Molecular integration, disease pathogenesis and therapeutic opportunities (Review)

Yi Liu, Xianda Che, Wei Wei, Chong Teng, Huimin Li
Article Number: 227
Published online on: 22 June 2026

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Metabolic messengers from the gut to the joint: Toward precision management of osteoarthritis (Review)

Ruipu Zhang, Liang Zhang, Yiqun Wang, Xin Kang, Jiang Zheng
Article Number: 226
Published online on: 22 June 2026

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Retraction Open Access

[Retracted] Protection of telomeres 1 protein levels are associated with telomere length in gastric cancer

Kiyomu Fujii, Tomonori Sasahira, Yukiko Moriwaka, Naohide Oue, Wataru Yasui, Hiroki Kuniyasu
Article Number: 225
Published online on: 22 June 2026

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Molecular mechanism of hydromorphone preconditioning in cerebral ischemia/reperfusion‑induced inflammatory injury

Jing Yao, Zeqing Huang, Songze Li, Minghui Lun, Jianing Fan
Article Number: 224
Published online on: 18 June 2026

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Oridonin ameliorates ulcerative colitis by regulating the PI3K/AKT/mTOR signaling pathway to activate autophagy

Zhongxing Miao, Baohong Liu, Xingzhi Zhou, Mengru Lu, Ni Jia, Huamin Zhang, Ying Qi, Xiaoyu Tan, Qinggao Zhang
Article Number: 223
Published online on: 18 June 2026

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Article

Arsenic exposure and skin cancer: Mechanisms, clinical evidence and public health implications (Review)

Dimitrios A. Andreikos, Michael Aschner, Dimitrios C. Ziogas, Aristidis Tsatsakis, Demetrios A. Spandidos
Article Number: 222
Published online on: 18 June 2026

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Targeting glutathione metabolism for tumor radiosensitization (Review)

Haonan Xu, Meng Du, Xiaowen Liang, Xilin Xiao, Zhiyi Chen
Article Number: 221
Published online on: 16 June 2026

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Effects of exercise‑derived extracellular vesicles: Epigenetic regulatory mechanisms and protective roles (Review)

Xinxin Zhang, Biao Zhang
Article Number: 220
Published online on: 15 June 2026

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Moderate downregulation of NDUFA13 promotes cardiomyocytes proliferation and heart regeneration through the glycolysis/c‑Myc/Ccnd1 axis

Ying Gao, Ningjing Qian, Junyan Jin, Jiayi Liu, Bingqi Wang, Yaping Wang
Article Number: 219
Published online on: 12 June 2026

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Correction Open Access

[Corrigendum] (‑)‑Epigallocatechin‑3‑gallate attenuates myocardial injury induced by ischemia/reperfusion in diabetic rats and in H9c2 cells under hyperglycemic conditions

Yang Wu, Zhong-Yuan Xia, Bo Zhao, Yan Leng, Juan Dou, Qing-Tao Meng, Shao-Qing Lei, Zhi-Ze Chen, Jie Zhu
Article Number: 218
Published online on: 10 June 2026

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Melatonin ameliorates circadian rhythm disruption induced erectile dysfunction by inhibiting oxidative stress mediated pyroptosis via Nrf2/HO‑1 axis

Qingtao Yang, Wei Li, Qi Yu, Jiang Shi, Lu Yang, Jun Qiao, Xi Wei, Changshi Gu, Fa Sun, Tao Li
Article Number: 217
Published online on: 09 June 2026

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Spatial architecture of immunometabolism: Mitochondrial‑organelle interfaces in immune signaling (Review)

Yaping Wu, Hao Yu, Ling Xia, Li Yang, Yu Zhou, Qian Yu
Article Number: 216
Published online on: 08 June 2026

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Urea cycle dysregulation and arginine pathways in the pathogenesis of NAFLD and NASH (Review)

Boying Zhu, Chaoyang Wang, Peng Liu, Zhifeng Qu, Ran Qi, Shengjiang Chen, Huanzhang Niu
Article Number: 215
Published online on: 08 June 2026

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Article Open Access

Withaferin A, a candidate drug for lupus nephritis, confers renal protection via Pon1‑mediated attenuation of oxidative stress

Miao Xue, Junshuai Feng, Xiaorong Mao
Article Number: 214
Published online on: 08 June 2026

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Retraction Open Access

[Retracted] Classical dendritic cells regulate acute lung inflammation and injury in mice with lipopolysaccharide‑induced acute respiratory distress syndrome

Lang Li, Liang Dong, Dan Zhao, Fei Gao, Jie Yan
Article Number: 213
Published online on: 08 June 2026

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Plant‑derived natural products alleviate dexamethasone‑induced skeletal muscle atrophy by modulating FoxO (Review)

Wei Dai, Jiabin Wu, Xiaotong Ma, Mingyu Wu, Ke Li, Haoyang Gao, Wenhong Wang, Weihua Xiao
Article Number: 212
Published online on: 05 June 2026

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Functional hydrogels in cardiovascular therapy: Design, applications and clinical challenges (Review)

Zheming Yang, Jiayin Li, Lingxiao Zhao, Dali Zhang, Chenghui Yan, Dan Liu, Yaling Han
Article Number: 211
Published online on: 04 June 2026

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Experimental rodent models of cardiorenal syndrome types 3 and 4: Insights and clinical relevance (Review)

Stefanny M. Figueroa, Siyi Huang, Javier Reyes‑Osorio, Jean-Jacques Boffa, Cristián A. Amador, Christos E. Chadjichristos, Louis Boutin
Article Number: 210
Published online on: 04 June 2026

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Expression of Concern Open Access

[Expression of Concern] Novel insights into the role of HSP90 in cytoprotection of H2S against chemical hypoxia‑induced injury in H9c2  cardiac myocytes

Zhanli Yang, Chuntao Yang, Liangcan Xiao, Xinxue Liao, Aiping Lan, Xiuyu Wang, Ruixian Guo, Peixi Chen, Chengheng Hu, Jianqiang Feng
Article Number: 209
Published online on: 03 June 2026

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Article Open Access

Microbiota‑derived indole‑3‑propionic acid reprograms bone marrow stem cell fate via PPARγ suppression to rescue osteoporosis

Jinwu Bai, Ruideng Wang, Jixing Fan, Shilong Su, Gao Si, Qinyong You, Ao Sun, Daole Hu, Shan Gao, Yang Lv, Fang Zhou
Article Number: 208
Published online on: 03 June 2026

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Lactate regulates osteoclastogenesis via H3k18la in osteoarthritis

Zhibo Fan, Qiyue Fu, Tao Sun, Yutong Zhong, Yuefan Ma, Jingwei Jian, Shuosheng Yuan, Shenghong Li, Xiaomei Xu
Article Number: 207
Published online on: 02 June 2026

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Retraction Open Access

[Retracted] miR‑215 promotes epithelial to mesenchymal transition and proliferation by regulating LEFTY2 in endometrial cancert

Xiaoxu Gao, Yan Cai, Ruifang An
Article Number: 206
Published online on: 02 June 2026

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Review

Multi‑scale experimental models for the study of angiogenesis (Review)

Qin Yu, Jiarui Hu, Shuangshuang Yuan, Jiexia Gan, Mao Luo, Jianbo Wu, Liqun Wang
Article Number: 205
Published online on: 28 May 2026

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Targeting lactylation in hepatocellular carcinoma: Mechanistic insights and therapeutic opportunities (Review)

Lianting Chen, Feiqiong Gao, Qianru Mei, Yujie Li, Qun Cai, Xudong Feng
Article Number: 204
Published online on: 28 May 2026

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Oxygen‑sensing histone demethylase KDM6A modulates chondrocyte‑to‑osteoblast transdifferentiation by activating the Wnt/β‑catenin pathway

Yi Rong, Hao Yu, Heng Yin, Shaoshuo Li, Jianwei Wang, Zhongyuan Shen, Xinxin Ding, Fanchen Bu, Tianyi Dai, Gean Wu, Zhen Hua
Article Number: 203
Published online on: 28 May 2026

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Journal Cover
September-2026 Volume 58 Issue 3

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Impact Factor: 8.5

CiteScore: 9.7

CiteScore Rank: Q1: #35/357 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 1.28

SCImago Journal Rank (SJR): 1.381

Article Open Access

FLI1 enhances the malignant phenotype of glioma cells and exerts immunomodulatory effects through feedback crosstalk with exonic circRNA FECR1 and interferon‑induced ISG15

Xue Wen, Xiaoyi Gu, Xu Yan, Naifei Chen, Lei Zhou, Hui Li, Andrew R. Hoffman, Wei Li, Ji-Fan Hu, Jiuwei Cui
Article Number: 241
Published online on: 01 July 2026

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Role of ZEB1 in angiogenesis and therapeutic potential (Review)

Ruoxin Ren, Chunxiao Yan, Yao Xiang, Lin Jin, Fang Cheng, Lijun Zhang
Article Number: 240
Published online on: 01 July 2026

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Review Open Access

Endothelial dysfunction: A central mechanism linking autosomal dominant polycystic kidney disease and intracranial aneurysms (Review)

Xiaohong Xu, Ruyi Xu, Liexiang Zhang
Article Number: 239
Published online on: 01 July 2026

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