Μolecular impact of bone morphogenetic protein 7, on lung cancer cells and its clinical significance

  • Authors:
    • Yinan Liu
    • Jinfeng Chen
    • Yue Yang
    • Lijian Zhang
    • Wen G. Jiang
  • View Affiliations

  • Published online on: March 23, 2012     https://doi.org/10.3892/ijmm.2012.948
  • Pages: 1016-1024
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

The aim of this study was to investigate the expression of bone morphogenetic protein 7 (BMP7), in human pulmonary cancer tissues/cells and to evaluate the cellular impact of bone morphogenetic proteins on pulmonary cancer cells. BMP7 expression was determined in human lung cancer cell lines. The invasiveness and growth of cells transfected with BMP7, in vitro, were evaluated using the in vitro invasion assay and in vitro tumour models. Cellular migration was analysed using wounding assays. BMP7-positive tumours correlated with the absence of bone metastasis (P=0.040). In this analysis, we identified that 4 of 4 small cell lung cancer (SCLC) tissue specimens had no BMP7 expression, which illustrated that BMP7 may have no role in SCLC. BMP7 expression was not correlated with the overall survival time in lung cancer patients. Downregulation of BMP7 expression significantly inhibited the invasiveness of SPC-A1 cells (P<0.001) and forced-expression of BMP7 dramatically increased the motility of A549 cells. Overexpression of BMP7 in A549 cells and its knockdown in SPC-A1 cells did not significantly alter proliferation compared with the control cells (P>0.5 respectively). In conclusion, we have demonstrated that BMP7 has an important role in controlling lung cancer cell motility and invasiveness, without affecting the growth process, cell proliferation and cell apoptosis. A higher BMP7 expression may be an indicator for bone metastasis. The therapeutic role of BMP7 warrants further investigation.

Related Articles

Journal Cover

June 2012
Volume 29 Issue 6

Print ISSN: 1107-3756
Online ISSN:1791-244X

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
APA
Liu, Y., Chen, J., Yang, Y., Zhang, L., & Jiang, W.G. (2012). Μolecular impact of bone morphogenetic protein 7, on lung cancer cells and its clinical significance . International Journal of Molecular Medicine, 29, 1016-1024. https://doi.org/10.3892/ijmm.2012.948
MLA
Liu, Y., Chen, J., Yang, Y., Zhang, L., Jiang, W. G."Μolecular impact of bone morphogenetic protein 7, on lung cancer cells and its clinical significance ". International Journal of Molecular Medicine 29.6 (2012): 1016-1024.
Chicago
Liu, Y., Chen, J., Yang, Y., Zhang, L., Jiang, W. G."Μolecular impact of bone morphogenetic protein 7, on lung cancer cells and its clinical significance ". International Journal of Molecular Medicine 29, no. 6 (2012): 1016-1024. https://doi.org/10.3892/ijmm.2012.948