Potent inhibitory effect of Foeniculum vulgare Miller extract on osteoclast differentiation and ovariectomy-induced bone loss

Kim,Tae-Ho; Kim,Hyun-Ju; Lee,Sang-Han; Kim,Shin-Yoon

doi:10.3892/ijmm.2012.950

June 2012 Volume 29 Issue 6

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June 2012 Volume 29 Issue 6

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Article

Potent inhibitory effect of Foeniculum vulgare Miller extract on osteoclast differentiation and ovariectomy-induced bone loss

Authors:
- Tae-Ho Kim
- Hyun-Ju Kim
- Sang-Han Lee
- Shin-Yoon Kim
View Affiliations / Copyright

Affiliations: Skeletal Diseases Genome Research Center, Kyungpook National University Hospital, Daegu 700‑412, Republic of Korea, Department of Food Science and Biotechnology, Kyungpook National University, Daegu 702-701, Republic of Korea
Pages: 1053-1059
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Published online on: March 23, 2012

https://doi.org/10.3892/ijmm.2012.950
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Abstract

Inhibition of osteoclast differentiation and bone resorption is considered an effective therapeutic approach to the treatment of postmenopausal bone loss. To find natural compounds that may inhibit osteoclastogenesis, we screened herbal extracts on bone marrow cultures. In this study, we found that an aqueous extract of Foeniculum vulgare Miller seed (FvMs) at low concentration, which has traditionally been used as a treatment for a variety of ailments, inhibits the osteoclast differentiation and bone resorptive activity of mature osteoclasts. We further investigated the effects of FvMs on ovariectomy (OVX)-induced bone loss using microcomputed tomography, biomechanical tests and serum marker assays for bone remodeling. Oral administration of FvMs (30 mg or 100 mg/kg/day) for 6 weeks had an intermediary effect on the prevention of femoral bone mineral density (BMD), bone mineral content (BMC), and other parameters compared to OVX controls. In addition, FvMs slightly decreased bone turnover markers that were accelerated by OVX. The bone-protective effects of FvMs may be due to suppression of an OVX-induced increase in bone turnover. Collectively, our findings indicate that FvMs have potential in preventing bone loss in postmenopausal osteoporosis by reducing both osteoclast differentiation and function.

Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Potent inhibitory effect of Foeniculum vulgare Miller extract on osteoclast differentiation and ovariectomy-induced bone loss

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Abstract

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