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International Journal of Molecular Medicine
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May 2013 Volume 31 Issue 5

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Article

Transplantation of Flk-1+ human bone marrow-derived mesenchymal stem cells promotes behavioral recovery and anti-inflammatory and angiogenesis effects in an intracerebral hemorrhage rat model

  • Authors:
    • Xin-Jie Bao
    • Fu-Yi Liu
    • Shan Lu
    • Qin Han
    • Ming Feng
    • Jun-Ji Wei
    • Gui-Lin Li
    • Robert Chun-Hua Zhao
    • Ren-Zhi Wang
  • View Affiliations / Copyright

    Affiliations: Department of Neurosurgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, P.R. China, China National Center for Biotechnology Development, Beijing 100036, P.R. China, Institute of Basic Medical Sciences and School of Basic Medicine, Center of Excellence in Tissue Engineering, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100005, P.R. China, Institute of Basic Medical Sciences and School of Basic Medicine, Center of Excellence in Tissue Engineering, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100005, P.R. China
  • Pages: 1087-1096
    |
    Published online on: March 5, 2013
       https://doi.org/10.3892/ijmm.2013.1290
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Abstract

Mesenchymal stem cells (MSCs) have been successfully used for the treatment of experimental intracerebral hemorrhage (ICH). However, the neuroprotective mechanisms through which MSCs improve neurological functional recovery are not fully understood. In the present study, we tested the hypothesis that treatment with MSCs inhibits inflammation after ICH and reduces subsequent brain injury. Adult rats subjected to stereotaxic injection of collagenase VII were transplanted with a subpopulation of human bone marrow-derived MSCs (hBMSCs), termed fetal liver kinase (Flk)-1+ hBMSCs, or saline into the ipsilateral brain parenchyma 1 day after ICH. Significant recovery of behavior was noted in the Flk-1+ hBMSC-treated rats beginning 3 days after ICH compared with the control group. Brain water content was significantly decreased in the ipsilateral hemispheres of the Flk-1+ hBMSC-treated rats when compared with the controls 3 days after ICH. The relative hemorrhage volume was reduced 55 days after Flk-1+ hBMSC treatment. However, this change was not statistically significant. Flk-1+ hBMSCs significantly inhibited the proliferation of rat peripheral blood mononuclear cells (rPBMCs) induced in a mixed lymphocyte reaction. Consistently, we found a significant anti-inflammatory effect of Flk-1+ hBMSCs on the ICH brain, including a decrease in neutrophil infiltration and microglial activation in the peri-ICH area, and downregulation of inflammatory mediators, such as interleukin (IL)-1β, IL-2, IL-4, IL-6, and tumor necrosis factor (TNF)-α. In addition, Flk-1+ hBMSC treatment significantly increased vascular density in the peri-ICH area, and transplanted Flk-1+ hBMSCs were found to be incorporated into the cerebral vasculature 55 days after transplantation. Overall, these data suggest an essential role for Flk-1+ hBMSCs in reducing inflammatory infiltration, promoting angiogenesis, and improving functional recovery after ICH in rats.
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1 

Heiskanen O: Treatment of spontaneous intracerebral and intracerebellar hemorrhages. Stroke. 24:I94–I95. 1993.PubMed/NCBI

2 

Qureshi AI, Tuhrim S, Broderick JP, Batjer HH, Hondo H and Hanley DF: Spontaneous intracerebral hemorrhage. N Engl J Med. 344:1450–1460. 2001. View Article : Google Scholar : PubMed/NCBI

3 

Lyden PD and Zivin JA: Hemorrhagic transformation after cerebral ischemia: mechanisms and incidence. Cerebrovasc Brain Metab Rev. 5:1–16. 1993.PubMed/NCBI

4 

Hacke W, Kaste M, Bluhmki E, et al: Thrombolysis with alteplase 3 to 4.5 hours after acute ischemic stroke. N Engl J Med. 359:1317–1329. 2008. View Article : Google Scholar

5 

Aronowski J and Hall CE: New horizons for primary intracerebral hemorrhage treatment: experience from preclinical studies. Neurol Res. 27:268–279. 2005. View Article : Google Scholar : PubMed/NCBI

6 

Qureshi AI, Mendelow AD and Hanley DF: Intracerebral haemorrhage. Lancet. 373:1632–1644. 2009. View Article : Google Scholar : PubMed/NCBI

7 

Wang J and Doré S: Inflammation after intracerebral hemorrhage. J Cereb Blood Flow Metab. 27:894–908. 2007.

8 

Kim J, Lee S, Kon C, et al: Systemic transplantation of human adipose stem cells attenuated cerebral inflammation and degeneration in a hemorrhagic stroke model. Brain Res. 1183:43–50. 2007. View Article : Google Scholar : PubMed/NCBI

9 

Lee S, Chu K, Jung K, et al: Anti-inflammatory mechanism of intravascular neural stem cell transplantation in haemorrhagic stroke. Brain. 131:616–629. 2008. View Article : Google Scholar : PubMed/NCBI

10 

Seyfried D, Ding J, Han Y, Li Y, Chen J and Chopp M: Effects of intravenous administration of human bone marrow stromal cells after intracerebral hemorrhage in rats. J Neurosurg. 104:313–318. 2006. View Article : Google Scholar : PubMed/NCBI

11 

Zhang H, Huang Z, Xu Y and Zhang S: Differentiation and neurological benefit of the mesenchymal stem cells transplanted into the rat brain following intracerebral hemorrhage. Neurol Res. 28:104–112. 2006. View Article : Google Scholar

12 

Feng M, Zhu H, Zhu Z, et al: Serial 18F-FDG PET demonstrates benefit of human mesenchymal stem cells in treatment of intracerebral hematoma: a translational study in a primate model. J Nucl Med. 52:90–97. 2011.

13 

Deng W, Han Q, Liao L, et al: Allogeneic bone marrow-derived Flk-1+Sca-1− mesenchymal stem cells leads to stable mixed chimerism and donor-specific tolerance. Exp Hematol. 32:861–867. 2004.PubMed/NCBI

14 

Xu G, Zhang L, Ren G, Yuan Z, Zhang Y, Zhao RC and Shi Y: Immunosuppressive properties of cloned bone marrow mesenchymal stem cells. Cell Res. 17:240–248. 2007.PubMed/NCBI

15 

Zhang B, Liu R, Shi D, et al: Mesenchymal stem cells induce mature dendritic cells into a novel Jagged-2-dependent regulatory dendritic cell population. Blood. 113:46–57. 2009. View Article : Google Scholar

16 

Tan J, Wu W, Xu X, et al: Induction therapy with autologous mesenchymal stem cells in living-related kidney transplants: a randomized controlled trial. JAMA. 307:1169–1177. 2012. View Article : Google Scholar

17 

Saito S, Nakayama T, Hashimoto N, et al: Mesenchymal stem cells stably transduced with a dominant-negative inhibitor of CCL2 greatly attenuate bleomycin-induced lung damage. Am J Pathol. 179:1088–1094. 2011. View Article : Google Scholar : PubMed/NCBI

18 

Williams AR and Hare JM: Mesenchymal stem cells: biology, pathophysiology, translational findings, and therapeutic implications for cardiac disease. Circ Res. 109:923–940. 2011. View Article : Google Scholar

19 

Morando S, Vigo T, Esposito M, et al: The therapeutic effect of mesenchymal stem cell transplantation in experimental autoimmune encephalomyelitis is mediated by peripheral and central mechanisms. Stem Cell Res Ther. 3:32012. View Article : Google Scholar

20 

Fang B, Liao L, Shi M, Yang S and Zhao RC: Multipotency of Flk1+CD34− progenitors derived from human fetal bone marrow. J Lab Clin Med. 143:230–240. 2004.PubMed/NCBI

21 

Fang B, Shi M, Liao L, Yang S, Liu Y and Zhao RC: Multiorgan engraftment and multilineage differentiation by human fetal bone marrow Flk1+/CD31−/CD34− progenitors. J Hematother Stem Cell Res. 12:603–613. 2003. View Article : Google Scholar : PubMed/NCBI

22 

Liu L, Sun Z, Chen B, et al: Ex vivo expansion and in vivo infusion of bone marrow-derived Flk-1+CD31−CD34− mesenchymal stem cells: feasibility and safety from monkey to human. Stem Cells Dev. 15:349–357. 2006. View Article : Google Scholar : PubMed/NCBI

23 

Zhou H, Guo M, Bian CJ, et al: Efficacy of bone marrow-derived mesenchymal stem cells in the treatment of sclerodermatous chronic graft-versus-host disease: clinical report. Biol Blood Marrow Transplant. 16:403–412. 2010. View Article : Google Scholar : PubMed/NCBI

24 

Bao X, Feng M, Wei J, et al: Transplantation of Flk-1+ human bone marrow-derived mesenchymal stem cells promotes angiogenesis and neurogenesis after cerebral ischemia in rats. Eur J Neurosci. 34:87–98. 2011.

25 

Gong C, Hoff JT and Keep RF: Acute inflammatory reaction following experimental intracerebral hemorrhage in rat. Brain Res. 871:57–65. 2000. View Article : Google Scholar : PubMed/NCBI

26 

Nauta AJ and Fibbe WE: Immunomodulatory properties of mesenchymal stromal cells. Blood. 110:3499–3506. 2007. View Article : Google Scholar : PubMed/NCBI

27 

Li J, Zhu H, Liu Y, et al: Human mesenchymal stem cell transplantation protects against cerebral ischemic injury and upregulates interleukin-10 expression in Macaca fascicularis. Brain Res. 1334:65–72. 2010. View Article : Google Scholar

28 

Bao X, Wei J, Feng M, et al: Transplantation of human bone marrow-derived mesenchymal stem cells promotes behavioral recovery and endogenous neurogenesis after cerebral ischemia in rats. Brain Res. 1367:103–113. 2011. View Article : Google Scholar

29 

Li Y, Chen J, Chen XG, et al: Human marrow stromal cell therapy for stroke in rat: neurotrophins and functional recovery. Neurology. 59:514–523. 2002. View Article : Google Scholar : PubMed/NCBI

30 

Terada N, Hamazaki T, Oka M, et al: Bone marrow cells adopt the phenotype of other cells by spontaneous cell fusion. Nature. 416:542–545. 2002. View Article : Google Scholar : PubMed/NCBI

31 

Castro RF, Jackson KA, Goodell MA, Robertson CS, Liu H and Shine HD: Failure of bone marrow cells to transdifferentiate into neural cells in vivo. Science. 297:12992002. View Article : Google Scholar : PubMed/NCBI

32 

Chen J, Zhang ZG, Li Y, et al: Intravenous administration of human bone marrow stromal cells induces angiogenesis in the ischemic boundary zone after stroke in rats. Circ Res. 92:692–699. 2003. View Article : Google Scholar : PubMed/NCBI

33 

Shen LH, Li Y, Chen J, et al: One-year follow-up after bone marrow stromal cell treatment in middle-aged female rats with stroke. Stroke. 38:2150–2156. 2007.PubMed/NCBI

34 

Schott RJ and Morrow LA: Growth factors and angiogenesis. Cardiovasc Res. 27:1155–1161. 1993. View Article : Google Scholar : PubMed/NCBI

35 

Zacharek A, Chen J, Cui X, et al: Angiopoietin1/Tie2 and VEGF/Flk1 induced by MSC treatment amplifies angiogenesis and vascular stabilization after stroke. J Cereb Blood Flow Metab. 27:1684–1691. 2007. View Article : Google Scholar : PubMed/NCBI

36 

Stem Cell Therapies as an Emerging Paradigm in Stroke Participants. The STEPS Participants: Stem cell therapies as an emerging paradigm in stroke (STEPS): bridging basic and clinical science for cellular and neurogenic factor therapy in treating stroke. Stroke. 40:510–515. 2009. View Article : Google Scholar

37 

Han Q, Sun Z, Liu L, Chen B, Cao Y, Li K and Zhao RC: Impairment in immuno-modulatory function of Flk1+ CD31−CD34− MSCs from MDA-RA patients. Leuk Res. 31:1469–1478. 2007. View Article : Google Scholar : PubMed/NCBI

38 

Parent JM, Valentin VV and Lowenstein DH: Prolonged seizures increase proliferating neuroblasts in the adult rat subventricular zone-olfactory bulb pathway. J Neurosci. 22:3174–3188. 2002.PubMed/NCBI

39 

Henriksson HB, Svanvik T, Jonsson M, Hagman M, Horn M, Lindahl A and Brisby H: Transplantation of human mesenchymal stems cells into intervertebral discs in a xenogeneic porcine model. Spine. 34:141–148. 2009. View Article : Google Scholar : PubMed/NCBI

40 

Swanson RA, Morton MT, Tsao-Wu G, Savalos RA, Davidson C and Sharp FR: A semiautomated method for measuring brain infarct volume. J Cereb Blood Flow Metab. 10:290–293. 1990.PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Bao X, Liu F, Lu S, Han Q, Feng M, Wei J, Li G, Zhao RC and Wang R: Transplantation of Flk-1+ human bone marrow-derived mesenchymal stem cells promotes behavioral recovery and anti-inflammatory and angiogenesis effects in an intracerebral hemorrhage rat model. Int J Mol Med 31: 1087-1096, 2013.
APA
Bao, X., Liu, F., Lu, S., Han, Q., Feng, M., Wei, J. ... Wang, R. (2013). Transplantation of Flk-1+ human bone marrow-derived mesenchymal stem cells promotes behavioral recovery and anti-inflammatory and angiogenesis effects in an intracerebral hemorrhage rat model. International Journal of Molecular Medicine, 31, 1087-1096. https://doi.org/10.3892/ijmm.2013.1290
MLA
Bao, X., Liu, F., Lu, S., Han, Q., Feng, M., Wei, J., Li, G., Zhao, R. C., Wang, R."Transplantation of Flk-1+ human bone marrow-derived mesenchymal stem cells promotes behavioral recovery and anti-inflammatory and angiogenesis effects in an intracerebral hemorrhage rat model". International Journal of Molecular Medicine 31.5 (2013): 1087-1096.
Chicago
Bao, X., Liu, F., Lu, S., Han, Q., Feng, M., Wei, J., Li, G., Zhao, R. C., Wang, R."Transplantation of Flk-1+ human bone marrow-derived mesenchymal stem cells promotes behavioral recovery and anti-inflammatory and angiogenesis effects in an intracerebral hemorrhage rat model". International Journal of Molecular Medicine 31, no. 5 (2013): 1087-1096. https://doi.org/10.3892/ijmm.2013.1290
Copy and paste a formatted citation
x
Spandidos Publications style
Bao X, Liu F, Lu S, Han Q, Feng M, Wei J, Li G, Zhao RC and Wang R: Transplantation of Flk-1+ human bone marrow-derived mesenchymal stem cells promotes behavioral recovery and anti-inflammatory and angiogenesis effects in an intracerebral hemorrhage rat model. Int J Mol Med 31: 1087-1096, 2013.
APA
Bao, X., Liu, F., Lu, S., Han, Q., Feng, M., Wei, J. ... Wang, R. (2013). Transplantation of Flk-1+ human bone marrow-derived mesenchymal stem cells promotes behavioral recovery and anti-inflammatory and angiogenesis effects in an intracerebral hemorrhage rat model. International Journal of Molecular Medicine, 31, 1087-1096. https://doi.org/10.3892/ijmm.2013.1290
MLA
Bao, X., Liu, F., Lu, S., Han, Q., Feng, M., Wei, J., Li, G., Zhao, R. C., Wang, R."Transplantation of Flk-1+ human bone marrow-derived mesenchymal stem cells promotes behavioral recovery and anti-inflammatory and angiogenesis effects in an intracerebral hemorrhage rat model". International Journal of Molecular Medicine 31.5 (2013): 1087-1096.
Chicago
Bao, X., Liu, F., Lu, S., Han, Q., Feng, M., Wei, J., Li, G., Zhao, R. C., Wang, R."Transplantation of Flk-1+ human bone marrow-derived mesenchymal stem cells promotes behavioral recovery and anti-inflammatory and angiogenesis effects in an intracerebral hemorrhage rat model". International Journal of Molecular Medicine 31, no. 5 (2013): 1087-1096. https://doi.org/10.3892/ijmm.2013.1290
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