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International Journal of Molecular Medicine
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Article

Suppression of endoplasmic reticulum stress-induced invasion and migration of breast cancer cells through the downregulation of heparanase

Retraction in: /10.3892/ijmm.2021.5021
  • Authors:
    • Yang Li
    • Hao Liu
    • Ying Ying Huang
    • Long Jian Pu
    • Xu Dong Zhang
    • Chen Chen Jiang
    • Zhi Wen Jiang
  • View Affiliations / Copyright

    Affiliations: Faculty of Pharmacy, Bengbu Medical College, Bengbu, Anhui 233000, P.R. China, Immunology and Oncology Unit, Calvary Mater Newcastle Hospital, Newcastle, NSW 2300, Australia
  • Pages: 1234-1242
    |
    Published online on: March 5, 2013
       https://doi.org/10.3892/ijmm.2013.1292
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Abstract

Tumor metastasis is the ultimate stage of cancer, and the primary cause of mortality in patients. Tumor cells breaking through the natural barrier consisting of the basement membrane (BM) and extracellular matrix (ECM) is the a crucial step in tumor invasion and metastasis. Thus, protecting this barrier is the key to reducing mortality. Heparanase is a mammalian endo-β-glucuronidase which has been found to promote the cleavage of heparan sulfate (HS), and plays a significant role in tumor cell invasion and metastasis. Although chemotherapeutic reagents have a strong antitumor activity, they may promote the invasion and migration of cancer cells, as has been observed during clinical treatment. Chemotherapeutic reagents can induce endoplasmic reticulum (ER) stress; in this study, we used adriamycin (ADM) and a classical ER stress inducer, tunicamycin (TM). We report that the activation of ER stress is involved in the enhanced invasion and migration ability of breast cancer cells and we hypothesized that this effect is associated with the activation of heparanase. In support of this, we used the heparanase inhibitor, OGT2115, and low molecular weight heparin (LMWH) to inhibit the expression and activity of heparanase, and we found that the invasion and migration ability of the cells was suppressed. Our findings demonstrate that heparanase inhibitors suppress breast cancer cell invasion and migration induced by ER stress, and provide a strong rationale for the development of heparanase-based therapeutics for the prevention of metastasis induced by chemotherapeutic reagents.
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Copy and paste a formatted citation
Spandidos Publications style
Li Y, Liu H, Huang YY, Pu LJ, Zhang XD, Jiang CC and Jiang ZW: Suppression of endoplasmic reticulum stress-induced invasion and migration of breast cancer cells through the downregulation of heparanase Retraction in /10.3892/ijmm.2021.5021. Int J Mol Med 31: 1234-1242, 2013.
APA
Li, Y., Liu, H., Huang, Y.Y., Pu, L.J., Zhang, X.D., Jiang, C.C., & Jiang, Z.W. (2013). Suppression of endoplasmic reticulum stress-induced invasion and migration of breast cancer cells through the downregulation of heparanase Retraction in /10.3892/ijmm.2021.5021. International Journal of Molecular Medicine, 31, 1234-1242. https://doi.org/10.3892/ijmm.2013.1292
MLA
Li, Y., Liu, H., Huang, Y. Y., Pu, L. J., Zhang, X. D., Jiang, C. C., Jiang, Z. W."Suppression of endoplasmic reticulum stress-induced invasion and migration of breast cancer cells through the downregulation of heparanase Retraction in /10.3892/ijmm.2021.5021". International Journal of Molecular Medicine 31.5 (2013): 1234-1242.
Chicago
Li, Y., Liu, H., Huang, Y. Y., Pu, L. J., Zhang, X. D., Jiang, C. C., Jiang, Z. W."Suppression of endoplasmic reticulum stress-induced invasion and migration of breast cancer cells through the downregulation of heparanase Retraction in /10.3892/ijmm.2021.5021". International Journal of Molecular Medicine 31, no. 5 (2013): 1234-1242. https://doi.org/10.3892/ijmm.2013.1292
Copy and paste a formatted citation
x
Spandidos Publications style
Li Y, Liu H, Huang YY, Pu LJ, Zhang XD, Jiang CC and Jiang ZW: Suppression of endoplasmic reticulum stress-induced invasion and migration of breast cancer cells through the downregulation of heparanase Retraction in /10.3892/ijmm.2021.5021. Int J Mol Med 31: 1234-1242, 2013.
APA
Li, Y., Liu, H., Huang, Y.Y., Pu, L.J., Zhang, X.D., Jiang, C.C., & Jiang, Z.W. (2013). Suppression of endoplasmic reticulum stress-induced invasion and migration of breast cancer cells through the downregulation of heparanase Retraction in /10.3892/ijmm.2021.5021. International Journal of Molecular Medicine, 31, 1234-1242. https://doi.org/10.3892/ijmm.2013.1292
MLA
Li, Y., Liu, H., Huang, Y. Y., Pu, L. J., Zhang, X. D., Jiang, C. C., Jiang, Z. W."Suppression of endoplasmic reticulum stress-induced invasion and migration of breast cancer cells through the downregulation of heparanase Retraction in /10.3892/ijmm.2021.5021". International Journal of Molecular Medicine 31.5 (2013): 1234-1242.
Chicago
Li, Y., Liu, H., Huang, Y. Y., Pu, L. J., Zhang, X. D., Jiang, C. C., Jiang, Z. W."Suppression of endoplasmic reticulum stress-induced invasion and migration of breast cancer cells through the downregulation of heparanase Retraction in /10.3892/ijmm.2021.5021". International Journal of Molecular Medicine 31, no. 5 (2013): 1234-1242. https://doi.org/10.3892/ijmm.2013.1292
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