Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
International Journal of Molecular Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1107-3756 Online ISSN: 1791-244X
Journal Cover
May 2013 Volume 31 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
May 2013 Volume 31 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Heme oxygenase/carbon monoxide pathway inhibition plays a role in ameliorating fibrosis following splenectomy

  • Authors:
    • Qiu-Ming Wang
    • Zhi-Jun Duan
    • Jian-Ling Du
    • Shi-Bin Guo
    • Xiao-Yu Sun
    • Zhen Liu
  • View Affiliations / Copyright

    Affiliations: Department of Gastroenterology, The First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning 116011, P.R. China, Department of Endocrinology, The First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning 116011, P.R. China
  • Pages: 1186-1194
    |
    Published online on: March 20, 2013
       https://doi.org/10.3892/ijmm.2013.1309
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Splenectomy is a recognized therapy for liver cirrhosis with splenomegaly, since it decreases free iron concentration that accompanies the destruction of red blood cells. Heme oxygenase (HO)-1 and its by-products, iron and carbon monoxide (CO), play crucial roles in hepatic fibrosis. The aim of the present study was to determine whether splenectomy in cirrhotic rats induced by bile duct ligation (BDL), through the HO/CO pathway, could slow down the development of liver fibrosis. Male Sprague-Dawley rats were divided randomly into the sham, BDL, splenectomy, Fe, zinc protoporphyrin (Znpp) and cobalt protoporphyrin (Copp) treatment groups, for inhibiting and inducing HO-1 expression. The level of HO-1 was detected by western blot analysis and reverse transcription-polymerase chain reaction. Serum carboxyhemoglobin (COHb), iron and portal vein pressure (PVP) were also quantified. Liver iron was measured by atomic absorption spectrometry with acetylene-air flame atomization. HO-1 and α-smooth muscle actin (α-SMA) were localized by immunohistochemistry. Liver and spleen iron were visualized by Perls' Prussian blue staining. Hepatic fibrosis was assessed using hematoxylin and eosin (H&E) staining. Enzyme-linked immunosorbent assay (ELISA) was used to detect serum transforming growth factor-β1 (TGF-β1). The results showed that liver, spleen and serum levels of HO-1, COHb and iron were greatly enhanced in the BDL group compared with the sham group; they were reduced following splenectomy and Znpp treatment, but were elevated in the Copp and Fe groups. Hydroxyproline, TGF-β1, α-SMA, PVP and malonaldehyde levels were lower in the splenectomy and Znpp groups compared to BDL, while higher levels were observed in the Copp and Fe-treated groups. Our study shows that splenectomy reduces iron and CO levels in part by reducing HO-1 expression, and it decreases portal pressure and slightly decreases hepatic fibroproliferation.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

View References

1 

Imura S, Shimada M, Utsunomiya T, et al: Impact of splenectomy in patients with liver cirrhosis: Results from 18 patients in a single center experience. Hepatol Res. 40:894–900. 2010. View Article : Google Scholar : PubMed/NCBI

2 

Ito K, Ozasa H, Noda Y and Horikawa S: Splenic artery ligation ameliorates hepatic ischemia and reperfusion injury in rats. Liver Int. 26:254–260. 2006. View Article : Google Scholar : PubMed/NCBI

3 

Ito K, Ozasa H and Horikawa S: Effects of prior splenectomy on remnant liver after partial hepatectomy with Pringle maneuver in rats. Liver Int. 25:438–444. 2005. View Article : Google Scholar : PubMed/NCBI

4 

Shimada M, Ijichi H, Yonemura Y, et al: The impact of splenectomy or splenic artery ligation on the outcome of a living donor adult liver transplantation using a left lobe graft. Hepatogastroenterology. 51:625–629. 2004.PubMed/NCBI

5 

Chen XP, Wu ZD, Huang ZY and Qiu FZ: Use of hepatectomy and splenectomy to treat hepatocellular carcinoma with cirrhotic hypersplenism. Br J Surg. 92:334–339. 2005. View Article : Google Scholar : PubMed/NCBI

6 

Uehara H, Akahoshi T, Kawanaka H, et al: Endothelin-1 derived from spleen-activated Rho-kinase pathway in rats with secondary biliary cirrhosis. Hepatol Res. 42:1039–1047. 2012. View Article : Google Scholar : PubMed/NCBI

7 

Arakawa Y, Shimada M, Uchiyama H, et al: Beneficial effects of splenectomy on massive hepatectomy model in rats. Hepatol Res. 39:391–397. 2009. View Article : Google Scholar : PubMed/NCBI

8 

Ito K, Ozasa H, Yoneya R and Horikawa S: Splenectomy ameliorates hepatic ischemia and reperfusion injury mediated by heme oxygenase-1 induction in the rat. Liver. 22:467–473. 2002. View Article : Google Scholar : PubMed/NCBI

9 

Tarquini R, Masini E, La Villa G, et al: Increased plasma carbon monoxide in patients with viral cirrhosis and hyperdynamic circulation. Am J Gastroenterol. 104:891–897. 2009. View Article : Google Scholar : PubMed/NCBI

10 

Duan ZJ, Yang D, Wang F, Sun YJ, Sun XY and Zheng ML: Heme oxygenase-1 regulates the major route involved in formation of immune hepatic fibrosis in rats. Chin Med J. 123:3304–3308. 2010.PubMed/NCBI

11 

Sass G, Barikbin R and Tiegs G: The multiple functions of heme oxygenase-1 in the liver. Z Gastroenterol. 50:34–40. 2012. View Article : Google Scholar : PubMed/NCBI

12 

Naik JS, O’Donaughy TL and Walker BR: Endogenous carbon monoxide is an endothelial-derived vasodilator factor in the mesenteric circulation. Am J Physiol Heart Circ Physiol. 284:H838–H845. 2003. View Article : Google Scholar : PubMed/NCBI

13 

Guo SB, Duan ZJ, Li Q and Sun XY: Effect of heme oxygenase-1 on renal function in rats with liver cirrhosis. World J Gastroenterol. 17:322–328. 2011. View Article : Google Scholar : PubMed/NCBI

14 

Guo SB, Duan ZJ, Li Q and Sun XY: Effects of heme oxygenase-1 on pulmonary function and structure in rats with liver cirrhosis. Chin Med J. 124:918–922. 2011.PubMed/NCBI

15 

Iwamoto T, Terai S, Mizunaga Y, et al: Splenectomy enhances the anti-fibrotic effect of bone marrow cell infusion and improves liver function in cirrhotic mice and patients. J Gastroenterol. 47:300–312. 2012. View Article : Google Scholar : PubMed/NCBI

16 

Brown KE, Dennery PA, Ridnour LA, et al: Effect of iron overload and dietary fat on indices of oxidative stress and hepatic fibrogenesis in rats. Liver Int. 23:232–242. 2003. View Article : Google Scholar : PubMed/NCBI

17 

Fallon MB, Abrams GA, McGrath JW, Hou Z and Luo B: Common bile duct ligation in the rat: a model of intrapulmonary vasodilatation and hepatopulmonary syndrome. Am J Physiol. 272:G779–G784. 1997.PubMed/NCBI

18 

Luo B, Abrams GA and Fallon MB: Endothelin-1 in the rat bile duct ligation model of hepatopulmonary syndrome: correlation with pulmonary dysfunction. J Hepatol. 29:571–578. 1998. View Article : Google Scholar : PubMed/NCBI

19 

Shackelford C, Long G, Wolf J, Okerberg C and Herbert R: Qualitative and quantitative analysis of nonneoplastic lesions in toxicology studies. Toxicol Pathol. 30:93–96. 2002. View Article : Google Scholar : PubMed/NCBI

20 

Kakinuma S, Tanaka Y, Chinzei R, et al: Human umbilical cord blood as a source of transplantable hepatic progenitor cells. Stem Cells. 21:217–227. 2003.PubMed/NCBI

21 

Ueda S, Yamanoi A, Hishikawa Y, Dhar DK, Tachibana M and Nagasue N: Transforming growth factor-beta1 released from the spleen exerts a growth inhibitory effect on liver regeneration in rats. Lab Invest. 83:1595–1603. 2003. View Article : Google Scholar : PubMed/NCBI

22 

Akahoshi T, Hashizume M, Tanoue K, et al: Role of the spleen in liver fibrosis in rats may be mediated by transforming growth factor beta-1. J Gastroenterol Hepatol. 17:59–65. 2002. View Article : Google Scholar : PubMed/NCBI

23 

Giles TD, Sander GE, Nossaman BD and Kadowitz PJ: Impaired vasodilation in the pathogenesis of hypertension: focus on nitric oxide, endothelial-derived hyperpolarizing factors, and prostaglandins. J Clin Hypertens. 14:198–205. 2012. View Article : Google Scholar

24 

Johnson RA, Kozma F and Colombari E: Carbon monoxide: from toxin to endogenous modulator of cardiovascular functions. Braz J Med Biol Res. 32:1–14. 1999. View Article : Google Scholar : PubMed/NCBI

25 

Furchgott RF and Jothianandan D: Endothelium-dependent and -independent vasodilation involving cyclic GMP: relaxation induced by nitric oxide, carbon monoxide and light. Blood Vessels. 28:52–61. 1991.

26 

Decaluwe K, Pauwels B, Verpoest S and Van de Voorde J: Divergent mechanisms involved in CO and CORM-2 induced vasorelaxation. Eur J Pharmacol. 674:370–377. 2012. View Article : Google Scholar : PubMed/NCBI

27 

Carter EP, Hartsfield CL, Miyazono M, Jakkula M, Morris KG Jr and McMurtry IF: Regulation of heme oxygenase-1 by nitric oxide during hepatopulmonary syndrome. Am J Physiol Lung Cell Mol Physiol. 283:L346–L353. 2002. View Article : Google Scholar : PubMed/NCBI

28 

Wang F, Duan ZJ and Sun YJ: Influence of heme oxygenase-1 expression on immune liver fibrosis induced by cobalt protoporphyrin in rats. World J Gastroenterol. 15:3009–3014. 2009. View Article : Google Scholar : PubMed/NCBI

29 

Barikbin R, Neureiter D, Wirth J, et al: Induction of heme oxygenase 1 prevents progression of liver fibrosis in Mdr2 knockout mice. Hepatology. 55:553–562. 2012. View Article : Google Scholar : PubMed/NCBI

30 

Khan ZA, Barbin YP, Cukiernik M, Adams PC and Chakrabarti S: Heme-oxygenase-mediated iron accumulation in the liver. Can J Physiol Pharmacol. 82:448–456. 2004. View Article : Google Scholar : PubMed/NCBI

31 

Kartikasari AE, Wagener FA, Yachie A, Wiegerinck ET, Kemna EH and Swinkels DW: Hepcidin suppression and defective iron recycling account for dysregulation of iron homeostasis in heme oxygenase-1 deficiency. J Cell Mol Med. 13:3091–3102. 2009. View Article : Google Scholar : PubMed/NCBI

32 

Crichton RR, Wilmet S, Legssyer R and Ward RJ: Molecular and cellular mechanisms of iron homeostasis and toxicity in mammalian cells. J Inorg Biochem. 91:9–18. 2002. View Article : Google Scholar : PubMed/NCBI

33 

Immenschuh S, Baumgart-Vogt E and Mueller S: Heme oxygenase-1 and iron in liver inflammation: a complex alliance. Curr Drug Targets. 11:1541–1550. 2010. View Article : Google Scholar : PubMed/NCBI

34 

Ramm GA and Ruddell RG: Iron homeostasis, hepatocellular injury, and fibrogenesis in hemochromatosis: the role of inflammation in a noninflammatory liver disease. Semin Liver Dis. 30:271–287. 2010. View Article : Google Scholar : PubMed/NCBI

35 

Pietrangelo A: Metals, oxidative stress, and hepatic fibrogenesis. Semin Liver Dis. 16:13–30. 1996. View Article : Google Scholar

36 

Deugnier Y and Turlin B: Pathology of hepatic iron overload. Semin Liver Dis. 31:260–271. 2011. View Article : Google Scholar

37 

Chen YC, Gines P, Yang J, et al: Increased vascular heme oxygenase-1 expression contributes to arterial vasodilation in experimental cirrhosis in rats. Hepatology. 39:1075–1087. 2004. View Article : Google Scholar : PubMed/NCBI

38 

Shi BM, Wang XY, Mu QL, Wu TH and Xu J: Value of portal hemodynamics and hypersplenism in cirrhosis staging. World J Gastroenterol. 11:708–711. 2005. View Article : Google Scholar : PubMed/NCBI

39 

Valero MA, Girones N, Garcia-Bodelon MA, et al: Anaemia in advanced chronic fasciolosis. Acta Trop. 108:35–43. 2008. View Article : Google Scholar : PubMed/NCBI

40 

Rhyu DY, Park J, Sharma BR and Ha H: Role of reactive oxygen species in transforming growth factor-beta1-induced extracellular matrix accumulation in renal tubular epithelial cells. Transplant Proc. 44:625–628. 2012. View Article : Google Scholar

41 

Urtasun R, Conde de la Rosa L and Nieto N: Oxidative and nitrosative stress and fibrogenic response. Clin Liver Dis. 12:769–790. viii2008. View Article : Google Scholar : PubMed/NCBI

42 

Yao P, Nussler A, Liu L, et al: Quercetin protects human hepatocytes from ethanol-derived oxidative stress by inducing heme oxygenase-1 via the MAPK/Nrf2 pathways. J Hepatol. 47:253–261. 2007. View Article : Google Scholar : PubMed/NCBI

43 

Okada K, Warabi E, Sugimoto H, et al: Nrf2 inhibits hepatic iron accumulation and counteracts oxidative stress-induced liver injury in nutritional steatohepatitis. J Gastroenterol. 47:924–935. 2012. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Wang Q, Duan Z, Du J, Guo S, Sun X and Liu Z: Heme oxygenase/carbon monoxide pathway inhibition plays a role in ameliorating fibrosis following splenectomy. Int J Mol Med 31: 1186-1194, 2013.
APA
Wang, Q., Duan, Z., Du, J., Guo, S., Sun, X., & Liu, Z. (2013). Heme oxygenase/carbon monoxide pathway inhibition plays a role in ameliorating fibrosis following splenectomy. International Journal of Molecular Medicine, 31, 1186-1194. https://doi.org/10.3892/ijmm.2013.1309
MLA
Wang, Q., Duan, Z., Du, J., Guo, S., Sun, X., Liu, Z."Heme oxygenase/carbon monoxide pathway inhibition plays a role in ameliorating fibrosis following splenectomy". International Journal of Molecular Medicine 31.5 (2013): 1186-1194.
Chicago
Wang, Q., Duan, Z., Du, J., Guo, S., Sun, X., Liu, Z."Heme oxygenase/carbon monoxide pathway inhibition plays a role in ameliorating fibrosis following splenectomy". International Journal of Molecular Medicine 31, no. 5 (2013): 1186-1194. https://doi.org/10.3892/ijmm.2013.1309
Copy and paste a formatted citation
x
Spandidos Publications style
Wang Q, Duan Z, Du J, Guo S, Sun X and Liu Z: Heme oxygenase/carbon monoxide pathway inhibition plays a role in ameliorating fibrosis following splenectomy. Int J Mol Med 31: 1186-1194, 2013.
APA
Wang, Q., Duan, Z., Du, J., Guo, S., Sun, X., & Liu, Z. (2013). Heme oxygenase/carbon monoxide pathway inhibition plays a role in ameliorating fibrosis following splenectomy. International Journal of Molecular Medicine, 31, 1186-1194. https://doi.org/10.3892/ijmm.2013.1309
MLA
Wang, Q., Duan, Z., Du, J., Guo, S., Sun, X., Liu, Z."Heme oxygenase/carbon monoxide pathway inhibition plays a role in ameliorating fibrosis following splenectomy". International Journal of Molecular Medicine 31.5 (2013): 1186-1194.
Chicago
Wang, Q., Duan, Z., Du, J., Guo, S., Sun, X., Liu, Z."Heme oxygenase/carbon monoxide pathway inhibition plays a role in ameliorating fibrosis following splenectomy". International Journal of Molecular Medicine 31, no. 5 (2013): 1186-1194. https://doi.org/10.3892/ijmm.2013.1309
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team