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Article

Protective effects of osthole against myocardial ischemia/reperfusion injury in rats

  • Authors:
    • Xian-Yue Wang
    • Wen-Peng Dong
    • Sheng-Hui Bi
    • Zhi-Guo Pan
    • Hao Yu
    • Xiao-Wu Wang
    • Tao Ma
    • Jun Wang
    • Wei-Da Zhang
  • View Affiliations / Copyright

    Affiliations: Department of Cardiovascular Surgery, Guangzhou General Hospital of Guangzhou Military Command, Guangzhou, Guangdong 510010, P.R. China, Intensive Care Unit, Guangzhou General Hospital of Guangzhou Military Command, Guangzhou, Guangdong 510010, P.R. China
  • Pages: 365-372
    |
    Published online on: May 21, 2013
       https://doi.org/10.3892/ijmm.2013.1386
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Abstract

Osthole, a bioactive simple coumarin derivative extracted from a number of medicinal plants, such as Cnidium monnieri and Angelica pubescens, has been shown to exert a variety of pharmacological activities and is considered to have potential therapeutic applications. In this study, we investigated the protective effects of osthole against myocardial ischemia/reperfusion (I/R) injury in rats. Male Sprague-Dawley rats were randomly assigned to 1 of 5 groups: the sham-oeprated control group (control), the vehicle group (vehicle), and 3 treatment groups, which were treated with osthole at the concentration of 1, 10 or 50 mg/kg (intraperitoneally), respectively, upon the initiation of myocardial ischemia. Treatment with osthole suppressed the formation of lipid peroxidation products, enhanced the capacities of antioxidant enzymes and inhibited the expression of inflammatory cytokines following myocardial I/R injury. Moreover, treatment with osthole reduced high-mobility group box protein 1 (HMGB1) and phosphorylated nuclear factor (NF)-κB expression in ischemic myocardial tissue. These results demonstrate the protective effects of osthole against myocardial I/R injury in rats and suggest that these effects may be associated with its antioxidant and anti-inflammatory activities.
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Copy and paste a formatted citation
Spandidos Publications style
Wang X, Dong W, Bi S, Pan Z, Yu H, Wang X, Ma T, Wang J and Zhang W: Protective effects of osthole against myocardial ischemia/reperfusion injury in rats. Int J Mol Med 32: 365-372, 2013.
APA
Wang, X., Dong, W., Bi, S., Pan, Z., Yu, H., Wang, X. ... Zhang, W. (2013). Protective effects of osthole against myocardial ischemia/reperfusion injury in rats. International Journal of Molecular Medicine, 32, 365-372. https://doi.org/10.3892/ijmm.2013.1386
MLA
Wang, X., Dong, W., Bi, S., Pan, Z., Yu, H., Wang, X., Ma, T., Wang, J., Zhang, W."Protective effects of osthole against myocardial ischemia/reperfusion injury in rats". International Journal of Molecular Medicine 32.2 (2013): 365-372.
Chicago
Wang, X., Dong, W., Bi, S., Pan, Z., Yu, H., Wang, X., Ma, T., Wang, J., Zhang, W."Protective effects of osthole against myocardial ischemia/reperfusion injury in rats". International Journal of Molecular Medicine 32, no. 2 (2013): 365-372. https://doi.org/10.3892/ijmm.2013.1386
Copy and paste a formatted citation
x
Spandidos Publications style
Wang X, Dong W, Bi S, Pan Z, Yu H, Wang X, Ma T, Wang J and Zhang W: Protective effects of osthole against myocardial ischemia/reperfusion injury in rats. Int J Mol Med 32: 365-372, 2013.
APA
Wang, X., Dong, W., Bi, S., Pan, Z., Yu, H., Wang, X. ... Zhang, W. (2013). Protective effects of osthole against myocardial ischemia/reperfusion injury in rats. International Journal of Molecular Medicine, 32, 365-372. https://doi.org/10.3892/ijmm.2013.1386
MLA
Wang, X., Dong, W., Bi, S., Pan, Z., Yu, H., Wang, X., Ma, T., Wang, J., Zhang, W."Protective effects of osthole against myocardial ischemia/reperfusion injury in rats". International Journal of Molecular Medicine 32.2 (2013): 365-372.
Chicago
Wang, X., Dong, W., Bi, S., Pan, Z., Yu, H., Wang, X., Ma, T., Wang, J., Zhang, W."Protective effects of osthole against myocardial ischemia/reperfusion injury in rats". International Journal of Molecular Medicine 32, no. 2 (2013): 365-372. https://doi.org/10.3892/ijmm.2013.1386
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