Protective effects of osthole against myocardial ischemia/reperfusion injury in rats

  • Authors:
    • Xian-Yue Wang
    • Wen-Peng Dong
    • Sheng-Hui Bi
    • Zhi-Guo Pan
    • Hao Yu
    • Xiao-Wu Wang
    • Tao Ma
    • Jun Wang
    • Wei-Da Zhang
  • View Affiliations

  • Published online on: May 21, 2013     https://doi.org/10.3892/ijmm.2013.1386
  • Pages: 365-372
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Abstract

Osthole, a bioactive simple coumarin derivative extracted from a number of medicinal plants, such as Cnidium monnieri and Angelica pubescens, has been shown to exert a variety of pharmacological activities and is considered to have potential therapeutic applications. In this study, we investigated the protective effects of osthole against myocardial ischemia/reperfusion (I/R) injury in rats. Male Sprague-Dawley rats were randomly assigned to 1 of 5 groups: the sham-oeprated control group (control), the vehicle group (vehicle), and 3 treatment groups, which were treated with osthole at the concentration of 1, 10 or 50 mg/kg (intraperitoneally), respectively, upon the initiation of myocardial ischemia. Treatment with osthole suppressed the formation of lipid peroxidation products, enhanced the capacities of antioxidant enzymes and inhibited the expression of inflammatory cytokines following myocardial I/R injury. Moreover, treatment with osthole reduced high-mobility group box protein 1 (HMGB1) and phosphorylated nuclear factor (NF)-κB expression in ischemic myocardial tissue. These results demonstrate the protective effects of osthole against myocardial I/R injury in rats and suggest that these effects may be associated with its antioxidant and anti-inflammatory activities.
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August 2013
Volume 32 Issue 2

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Spandidos Publications style
Wang X, Dong W, Bi S, Pan Z, Yu H, Wang X, Ma T, Wang J and Zhang W: Protective effects of osthole against myocardial ischemia/reperfusion injury in rats. Int J Mol Med 32: 365-372, 2013
APA
Wang, X., Dong, W., Bi, S., Pan, Z., Yu, H., Wang, X. ... Zhang, W. (2013). Protective effects of osthole against myocardial ischemia/reperfusion injury in rats. International Journal of Molecular Medicine, 32, 365-372. https://doi.org/10.3892/ijmm.2013.1386
MLA
Wang, X., Dong, W., Bi, S., Pan, Z., Yu, H., Wang, X., Ma, T., Wang, J., Zhang, W."Protective effects of osthole against myocardial ischemia/reperfusion injury in rats". International Journal of Molecular Medicine 32.2 (2013): 365-372.
Chicago
Wang, X., Dong, W., Bi, S., Pan, Z., Yu, H., Wang, X., Ma, T., Wang, J., Zhang, W."Protective effects of osthole against myocardial ischemia/reperfusion injury in rats". International Journal of Molecular Medicine 32, no. 2 (2013): 365-372. https://doi.org/10.3892/ijmm.2013.1386