|
1
|
Saadia R and Schein M: Multiple organ
failure. How valid is the ‘two hit’ model? J Accid Emerg Med.
16:163–166. 1999.
|
|
2
|
Rotstein OD: Modeling the two-hit
hypothesis for evaluating strategies to prevent organ injury after
shock/resuscitation. J Trauma. 54:S203–S206. 2003.PubMed/NCBI
|
|
3
|
West MA, Li MH, Seatter SC and Bubrick MP:
Pre-exposure to hypoxia or septic stimuli differentially regulates
endotoxin release of tumor necrosis factor, interleukin-6,
interleukin-1, prostaglandin E2, nitric oxide, and superoxide by
macrophages. J Trauma. 37:82–89. 1994. View Article : Google Scholar
|
|
4
|
Kim SY, Choi YJ, Joung SM, Lee BH, Jung YS
and Lee JY: Hypoxic stress up-regulates the expression of Toll-like
receptor 4 in macrophages via hypoxia-inducible factor. Immunology.
129:516–524. 2010. View Article : Google Scholar : PubMed/NCBI
|
|
5
|
Brehmer F, Bendix I, Prager S, van de
Looij Y, Reinboth BS, Zimmermanns J, Schlager GW, Brait D,
Sifringer M, Endesfelder S, Sizonenko S, Mallard C, Bührer C,
Felderhoff-Mueser U and Gerstner B: Interaction of inflammation and
hyperoxia in a rat model of neonatal white matter damage. PLoS One.
7:e490232012. View Article : Google Scholar : PubMed/NCBI
|
|
6
|
Cheng XQ, Song LJ, Li H, Di H, Zhang YY
and Chen DF: Beneficial effect of the polysaccharides from
Bupleurum smithii var. parvifolium on ‘two-hit’ acute lung injury
in rats. Inflammation. 35:1715–1722. 2012.
|
|
7
|
Kox M, Vaneker M, van der Hoeven JG,
Scheffer GJ, Hoedemaekers CW and Pickkers P: Effects of vagus nerve
stimulation and vagotomy on systemic and pulmonary inflammation in
a two-hit model in rats. PLoS One. 7:e344312012. View Article : Google Scholar : PubMed/NCBI
|
|
8
|
Szabo C: Role of poly(ADP-ribose)
synthetase in inflammation. Eur J Pharmacol. 350:1–19. 1998.
View Article : Google Scholar : PubMed/NCBI
|
|
9
|
Pacher P and Szabo C: Role of
poly(ADP-ribose) polymerase 1 (PARP-1) in cardiovascular diseases:
the therapeutic potential of PARP inhibitors. Cardiovasc Drug Rev.
25:235–260. 2007. View Article : Google Scholar : PubMed/NCBI
|
|
10
|
Graziani G and Szabo C: Clinical
perspectives of PARP inhibitors. Pharmacol Res. 52:109–118. 2005.
View Article : Google Scholar : PubMed/NCBI
|
|
11
|
Erdélyi K, Bai P, Kovács I, Szabó E,
Mocsár G, Kakuk A, Szabo C, Gergely P and Virág L: Dual role of
poly(ADP-ribose) glycohydrolase in the regulation of cell death in
oxidatively stressed A549 cells. FASEB J. 23:3553–3563.
2009.PubMed/NCBI
|
|
12
|
Salzman A, Denenberg AG, Ueta I, O’Connor
M, Linn SC and Szabo C: Induction and activity of nitric oxide
synthase in cultured human intestinal epithelial monolayers. Am J
Physiol. 270:G565–G573. 1996.PubMed/NCBI
|
|
13
|
Jakovljevic B, Novakov-Mikic A, Brkic S,
Bogavac MA, Tomic S and Miler V: Lipid peroxidation in the first
trimester of pregnancy. J Matern Fetal Neonatal Med. 25:1316–1318.
2012. View Article : Google Scholar : PubMed/NCBI
|
|
14
|
Suzuki K, Olah G, Modis K, Coletta C, Kulp
G, Gerö D, Szoleczky P, Chang T, Zhou Z, Wu L, Wang R,
Papapetropoulos A and Szabo C: Hydrogen sulfide replacement therapy
protects the vascular endothelium in hyperglycemia by preserving
mitochondrial function. Proc Natl Acad Sci USA. 108:13829–13834.
2011. View Article : Google Scholar : PubMed/NCBI
|
|
15
|
Módis K, Gero D, Erdélyi K, Szoleczky P,
DeWitt D and Szabo C: Cellular bioenergetics is regulated by PARP1
under resting conditions and during oxidative stress. Biochem
Pharmacol. 83:633–643. 2012.PubMed/NCBI
|
|
16
|
Southan GJ, Zingarelli B, O’Connor M,
Salzman AL and Szabo C: Spontaneous rearrangement of
aminoalkylisothioureas into mercaptoalkylguanidines, a novel class
of nitric oxide synthase inhibitors with selectivity towards the
inducible isoform. Br J Pharmacol. 117:619–632. 1996. View Article : Google Scholar
|
|
17
|
Gerö D, Módis K, Nagy N, Szoleczky P, Tóth
ZD, Dormán G and Szabo C: Oxidant-induced cardiomyocyte injury:
identification of the cytoprotective effect of a dopamine 1
receptor agonist using a cell-based high-throughput assay. Int J
Mol Med. 20:749–761. 2007.PubMed/NCBI
|
|
18
|
Virág L and Szabo C: Purines inhibit
poly(ADP-ribose) polymerase activation and modulate oxidant-induced
cell death. FASEB J. 15:99–107. 2011.PubMed/NCBI
|
|
19
|
Virág L, Scott GS, Cuzzocrea S, Marmer D,
Salzman AL and Szabo C: Peroxynitrite-induced thymocyte apoptosis:
the role of caspases and poly(ADP-ribose) synthetase (PARS)
activation. Immunology. 94:345–355. 1998.PubMed/NCBI
|
|
20
|
Virág L, Salzman AL and Szabo C:
Poly(ADP-ribose) synthetase activation mediates mitochondrial
injury during oxidant-induced cell death. J Immunol. 161:3753–3759.
1998.PubMed/NCBI
|
|
21
|
Ha HC and Snyder SH: Poly(ADP-ribose)
polymerase is a mediator of necrotic cell death by ATP depletion.
Proc Natl Acad Sci USA. 96:13978–13982. 1999. View Article : Google Scholar : PubMed/NCBI
|
|
22
|
Szoleczky P, Módis K, Nagy N, Dóri Tóth Z,
DeWitt D, Szabo C and Gero D: Identification of agents that reduce
renal hypoxia-reoxygenation injury using cell-based screening:
purine nucleosides are alternative energy sources in LLC-PK1 cells
during hypoxia. Arch Biochem Biophys. 517:53–70. 2012.
|
|
23
|
Szabo C, Saunders C, O’Connor M and
Salzman AL: Peroxynitrite causes energy depletion and increases
permeability via activation of poly(ADP-ribose) synthetase in
pulmonary epithelial cells. Am J Respir Cell Mol Biol. 16:105–109.
1997. View Article : Google Scholar : PubMed/NCBI
|
|
24
|
Kennedy M, Denenberg AG, Szabo C and
Salzman AL: Poly(ADP-ribose) synthetase activation mediates
increased permeability induced by peroxynitrite in Caco-2BBe cells.
Gastroenterology. 114:510–518. 1998. View Article : Google Scholar : PubMed/NCBI
|
|
25
|
Liaudet L, Szabó A, Soriano FG, Zingarelli
B, Szabo C and Salzman AL: Poly(ADP-ribose) synthetase mediates
intestinal mucosal barrier dysfunction after mesenteric ischemia.
Shock. 14:134–141. 2000. View Article : Google Scholar : PubMed/NCBI
|
|
26
|
Shimoda K, Murakami K, Enkhbaatar P,
Traber LD, Cox RA, Hawkins HK, Schmalstieg FC, Komjati K, Mabley
JG, Szabo C, Salzman AL and Traber DL: Effect of poly(ADP ribose)
synthetase inhibition on burn and smoke inhalation injury in sheep.
Am J Physiol Lung Cell Mol Physiol. 285:L240–L249. 2003. View Article : Google Scholar : PubMed/NCBI
|
|
27
|
Szabo C, Lim LH, Cuzzocrea S, Getting SJ,
Zingarelli B, Flower RJ, Salzman AL and Perretti M: Inhibition of
poly(ADP-ribose) synthetase attenuates neutrophil recruitment and
exerts antiinflammatory effects. J Exp Med. 186:1041–1049. 1997.
View Article : Google Scholar : PubMed/NCBI
|
|
28
|
Cuzzocrea S, Zingarelli B, Gilad E, Hake
P, Salzman AL and Szabo C: Protective effects of 3-aminobenzamide,
an inhibitor of poly(ADP-ribose) synthase in a carrageenan-induced
model of local inflammation. Eur J Pharmacol. 342:67–76. 1998.
View Article : Google Scholar : PubMed/NCBI
|
|
29
|
Veres B, Gallyas F Jr, Varbiro G, Berente
Z, Osz E, Szekeres G, Szabo C and Sumegi B: Decrease of the
inflammatory response and induction of the Akt/protein kinase B
pathway by poly(ADP-ribose) polymerase 1 inhibitor in
endotoxin-induced septic shock. Biochem Pharmacol. 65:1373–1382.
2003. View Article : Google Scholar : PubMed/NCBI
|
|
30
|
Goldfarb RD, Marton A, Szabó E, Virág L,
Salzman AL, Glock D, Akhter I, McCarthy R, Parrillo JE and Szabo C:
Protective effect of a novel, potent inhibitor of poly(adenosine
5′-diphosphate-ribose) synthetase in a porcine model of severe
bacterial sepsis. Crit Care Med. 30:974–980. 2002.
|
|
31
|
Soriano FG, Liaudet L, Szabó E, Virág L,
Mabley JG, Pacher P and Szabo C: Resistance to acute septic
peritonitis in poly(ADP-ribose) polymerase-1-deficient mice. Shock.
17:286–292. 2002. View Article : Google Scholar : PubMed/NCBI
|
|
32
|
Bai P and Virág L: Role of
poly(ADP-ribose) polymerases in the regulation of inflammatory
processes. FEBS Lett. 586:3771–3777. 2012. View Article : Google Scholar : PubMed/NCBI
|
|
33
|
Cantoni O and Guidarelli A: Peroxynitrite
damages U937 cell DNA via the intermediate formation of
mitochondrial oxidants. IUBMB Life. 60:753–756. 2008. View Article : Google Scholar : PubMed/NCBI
|
|
34
|
Jean JC, Liu Y and Joyce-Brady M: The
importance of gamma-glutamyl transferase in lung glutathione
homeostasis and antioxidant defense. Biofactors. 17:161–173. 2003.
View Article : Google Scholar : PubMed/NCBI
|
|
35
|
Cuzzocrea S, Zingarelli B, O’Connor M,
Salzman AL and Szabo C: Effect of L-buthionine-(S,R)-sulphoximine,
an inhibitor of gamma-glutamylcysteine synthetase on peroxynitrite-
and endotoxic shock-induced vascular failure. Br J Pharmacol.
123:525–537. 1998. View Article : Google Scholar : PubMed/NCBI
|
|
36
|
Kiss L, Chen M, Gero D, Módis K, Lacza Z
and Szabo C: Effects of 7-ketocholesterol on the activity of
endothelial poly(ADP-ribose) polymerase and on
endothelium-dependent relaxant function. Int J Mol Med.
18:1113–1117. 2006.PubMed/NCBI
|
|
37
|
Mizumoto K, Glascott PA Jr and Farber JL:
Roles for oxidative stress and poly(ADP-ribosyl)ation in the
killing of cultured hepatocytes by methyl methanesulfonate. Biochem
Pharmacol. 46:1811–1818. 1993. View Article : Google Scholar : PubMed/NCBI
|
|
38
|
Bump EA and Brown JM: Role of glutathione
in the radiation response of mammalian cells in vitro and in vivo.
Pharmacol Ther. 47:117–136. 1990. View Article : Google Scholar : PubMed/NCBI
|
|
39
|
Zucker B, Hanusch J and Bauer G:
Glutathione depletion in fibroblasts is the basis for
apoptosis-induction by endogenous reactive oxygen species. Cell
Death Differ. 4:388–395. 1997. View Article : Google Scholar : PubMed/NCBI
|
|
40
|
Puhakka A, Ollikainen T, Soini Y, Kahlos
K, Säily M, Koistinen P, Pääkkö P, Linnainmaa K and Kinnula VL:
Modulation of DNA single-strand breaks by intracellular glutathione
in human lung cells exposed to asbestos fibers. Mutat Res.
514:7–17. 2002. View Article : Google Scholar : PubMed/NCBI
|
