|
1
|
Aller SG, Yu J, Ward A, et al: Structure
of P-glycoprotein reveals a molecular basis for poly-specific drug
binding. Science. 323:1718–1722. 2009. View Article : Google Scholar : PubMed/NCBI
|
|
2
|
Namanja HA, Emmert D, Davis DA, et al:
Toward eradicating HIV reservoirs in the brain: inhibiting
P-glycoprotein at the blood-brain barrier with prodrug abacavir
dimers. Am Chem Soc. 134:2976–2980. 2012. View Article : Google Scholar : PubMed/NCBI
|
|
3
|
Thiebaut F, Tsuruo T, Hamada H, et al:
Cellular localization of the multidrug-resistance gene product
P-glycoprotein in normal human tissues. Proc Natl Acad Sci USA.
84:7735–7738. 1987. View Article : Google Scholar : PubMed/NCBI
|
|
4
|
Choudhuri S and Klaassen CD: Structure,
function, expression, genomic organization, and single nucleotide
polymorphisms of human ABCB1 (MDR1), ABCC (MRP), and ABCG2 (BCRP)
efflux transporters. Int J Toxicol. 25:231–259. 2006. View Article : Google Scholar
|
|
5
|
Moon YJ, Zhang S and Morris ME: Real-time
quantitative polymerase chain reaction for BCRP, MDR1, and MRP1
mRNA levels in lymphocytes and monocytes. Acta Haematol.
118:169–175. 2007. View Article : Google Scholar : PubMed/NCBI
|
|
6
|
Kock K, Grube M, Jedlitschky G, et al:
Expression of adenosine triphosphate-binding cassette (ABC) drug
transporters in peripheral blood cells: relevance for physiology
and pharmacotherapy. Clin Pharmacokinet. 46:449–470. 2007.
View Article : Google Scholar : PubMed/NCBI
|
|
7
|
Varatharajan L and Thomas SA: The
transport of anti-HIV drugs across blood-CNS interfaces: summary of
current knowledge and recommendations for further research.
Antiviral Res. 82:A99–A109. 2009. View Article : Google Scholar : PubMed/NCBI
|
|
8
|
Rehermann B and Naoumov NV: Immunological
techniques in viral hepatitis. J Hepatol. 46:508–520. 2007.
View Article : Google Scholar : PubMed/NCBI
|
|
9
|
Giraud C, Declèves X, Perrot JY, et al:
High levels of P-glycoprotein activity in human lymphocytes in the
first 6 months of life. Clin Pharmacol Ther. 85:289–295. 2009.
View Article : Google Scholar : PubMed/NCBI
|
|
10
|
Livak KJ and Schmittgen TD: Analysis of
relative gene expression data using real-time quantitative PCR and
the 2(-Delta Delta C(T)) method. Methods. 25:402–440. 2001.
View Article : Google Scholar : PubMed/NCBI
|
|
11
|
Chaudhary PM, Mechetner EB and Roninson
IB: Expression and activity of the multidrug resistance
P-glycoprotein in human peripheral blood lymphocytes. Blood.
80:2735–2739. 1992.PubMed/NCBI
|
|
12
|
Lee CG and Gottesman MM: HIV-1 protease
inhibitors and the MDR1 multidrug transporter. J Clin Invest.
101:287–288. 1998. View Article : Google Scholar : PubMed/NCBI
|
|
13
|
Srinivas RV, Middlemas D, Flynn P and
Fridland A: Human immunodeficiency virus protease inhibitors serve
as substrates for multidrug transporter proteins MDR1 and MRP1 but
retain antiviral efficacy in cell lines expressing these
transporters. Antimicrob Agents Chemother. 42:3157–3162. 1998.
|
|
14
|
Huisman MT, Smit JW and Schinkel AH:
Significance of P-glycoprotein for the pharmacology and clinical
use of HIV protease inhibitors. AIDS. 14:237–242. 2000. View Article : Google Scholar : PubMed/NCBI
|
|
15
|
Janneh O, Owen A, Chandler B, et al:
Modulation of the intracellular accumulation of saquinavir in
peripheral blood mononuclear cells by inhibitors of MRP1, MRP2, Pgp
and BCRP. AIDS. 19:2097–2102. 2005. View Article : Google Scholar : PubMed/NCBI
|
|
16
|
Perloff MD, von Moltke LL, Marchand JE and
Greenblatt DJ: Ritonavir induces P-glycoprotein expression,
multidrug resistance-associated protein (MRP1) expression, and drug
transporter-mediated activity in a human intestinal cell line. J
Pharm Sci. 90:1829–1837. 2001. View Article : Google Scholar
|
|
17
|
Perloff ES, Duan SX, Skolnik PR, et al:
Atazanavir: effects on P-Glycoprotein transport and CYP3A
metabolism in vitro. Drug Metab Dispos. 33:764–770. 2005.
View Article : Google Scholar : PubMed/NCBI
|
|
18
|
Huang L, Wring SA, Wooley JL, et al:
Induction of P-glycoprotein and cytochrome P450 3A by HIV protease
inhibitors. Drug Metab Dispos. 29:754–760. 2001.PubMed/NCBI
|
|
19
|
Mukwaya G, MacGregor T, Hoelscher D, et
al: Interaction of ritonavir-boosted tipranavir with loperamide
does not result in loperamideassociated neurologic side effects in
healthy volunteers. Antimicrob Agents Chemother. 49:4903–4910.
2005. View Article : Google Scholar : PubMed/NCBI
|
|
20
|
Gollapudi S and Gupta S: Human
immunodeficiency virus I-induced expression of P-glycoprotein.
Biochem Biophys Res Commun. 171:1002–1007. 1990. View Article : Google Scholar : PubMed/NCBI
|
|
21
|
Antonelli G, Turriziani O, Cianfriglia M,
et al: Resistance of HIV-1 to AZT might also involve the cellular
expression of multidrug resistance P-glycoprotein. AIDS Res Hum
Retroviruses. 8:1839–1844. 1992. View Article : Google Scholar : PubMed/NCBI
|
|
22
|
Weiss J, Rose J, Storch CH, et al:
Modulation of human BCRP (ABCG2) activity by anti-HIV drugs. J
Antimicrob Chemother. 59:238–245. 2007. View Article : Google Scholar : PubMed/NCBI
|
|
23
|
Stormer E, von Moltke LL, Perloff MD and
Greenblatt DJ: Differential modulation of P-glycoprotein expression
and activity by non-nucleoside HIV-1 reverse transcriptase
inhibitors in cell culture. Pharm Res. 19:1038–1045. 2002.
View Article : Google Scholar : PubMed/NCBI
|
|
24
|
Chandler B, Almond L, Ford J, et al: The
effects of protease inhibitors and nonnucleoside reverse
transcriptase inhibitors on P-glycoprotein expression in peripheral
blood mononuclear cells in vitro. J Acquir Immune Defic Syndr.
33:551–556. 2003. View Article : Google Scholar
|
|
25
|
De Maat MMR, Ekhart GC, Huitema ADR, et
al: Drug interactions between antiretroviral drugs and comedicated
agents. Clin Pharmacokinet. 42:223–282. 2003.PubMed/NCBI
|
|
26
|
Sankatsing SU, Beijnen JH, Schinkel AH, et
al: P-glycoprotein in human immunodeficiency virus type 1 infection
and therapy. Antimicrob Agents Chemother. 48:1073–1081. 2004.
View Article : Google Scholar : PubMed/NCBI
|
|
27
|
Andreana A, Aggarwal S, Gollapudi S, et
al: Abnormal expression of a 170-kilodalton P-glycoprotein encoded
by MDR1 gene, a metabolically active efflux pump, in
CD4+ and CD8+ T cells from patients with
human immunodeficiency virus type 1 infection. AIDS Res Hum
Retroviruses. 12:1457–1462. 1996. View Article : Google Scholar : PubMed/NCBI
|
|
28
|
Lucia MB, Cauda R, Landay AL, et al:
Transmembrane P-glycoprotein (P-gp/P-170) in HIV infection:
analysis of lymphocyte surface expression and drug-unrelated
function. AIDS Res Hum Retroviruses. 11:893–901. 1995. View Article : Google Scholar : PubMed/NCBI
|
|
29
|
Ford J, Hoggard PG, Owen A, et al: A
simplified approach to determining P-glycoprotein expression in
peripheral blood mononuclear cell subsets. J Immunol Methods.
274:129–137. 2003. View Article : Google Scholar : PubMed/NCBI
|
|
30
|
Chong AS, Markham PN, Gebel HM, et al:
Diverse multidrug-resistance-modification agents inhibit cytolytic
activity of natural killer cells. Cancer Immunol Immunother.
36:133–139. 1993. View Article : Google Scholar : PubMed/NCBI
|
|
31
|
Ludescher C, Pall G, Irschick EU and Gastl
G: Differential activity of P-glycoprotein in normal blood
lymphocyte subsets. Br J Haematol. 101:722–727. 1998. View Article : Google Scholar : PubMed/NCBI
|
|
32
|
Hayashi K, Pu H, Tian J, et al: HIV-Tat
protein induces P-glycoprotein expression in brain microvascular
endothelial cells. J Neurochem. 93:1231–1241. 2005. View Article : Google Scholar : PubMed/NCBI
|
|
33
|
Jorajuria S, Dereuddre-Bosquet N,
Naissant-Storck K, et al: Differential expression levels of MRP1,
MRP4, and MRP5 in response to human immunodeficiency virus
infection in human macrophages. Antimicrob Agents Chemother.
48:1889–1891. 2004. View Article : Google Scholar : PubMed/NCBI
|
|
34
|
Turriziani O, Gianotti N, Falasca F, et
al: Expression levels of MDR1, MRP1, MRP4, and MRP5 in peripheral
blood mononuclear cells from HIV infected patients failing
antiretroviral therapy. J Med Virol. 80:766–771. 2008. View Article : Google Scholar : PubMed/NCBI
|
|
35
|
Klimecki WT, Futscher BW, Grogan TM and
Dalton WS: P-glycoprotein expression and function in circulating
blood cells from normal volunteers. Blood. 83:2451–2458.
1994.PubMed/NCBI
|
|
36
|
Raviv Y, Puri A and Blumenthal R:
P-glycoprotein-overexpressing multidrug-resistant cells are
resistant to infection by enveloped viruses that enter via the
plasma membrane. FASEB J. 14:511–515. 2000.
|
|
37
|
Lee CG, Ramachandra M, Jeang KT, et al:
Effect of ABC transporters on HIV-1 infection: inhibition of virus
production by the MDR1 transporter. FASEB J. 14:516–522.
2000.PubMed/NCBI
|
|
38
|
Speck RR, Yu XF, Hildreth J and Flexner C:
Differential effects of p-glycoprotein and multidrug resistance
protein-1 on productive human immunodeficiency virus infection. J
Infect Dis. 186:332–340. 2002. View
Article : Google Scholar : PubMed/NCBI
|
