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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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May-2014 Volume 33 Issue 5

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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May-2014 Volume 33 Issue 5

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Article

Parthenolide exerts inhibitory effects on angiogenesis through the downregulation of VEGF/VEGFRs in colorectal cancer

  • Authors:
    • Se-Lim Kim
    • Soo-Teik Lee
    • Kieu Thi Thu Trang
    • Seong Hun Kim
    • In Hee Kim
    • Seung Ok Lee
    • Dae Ghon Kim
    • Sang-Wook Kim

  • View Affiliations / Copyright

    Affiliations: Department of Internal Medicine, Chonbuk National University Hospital, Jeonju, Jeonbuk 561-712, Republic of Korea
  • Pages: 1261-1267
    |
    Published online on: February 25, 2014
       https://doi.org/10.3892/ijmm.2014.1669
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Abstract

Parthenolide (PT) is responsible for the bioactivities of feverfew (Tanacetum parthenium). Apart from its potent anti-inflammatory effects, this compound has been reported to induce apoptosis in various cancer cells. However, little is known about its role in the process of tumor angiogenesis. In the present study, we investigated the effects and potential mechanisms of action of PT on angiogenesis in human colorectal cancer (CRC). The anti-angiogenic effects of PT were evaluated in cultured human umbilical vein endothelial cells (HUVECs) and in the human CRC cell lines, HT-29, SW620 and HCT116. PT markedly inhibited vascular cell migration and capillary-like structure formation even at a dose which had not effects on cell viability. PT also suppressed the expression of angiogenic biomarker proteins [vascular endothelial growth factor (VEGF), VEGF receptor (VEGFR)1 and VEGFR2] in both the HUVECs and CRC cells. Additionally, PT effectively inhibited tumor neovascularization in a HT-29 xenograft model. These results indicate that PT suppresses angiogenesis by reducing the expression of VEGF and its receptors and may be a viable drug candidate in anti-angiogenesis therapies for human CRC.

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Copy and paste a formatted citation
Spandidos Publications style
Kim S, Lee S, Trang KT, Kim SH, Kim IH, Lee SO, Kim DG and Kim S: Parthenolide exerts inhibitory effects on angiogenesis through the downregulation of VEGF/VEGFRs in colorectal cancer. Int J Mol Med 33: 1261-1267, 2014.
APA
Kim, S., Lee, S., Trang, K.T., Kim, S.H., Kim, I.H., Lee, S.O. ... Kim, S. (2014). Parthenolide exerts inhibitory effects on angiogenesis through the downregulation of VEGF/VEGFRs in colorectal cancer. International Journal of Molecular Medicine, 33, 1261-1267. https://doi.org/10.3892/ijmm.2014.1669
MLA
Kim, S., Lee, S., Trang, K. T., Kim, S. H., Kim, I. H., Lee, S. O., Kim, D. G., Kim, S."Parthenolide exerts inhibitory effects on angiogenesis through the downregulation of VEGF/VEGFRs in colorectal cancer". International Journal of Molecular Medicine 33.5 (2014): 1261-1267.
Chicago
Kim, S., Lee, S., Trang, K. T., Kim, S. H., Kim, I. H., Lee, S. O., Kim, D. G., Kim, S."Parthenolide exerts inhibitory effects on angiogenesis through the downregulation of VEGF/VEGFRs in colorectal cancer". International Journal of Molecular Medicine 33, no. 5 (2014): 1261-1267. https://doi.org/10.3892/ijmm.2014.1669
Copy and paste a formatted citation
x
Spandidos Publications style
Kim S, Lee S, Trang KT, Kim SH, Kim IH, Lee SO, Kim DG and Kim S: Parthenolide exerts inhibitory effects on angiogenesis through the downregulation of VEGF/VEGFRs in colorectal cancer. Int J Mol Med 33: 1261-1267, 2014.
APA
Kim, S., Lee, S., Trang, K.T., Kim, S.H., Kim, I.H., Lee, S.O. ... Kim, S. (2014). Parthenolide exerts inhibitory effects on angiogenesis through the downregulation of VEGF/VEGFRs in colorectal cancer. International Journal of Molecular Medicine, 33, 1261-1267. https://doi.org/10.3892/ijmm.2014.1669
MLA
Kim, S., Lee, S., Trang, K. T., Kim, S. H., Kim, I. H., Lee, S. O., Kim, D. G., Kim, S."Parthenolide exerts inhibitory effects on angiogenesis through the downregulation of VEGF/VEGFRs in colorectal cancer". International Journal of Molecular Medicine 33.5 (2014): 1261-1267.
Chicago
Kim, S., Lee, S., Trang, K. T., Kim, S. H., Kim, I. H., Lee, S. O., Kim, D. G., Kim, S."Parthenolide exerts inhibitory effects on angiogenesis through the downregulation of VEGF/VEGFRs in colorectal cancer". International Journal of Molecular Medicine 33, no. 5 (2014): 1261-1267. https://doi.org/10.3892/ijmm.2014.1669
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