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Article

Connecting endoplasmic reticulum stress to autophagy through IRE1/JNK/beclin-1 in breast cancer cells

Retraction in: /10.3892/ijmm.2021.4997
  • Authors:
    • Xiu Cheng
    • Hao Liu
    • Chen-Chen Jiang
    • Lin Fang
    • Chao Chen
    • Xu-Dong Zhang
    • Zhi-Wen Jiang
  • View Affiliations / Copyright

    Affiliations: Faculty of Pharmacy, Bengbu Medical College, Anhui Engineering Technology Research Center of Biochemical Pharmaceuticals, Bengbu, Anhui 233030, P.R. China
  • Pages: 772-781
    |
    Published online on: June 25, 2014
       https://doi.org/10.3892/ijmm.2014.1822
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Abstract

Current experimental results indicate that endoplasmic reticulum (ER) stress activates the unfolded protein response (UPR), which rebuilds ER homeostasis, through which tumor cells can become resistant chemotherapeutic agents. Autophagy is a form of programmed cell death, but it can also play a cytoprotective role in tumor cells, indicating that it has an inverse function. The aim of the present study was to investigate whether tunicamycin (TM) induces autophagy, as well as whether the inhibition of autophagy enhances the apoptosis ofbreast cancer cells induced by TM. In addition, we wished to investigate the mechanisms through which specific UPR targets control autophagy. We found that MCF-7 and MDA-MB‑231 breast cancer cells were insensitive to TM at a relatively low concentration. As shown by western blot analysis, treatment with TM increased the expression of 78 kDa glucose-regulated protein (GRP78), inositol requiring enzyme 1 (IRE1), beclin-1, IRE1α, p-JNK and microtubule-associated protein 1 light chain 3 (LC3); the expression of p62 increased at an early time point during treatment and subsequently decreased. We also used the specific inhibitor of autophagy, 3-methyladenine (3-MA), to elucidate the role of autophagy in ER stress in the breast cancer cells treated with TM. The transformation of LC3-I to LC3-II which was induced by TM, was reversed following treatment with 3-MA. The inhibition of autophagy by 3-MA treatment enhanced the inhibitory and apoptotic rates of TM in the breast cancer cells, as shown by confocal microscopy and flow cytometry. TM increased the misfolded proteins that lead to the activation of ER stress-mediated protection and induced apoptosis paralleled by autophagy in breast cancer cells which was regulated by IRE1/JNK/beclin-1. Autophagy attenuates ER stress by clearing ubiquitinated proteins and decreasing apoptosis, which plays a protective role. The inhibition of autophagy or the promotion of ER stress may be used as therapeutic targets to improve the efficacy of chemotherapeutic drugs.
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View References

1 

Mann MJ and Hendershot LM: UPR activation alters chemosensitivity of tumor cells. Cancer Biol Ther. 5:736–740. 2006. View Article : Google Scholar : PubMed/NCBI

2 

Carrara M, Prischi F and Ali MM: UPR signal activation by luminal sensor domains. Int J Mol Sci. 14:6454–6466. 2013. View Article : Google Scholar : PubMed/NCBI

3 

Price J, Zaidi AK, Bohensky J, et al: Akt-1 mediates survival of chondrocytes from endoplasmic reticulum-induced stress. J Cell Physiol. 222:502–508. 2010.PubMed/NCBI

4 

Xi H, Kurtoglu M, Liu H, et al: 2-Deoxy-D-glucose activates autophagy via endoplasmic reticulum stress rather than ATP depletion. Cancer Chemother Pharmacol. 67:899–910. 2011. View Article : Google Scholar : PubMed/NCBI

5 

Ding WX, Ni HM, Gao W, et al: Differential effects of endoplasmic reticulum stress-induced autophagy on cell survival. J Biol Chem. 282:4702–4710. 2007. View Article : Google Scholar : PubMed/NCBI

6 

Yorimitsu T and Klionsky DJ: Endoplasmic reticulum stress: a new pathway to induce autophagy. Autophagy. 3:160–162. 2007. View Article : Google Scholar

7 

Wang WB, Feng LX, Yue QX, et al: Paraptosis accompanied by autophagy and apoptosis was induced by celastrol, a natural compound with influence on proteasome, ER stress and Hsp90. J Cell Physiol. 227:2196–2206. 2012. View Article : Google Scholar : PubMed/NCBI

8 

Jin S and White E: Role of autophagy in cancer: management of metabolic stress. Autophagy. 3:28–31. 2007. View Article : Google Scholar : PubMed/NCBI

9 

Marcilla-Etxenike A, Martin ML, Noguera-Salva MA, et al: 2-Hydroxyoleic acid induces ER stress and autophagy in various human glioma cell lines. PLoS One. 7:e482352012. View Article : Google Scholar : PubMed/NCBI

10 

Helgason GV, Holyoake TL and Ryan KM: Role of autophagy in cancer prevention, development and therapy. Essays Biochem. 55:133–151. 2013. View Article : Google Scholar : PubMed/NCBI

11 

Li J, Hou N, Faried A, et al: Inhibition of autophagy by 3-MA enhances the effect of 5-FU-induced apoptosis in colon cancer cells. Ann Surg Oncol. 16:761–771. 2009. View Article : Google Scholar : PubMed/NCBI

12 

Klionsky DJ: The molecular machinery of autophagy: unanswered questions. J Cell Sci. 118:7–18. 2005. View Article : Google Scholar : PubMed/NCBI

13 

Topisirovic I and Sonenberg N: Cell biology. Burn out or fade away? Science. 327:1210–1211. 2010. View Article : Google Scholar : PubMed/NCBI

14 

Kang R, Zeh HJ, Lotze MT and Tang D: The Beclin 1 network regulates autophagy and apoptosis. Cell Death Differ. 18:571–580. 2011. View Article : Google Scholar : PubMed/NCBI

15 

Pattingre S, Tassa A, Qu X, et al: Bcl-2 antiapoptotic proteins inhibit Beclin 1-dependent autophagy. Cell. 122:927–939. 2005. View Article : Google Scholar : PubMed/NCBI

16 

Hetz C, Bernasconi P, Fisher J, et al: Proapoptotic BAX and BAK modulate the unfolded protein response by a direct interaction with IRE1alpha. Science. 312:572–576. 2006. View Article : Google Scholar : PubMed/NCBI

17 

Klee M, Pallauf K, Alcala S, et al: Mitochondrial apoptosis induced by BH3-only molecules in the exclusive presence of endoplasmic reticular Bak. EMBO J. 28:1757–1768. 2009. View Article : Google Scholar : PubMed/NCBI

18 

Coutinho-Camillo CM, Lourenço SV, Nishimoto IN, et al: Expression of Bcl-2 family proteins and association with clinicopathological characteristics of oral squamous cell carcinoma. Histopathology. 57:304–316. 2010. View Article : Google Scholar : PubMed/NCBI

19 

Miloso M, Lourenco SV, Nishimoto IN, et al: MAPKs as mediators of cell fate determination: an approach to neurodegenerative diseases. Curr Med Chem. 15:538–548. 2008. View Article : Google Scholar : PubMed/NCBI

20 

Vacotto M, Coso O and Fiszer de Plazas S: Programmed cell death and differential JNK, p38 and ERK response in a prenatal acute hypoxic hypoxia model. Neurochem Int. 52:857–863. 2008. View Article : Google Scholar : PubMed/NCBI

21 

Qing Y, Liang Y, Du Q, et al: Apoptosis induced by trimethyltin chloride in human neuroblastoma cells SY5Y is regulated by a balance and cross-talk between NF-kappaB and MAPKs signaling pathways. Arch Toxicol. 87:1273–1285. 2013. View Article : Google Scholar : PubMed/NCBI

22 

Liu Z, Zhang YY, Zhang QW, et al: 3-Bromopyruvate induces apoptosis in breast cancer cells by downregulating Mcl-1 through the PI3K/Akt signaling pathway. Anticancer Drugs. 25:447–455. 2014. View Article : Google Scholar : PubMed/NCBI

23 

Crosti P, Malerba M and Bianchetti R: Tunicamycin and Brefeldin A induce in plant cells a programmed cell death showing apoptotic features. Protoplasma. 216:31–38. 2001. View Article : Google Scholar : PubMed/NCBI

24 

Guerrero AD, Welschhans RL, Chen M and Wang J: Cleavage of anti-apoptotic Bcl-2 family members after TCR stimulation contributes to the decision between T cell activation and apoptosis. J Immunol. 190:168–173. 2013. View Article : Google Scholar : PubMed/NCBI

25 

Rubinstein AD, Eisenstein M, Ber Y, et al: The autophagy protein Atg12 associates with antiapoptotic Bcl-2 family members to promote mitochondrial apoptosis. Mol Cell. 44:698–709. 2011. View Article : Google Scholar : PubMed/NCBI

26 

Kang SH, Choi EJ, Kim HW, et al: Complications in endoscopic-assisted open reduction and internal fixation of mandibular condyle fractures. Oral Surg Oral Med Oral Pathol Oral Radiol. 113:201–206. 2012. View Article : Google Scholar : PubMed/NCBI

27 

Pattingre S, Bauvy C, Carpentier S, et al: Role of JNK1-dependent Bcl-2 phosphorylation in ceramide-induced macroautophagy. J Biol Chem. 284:2719–2728. 2009. View Article : Google Scholar : PubMed/NCBI

28 

Bartolome AC, Guillen and Benito M: Autophagy plays a protective role in endoplasmic reticulum stress-mediated pancreatic beta cell death. Autophagy. 8:1757–1768. 2012. View Article : Google Scholar : PubMed/NCBI

29 

Bernales S, Papa FR and Walter P: Intracellular signaling by the unfolded protein response. Annu Rev Cell Dev Biol. 22:487–508. 2006. View Article : Google Scholar

30 

Ciechomska IA, Gabrusiewicz K, Szczepankiewicz AA and Kaminska B: cyclosporine a-induced cell death. Oncogene. 32:1518–1529. 2013.PubMed/NCBI

31 

Hoyer-Hansen M, Bastholm L, Szyniarowski P, et al: Control of macroautophagy by calcium, calmodulin-dependent kinase kinase-beta, and Bcl-2. Mol Cell. 25:193–205. 2007. View Article : Google Scholar : PubMed/NCBI

32 

Verfaillie T, Salazar M, Velasco G and Agostinis P: Linking ER stress to autophagy: potential implications for cancer therapy. Int J Cell Biol. 9305092010.

33 

Imaizumi K: Endoplasmic reticulum stress response involved in osteogenesis and chondrogenesis. Clin Calcium. 23:1759–1766. 2013.(In Japanese).

34 

Kouroku Y, Fujita E, Tanida I, et al: ER stress (PERK/eIF2alpha phosphorylation) mediates the polyglutamine-induced LC3 conversion, an essential step for autophagy formation. Cell Death Differ. 14:230–239. 2007. View Article : Google Scholar : PubMed/NCBI

35 

Hoyer-Hansen M and Jaattela M: Connecting endoplasmic reticulum stress to autophagy by unfolded protein response and calcium. Cell Death Differ. 14:1576–1582. 2007. View Article : Google Scholar : PubMed/NCBI

36 

Zhang J, Morris MW Jr, Dorsett-Martin WA, et al: Autophagy is involved in endoplasmic reticulum stress-induced cell death of rat hepatocytes. J Surg Res. 183:929–935. 2013. View Article : Google Scholar : PubMed/NCBI

37 

Deegan S, Saveljeva S, Gorman AM and Samali A: Stress-induced self-cannibalism: on the regulation of autophagy by endoplasmic reticulum stress. Cell Mol Life Sci. 70:2425–2441. 2013. View Article : Google Scholar : PubMed/NCBI

38 

Hu P, Lai D, Lu P, et al: ERK and Akt signaling pathways are involved in advanced glycation end product-induced autophagy in rat vascular smooth muscle cells. Int J Mol Med. 29:613–618. 2012.PubMed/NCBI

39 

Lee S, Lee SJ, Coronata AA, et al: Carbon monoxide confers protection in sepsis by enhancing Beclin 1-dependent autophagy and phagocytosis. Antioxid Redox Signal. 20:432–442. 2013. View Article : Google Scholar : PubMed/NCBI

40 

Park KJ, Lee SH, Lee CH, et al: Upregulation of Beclin-1 expression and phosphorylation of Bcl-2 and p53 are involved in the JNK-mediated autophagic cell death. Biochem Biophys Res Commun. 382:726–729. 2009. View Article : Google Scholar : PubMed/NCBI

41 

Marquez RT and Xu L: Bcl-2: Beclin 1 complex: multiple, mechanisms regulating autophagy/apoptosis toggle switch. Am J Cancer Res. 2:214–221. 2012.PubMed/NCBI

42 

Gao P, Bauvy C, Souquere S, et al: The Bcl-2 homology domain 3 mimetic gossypol induces both Beclin 1-dependent and Beclin 1-independent cytoprotective autophagy in cancer cells. J Biol Chem. 285:25570–25581. 2010. View Article : Google Scholar : PubMed/NCBI

43 

Wei Y, Sinha S and Levine B: Dual role of JNK1-mediated phosphorylation of Bcl-2 in autophagy and apoptosis regulation. Autophagy. 4:949–951. 2008. View Article : Google Scholar : PubMed/NCBI

44 

Liu L, Fang YQ, Xue ZF, et al: Beta-asarone attenuates ischemia-reperfusion-induced autophagy in rat brains via modulating JNK, p-JNK, Bcl-2 and Beclin 1. Eur J Pharmacol. 680:34–40. 2012. View Article : Google Scholar

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Copy and paste a formatted citation
Spandidos Publications style
Cheng X, Liu H, Jiang C, Fang L, Chen C, Zhang X and Jiang Z: Connecting endoplasmic reticulum stress to autophagy through IRE1/JNK/beclin-1 in breast cancer cells Retraction in /10.3892/ijmm.2021.4997. Int J Mol Med 34: 772-781, 2014.
APA
Cheng, X., Liu, H., Jiang, C., Fang, L., Chen, C., Zhang, X., & Jiang, Z. (2014). Connecting endoplasmic reticulum stress to autophagy through IRE1/JNK/beclin-1 in breast cancer cells Retraction in /10.3892/ijmm.2021.4997. International Journal of Molecular Medicine, 34, 772-781. https://doi.org/10.3892/ijmm.2014.1822
MLA
Cheng, X., Liu, H., Jiang, C., Fang, L., Chen, C., Zhang, X., Jiang, Z."Connecting endoplasmic reticulum stress to autophagy through IRE1/JNK/beclin-1 in breast cancer cells Retraction in /10.3892/ijmm.2021.4997". International Journal of Molecular Medicine 34.3 (2014): 772-781.
Chicago
Cheng, X., Liu, H., Jiang, C., Fang, L., Chen, C., Zhang, X., Jiang, Z."Connecting endoplasmic reticulum stress to autophagy through IRE1/JNK/beclin-1 in breast cancer cells Retraction in /10.3892/ijmm.2021.4997". International Journal of Molecular Medicine 34, no. 3 (2014): 772-781. https://doi.org/10.3892/ijmm.2014.1822
Copy and paste a formatted citation
x
Spandidos Publications style
Cheng X, Liu H, Jiang C, Fang L, Chen C, Zhang X and Jiang Z: Connecting endoplasmic reticulum stress to autophagy through IRE1/JNK/beclin-1 in breast cancer cells Retraction in /10.3892/ijmm.2021.4997. Int J Mol Med 34: 772-781, 2014.
APA
Cheng, X., Liu, H., Jiang, C., Fang, L., Chen, C., Zhang, X., & Jiang, Z. (2014). Connecting endoplasmic reticulum stress to autophagy through IRE1/JNK/beclin-1 in breast cancer cells Retraction in /10.3892/ijmm.2021.4997. International Journal of Molecular Medicine, 34, 772-781. https://doi.org/10.3892/ijmm.2014.1822
MLA
Cheng, X., Liu, H., Jiang, C., Fang, L., Chen, C., Zhang, X., Jiang, Z."Connecting endoplasmic reticulum stress to autophagy through IRE1/JNK/beclin-1 in breast cancer cells Retraction in /10.3892/ijmm.2021.4997". International Journal of Molecular Medicine 34.3 (2014): 772-781.
Chicago
Cheng, X., Liu, H., Jiang, C., Fang, L., Chen, C., Zhang, X., Jiang, Z."Connecting endoplasmic reticulum stress to autophagy through IRE1/JNK/beclin-1 in breast cancer cells Retraction in /10.3892/ijmm.2021.4997". International Journal of Molecular Medicine 34, no. 3 (2014): 772-781. https://doi.org/10.3892/ijmm.2014.1822
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