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International Journal of Molecular Medicine
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September-2014 Volume 34 Issue 3

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

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International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Article

The WWOX gene inhibits the growth of U266 multiple myeloma cells by triggering the intrinsic apoptotic pathway

  • Authors:
    • Hongsheng Zhang
    • Lingying Kong
    • Zhaolei Cui
    • Wei Du
    • Yihui He
    • Zhi Yang
    • Li Wang
    • Xiaoyan Chen
  • View Affiliations / Copyright

    Affiliations: Department of Pathology, Affiliated People's Hospital of Fujian University of Traditional Chinese Medicine, Fuzhou, Fujian 350004, P.R. China, Department of Pathology, Fujian Provincial Hospital, Fuzhou, Fujian 350001, P.R. China
  • Pages: 804-809
    |
    Published online on: June 27, 2014
       https://doi.org/10.3892/ijmm.2014.1824
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Abstract

The role of the WW domain-containing oxidoreductase (WWOX) gene in multiple types of solid human cancers has been documented extensively. However, the functional role of WWOX in human multiple myeloma has not yet been fully elucidated. The present study aimed to investigate the effects of exogenous WWOX expression on the biological properties of U266 multiple myeloma cells, as well as the possible molecular mechanisms involved. In vitro experiments revealed that exogenous WWOX cDNA transfection resulted in marked growth arrest and the induction of apoptosis in the U266 multiple myeloma cells, accompanied by the activation of the intrinsic apoptotic pathway. Our data provide evidence that WWOX also plays a role as a tumor suppressor gene in multiple myeloma, possibly by suppressing cell proliferation and promoting apoptosis by triggering the intrinsic apoptotic pathway.
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Copy and paste a formatted citation
Spandidos Publications style
Zhang H, Kong L, Cui Z, Du W, He Y, Yang Z, Wang L and Chen X: The WWOX gene inhibits the growth of U266 multiple myeloma cells by triggering the intrinsic apoptotic pathway. Int J Mol Med 34: 804-809, 2014.
APA
Zhang, H., Kong, L., Cui, Z., Du, W., He, Y., Yang, Z. ... Chen, X. (2014). The WWOX gene inhibits the growth of U266 multiple myeloma cells by triggering the intrinsic apoptotic pathway. International Journal of Molecular Medicine, 34, 804-809. https://doi.org/10.3892/ijmm.2014.1824
MLA
Zhang, H., Kong, L., Cui, Z., Du, W., He, Y., Yang, Z., Wang, L., Chen, X."The WWOX gene inhibits the growth of U266 multiple myeloma cells by triggering the intrinsic apoptotic pathway". International Journal of Molecular Medicine 34.3 (2014): 804-809.
Chicago
Zhang, H., Kong, L., Cui, Z., Du, W., He, Y., Yang, Z., Wang, L., Chen, X."The WWOX gene inhibits the growth of U266 multiple myeloma cells by triggering the intrinsic apoptotic pathway". International Journal of Molecular Medicine 34, no. 3 (2014): 804-809. https://doi.org/10.3892/ijmm.2014.1824
Copy and paste a formatted citation
x
Spandidos Publications style
Zhang H, Kong L, Cui Z, Du W, He Y, Yang Z, Wang L and Chen X: The WWOX gene inhibits the growth of U266 multiple myeloma cells by triggering the intrinsic apoptotic pathway. Int J Mol Med 34: 804-809, 2014.
APA
Zhang, H., Kong, L., Cui, Z., Du, W., He, Y., Yang, Z. ... Chen, X. (2014). The WWOX gene inhibits the growth of U266 multiple myeloma cells by triggering the intrinsic apoptotic pathway. International Journal of Molecular Medicine, 34, 804-809. https://doi.org/10.3892/ijmm.2014.1824
MLA
Zhang, H., Kong, L., Cui, Z., Du, W., He, Y., Yang, Z., Wang, L., Chen, X."The WWOX gene inhibits the growth of U266 multiple myeloma cells by triggering the intrinsic apoptotic pathway". International Journal of Molecular Medicine 34.3 (2014): 804-809.
Chicago
Zhang, H., Kong, L., Cui, Z., Du, W., He, Y., Yang, Z., Wang, L., Chen, X."The WWOX gene inhibits the growth of U266 multiple myeloma cells by triggering the intrinsic apoptotic pathway". International Journal of Molecular Medicine 34, no. 3 (2014): 804-809. https://doi.org/10.3892/ijmm.2014.1824
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