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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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September-2014 Volume 34 Issue 3

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

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International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Article

Caspase-dependent signaling underlies glioblastoma cell death in response to the fungal metabolite, fusarochromanone

  • Authors:
    • Elahe Mahdavian
    • Monique Marshall
    • Patrick M. Martin
    • Patrice Cagle
    • Brian A. Salvatore
    • Quincy A. Quick
  • View Affiliations / Copyright

    Affiliations: Department of Chemistry and Physics, LSU-Shreveport, Shreveport, LA 71115, USA, Department of Biological Sciences, Tennessee State University, Nashville, TN 37209, USA, Department of Biology, North Carolina A&T State University, Greensboro, NC 27411, USA
  • Pages: 880-885
    |
    Published online on: July 9, 2014
       https://doi.org/10.3892/ijmm.2014.1842
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Abstract

Fungal metabolites continue to show promise as a viable class of anticancer agents. In the present study, we investigated the efficacy of the fungal metabolite, fusarochromanone (FC101), for its antitumor activities in glioblastomas, which have a median survival of less than two years and a poor clinical response to surgical resection, radiation therapy and chemotherapy. Using clinically applicable doses, we demonstrated that FC101 induced glioblastoma apoptotic cell death via caspase dependent signaling, as indicated by the cleavage of poly(ADP-ribose) polymerase, glioblastoma (PARP). FC101 also induced differential reactive oxygen species (ROS) levels in glioblastoma cells, contrasting a defined role of oxidative stress in apoptotic cell death observed with other fungal metabolites. Furthermore, the antitumorigenic effects of FC101 on tumor cell migration were assessed. Cell migration assays revealed that FC101 significantly reduced the migratory capacity of glioblastomas, which are incredibly invasive tumors. Taken together, the present study establishes FC101 as a candidate anticancer agent for the cooperative treatment of glioblastomas.
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Copy and paste a formatted citation
Spandidos Publications style
Mahdavian E, Marshall M, Martin PM, Cagle P, Salvatore BA and Quick QA: Caspase-dependent signaling underlies glioblastoma cell death in response to the fungal metabolite, fusarochromanone. Int J Mol Med 34: 880-885, 2014.
APA
Mahdavian, E., Marshall, M., Martin, P.M., Cagle, P., Salvatore, B.A., & Quick, Q.A. (2014). Caspase-dependent signaling underlies glioblastoma cell death in response to the fungal metabolite, fusarochromanone. International Journal of Molecular Medicine, 34, 880-885. https://doi.org/10.3892/ijmm.2014.1842
MLA
Mahdavian, E., Marshall, M., Martin, P. M., Cagle, P., Salvatore, B. A., Quick, Q. A."Caspase-dependent signaling underlies glioblastoma cell death in response to the fungal metabolite, fusarochromanone". International Journal of Molecular Medicine 34.3 (2014): 880-885.
Chicago
Mahdavian, E., Marshall, M., Martin, P. M., Cagle, P., Salvatore, B. A., Quick, Q. A."Caspase-dependent signaling underlies glioblastoma cell death in response to the fungal metabolite, fusarochromanone". International Journal of Molecular Medicine 34, no. 3 (2014): 880-885. https://doi.org/10.3892/ijmm.2014.1842
Copy and paste a formatted citation
x
Spandidos Publications style
Mahdavian E, Marshall M, Martin PM, Cagle P, Salvatore BA and Quick QA: Caspase-dependent signaling underlies glioblastoma cell death in response to the fungal metabolite, fusarochromanone. Int J Mol Med 34: 880-885, 2014.
APA
Mahdavian, E., Marshall, M., Martin, P.M., Cagle, P., Salvatore, B.A., & Quick, Q.A. (2014). Caspase-dependent signaling underlies glioblastoma cell death in response to the fungal metabolite, fusarochromanone. International Journal of Molecular Medicine, 34, 880-885. https://doi.org/10.3892/ijmm.2014.1842
MLA
Mahdavian, E., Marshall, M., Martin, P. M., Cagle, P., Salvatore, B. A., Quick, Q. A."Caspase-dependent signaling underlies glioblastoma cell death in response to the fungal metabolite, fusarochromanone". International Journal of Molecular Medicine 34.3 (2014): 880-885.
Chicago
Mahdavian, E., Marshall, M., Martin, P. M., Cagle, P., Salvatore, B. A., Quick, Q. A."Caspase-dependent signaling underlies glioblastoma cell death in response to the fungal metabolite, fusarochromanone". International Journal of Molecular Medicine 34, no. 3 (2014): 880-885. https://doi.org/10.3892/ijmm.2014.1842
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