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Article

Interleukin-10 influences susceptibility to experimental autoimmune thyroiditis independently of the H-2 gene

  • Authors:
    • Zhenqian Yu
    • Tong Liu
    • Shanshan Liu
    • Hongjin Zou
    • Xuren Sun
    • Xiaoguang Shi
    • Yushu Li
    • Zhongyan Shan
    • Weiping Teng
  • View Affiliations / Copyright

    Affiliations: Department of Endocrinology and Metabolism, Institute of Endocrinology, Liaoning Provincial Key Laboratory of Endocrine Diseases, The First Affiliated Hospital of China Medical University, Shenyang, Liaoning 110001, P.R. China, Department of Gastroenterology, The First Affiliated Hospital of China Medical University, Shenyang, Liaoning 110001, P.R. China
  • Pages: 413-424
    |
    Published online on: December 5, 2014
       https://doi.org/10.3892/ijmm.2014.2025
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Abstract

Both BALB/c and C57BL/6 mice are relatively resistant to experimental autoimmune thyroiditis (EAT) due to their histocompatibility (H-2) genetic background; however, susceptibility to EAT is also influenced by other genetic factors. Given the curative effect of interleukin-10 (IL-10) on thyroiditis, in the present study, we investigated whether IL-10 functions as a non-H-2 genetic factor that influences the development of EAT in mice with an EAT-resistant genetic background. In this study, we observed that the development of EAT could be induced in both C57BL/6 IL-10‑deficient (IL-10-/-) and BALB/c IL-10-/- female mice following immunization with mTg, which indicated that IL-10 may be a non-H-2 factor that affects susceptibility to EAT. However, the role of the H-2 factor remained dominant, as the incidence of EAT was low and its severity was mild. We further investigated the underlying pathogenic mechanisms of EAT in IL-10-/- female mice. We found that Th1 cells, Th17 cells, CD4+CD25+Foxp3+ regulatory T cells, and their associated cytokines were all involved in the development of EAT. The absence of IL-10 promoted the polarization of pathogenic cells and the production of associated cytokines, and suppressed the proliferation of protective T cell clones. Together, these factors may contribute to the development of EAT in IL-10-/- mice. In conclusion, our data demonstrate that IL-10 plays a critical role in the susceptibility to EAT, and a better understanding of the role of IL-10 in autoimmune thyroiditis may facilitate the development of novel strategies for the treatment of autoimmune thyroid diseases.
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Copy and paste a formatted citation
Spandidos Publications style
Yu Z, Liu T, Liu S, Zou H, Sun X, Shi X, Li Y, Shan Z and Teng W: Interleukin-10 influences susceptibility to experimental autoimmune thyroiditis independently of the H-2 gene. Int J Mol Med 35: 413-424, 2015.
APA
Yu, Z., Liu, T., Liu, S., Zou, H., Sun, X., Shi, X. ... Teng, W. (2015). Interleukin-10 influences susceptibility to experimental autoimmune thyroiditis independently of the H-2 gene. International Journal of Molecular Medicine, 35, 413-424. https://doi.org/10.3892/ijmm.2014.2025
MLA
Yu, Z., Liu, T., Liu, S., Zou, H., Sun, X., Shi, X., Li, Y., Shan, Z., Teng, W."Interleukin-10 influences susceptibility to experimental autoimmune thyroiditis independently of the H-2 gene". International Journal of Molecular Medicine 35.2 (2015): 413-424.
Chicago
Yu, Z., Liu, T., Liu, S., Zou, H., Sun, X., Shi, X., Li, Y., Shan, Z., Teng, W."Interleukin-10 influences susceptibility to experimental autoimmune thyroiditis independently of the H-2 gene". International Journal of Molecular Medicine 35, no. 2 (2015): 413-424. https://doi.org/10.3892/ijmm.2014.2025
Copy and paste a formatted citation
x
Spandidos Publications style
Yu Z, Liu T, Liu S, Zou H, Sun X, Shi X, Li Y, Shan Z and Teng W: Interleukin-10 influences susceptibility to experimental autoimmune thyroiditis independently of the H-2 gene. Int J Mol Med 35: 413-424, 2015.
APA
Yu, Z., Liu, T., Liu, S., Zou, H., Sun, X., Shi, X. ... Teng, W. (2015). Interleukin-10 influences susceptibility to experimental autoimmune thyroiditis independently of the H-2 gene. International Journal of Molecular Medicine, 35, 413-424. https://doi.org/10.3892/ijmm.2014.2025
MLA
Yu, Z., Liu, T., Liu, S., Zou, H., Sun, X., Shi, X., Li, Y., Shan, Z., Teng, W."Interleukin-10 influences susceptibility to experimental autoimmune thyroiditis independently of the H-2 gene". International Journal of Molecular Medicine 35.2 (2015): 413-424.
Chicago
Yu, Z., Liu, T., Liu, S., Zou, H., Sun, X., Shi, X., Li, Y., Shan, Z., Teng, W."Interleukin-10 influences susceptibility to experimental autoimmune thyroiditis independently of the H-2 gene". International Journal of Molecular Medicine 35, no. 2 (2015): 413-424. https://doi.org/10.3892/ijmm.2014.2025
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