Continuous irradiation with a 633-nm light-emitting diode exerts an anti-aging effect on human skin cells

  • Authors:
    • Hak Sun Kim
    • Won Sang Park
    • Jong-In Baek
    • Bo-Sub Lee
    • Dae Sung Yoo
    • Si Jun Park
  • View Affiliations

  • Published online on: December 9, 2014     https://doi.org/10.3892/ijmm.2014.2030
  • Pages: 383-390
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Abstract

Accumulating evidence has indicated that the light source emitted from light‑emitting diode (LED) has a potential anti-aging effect on human skin. Studies using single and interval LED irradiation have documented such effects; however, to the best of our knowledge, the anti-aging effects of continuous LED irradiation have not yet been investigated. In the present study, we demonstrated that continuous irradiation with a 633±3-nm LED exerted anti-aging effects in both in vitro and ex vivo experiments. More specifically, irradiation with a 633-nm LED for 2 days increased the synthesis of type 1 procollagen and decreased the expression of matrix metalloproteinase (MMP)1 and MMP2 in skin fibroblasts. In addition, irradiation with a 633-nm LED decreased the expression levels of inflammatory genes, such has cyclooxygenase-2 (COX-2), and interleukin-1-α (IL-1α) in keratinocytes. Furthermore, a 14-day LED irradiation moderately increased keratinocyte proliferation. Using human skin explants, we confirmed the safety of this 633-nm LED irradiation, which resulted in unaltered morphology and allergy-free potential in human tissue. Overall, these data provide insight into the anti-aging effects of continuous LED irradiation on human skin.
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February-2015
Volume 35 Issue 2

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Spandidos Publications style
Kim HS, Park WS, Baek J, Lee B, Yoo DS and Park SJ: Continuous irradiation with a 633-nm light-emitting diode exerts an anti-aging effect on human skin cells. Int J Mol Med 35: 383-390, 2015.
APA
Kim, H.S., Park, W.S., Baek, J., Lee, B., Yoo, D.S., & Park, S.J. (2015). Continuous irradiation with a 633-nm light-emitting diode exerts an anti-aging effect on human skin cells. International Journal of Molecular Medicine, 35, 383-390. https://doi.org/10.3892/ijmm.2014.2030
MLA
Kim, H. S., Park, W. S., Baek, J., Lee, B., Yoo, D. S., Park, S. J."Continuous irradiation with a 633-nm light-emitting diode exerts an anti-aging effect on human skin cells". International Journal of Molecular Medicine 35.2 (2015): 383-390.
Chicago
Kim, H. S., Park, W. S., Baek, J., Lee, B., Yoo, D. S., Park, S. J."Continuous irradiation with a 633-nm light-emitting diode exerts an anti-aging effect on human skin cells". International Journal of Molecular Medicine 35, no. 2 (2015): 383-390. https://doi.org/10.3892/ijmm.2014.2030