Association between histone deacetylases and the loss of cochlear hair cells: Role of the former in noise-induced hearing loss

  • Authors:
    • Li-Ting Wen
    • Jie Wang
    • Ye Wang
    • Fu-Quan Chen
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  • Published online on: June 5, 2015     https://doi.org/10.3892/ijmm.2015.2236
  • Pages: 534-540
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Abstract

Noise-induced hearing loss (NIHL) is one of the most frequent disabilities in industrialized countries. It has been demonstrated that hair cell loss in the auditory end organ may account for the majority of ear pathological conditions. Previous studies have indicated that histone deacetylases (HDACs) play an important role in neurodegenerative diseases, including hearing impairment, in older persons. Thus, we hypothesized that the inhibition of HDACs would prevent hair cell loss and, consequently, NIHL. In the present study, a CBA/J mouse model of NIHL was established. Following an injection with the HDAC inhibitor, suberoylanilide hydroxamic acid (SAHA), the expression levels of HDAC1, HDAC4 and acetyl-histone H3 (Lys9) (H3‑AcK9) were measured. The number of hair cells was quantified and their morphology was observed. The results revealed that 1 h following exposure to 110 dB SPL broadband noise, there was a significant increase in HDAC1 and HDAC4 expression, and a marked decrease in the H3‑AcK9 protein levels, as shown by western blot analysis. Pre-treatment with SAHA significantly inhibited these effects. Two weeks following exposure to noise, the mice exhibited significant hearing impairment and an obvious loss in the number of outer hair cells. An abnormal cell morphology with cilia damage was also observed. Pre-treatment with SAHA markedly attenuated these noise‑induced effects. Taken together, the findings of our study suggest that HDAC expression is associated with outer hair cell function and plays a significant role in NIHL. Our data indicate that SAHA may be a potential therapeutic agent for the prevention of NIHL.
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August-2015
Volume 36 Issue 2

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Spandidos Publications style
Wen L, Wang J, Wang Y and Chen F: Association between histone deacetylases and the loss of cochlear hair cells: Role of the former in noise-induced hearing loss. Int J Mol Med 36: 534-540, 2015
APA
Wen, L., Wang, J., Wang, Y., & Chen, F. (2015). Association between histone deacetylases and the loss of cochlear hair cells: Role of the former in noise-induced hearing loss. International Journal of Molecular Medicine, 36, 534-540. https://doi.org/10.3892/ijmm.2015.2236
MLA
Wen, L., Wang, J., Wang, Y., Chen, F."Association between histone deacetylases and the loss of cochlear hair cells: Role of the former in noise-induced hearing loss". International Journal of Molecular Medicine 36.2 (2015): 534-540.
Chicago
Wen, L., Wang, J., Wang, Y., Chen, F."Association between histone deacetylases and the loss of cochlear hair cells: Role of the former in noise-induced hearing loss". International Journal of Molecular Medicine 36, no. 2 (2015): 534-540. https://doi.org/10.3892/ijmm.2015.2236