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Article

Integrative genomic analyses of the RNA-binding protein, RNPC1, and its potential role in cancer prediction

  • Authors:
    • Zhiming Ding
    • Hai-Wei Yang
    • Tian-Song Xia
    • Bo Wang
    • Qiang Ding
  • View Affiliations / Copyright

    Affiliations: Department of Neurosurgery, The Eastern Hospital of the First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong 510700, P.R. China, Department of Urology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu 210029, P.R. China, Department of Breast Surgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu 210029, P.R. China, Department of Medical Oncology, The Eastern Hospital of the First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong 510700, P.R. China
  • Pages: 473-484
    |
    Published online on: June 5, 2015
       https://doi.org/10.3892/ijmm.2015.2237
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Abstract

The RNA binding motif protein 38 (RBM38, also known as RNPC1) plays a pivotal role in regulating a wide range of biological processes, from cell proliferation and cell cycle arrest to cell myogenic differentiation. It was originally recognized as an oncogene, and was frequently found to be amplified in prostate, ovarian and colorectal cancer, chronic lymphocytic leukemia, colon carcinoma, esophageal cancer, dog lymphomas and breast cancer. In the present study, the complete RNPC1 gene was identified in a number of vertebrate genomes, suggesting that RNPC1 exists in all types of vertebrates, including fish, amphibians, birds and mammals. In the different genomes, the gene had a similar 4 exon/3 intron organization, and all the genetic loci were syntenically conserved. The phylogenetic tree demonstrated that the RNPC1 gene from the mammalian, bird, reptile and teleost lineage formed a species-specific cluster. A total of 34 functionally relevant single nucleotide polymorphisms (SNPs), including 14 SNPs causing missense mutations, 8 exonic splicing enhancer SNPs and 12 SNPs causing nonsense mutations, were identified in the human RNPC1 gene. RNPC1 was found to be expressed in bladder, blood, brain, breast, colorectal, eye, head and neck, lung, ovarian, skin and soft tissue cancer. In 14 of the 94 tests, an association between RNPC1 gene expression and cancer prognosis was observed. We found that the association between the expression of RNPC1 and prognosis varied in different types of cancer, and even in the same type of cancer from the different databases used. This suggests that the function of RNPC1 in these tumors may be multidimensional. The sex determining region Y (SRY)-box 5 (Sox5), runt-related transcription factor 3 (RUNX3), CCAAT displacement protein 1 (CUTL1), v-rel avian reticuloendotheliosis viral oncogene homolog (Rel)A, peroxisome proliferator-activated receptor γ isoform 2 (PPARγ2) and activating transcription factor 6 (ATF6) regulatory transcription factor binding sites were identified in the upstream (promoter) region of the RNPC1 gene, and may thus be involved in the effects of RNPC1 in tumors.
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1 

Kim MY, Hur J and Jeong S: Emerging roles of RNA and RNA-binding protein network in cancer cells. BMB Rep. 42:125–130. 2009. View Article : Google Scholar : PubMed/NCBI

2 

Krecic AM and Swanson MS: hnRNP complexes: composition, structure, and function. Curr Opin Cell Biol. 11:363–371. 1999. View Article : Google Scholar : PubMed/NCBI

3 

Dreyfuss G, Matunis MJ, Piñol-Roma S and Burd CG: hnRNP proteins and the biogenesis of mRNA. Annu Rev Biochem. 62:289–321. 1993. View Article : Google Scholar : PubMed/NCBI

4 

Audic Y and Hartley RS: Post-transcriptional regulation in cancer. Biol Cell. 96:479–498. 2004. View Article : Google Scholar : PubMed/NCBI

5 

Yisraeli JK: VICKZ proteins: a multi-talented family of regulatory RNA-binding proteins. Biol Cell. 97:87–96. 2005. View Article : Google Scholar

6 

Shu L, Yan W and Chen X: RNPC1, an RNA-binding protein and a target of the p53 family, is required for maintaining the stability of the basal and stress-induced p21 transcript. Genes Dev. 20:2961–2972. 2006. View Article : Google Scholar : PubMed/NCBI

7 

Cho SJ, Zhang J and Chen X: RNPC1 modulates the RNA-binding activity of, and cooperates with, HuR to regulate p21 mRNA stability. Nucleic Acids Res. 38:2256–2267. 2010. View Article : Google Scholar : PubMed/NCBI

8 

Miyamoto S, Hidaka K, Jin D and Morisaki T: RNA-binding proteins Rbm38 and Rbm24 regulate myogenic differentiation via p21-dependent and -independent regulatory pathways. Genes Cells. 14:1241–1252. 2009. View Article : Google Scholar : PubMed/NCBI

9 

Yan W, Zhang J, Zhang Y, Jung YS and Chen X: p73 expression is regulated by RNPC1, a target of the p53 family, via mRNA stability. Mol Cell Biol. 32:2336–2348. 2012. View Article : Google Scholar : PubMed/NCBI

10 

Yin T, Cho SJ and Chen X: RNPC1, an RNA-binding protein and a p53 target, regulates macrophage inhibitory cytokine-1 (MIC-1) expression through mRNA stability. J Biol Chem. 288:23680–23686. 2013. View Article : Google Scholar : PubMed/NCBI

11 

Zhang J, Jun Cho S and Chen X: RNPC1, an RNA-binding protein and a target of the p53 family, regulates p63 expression through mRNA stability. Proc Natl Acad Sci USA. 107:9614–9619. 2010. View Article : Google Scholar : PubMed/NCBI

12 

Xu E, Zhang J and Chen X: MDM2 expression is repressed by the RNA-binding protein RNPC1 via mRNA stability. Oncogene. 32:2169–2178. 2013. View Article : Google Scholar

13 

Zhang J, Cho SJ, Shu L, Yan W, Guerrero T, Kent M, Skorupski K, Chen H and Chen X: Translational repression of p53 by RNPC1, a p53 target overexpressed in lymphomas. Genes Dev. 25:1528–1543. 2011. View Article : Google Scholar : PubMed/NCBI

14 

Zheng SL, Xu J, Isaacs SD, Wiley K, Chang B, Bleecker ER, Walsh PC, Trent JM, Meyers DA and Isaacs WB: Evidence for a prostate cancer linkage to chromosome 20 in 159 hereditary prostate cancer families. Hum Genet. 108:430–435. 2001. View Article : Google Scholar : PubMed/NCBI

15 

Bar-Shira A, Pinthus JH, Rozovsky U, Goldstein M, Sellers WR, Yaron Y, Eshhar Z and Orr-Urtreger A: Multiple genes in human 20q13 chromosomal region are involved in an advanced prostate cancer xenograft. Cancer Res. 62:6803–6807. 2002.PubMed/NCBI

16 

Tanner MM, Grenman S, Koul A, Johannsson O, Meltzer P, Pejovic T, Borg A and Isola JJ: Frequent amplification of chromosomal region 20q12-q13 in ovarian cancer. Clin Cancer Res. 6:1833–1839. 2000.PubMed/NCBI

17 

Korn WM, Yasutake T, Kuo WL, Warren RS, Collins C, Tomita M, Gray J and Waldman FM: Chromosome arm 20q gains and other genomic alterations in colorectal cancer metastatic to liver, as analyzed by comparative genomic hybridization and fluorescence in situ hybridization. Genes Chromosomes Cancer. 25:82–90. 1999. View Article : Google Scholar : PubMed/NCBI

18 

Knösel T, Schlüns K, Stein U, Schwabe H, Schlag PM, Dietel M and Petersen I: Genetic imbalances with impact on survival in colorectal cancer patients. Histopathology. 43:323–331. 2003. View Article : Google Scholar : PubMed/NCBI

19 

Krackhardt AM, Witzens M, Harig S, Hodi FS, Zauls AJ, Chessia M, Barrett P and Gribben JG: Identification of tumor-associated antigens in chronic lymphocytic leukemia by SEREX. Blood. 100:2123–2131. 2002. View Article : Google Scholar : PubMed/NCBI

20 

Carvalho B, Postma C, Mongera S, Hopmans E, Diskin S, van de Wiel MA, van Criekinge W, Thas O, Matthäi A, Cuesta MA, et al: Multiple putative oncogenes at the chromosome 20q amplicon contribute to colorectal adenoma to carcinoma progression. Gut. 58:79–89. 2009. View Article : Google Scholar

21 

Hötte GJ, Linam-Lennon N, Reynolds JV and Maher SG: Radiation sensitivity of esophageal adenocarcinoma: the contribution of the RNA-binding protein RNPC1 and p21-mediated cell cycle arrest to radioresistance. Radiat Res. 177:272–279. 2012. View Article : Google Scholar : PubMed/NCBI

22 

Ginestier C, Cervera N, Finetti P, Esteyries S, Esterni B, Adélaïde J, Xerri L, Viens P, Jacquemier J, Charafe-Jauffret E, et al: Prognosis and gene expression profiling of 20q13-amplified breast cancers. Clin Cancer Res. 12:4533–4544. 2006. View Article : Google Scholar : PubMed/NCBI

23 

Letessier A, Sircoulomb F, Ginestier C, Cervera N, Monville F, Gelsi-Boyer V, Esterni B, Geneix J, Finetti P, Zemmour C, et al: Frequency, prognostic impact, and subtype association of 8p12, 8q24, 11q13, 12p13, 17q12, and 20q13 amplifications in breast cancers. BMC Cancer. 6:2452006. View Article : Google Scholar : PubMed/NCBI

24 

Xue JQ, Xia TS, Liang XQ, Zhou W, Cheng L, Shi L, Wang Y and Ding Q: RNA-binding protein RNPC1: Acting as a tumor suppressor in breast cancer. BMC Cancer. 14:3222014. View Article : Google Scholar : PubMed/NCBI

25 

Feldstein O, Ben-Hamo R, Bashari D, Efroni S and Ginsberg D: RBM38 is a direct transcriptional target of E2F1 that limits E2F1-induced proliferation. Mol Cancer Res. 10:1169–1177. 2012. View Article : Google Scholar : PubMed/NCBI

26 

Léveillé N, Elkon R, Davalos V, Manoharan V, Hollingworth D, Oude Vrielink J, le Sage C, Melo CA, Horlings HM, Wesseling J, et al: Selective inhibition of microRNA accessibility by RBM38 is required for p53 activity. Nat Commun. 2:5132011. View Article : Google Scholar : PubMed/NCBI

27 

Yang L, Luo Y and Wei J: Integrative genomic analyses on Ikaros and its expression related to solid cancer prognosis. Oncol Rep. 24:571–577. 2010. View Article : Google Scholar : PubMed/NCBI

28 

Yang L, Luo Y, Wei J and He S: Integrative genomic analyses on IL28RA, the common receptor of interferon-lambda1, -lambda2 and -lambda3. Int J Mol Med. 25:807–812. 2010.PubMed/NCBI

29 

Yang L, Wei J and He S: Integrative genomic analyses on interferon-lambdas and their roles in cancer prediction. Int J Mol Med. 25:299–304. 2010.PubMed/NCBI

30 

Yu H, Yuan J, Xiao C and Qin Y: Integrative genomic analyses of recepteur d’origine nantais and its prognostic value in cancer. Int J Mol Med. 31:1248–1254. 2013.PubMed/NCBI

31 

Wang M, Wei X, Shi L, Chen B, Zhao G and Yang H: Integrative genomic analyses of the histamine H1 receptor and its role in cancer prediction. Int J Mol Med. 33:1019–1026. 2014.PubMed/NCBI

32 

Wang B, Chen K, Xu W, Chen D, Tang W and Xia TS: Integrative genomic analyses of secreted protein acidic and rich in cysteine and its role in cancer prediction. Mol Med Rep. 10:1461–1468. 2014.PubMed/NCBI

33 

Wang B, Xu W, Tan M, Xiao Y, Yang H and Xia TS: Integrative genomic analyses of a novel cytokine, interleukin-34 and its potential role in cancer prediction. Int J Mol Med. 35:92–102. 2015.

34 

Kumar S, Nei M, Dudley J and Tamura K: MEGA: A biologist-centric software for evolutionary analysis of DNA and protein sequences. Brief Bioinform. 9:299–306. 2008. View Article : Google Scholar : PubMed/NCBI

35 

Yang Z: PAML: aA program package for phylogenetic analysis by maximum likelihood. Comput Appl Biosci. 13:555–556. 1997.PubMed/NCBI

36 

Yang Z, Nielsen R, Goldman N and Pedersen AM: Codon-substitution models for heterogeneous selection pressure at amino acid sites. Genetics. 155:431–449. 2000.PubMed/NCBI

37 

Forbes SA, Bindal N, Bamford S, Cole C, Kok CY, Beare D, Jia M, Shepherd R, Leung K, Menzies A, et al: COSMIC: Mining complete cancer genomes in the Catalogue of Somatic Mutations in Cancer. Nucleic Acids Res. 39:D945–D950. 2011. View Article : Google Scholar :

38 

Parkinson H, Sarkans U, Shojatalab M, Abeygunawardena N, Contrino S, Coulson R, Farne A, Lara GG, Holloway E, Kapushesky M, et al: ArrayExpress - a public repository for microarray gene expression data at the EBI. Nucleic Acids Res. 33:D553–D555. 2005. View Article : Google Scholar

39 

Mizuno H, Kitada K, Nakai K and Sarai A: PrognoScan: a new database for meta-analysis of the prognostic value of genes. BMC Med Genomics. 2:182009. View Article : Google Scholar : PubMed/NCBI

40 

Xue JQ, Xia TS, Liang XQ, Zhou W, Cheng L, Shi L, Wang Y and Ding Q: RNA-binding protein RNPC1: Acting as a tumor suppressor in breast cancer. BMC Cancer. 14:3222014. View Article : Google Scholar : PubMed/NCBI

41 

Renjie W and Haiqian L: MiR-132, miR-15a and miR-16 synergistically inhibit pituitary tumor cell proliferation, invasion and migration by targeting Sox5. Cancer Lett. 356:568–578. 2015. View Article : Google Scholar

42 

Pei XH, Lv XQ and Li HX: Sox5 induces epithelial to mesenchymal transition by transactivation of Twist1. Biochem Biophys Res Commun. 446:322–327. 2014. View Article : Google Scholar : PubMed/NCBI

43 

Kang KA, Kim KC, Bae SC and Hyun JW: Oxidative stress induces proliferation of colorectal cancer cells by inhibiting RUNX3 and activating the Akt signaling pathway. Int J Oncol. 43:1511–1516. 2013.PubMed/NCBI

44 

Xu HW, Ren F, Yu YM and Cai CZ: Runx3 expression in lymph nodes with metastasis is associated with the outcome of gastric cancer patients. Oncol Lett. 2:1275–1279. 2011.

45 

Yu GP, Ji Y, Chen GQ, Huang B, Shen K, Wu S and Shen ZY: Application of RUNX3 gene promoter methylation in the diagnosis of non-small cell lung cancer. Oncol Lett. 3:159–162. 2012.PubMed/NCBI

46 

Han YX and Liang DY: The role of the tumor suppressor RUNX3 in giant cell tumor of the bone. Int J Oncol. 40:673–678. 2012.

47 

Bian J, Li B, Zeng X, Hu H, Hong Y, Ouyang H, Zhang X, Wang Z, Zhu H, Lei P, et al: Mutation of TGF-β receptor II facilitates human bladder cancer progression through altered TGF-β1 signaling pathway. Int J Oncol. 43:1549–1559. 2013.PubMed/NCBI

48 

Liu KC, Lin BS, Zhao M, Wang KY and Lan XP: Cutl1: A potential target for cancer therapy. Cell Signal. 25:349–354. 2013. View Article : Google Scholar

49 

Claudius AK, Kankipati CS, Kilari RS, Hassan S, Guest K, Russell ST, Perry CJ, Stark LA and Nicholl ID: Identification of aspirin analogues that repress NF-κB signalling and demonstrate anti-proliferative activity towards colorectal cancer in vitro and in vivo. Oncol Rep. 32:1670–1680. 2014.PubMed/NCBI

50 

Zhang J, Kou YB, Zhu JS, Chen WX and Li S: Knockdown of HMGB1 inhibits growth and invasion of gastric cancer cells through the NF-κB pathway in vitro and in vivo. Int J Oncol. 44:1268–1276. 2014.PubMed/NCBI

51 

Guan Z, Ding C, Du Y, Zhang K, Zhu JN, Zhang T, He D, Xu S, Wang X and Fan J: HAF drives the switch of HIF-1α to HIF-2α by activating the NF-κB pathway, leading to malignant behavior of T24 bladder cancer cells. Int J Oncol. 44:393–402. 2014.

52 

Yu L, Mu Y, Sa N, Wang H and Xu W: Tumor necrosis factor α induces epithelial-mesenchymal transition and promotes metastasis via NF-κB signaling pathway-mediated TWIST expression in hypopharyngeal cancer. Oncol Rep. 31:321–327. 2014.

53 

Xue M, Li X, Wu W, Zhang S, Wu S, Li Z and Chen W: Upregulation of long non-coding RNA urothelial carcinoma associated 1 by CCAAT/enhancer binding protein α contributes to bladder cancer cell growth and reduced apoptosis. Oncol Rep. 31:1993–2000. 2014.PubMed/NCBI

54 

Weng W, Wang M, Xie S, Long Y, Li F, Sun F, Yu Y and Li Z: YY1-C/EBPα-miR34a regulatory circuitry is involved in renal cell carcinoma progression. Oncol Rep. 31:1921–1927. 2014.PubMed/NCBI

55 

Wei W, Hu Z, Fu H, Tie Y, Zhang H, Wu Y and Zheng X: MicroRNA-1 and microRNA-499 downregulate the expression of the ets1 proto-oncogene in HepG2 cells. Oncol Rep. 28:701–706. 2012.PubMed/NCBI

56 

Shaikhibrahim Z and Wernert N: ETS transcription factors and prostate cancer: The role of the family prototype ETS-1 (Review). Int J Oncol. 40:1748–1754. 2012.PubMed/NCBI

57 

Metzeler KH, Hummel M, Bloomfield CD, Spiekermann K, Braess J, Sauerland MC, Heinecke A, Radmacher M, Marcucci G, Whitman SP, et al Cancer and Leukemia Group B; German AML Cooperative Group: An 86-probe-set gene-expression signature predicts survival in cytogenetically normal acute myeloid leukemia. Blood. 112:4193–4201. 2008. View Article : Google Scholar : PubMed/NCBI

58 

Phillips HS, Kharbanda S, Chen R, Forrest WF, Soriano RH, Wu TD, Misra A, Nigro JM, Colman H, Soroceanu L, et al: Molecular subclasses of high-grade glioma predict prognosis, delineate a pattern of disease progression, and resemble stages in neurogenesis. Cancer Cell. 9:157–173. 2006. View Article : Google Scholar : PubMed/NCBI

59 

Anders CK, Acharya CR, Hsu DS, Broadwater G, Garman K, Foekens JA, Zhang Y, Wang Y, Marcom K, Marks JR, et al: Age-specific differences in oncogenic pathway deregulation seen in human breast tumors. PLoS One. 3:e13732008. View Article : Google Scholar : PubMed/NCBI

60 

Schmidt M, Böhm D, von Törne C, Steiner E, Puhl A, Pilch H, Lehr HA, Hengstler JG, Kölbl H and Gehrmann M: The humoral immune system has a key prognostic impact in node-negative breast cancer. Cancer Res. 68:5405–5413. 2008. View Article : Google Scholar : PubMed/NCBI

61 

Jain AN, Chin K, Børresen-Dale AL, Erikstein BK, Eynstein Lonning P, Kaaresen R and Gray JW: Quantitative analysis of chromosomal CGH in human breast tumors associates copy number abnormalities with p53 status and patient survival. Proc Natl Acad Sci USA. 98:7952–7957. 2001. View Article : Google Scholar : PubMed/NCBI

62 

Smith JJ, Deane NG, Wu F, Merchant NB, Zhang B, Jiang A, Lu P, Johnson JC, Schmidt C, Bailey CE, et al: Experimentally derived metastasis gene expression profile predicts recurrence and death in patients with colon cancer. Gastroenterology. 138:958–968. 2010. View Article : Google Scholar

63 

Laurent C, Valet F, Planque N, Silveri L, Maacha S, Anezo O, Hupe P, Plancher C, Reyes C, Albaud B, et al: High PTP4A3 phosphatase expression correlates with metastatic risk in uveal melanoma patients. Cancer Res. 71:666–674. 2011. View Article : Google Scholar

64 

Director’s Challenge Consortium for the Molecular Classification of Lung Adenocarcinoma; Shedden K, Taylor JM, Enkemann SA, Tsao MS, Yeatman TJ, Gerald WL, Eschrich S, Jurisica I, Giordano TJ, Misek DE, et al: Gene expression-based survival prediction in lung adenocarcinoma: a multi-site, blinded validation study. Nat Med. 14:822–827. 2008. View Article : Google Scholar : PubMed/NCBI

65 

Hammerman PS, Lawrence MS, Voet D, Jing R, Cibulskis K, Sivachenko A, Stojanov P, McKenna A, Lander ES, Gabriel S, et al Cancer Genome Atlas Research Network: Comprehensive genomic characterization of squamous cell lung cancers. Nature. 489:519–525. 2012. View Article : Google Scholar

66 

Yamauchi M, Yamaguchi R, Nakata A, Kohno T, Nagasaki M, Shimamura T, Imoto S, Saito A, Ueno K, Hatanaka Y, et al: Epidermal growth factor receptor tyrosine kinase defines critical prognostic genes of stage I lung adenocarcinoma. PLoS One. 7:e439232012. View Article : Google Scholar : PubMed/NCBI

67 

Tomida S, Koshikawa K, Yatabe Y, Harano T, Ogura N, Mitsudomi T, Some M, Yanagisawa K and Takahashi T, Osada H and Takahashi T: Gene expression-based, individualized outcome prediction for surgically treated lung cancer patients. Oncogene. 23:5360–5370. 2004. View Article : Google Scholar : PubMed/NCBI

68 

Bild AH, Yao G, Chang JT, Wang Q, Potti A, Chasse D, Joshi MB, Harpole D, Lancaster JM, Berchuck A, et al: Oncogenic pathway signatures in human cancers as a guide to targeted therapies. Nature. 439:353–357. 2006. View Article : Google Scholar

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Copy and paste a formatted citation
Spandidos Publications style
Ding Z, Yang H, Xia T, Wang B and Ding Q: Integrative genomic analyses of the RNA-binding protein, RNPC1, and its potential role in cancer prediction. Int J Mol Med 36: 473-484, 2015.
APA
Ding, Z., Yang, H., Xia, T., Wang, B., & Ding, Q. (2015). Integrative genomic analyses of the RNA-binding protein, RNPC1, and its potential role in cancer prediction. International Journal of Molecular Medicine, 36, 473-484. https://doi.org/10.3892/ijmm.2015.2237
MLA
Ding, Z., Yang, H., Xia, T., Wang, B., Ding, Q."Integrative genomic analyses of the RNA-binding protein, RNPC1, and its potential role in cancer prediction". International Journal of Molecular Medicine 36.2 (2015): 473-484.
Chicago
Ding, Z., Yang, H., Xia, T., Wang, B., Ding, Q."Integrative genomic analyses of the RNA-binding protein, RNPC1, and its potential role in cancer prediction". International Journal of Molecular Medicine 36, no. 2 (2015): 473-484. https://doi.org/10.3892/ijmm.2015.2237
Copy and paste a formatted citation
x
Spandidos Publications style
Ding Z, Yang H, Xia T, Wang B and Ding Q: Integrative genomic analyses of the RNA-binding protein, RNPC1, and its potential role in cancer prediction. Int J Mol Med 36: 473-484, 2015.
APA
Ding, Z., Yang, H., Xia, T., Wang, B., & Ding, Q. (2015). Integrative genomic analyses of the RNA-binding protein, RNPC1, and its potential role in cancer prediction. International Journal of Molecular Medicine, 36, 473-484. https://doi.org/10.3892/ijmm.2015.2237
MLA
Ding, Z., Yang, H., Xia, T., Wang, B., Ding, Q."Integrative genomic analyses of the RNA-binding protein, RNPC1, and its potential role in cancer prediction". International Journal of Molecular Medicine 36.2 (2015): 473-484.
Chicago
Ding, Z., Yang, H., Xia, T., Wang, B., Ding, Q."Integrative genomic analyses of the RNA-binding protein, RNPC1, and its potential role in cancer prediction". International Journal of Molecular Medicine 36, no. 2 (2015): 473-484. https://doi.org/10.3892/ijmm.2015.2237
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