Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
International Journal of Molecular Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1107-3756 Online ISSN: 1791-244X
Journal Cover
November-2016 Volume 38 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
November-2016 Volume 38 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Lrrc75b is a novel negative regulator of C2C12 myogenic differentiation

  • Authors:
    • Yuechun Zhong
    • Liyi Zou
    • Zonggui Wang
    • Yaqiong Pan
    • Zhong Dai
    • Xinguang Liu
    • Liao Cui
    • Changqing Zuo
  • View Affiliations / Copyright

    Affiliations: Department of Pharmacology, Guangdong Medical University, Dongguan, Guangdong 523808, P.R. China, Department of Biochemistry and Molecular Biology, Guangdong Medical University, Dongguan, Guangdong 523808, P.R. China
    Copyright: © Zhong et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 1411-1418
    |
    Published online on: September 15, 2016
       https://doi.org/10.3892/ijmm.2016.2738
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Many transcription factors and signaling molecules involved in the guidance of myogenic differentiation have been investigated in previous studies. However, the precise molecular mechanisms of myogenic differentiation remain largely unknown. In the present study, by performing a meta-analysis of C2C12 myogenic differentiation microarray data, we found that leucine-rich repeat-containing 75B (Lrrc75b), also known as AI646023, a molecule of unknown biological function, was downregulated during C2C12 myogenic differentiation. The knockdown of Lrrc75b using specific siRNA in C2C12 myoblasts markedly enhanced the expression of muscle-specific myogenin and increased myoblast fusion and the myotube diameter. By contrast, the adenovirus-mediated overexpression of Lrrc75b in C2C12 cells markedly inhibited myoblast differentiation accompanied by a decrease in myogenin expression. In addition, the phosphorylation of extracellular signal-regulated kinase 1/2 (Erk1/2) was suppressed in the cells in which Lrrc75b was silenced. Taken together, our results demonstrate that Lrrc75b is a novel suppressor of C2C12 myogenic differentiation by modulating myogenin and Erk1/2 signaling.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

View References

1 

Ge Y, Waldemer RJ, Nalluri R, Nuzzi PD and Chen J: Flt3L is a novel regulator of skeletal myogenesis. J Cell Sci. 126:3370–3379. 2013. View Article : Google Scholar : PubMed/NCBI

2 

Miyake M, Hayashi S, Iwasaki S, Uchida T, Watanabe K, Ohwada S, Aso H and Yamaguchi T: TIEG1 negatively controls the myoblast pool indispensable for fusion during myogenic differentiation of C2C12 cells. J Cell Physiol. 226:1128–1136. 2011. View Article : Google Scholar

3 

Calhabeu F, Hayashi S, Morgan JE, Relaix F and Zammit PS: Alveolar rhabdomyosarcoma-associated proteins PAX3/FOXO1A and PAX7/FOXO1A suppress the transcriptional activity of MyoD-target genes in muscle stem cells. Oncogene. 32:651–662. 2013. View Article : Google Scholar

4 

Zhang RP, Liu HH, Wang HH, Wang Y, Han CC, Li L, He H, Xu HY, Xu F and Wang JW: Silencing Pax3 by shRNA inhibits the proliferation and differentiation of duck (Anas platyrhynchos) myoblasts. Mol Cell Biochem. 386:211–222. 2014. View Article : Google Scholar

5 

Dey BK, Gagan J and Dutta A: miR-206 and -486 induce myoblast differentiation by downregulating Pax7. Mol Cell Biol. 31:203–214. 2011. View Article : Google Scholar :

6 

Wu SL, Li GZ, Chou CY, Tsai MS, Chen YP, Li CJ, Liou GG, Chang WW, Chen SL and Wang SH: Double homeobox gene, Duxbl, promotes myoblast proliferation and abolishes myoblast differentiation by blocking MyoD transactivation. Cell Tissue Res. 358:551–566. 2014. View Article : Google Scholar : PubMed/NCBI

7 

Averous J, Gabillard JC, Seiliez I and Dardevet D: Leucine limitation regulates myf5 and MyoD expression and inhibits myoblast differentiation. Exp Cell Res. 318:217–227. 2012. View Article : Google Scholar

8 

Naka A, Iida KT, Nakagawa Y, Iwasaki H, Takeuchi Y, Satoh A, Matsuzaka T, Ishii KA, Kobayashi K, Yatoh S, et al: TFE3 inhibits myoblast differentiation in C2C12 cells via down-regulating gene expression of myogenin. Biochem Biophys Res Commun. 430:664–669. 2013. View Article : Google Scholar

9 

Antoniou A, Mastroyiannopoulos NP, Uney JB and Phylactou LA: miR-186 inhibits muscle cell differentiation through myogenin regulation. J Biol Chem. 289:3923–3935. 2014. View Article : Google Scholar : PubMed/NCBI

10 

Brown DM, Parr T and Brameld JM: Myosin heavy chain mRNA isoforms are expressed in two distinct cohorts during C2C12 myogenesis. J Muscle Res Cell Motil. 32:383–390. 2012. View Article : Google Scholar

11 

Wang L, Chen X, Zheng Y, Li F, Lu Z, Chen C, Liu J, Wang Y, Peng Y, Shen Z, et al: MiR-23a inhibits myogenic differentiation through down regulation of fast myosin heavy chain isoforms. Exp Cell Res. 318:2324–2334. 2012. View Article : Google Scholar : PubMed/NCBI

12 

Wang M, Yu H, Kim YS, Bidwell CA and Kuang S: Myostatin facilitates slow and inhibits fast myosin heavy chain expression during myogenic differentiation. Biochem Biophys Res Commun. 426:83–88. 2012. View Article : Google Scholar : PubMed/NCBI

13 

Brunetti A and Goldfine ID: Role of myogenin in myoblast differentiation and its regulation by fibroblast growth factor. J Biol Chem. 265:5960–5963. 1990.PubMed/NCBI

14 

Hasty P, Bradley A, Morris JH, Edmondson DG, Venuti JM, Olson EN and Klein WH: Muscle deficiency and neonatal death in mice with a targeted mutation in the myogenin gene. Nature. 364:501–506. 1993. View Article : Google Scholar : PubMed/NCBI

15 

Park SY, Yun Y, Kim MJ and Kim IS: Myogenin is a positive regulator of MEGF10 expression in skeletal muscle. Biochem Biophys Res Commun. 450:1631–1637. 2014. View Article : Google Scholar : PubMed/NCBI

16 

Yang ZJ, Broz DK, Noderer WL, Ferreira JP, Overton KW, Spencer SL, Meyer T, Tapscott SJ, Attardi LD and Wang CL: p53 suppresses muscle differentiation at the myogenin step in response to genotoxic stress. Cell Death Differ. 22:560–573. 2015. View Article : Google Scholar :

17 

Braun T and Gautel M: Transcriptional mechanisms regulating skeletal muscle differentiation, growth and homeostasis. Nat Rev Mol Cell Biol. 12:349–361. 2011. View Article : Google Scholar : PubMed/NCBI

18 

Harrison BC, Allen DL and Leinwand LA: IIB or not IIB? Regulation of myosin heavy chain gene expression in mice and men. Skelet Muscle. 1:52011. View Article : Google Scholar : PubMed/NCBI

19 

Wu H, Wang X, Liu S, Wu Y, Zhao T, Chen X, Zhu L, Wu Y, Ding X, Peng X, et al: Sema4C participates in myogenic differentiation in vivo and in vitro through the p38 MAPK pathway. Eur J Cell Biol. 86:331–344. 2007. View Article : Google Scholar : PubMed/NCBI

20 

Terada K, Misao S, Katase N, Nishimatsu S and Nohno T: Interaction of Wnt signaling with BMP/Smad signaling during the transition from cell proliferation to myogenic differentiation in mouse myoblast-derived cells. Int J Cell Biol. 2013:6162942013. View Article : Google Scholar : PubMed/NCBI

21 

von Maltzahn J, Chang NC, Bentzinger CF and Rudnicki MA: Wnt signaling in myogenesis. Trends Cell Biol. 22:602–609. 2012. View Article : Google Scholar : PubMed/NCBI

22 

Harada T, Horinouchi T, Higa T, Hoshi A, Higashi T, Terada K, Mai Y, Nepal P, Horiguchi M, Hatate C, et al: Endothelin-1 activates extracellular signal-regulated kinases 1/2 via trans-activation of platelet-derived growth factor receptor in rat L6 myoblasts. Life Sci. 104:24–31. 2014. View Article : Google Scholar : PubMed/NCBI

23 

Feng Y, Niu LL, Wei W, Zhang WY, Li XY, Cao JH and Zhao SH: A feedback circuit between miR-133 and the ERK1/2 pathway involving an exquisite mechanism for regulating myoblast proliferation and differentiation. Cell Death Dis. 4:e9342013. View Article : Google Scholar : PubMed/NCBI

24 

Hindi SM, Tajrishi MM and Kumar A: Signaling mechanisms in mammalian myoblast fusion. Sci Signal. 6:re22013. View Article : Google Scholar : PubMed/NCBI

25 

Wang M, Amano SU, Flach RJR, Chawla A, Aouadi M and Czech MP: Identification of Map4k4 as a novel suppressor of skeletal muscle differentiation. Mol Cell Biol. 33:678–687. 2013. View Article : Google Scholar :

26 

Kajava AV: Structural diversity of leucine-rich repeat proteins. J Mol Biol. 277:519–527. 1998. View Article : Google Scholar : PubMed/NCBI

27 

Tominaga K, Kondo C, Kagata T, Hishida T, Nishizuka M and Imagawa M: The novel gene fad158, having a transmembrane domain and leucine-rich repeat, stimulates adipocyte differentiation. J Biol Chem. 279:34840–34848. 2004. View Article : Google Scholar : PubMed/NCBI

28 

Kim T, Kim K, Lee SH, So HS, Lee J, Kim N and Choi Y: Identification of LRRc17 as a negative regulator of receptor activator of NF-κB ligand (RANKL)-induced osteoclast differentiation. J Biol Chem. 284:15308–15316. 2009. View Article : Google Scholar : PubMed/NCBI

29 

Wilhite SE and Barrett T: Strategies to explore functional genomics data sets in NCBI's GEO database. Methods Mol Biol. 802:41–53. 2012. View Article : Google Scholar

30 

Dennis G Jr, Sherman BT, Hosack DA, Yang J, Gao W, Lane HC and Lempicki RA: DAVID: database for annotation, visualization, and integrated discovery. Genome Biol. 4:32003. View Article : Google Scholar

31 

Kocić J1, Santibañez JF, Krstić A, Mojsilović S, Dorđević IO, Trivanović D, Ilić V and Bugarski D: Interleukin 17 inhibits myogenic and promotes osteogenic differentiation of C2C12 myoblasts by activating ERK1, 2. Biochim Biophys Acta. 1823:838–849. 2012. View Article : Google Scholar

32 

Bennett AM and Tonks NK: Regulation of distinct stages of skeletal muscle differentiation by mitogen-activated protein kinases. Science. 278:1288–1291. 1997. View Article : Google Scholar : PubMed/NCBI

33 

Assou S, Le Carrour T, Tondeur S, Ström S, Gabelle A, Marty S, Nadal L, Pantesco V, Réme T, Hugnot JP, et al: A meta-analysis of human embryonic stem cells transcriptome integrated into a web-based expression atlas. Stem Cells. 25:961–973. 2007. View Article : Google Scholar : PubMed/NCBI

34 

Chen X, Liang S, Zheng W, Liao Z, Shang T and Ma W: Meta-analysis of nasopharyngeal carcinoma microarray data explores mechanism of EBV-regulated neoplastic transformation. BMC Genomics. 9:3222008. View Article : Google Scholar : PubMed/NCBI

35 

Katase N, Terada K, Suzuki T, Nishimatsu S and Nohno T: miR-487b, miR-3963 and miR-6412 delay myogenic differentiation in mouse myoblast-derived C2C12 cells. BMC Cell Biol. 16:132015. View Article : Google Scholar : PubMed/NCBI

36 

Ge X, Zhang Y, Park S, Cong X, Gerrard DE and Jiang H: Stac3 inhibits myoblast differentiation into myotubes. PLoS One. 9:e959262014. View Article : Google Scholar : PubMed/NCBI

37 

Gredinger E, Gerber AN, Tamir Y, Tapscott SJ and Bengal E: Mitogen-activated protein kinase pathway is involved in the differentiation of muscle cells. J Biol Chem. 273:10436–10444. 1998. View Article : Google Scholar : PubMed/NCBI

38 

Jones NC, Fedorov YV, Rosenthal RS and Olwin BB: ERK1/2 is required for myoblast proliferation but is dispensable for muscle gene expression and cell fusion. J Cell Physiol. 186:104–115. 2001. View Article : Google Scholar : PubMed/NCBI

39 

Li J and Johnson SE: ERK2 is required for efficient terminal differentiation of skeletal myoblasts. Biochem Biophys Res Commun. 345:1425–1433. 2006. View Article : Google Scholar : PubMed/NCBI

40 

Li X, Wang X, Zhang P, Zhu L, Zhao T, Liu S, Wu Y, Chen X and Fan M: Extracellular signal-regulated kinase 1/2 mitogen-activated protein kinase pathway is involved in inhibition of myogenic differentiation of myoblasts by hypoxia. Exp Physiol. 97:257–264. 2012. View Article : Google Scholar

41 

Riuzzi F, Sorci G and Donato R: S100B stimulates myoblast proliferation and inhibits myoblast differentiation by independently stimulating ERK1/2 and inhibiting p38 MAPK. J Cell Physiol. 207:461–470. 2006. View Article : Google Scholar : PubMed/NCBI

42 

Yang W, Chen Y, Zhang Y, Wang X, Yang N and Zhu D: Extracellular signal-regulated kinase 1/2 mitogen-activated protein kinase pathway is involved in myostatin-regulated differentiation repression. Cancer Res. 66:1320–1326. 2006. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Zhong Y, Zou L, Wang Z, Pan Y, Dai Z, Liu X, Cui L and Zuo C: Lrrc75b is a novel negative regulator of C2C12 myogenic differentiation. Int J Mol Med 38: 1411-1418, 2016.
APA
Zhong, Y., Zou, L., Wang, Z., Pan, Y., Dai, Z., Liu, X. ... Zuo, C. (2016). Lrrc75b is a novel negative regulator of C2C12 myogenic differentiation. International Journal of Molecular Medicine, 38, 1411-1418. https://doi.org/10.3892/ijmm.2016.2738
MLA
Zhong, Y., Zou, L., Wang, Z., Pan, Y., Dai, Z., Liu, X., Cui, L., Zuo, C."Lrrc75b is a novel negative regulator of C2C12 myogenic differentiation". International Journal of Molecular Medicine 38.5 (2016): 1411-1418.
Chicago
Zhong, Y., Zou, L., Wang, Z., Pan, Y., Dai, Z., Liu, X., Cui, L., Zuo, C."Lrrc75b is a novel negative regulator of C2C12 myogenic differentiation". International Journal of Molecular Medicine 38, no. 5 (2016): 1411-1418. https://doi.org/10.3892/ijmm.2016.2738
Copy and paste a formatted citation
x
Spandidos Publications style
Zhong Y, Zou L, Wang Z, Pan Y, Dai Z, Liu X, Cui L and Zuo C: Lrrc75b is a novel negative regulator of C2C12 myogenic differentiation. Int J Mol Med 38: 1411-1418, 2016.
APA
Zhong, Y., Zou, L., Wang, Z., Pan, Y., Dai, Z., Liu, X. ... Zuo, C. (2016). Lrrc75b is a novel negative regulator of C2C12 myogenic differentiation. International Journal of Molecular Medicine, 38, 1411-1418. https://doi.org/10.3892/ijmm.2016.2738
MLA
Zhong, Y., Zou, L., Wang, Z., Pan, Y., Dai, Z., Liu, X., Cui, L., Zuo, C."Lrrc75b is a novel negative regulator of C2C12 myogenic differentiation". International Journal of Molecular Medicine 38.5 (2016): 1411-1418.
Chicago
Zhong, Y., Zou, L., Wang, Z., Pan, Y., Dai, Z., Liu, X., Cui, L., Zuo, C."Lrrc75b is a novel negative regulator of C2C12 myogenic differentiation". International Journal of Molecular Medicine 38, no. 5 (2016): 1411-1418. https://doi.org/10.3892/ijmm.2016.2738
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team