Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
International Journal of Molecular Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1107-3756 Online ISSN: 1791-244X
Journal Cover
November-2016 Volume 38 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
November-2016 Volume 38 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Baicalin attenuates inflammation in mice with OVA-induced asthma by inhibiting NF-κB and suppressing CCR7/CCL19/CCL21

  • Authors:
    • Jiaqi Liu
    • Ying Wei
    • Qingli Luo
    • Fei Xu
    • Zhengxiao Zhao
    • Hongying Zhang
    • Linwei Lu
    • Jing Sun
    • Feng Liu
    • Xin Du
    • Mihui Li
    • Kai Wei
    • Jingcheng Dong
  • View Affiliations / Copyright

    Affiliations: Department of Integrative Medicine, Huashan Hospital, Fudan University, Shanghai 200040, P.R. China
  • Pages: 1541-1548
    |
    Published online on: September 21, 2016
       https://doi.org/10.3892/ijmm.2016.2743
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Baicalin, extracted and purified from the Chinese medicinal plant, Scutellaria baicalensis Georgi (Huang qin in Chinese), exhibits potent anti-inflammatory activity against asthma. However, it remains unknown whether baicalin inhibits the activity of CC chemokine receptor 7 (CCR7) and its ligands, which are crucial for the initiation of airway inflammation. In the present study, we investigated the effects of baicalin on CCR7 and its ligands, CCL19 and CCL21, as well as on the nuclear factor-κB (NF-κB) pathway in a mouse model of asthma. A mouse model of acute asthma was established by exposing the mice to ovalbumin (OVA) (by intraperitoneal injection and inhalational challenge). Within 24 h of the final OVA challenge, lung function was detected by direct airway resistance analysis. Lung tissues were examined for pathological changes. Inflammatory cell counts in bronchoalveolar lavage fluid (BALF) were assessed. ELISA was utilized to evaluate the OVA-IgE, CCL19 and CCL21 levels in BALF. The interleukin (IL)-6 and tumor necrosis factor (TNF)-α levels in serum were also detected by ELISA. The protein expression levels of CCR7, as well as that of phosphorylated IκBα (p-IκBα) and phosphorylated p65 (p-p65) were determined by western blot analysis and RT-qPCR was used to determine the CCR7 mRNA levels. Our data demonstrated that the oral administration of baicalin significantly improved pulmonary function and attenuated inflammatory cell infiltration into the lungs. Baicalin also decreased the levels of OVA-IgE, IL-6, TNF-α and CCR7, as well as those of its ligand, CCL19; the levels of NF-κB were also markedly suppressed by baicalin. The CCR7 mRNA level was substantially decreased. Our results thus suggest that baicalin exerts an inhibitory effect on airway inflammation, and this effect may be associated with the inhibition of CCR7 and CCL19/CCL21, which may provide new mechanistic insight into the anti‑inflammatory effects of baicalin.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

Figure 6

Figure 7

Figure 8

View References

1 

Olin JT and Wechsler ME: Asthma: pathogenesis and novel drugs for treatment. BMJ. 349:g55172014. View Article : Google Scholar : PubMed/NCBI

2 

Kaur D, Saunders R, Berger P, Siddiqui S, Woodman L, Wardlaw A, Bradding P and Brightling CE: Airway smooth muscle and mast cell-derived CC chemokine ligand 19 mediate airway smooth muscle migration in asthma. Am J Respir Crit Care Med. 174:1179–1188. 2006. View Article : Google Scholar : PubMed/NCBI

3 

Saunders R, Sutcliffe A, Kaur D, Siddiqui S, Hollins F, Wardlaw A, Bradding P and Brightling C: Airway smooth muscle chemokine receptor expression and function in asthma. Clin Exp Allergy. 39:1684–1692. 2009. View Article : Google Scholar : PubMed/NCBI

4 

Yamashita N, Tashimo H, Matsuo Y, Ishida H, Yoshiura K, Sato K, Yamashita N, Kakiuchi T and Ohta K: Role of CCL21 and CCL19 in allergic inflammation in the ovalbumin-specific murine asthmatic model. J Allergy Clin Immunol. 117:1040–1046. 2006. View Article : Google Scholar : PubMed/NCBI

5 

Sennikov SV, Falaleeva SA, Shkaruba NS, Chumasova OA, Obleukhova IA, Sizikov AE and Kurilin VV: Maturation and cytokine production potential of dendritic cells isolated from rheumatoid arthritis patients peripheral blood and induced in vitro. Hum Immunol. pii: S0198–8859(16)30158-6. 2016. View Article : Google Scholar : PubMed/NCBI

6 

Akuthota P, Ueki S, Estanislau J and Weller PF: Human eosinophils express functional CCR7. Am J Respir Cell Mol Biol. 48:758–764. 2013. View Article : Google Scholar : PubMed/NCBI

7 

Jung YW, Kim HG, Perry CJ and Kaech SM: CCR7 expression alters memory CD8 T-cell homeostasis by regulating occupancy in IL-7- and IL-15-dependent niches. Proc Natl Acad Sci USA. 113:8278–8283. 2016. View Article : Google Scholar : PubMed/NCBI

8 

Moschovakis GL, Bubke A, Dittrich-Breiholz O, Braun A, Prinz I, Kremmer E and Förster R: Deficient CCR7 signaling promotes TH2 polarization and B-cell activation in vivo. Eur J Immunol. 42:48–57. 2012. View Article : Google Scholar

9 

Boislève F, Kerdine-Romer S, Rougier-Larzat N and Pallardy M: Nickel and DNCB induce CCR7 expression on human dendritic cells through different signalling pathways: role of TNF-alpha and MAPK. J Invest Dermatol. 123:494–502. 2004. View Article : Google Scholar : PubMed/NCBI

10 

Pahne-Zeppenfeld J, Schröer N, Walch-Rückheim B, Oldak M, Gorter A, Hegde S and Smola S: Cervical cancer cell-derived interleukin-6 impairs CCR7-dependent migration of MMP-9-expressing dendritic cells. Int J Cancer. 134:2061–2073. 2014. View Article : Google Scholar

11 

Johnston B and Butcher EC: Chemokines in rapid leukocyte adhesion triggering and migration. Semin Immunol. 14:83–92. 2002. View Article : Google Scholar : PubMed/NCBI

12 

Ben-Baruch A: Organ selectivity in metastasis: regulation by chemokines and their receptors. Clin Exp Metastasis. 25:345–356. 2008. View Article : Google Scholar

13 

Comerford I, Harata-Lee Y, Bunting MD, Gregor C, Kara EE and McColl SR: A myriad of functions and complex regulation of the CCR7/CCL19/CCL21 chemokine axis in the adaptive immune system. Cytokine Growth Factor Rev. 24:269–283. 2013. View Article : Google Scholar : PubMed/NCBI

14 

Höpken UE, Foss HD, Meyer D, Hinz M, Leder K, Stein H and Lipp M: Up-regulation of the chemokine receptor CCR7 in classical but not in lymphocyte-predominant Hodgkin disease correlates with distinct dissemination of neoplastic cells in lymphoid organs. Blood. 99:1109–1116. 2002. View Article : Google Scholar : PubMed/NCBI

15 

Cui L, Feng L, Zhang ZH and Jia XB: The anti-inflammation effect of baicalin on experimental colitis through inhibiting TLR4/NF-κB pathway activation. Int Immunopharmacol. 23:294–303. 2014. View Article : Google Scholar : PubMed/NCBI

16 

Sun J, Li L, Wu J, Liu B, Gong W, Lv Y, Luo Q, Duan X and Dong J: Effects of baicalin on airway remodeling in asthmatic mice. Planta Med. 79:199–206. 2013. View Article : Google Scholar : PubMed/NCBI

17 

Ma C, Ma Z, Fu Q and Ma S: Anti-asthmatic effects of baicalin in a mouse model of allergic asthma. Phytother Res. 28:231–237. 2014. View Article : Google Scholar

18 

Pichavant M, Goya S, Hamelmann E, Gelfand EW and Umetsu DT: Animal models of airway sensitization. Curr Protoc Immunol. Chapter 15: Unit15.18. 2007. View Article : Google Scholar

19 

Underwood S, Foster M, Raeburn D, Bottoms S and Karlsson JA: Time-course of antigen-induced airway inflammation in the guinea-pig and its relationship to airway hyperresponsiveness. Eur Respir J. 8:2104–13. 1995. View Article : Google Scholar : PubMed/NCBI

20 

Chu DK, Al-Garawi A, Llop-Guevara A, Pillai RA, Radford K, Shen P, Walker TD, Goncharova S, Calhoun WJ, Nair P and Jordana M: Therapeutic potential of anti-IL-6 therapies for granulocytic airway inflammation in asthma. Allergy Asthma Clin Immunol. 11:142015. View Article : Google Scholar : PubMed/NCBI

21 

Rose-John S, Scheller J, Elson G and Jones SA: Interleukin-6 biology is coordinated by membrane-bound and soluble receptors: role in inflammation and cancer. J Leukoc Biol. 80:227–236. 2006. View Article : Google Scholar : PubMed/NCBI

22 

Brightling C, Berry M and Amrani Y: Targeting TNF-α: a novel therapeutic approach for asthma. J Allergy Clin Immunol. 121:5–10; quiz 11–12. 2008. View Article : Google Scholar

23 

Gagliardo R, Chanez P, Profita M, Bonanno A, Albano GD, Montalbano AM, Pompeo F, Gagliardo C, Merendino AM and Gjomarkaj M: IkappaB kinase-driven nuclear factor-kappaB activation in patients with asthma and chronic obstructive pulmonary disease. J Allergy Clin Immunol. 128:635–645. 2011. View Article : Google Scholar

24 

Berry M, Brightling C, Pavord I and Wardlaw A: TNF-α in asthma. Curr Opin Pharmacol. 7:279–282. 2007. View Article : Google Scholar : PubMed/NCBI

25 

Robinson MB, Deshpande DA, Chou J, Cui W, Smith S, Langefeld C, Hastie AT, Bleecker ER and Hawkins GA: IL-6 trans-signaling increases expression of airways disease genes in airway smooth muscle. Am J Physiol Lung Cell Mol Physiol. 309:L129–L138. 2015. View Article : Google Scholar : PubMed/NCBI

26 

Sun J, Wu J, Xu C, Luo Q, Li B and Dong J: Paeoniflorin attenuates allergic inflammation in asthmatic mice. Int Immunopharmacol. 24:88–94. 2015. View Article : Google Scholar

27 

Wei Y, Luo QL, Sun J, Chen MX, Liu F and Dong JC: Bu-Shen-Yi-Qi formulae suppress chronic airway inflammation and regulate Th17/Treg imbalance in the murine ovalbumin asthma model. J Ethnopharmacol. 164:368–377. 2015. View Article : Google Scholar : PubMed/NCBI

28 

Le Y, Zhou Y, Iribarren P and Wang J: Chemokines and chemokine receptors: their manifold roles in homeostasis and disease. Cell Mol Immunol. 1:95–104. 2004.

29 

Ebert LM, Schaerli P and Moser B: Chemokine-mediated control of T cell traffic in lymphoid and peripheral tissues. Mol Immunol. 42:799–809. 2005. View Article : Google Scholar : PubMed/NCBI

30 

Lambrecht BN: Allergen uptake and presentation by dendritic cells. Curr Opin Allergy Clin Immunol. 1:51–59. 2001. View Article : Google Scholar

31 

Choi B, Lim HC, Lee ES, Anower AKMM and Sohn S: CCL21 attenuates HSV-induced inflammation through up-regulation of CD8+ memory cells. Immunobiology. 218:579–590. 2013. View Article : Google Scholar

32 

Förster R, Davalos-Misslitz AC and Rot A: CCR7 and its ligands: balancing immunity and tolerance. Nat Rev Immunol. 8:362–371. 2008. View Article : Google Scholar : PubMed/NCBI

33 

Worbs T and Förster R: A key role for CCR7 in establishing central and peripheral tolerance. Trends Immunol. 28:274–280. 2007. View Article : Google Scholar : PubMed/NCBI

34 

Hintzen G, Ohl L, del Rio ML, Rodriguez-Barbosa JI, Pabst O, Kocks JR, Krege J, Hardtke S and Förster R: Induction of tolerance to innocuous inhaled antigen relies on a CCR7-dependent dendritic cell-mediated antigen transport to the bronchial lymph node. J Immunol. 177:7346–7354. 2006. View Article : Google Scholar : PubMed/NCBI

35 

Ato M, Stäger S, Engwerda CR and Kaye PM: Defective CCR7 expression on dendritic cells contributes to the development of visceral leishmaniasis. Nat Immunol. 3:1185–1191. 2002. View Article : Google Scholar : PubMed/NCBI

36 

Saban DR: The chemokine receptor CCR7 expressed by dendritic cells: a key player in corneal and ocular surface inflammation. Ocul Surf. 12:87–99. 2014. View Article : Google Scholar : PubMed/NCBI

37 

Schmidt-Weber CB, Akdis M and Akdis CA: TH17 cells in the big picture of immunology. J Allergy Clin Immunol. 120:247–54. 2007. View Article : Google Scholar : PubMed/NCBI

38 

Yokoyama A, Kohno N, Fujino S, Hamada H, Inoue Y, Fujioka S, Ishida S and Hiwada K: Circulating interleukin-6 levels in patients with bronchial asthma. Am J Respir Crit Care Med. 151:1354–1358. 1995. View Article : Google Scholar : PubMed/NCBI

39 

Hutchison S, Choo-Kang BSW, Bundick RV, Leishman AJ, Brewer JM, McInnes IB and Garside P: Tumour necrosis factor-α blockade suppresses murine allergic airways inflammation. Clin Exp Immunol. 151:114–122. 2008. View Article : Google Scholar

40 

Hunter CA and Jones SA: IL-6 as a keystone cytokine in health and disease. Nat Immunol. 16:448–457. 2015. View Article : Google Scholar : PubMed/NCBI

41 

Nishimoto N and Kishimoto T: Inhibition of IL-6 for the treatment of inflammatory diseases. Curr Opin Pharmacol. 4:386–391. 2004. View Article : Google Scholar : PubMed/NCBI

42 

Berry MA, Hargadon B, Shelley M, Parker D, Shaw DE, Green RH, Bradding P, Brightling CE, Wardlaw AJ and Pavord ID: Evidence of a role of tumor necrosis factor alpha in refractory asthma. N Engl J Med. 354:697–708. 2006. View Article : Google Scholar : PubMed/NCBI

43 

Howarth PH, Babu KS, Arshad HS, Lau L, Buckley M, McConnell W, Beckett P, Al Ali M, Chauhan A, Wilson SJ, et al: Tumour necrosis factor (TNF alpha) as a novel therapeutic target in symptomatic corticosteroid dependent asthma. Thorax. 60:1012–1018. 2005. View Article : Google Scholar : PubMed/NCBI

44 

Kuwabara T, Tanaka Y, Ishikawa F, Kondo M, Sekiya H and Kakiuchi T: CCR7 ligands up-regulate IL-23 through PI3-kinase and NF-kappa B pathway in dendritic cells. J Leukoc Biol. 92:309–318. 2012. View Article : Google Scholar : PubMed/NCBI

45 

Zhang H and Sun SC: NF-κB in inflammation and renal diseases. Cell Biosci. 5:632015. View Article : Google Scholar

46 

Liu FY, Zhao ZJ, Li P, Ding X, Guo N, Yang LL, Zong ZH and Sun CF: NF-κB participates in chemokine receptor 7-mediated cell survival in metastatic squamous cell carcinoma of the head and neck. Oncol Rep. 25:383–391. 2011.

47 

Sánchez-Sánchez N, Riol-Blanco L, de la Rosa G, Puig-Kröger A, García-Bordas J, Martín D, Longo N, Cuadrado A, Cabañas C, Corbí AL, et al: Chemokine receptor CCR7 induces intracellular signaling that inhibits apoptosis of mature dendritic cells. Blood. 104:619–625. 2004. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Liu J, Wei Y, Luo Q, Xu F, Zhao Z, Zhang H, Lu L, Sun J, Liu F, Du X, Du X, et al: Baicalin attenuates inflammation in mice with OVA-induced asthma by inhibiting NF-κB and suppressing CCR7/CCL19/CCL21. Int J Mol Med 38: 1541-1548, 2016.
APA
Liu, J., Wei, Y., Luo, Q., Xu, F., Zhao, Z., Zhang, H. ... Dong, J. (2016). Baicalin attenuates inflammation in mice with OVA-induced asthma by inhibiting NF-κB and suppressing CCR7/CCL19/CCL21. International Journal of Molecular Medicine, 38, 1541-1548. https://doi.org/10.3892/ijmm.2016.2743
MLA
Liu, J., Wei, Y., Luo, Q., Xu, F., Zhao, Z., Zhang, H., Lu, L., Sun, J., Liu, F., Du, X., Li, M., Wei, K., Dong, J."Baicalin attenuates inflammation in mice with OVA-induced asthma by inhibiting NF-κB and suppressing CCR7/CCL19/CCL21". International Journal of Molecular Medicine 38.5 (2016): 1541-1548.
Chicago
Liu, J., Wei, Y., Luo, Q., Xu, F., Zhao, Z., Zhang, H., Lu, L., Sun, J., Liu, F., Du, X., Li, M., Wei, K., Dong, J."Baicalin attenuates inflammation in mice with OVA-induced asthma by inhibiting NF-κB and suppressing CCR7/CCL19/CCL21". International Journal of Molecular Medicine 38, no. 5 (2016): 1541-1548. https://doi.org/10.3892/ijmm.2016.2743
Copy and paste a formatted citation
x
Spandidos Publications style
Liu J, Wei Y, Luo Q, Xu F, Zhao Z, Zhang H, Lu L, Sun J, Liu F, Du X, Du X, et al: Baicalin attenuates inflammation in mice with OVA-induced asthma by inhibiting NF-κB and suppressing CCR7/CCL19/CCL21. Int J Mol Med 38: 1541-1548, 2016.
APA
Liu, J., Wei, Y., Luo, Q., Xu, F., Zhao, Z., Zhang, H. ... Dong, J. (2016). Baicalin attenuates inflammation in mice with OVA-induced asthma by inhibiting NF-κB and suppressing CCR7/CCL19/CCL21. International Journal of Molecular Medicine, 38, 1541-1548. https://doi.org/10.3892/ijmm.2016.2743
MLA
Liu, J., Wei, Y., Luo, Q., Xu, F., Zhao, Z., Zhang, H., Lu, L., Sun, J., Liu, F., Du, X., Li, M., Wei, K., Dong, J."Baicalin attenuates inflammation in mice with OVA-induced asthma by inhibiting NF-κB and suppressing CCR7/CCL19/CCL21". International Journal of Molecular Medicine 38.5 (2016): 1541-1548.
Chicago
Liu, J., Wei, Y., Luo, Q., Xu, F., Zhao, Z., Zhang, H., Lu, L., Sun, J., Liu, F., Du, X., Li, M., Wei, K., Dong, J."Baicalin attenuates inflammation in mice with OVA-induced asthma by inhibiting NF-κB and suppressing CCR7/CCL19/CCL21". International Journal of Molecular Medicine 38, no. 5 (2016): 1541-1548. https://doi.org/10.3892/ijmm.2016.2743
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team