|
1
|
Torre LA, Bray F, Siegel RL, Ferlay J,
Lortet-Tieulent J and Jemal A: Global cancer statistics, 2012. CA
Cancer J Clin. 65:87–108. 2015. View Article : Google Scholar : PubMed/NCBI
|
|
2
|
Stewart B and Wild C: World Cancer Report
2014. International Agency for Research on Cancer, World Health
Organization; Lyon, France: 2014
|
|
3
|
Cabrera R and Nelson DR: Review article:
the management of hepatocellular carcinoma. Aliment Pharmacol Ther.
31:461–476. 2010. View Article : Google Scholar
|
|
4
|
Fletcher A, Choudhury A and Alam N:
Metastatic bladder cancer: a review of current management. ISRN
Urol. 2011:5452412011.PubMed/NCBI
|
|
5
|
Baldo BA and Pham NH: Adverse reactions to
targeted and non-targeted chemotherapeutic drugs with emphasis on
hypersensitivity responses and the invasive metastatic switch.
Cancer Metastasis Rev. 32:723–761. 2013. View Article : Google Scholar : PubMed/NCBI
|
|
6
|
Zhang QH, Wu CF, Duan L and Yang JY:
Protective effects of ginsenoside Rg(3) against
cyclophosphamide-induced DNA damage and cell apoptosis in mice.
Arch Toxicol. 82:117–123. 2008. View Article : Google Scholar
|
|
7
|
Lü JM, Yao Q and Chen C: Ginseng
compounds: an update on their molecular mechanisms and medical
applications. Curr Vasc Pharmacol. 7:293–302. 2009. View Article : Google Scholar : PubMed/NCBI
|
|
8
|
Liu L, Zhu XM, Wang QJ, Zhang DL, Fang ZM,
Wang CY, Wang Z, Sun BS, Wu H and Sung CK: Enzymatic preparation of
20(S, R)-protopanaxadiol by transformation of 20(S, R)-Rg3 from
black ginseng. Phytochemistry. 71:1514–1520. 2010. View Article : Google Scholar : PubMed/NCBI
|
|
9
|
Gum SI and Cho MK: The amelioration of
N-acetyl-p-benzoquinone imine toxicity by ginsenoside Rg3: the role
of Nrf2-mediated detoxification and Mrp1/Mrp3 transports. Oxid Med
Cell Longev. 2013:9579472013. View Article : Google Scholar : PubMed/NCBI
|
|
10
|
He B, Chen P, Yang J, Yun Y, Zhang X, Yang
R and Shen Z: Neuroprotective effect of 20(R)-ginsenoside Rg(3)
against transient focal cerebral ischemia in rats. Neurosci Lett.
526:106–111. 2012. View Article : Google Scholar : PubMed/NCBI
|
|
11
|
Kwok HH, Guo GL, Lau JK, Cheng YK, Wang
JR, Jiang ZH, Keung MH, Mak NK, Yue PY and Wong RN: Stereoisomers
ginsenosides-20(S)-Rg3 and -20(R)-Rg3 differentially induce
angiogenesis through peroxisome proliferator-activated
receptor-gamma. Biochem Pharmacol. 83:893–902. 2012. View Article : Google Scholar : PubMed/NCBI
|
|
12
|
Wei X, Chen J, Su F, Su X, Hu T and Hu S:
Stereospecificity of ginsenoside Rg3 in promotion of the immune
response to ovalbumin in mice. Int Immunol. 24:465–471. 2012.
View Article : Google Scholar : PubMed/NCBI
|
|
13
|
Xu Y, Zhang P, Wang C, Shan Y, Wang D,
Qian F, Sun M and Zhu C: Effect of ginsenoside Rg3 on tyrosine
hydroxylase and related mechanisms in the forced swimming-induced
fatigue rats. J Ethnopharmacol. 150:138–147. 2013. View Article : Google Scholar : PubMed/NCBI
|
|
14
|
Wei X, Su F, Su X, Hu T and Hu S:
Stereospecific antioxidant effects of ginsenoside Rg3 on oxidative
stress induced by cyclophosphamide in mice. Fitoterapia.
83:636–642. 2012. View Article : Google Scholar : PubMed/NCBI
|
|
15
|
Joo EJ, Chun J, Ha YW, Ko HJ, Xu MY and
Kim YS: Novel roles of ginsenoside Rg3 in apoptosis through
downregulation of epidermal growth factor receptor. Chem Biol
Interact. 233:25–34. 2015. View Article : Google Scholar : PubMed/NCBI
|
|
16
|
Park HM, Kim SJ, Kim JS and Kang HS:
Reactive oxygen species mediated ginsenoside Rg3- and Rh2-induced
apoptosis in hepatoma cells through mitochondrial signaling
pathways. Food Chem Toxicol. 50:2736–2741. 2012. View Article : Google Scholar : PubMed/NCBI
|
|
17
|
Kim BM, Kim DH, Park JH, Na HK and Surh
YJ: Ginsenoside Rg3 induces apoptosis of human breast cancer
(MDA-MB-231) cells. J Cancer Prev. 18:177–185. 2013. View Article : Google Scholar : PubMed/NCBI
|
|
18
|
Liu TG, Huang Y, Cui DD, Huang XB, Mao SH,
Ji LL, Song HB and Yi C: Inhibitory effect of ginsenoside Rg3
combined with gemcitabine on angiogenesis and growth of lung cancer
in mice. BMC Cancer. 9:2502009. View Article : Google Scholar : PubMed/NCBI
|
|
19
|
Kim WY, Kim JM, Han SB, Lee SK, Kim ND,
Park MK, Kim CK and Park JH: Steaming of ginseng at high
temperature enhances biological activity. J Nat Prod. 63:1702–1704.
2000. View Article : Google Scholar
|
|
20
|
Kim IW, Sun WS, Yun BS, Kim NR, Min D and
Kim SK: Characterizing a full spectrum of physico-chemical
properties of (20S)- and (20R)-ginsenoside Rg3 to be proposed as
standard reference materials. J Ginseng Res. 37:124–134. 2013.
View Article : Google Scholar : PubMed/NCBI
|
|
21
|
Nag SA, Qin JJ, Wang W, Wang MH, Wang H
and Zhang R: Ginsenosides as anticancer agents: in vitro and in
vivo activities, structure-activity relationships, and molecular
mechanisms of action. Front Pharmacol. 3:252012. View Article : Google Scholar : PubMed/NCBI
|
|
22
|
Wani MC, Taylor HL, Wall ME, Coggon P and
McPhail AT: Plant antitumor agents VI The isolation and structure
of taxol, a novel antileukemic and antitumor agent from Taxus
brevifolia. J Am Chem Soc. 93:2325–2327. 1971. View Article : Google Scholar : PubMed/NCBI
|
|
23
|
Yun TK, Lee YS, Lee YH, Kim SI and Yun HY:
Anticarcinogenic effect of Panax ginseng C.A. Meyer and
identification of active compounds. J Korean Med Sci. 16(Suppl):
S6–S18. 2001. View Article : Google Scholar : PubMed/NCBI
|
|
24
|
Yu Y, Zhang C, Liu L and Li X: Hepatic
arterial administration of ginsenoside Rg3 and transcatheter
arterial embolization for the treatment of VX2 liver carcinomas.
Exp Ther Med. 5:761–766. 2013.PubMed/NCBI
|
|
25
|
Amelio I, Melino G and Knight RA: Cell
death pathology: cross-talk with autophagy and its clinical
implications. Biochem Biophys Res Commun. 414:277–281. 2011.
View Article : Google Scholar : PubMed/NCBI
|
|
26
|
Hanahan D and Weinberg RA: Hallmarks of
cancer: the next generation. Cell. 144:646–674. 2011. View Article : Google Scholar : PubMed/NCBI
|
|
27
|
Karmakar S, Banik NL, Patel SJ and Ray SK:
Curcumin activated both receptor-mediated and mitochondria-mediated
proteolytic pathways for apoptosis in human glioblastoma T98G
cells. Neurosci Lett. 407:53–58. 2006. View Article : Google Scholar : PubMed/NCBI
|
|
28
|
Wang JH, Nao JF, Zhang M and He P:
20(s)-ginsenoside Rg3 promotes apoptosis in human ovarian cancer
HO-8910 cells through PI3K/Akt and XIAP pathways. Tumour Biol.
35:11985–11994. 2014. View Article : Google Scholar : PubMed/NCBI
|
|
29
|
Jiang JW, Chen XM, Chen XH and Zheng SS:
Ginsenoside Rg3 inhibit hepatocellular carcinoma growth via
intrinsic apoptotic pathway. World J Gastroenterol. 17:3605–3613.
2011. View Article : Google Scholar : PubMed/NCBI
|
|
30
|
Choi YJ, Lee HJ, Kang DW, Han IH, Choi BK
and Cho WH: Ginsenoside Rg3 induces apoptosis in the U87MG human
glioblastoma cell line through the MEK signaling pathway and
reactive oxygen species. Oncol Rep. 30:1362–1370. 2013.PubMed/NCBI
|
|
31
|
Chen J, Peng H, Ou-Yang X and He X:
Research on the antitumor effect of ginsenoside Rg3 in B16 melanoma
cells. Melanoma Res. 18:322–329. 2008. View Article : Google Scholar : PubMed/NCBI
|
|
32
|
Park EH, Kim YJ, Yamabe N, Park SH, Kim
HK, Jang HJ, Kim JH, Cheon GJ, Ham J and Kang KS: Stereospecific
anticancer effects of ginsenoside Rg3 epimers isolated from
heat-processed American ginseng on human gastric cancer cell. J
Ginseng Res. 38:22–27. 2014. View Article : Google Scholar : PubMed/NCBI
|
|
33
|
Zhang C, Liu L, Yu Y, Chen B, Tang C and
Li X: Antitumor effects of ginsenoside Rg3 on human hepatocellular
carcinoma cells. Mol Med Rep. 5:1295–1298. 2012.PubMed/NCBI
|
|
34
|
Zhang F, Li M, Wu X, Hu Y, Cao Y, Wang X,
Xiang S, Li H, Jiang L, Tan Z, et al: 20(S)-ginsenoside Rg3
promotes senescence and apoptosis in gallbladder cancer cells via
the p53 pathway. Drug Des Devel Ther. 9:3969–3987. 2015.PubMed/NCBI
|
|
35
|
Kim BM, Kim DH, Park JH, Surh YJ and Na
HK: Ginsenoside Rg3 inhibits constitutive activation of NF-κB
signaling in human breast cancer (MDA-MB-231) cells: ERK and Akt as
potential upstream targets. J Cancer Prev. 19:23–30. 2014.
View Article : Google Scholar : PubMed/NCBI
|
|
36
|
Yuan HD, Quan HY, Zhang Y, Kim SH and
Chung SH: 20(S)-ginsenoside Rg3-induced apoptosis in HT-29 colon
cancer cells is associated with AMPK signaling pathway. Mol Med
Rep. 3:825–831. 2010.
|
|
37
|
Aziz F, Wang X, Liu J and Yan Q:
Ginsenoside Rg3 induces FUT4-mediated apoptosis in H. pylori
CagA-treated gastric cancer cells by regulating SP1 and HSF1
expressions. Toxicol In Vitro. 31:158–166. 2016. View Article : Google Scholar
|
|
38
|
Wu K, Li N, Sun H, Xu T, Jin F and Nie J:
Endoplasmic reticulum stress activation mediates Ginseng
Rg3-induced anti-gallbladder cancer cell activity. Biochem Biophys
Res Commun. 466:369–375. 2015. View Article : Google Scholar : PubMed/NCBI
|
|
39
|
Kim BJ, Nah SY, Jeon JH, So I and Kim SJ:
Transient receptor potential melastatin 7 channels are involved in
ginsenoside Rg3-induced apoptosis in gastric cancer cells. Basic
Clin Pharmacol Toxicol. 109:233–239. 2011. View Article : Google Scholar : PubMed/NCBI
|
|
40
|
Kim HS, Lee EH, Ko SR, Choi KJ, Park JH
and Im DS: Effects of ginsenosides Rg3 and Rh2 on the proliferation
of prostate cancer cells. Arch Pharm Res. 27:429–435. 2004.
View Article : Google Scholar : PubMed/NCBI
|
|
41
|
Shan X, Aziz F, Tian LL, Wang XQ, Yan Q
and Liu JW: Ginsenoside Rg3-induced EGFR/MAPK pathway deactivation
inhibits melanoma cell proliferation by decreasing FUT4/LeY
expression. Int J Oncol. 46:1667–1676. 2015.PubMed/NCBI
|
|
42
|
Lee SY, Kim GT, Roh SH, Song JS, Kim HJ,
Hong SS, Kwon SW and Park JH: Proteomic analysis of the anti-cancer
effect of 20S-ginsenoside Rg3 in human colon cancer cell lines.
Biosci Biotechnol Biochem. 73:811–816. 2009. View Article : Google Scholar : PubMed/NCBI
|
|
43
|
He BC, Gao JL, Luo X, Luo J, Shen J, Wang
L, Zhou Q, Wang YT, Luu HH, Haydon RC, et al: Ginsenoside Rg3
inhibits colorectal tumor growth through the down-regulation of
Wnt/β-catenin signaling. Int J Oncol. 38:437–445. 2011. View Article : Google Scholar
|
|
44
|
Luo X, Wang CZ, Chen J, Song WX, Luo J,
Tang N, He BC, Kang Q, Wang Y, Du W, et al: Characterization of
gene expression regulated by American ginseng and ginsenoside Rg3
in human colorectal cancer cells. Int J Oncol. 32:975–983.
2008.PubMed/NCBI
|
|
45
|
Sin S, Kim SY and Kim SS: Chronic
treatment with ginsenoside Rg3 induces Akt-dependent senescence in
human glioma cells. Int J Oncol. 41:1669–1674. 2012.PubMed/NCBI
|
|
46
|
Wang CZ, Aung HH, Zhang B, Sun S, Li XL,
He H, Xie JT, He TC, Du W and Yuan CS: Chemopreventive effects of
heat-processed Panax quinquefolius root on human breast cancer
cells. Anticancer Res. 28:2545–2551. 2008.PubMed/NCBI
|
|
47
|
Shan X, Fu YS, Aziz F, Wang XQ, Yan Q and
Liu JW: Ginsenoside Rg3 inhibits melanoma cell proliferation
through down-regulation of histone deacetylase 3 (HDAC3) and
increase of p53 acetylation. PLoS One. 9:e1154012014. View Article : Google Scholar : PubMed/NCBI
|
|
48
|
Chen XP, Qian LL, Jiang H and Chen JH:
Ginsenoside Rg3 inhibits CXCR4 expression and related migrations in
a breast cancer cell line. Int J Clin Oncol. 16:519–523. 2011.
View Article : Google Scholar : PubMed/NCBI
|
|
49
|
Deryugina EI and Quigley JP: Matrix
metalloproteinases and tumor metastasis. Cancer Metastasis Rev.
25:9–34. 2006. View Article : Google Scholar : PubMed/NCBI
|
|
50
|
Xu TM, Cui MH, Xin Y, Gu LP, Jiang X, Su
MM, Wang DD and Wang WJ: Inhibitory effect of ginsenoside Rg3 on
ovarian cancer metastasis. Chin Med J (Engl). 121:1394–1397.
2008.
|
|
51
|
Lee SG, Kang YJ and Nam JO:
Anti-metastasis effects of ginsenoside Rg3 in B16F10 Cells. J
Microbiol Biotechnol. 25:1997–2006. 2015. View Article : Google Scholar : PubMed/NCBI
|
|
52
|
Junmin S, Hongxiang L, Zhen L, Chao Y and
Chaojie W: Ginsenoside Rg3 inhibits colon cancer cell migration by
suppressing nuclear factor kappa B activity. J Tradit Chin Med.
35:440–444. 2015. View Article : Google Scholar : PubMed/NCBI
|
|
53
|
Kim YJ, Choi WI, Jeon BN, Choi KC, Kim K,
Kim TJ, Ham J, Jang HJ, Kang KS and Ko H: Stereospecific effects of
ginsenoside 20-Rg3 inhibits TGF-β1-induced epithelial-mesenchymal
transition and suppresses lung cancer migration, invasion and
anoikis resistance. Toxicology. 322:23–33. 2014. View Article : Google Scholar : PubMed/NCBI
|
|
54
|
Liu T, Zhao L, Zhang Y, Chen W, Liu D, Hou
H, Ding L and Li X: Ginsenoside 20(S)-Rg3 targets HIF-1α to block
hypoxia-induced epithelial-mesenchymal transition in ovarian cancer
cells. PLoS One. 9:e1038872014. View Article : Google Scholar
|
|
55
|
Pan XY, Guo H, Han J, Hao F, An Y, Xu Y,
Xiaokaiti Y, Pan Y and Li XJ: Ginsenoside Rg3 attenuates cell
migration via inhibition of aquaporin 1 expression in PC-3M
prostate cancer cells. Eur J Pharmacol. 683:27–34. 2012. View Article : Google Scholar : PubMed/NCBI
|
|
56
|
Chen QJ, Zhang MZ and Wang LX: Gensenoside
Rg3 inhibits hypoxia-induced VEGF expression in human cancer cells.
Cell Physiol Biochem. 26:849–858. 2010. View Article : Google Scholar
|
|
57
|
Yue PY, Wong DY, Wu PK, Leung PY, Mak NK,
Yeung HW, Liu L, Cai Z, Jiang ZH, Fan TP and Wong RN: The
angiosuppressive effects of 20(R)- ginsenoside Rg3. Biochem
Pharmacol. 72:437–445. 2006. View Article : Google Scholar : PubMed/NCBI
|
|
58
|
Kim JW, Jung SY, Kwon YH, Lee SH, Lee JH,
Lee BY and Kwon SM: Ginsenoside Rg3 inhibits endothelial progenitor
cell differentiation through attenuation of VEGF-dependent Akt/eNOS
signaling. Phytother Res. 26:1286–1293. 2012. View Article : Google Scholar : PubMed/NCBI
|
|
59
|
Kim JW, Jung SY, Kwon YH, Lee JH, Lee YM,
Lee BY and Kwon SM: Ginsenoside Rg3 attenuates tumor angiogenesis
via inhibiting bioactivities of endothelial progenitor cells.
Cancer Biol Ther. 13:504–515. 2012. View Article : Google Scholar : PubMed/NCBI
|
|
60
|
Guo JQ, Zheng QH, Chen H, Chen L, Xu JB,
Chen MY, Lu D, Wang ZH, Tong HF and Lin S: Ginsenoside Rg3
inhibition of vasculogenic mimicry in pancreatic cancer through
downregu-lation of VE cadherin/EphA2/MMP9/MMP2 expression. Int J
Oncol. 45:1065–1072. 2014.PubMed/NCBI
|
|
61
|
Lee YJ, Lee S, Ho JN, Byun SS, Hong SK,
Lee SE and Lee E: Synergistic antitumor effect of ginsenoside Rg3
and cisplatin in cisplatin resistant bladder tumor cell line. Oncol
Rep. 32:1803–1808. 2014.PubMed/NCBI
|
|
62
|
Che JB, Liu ZH, Ma HB, Li Y, Zhao H, Li
XH, Liu WC and Shi GN: Influence of As O inhibition of lung cancer
NCI-H1299 cells and on subsistence 2 3 combined with ginsenosides
Rg3 on of nude mice bearing hepatoma. Asian Pac J Trop Med.
7:772–775. 2014. View Article : Google Scholar : PubMed/NCBI
|
|
63
|
Wang X, Chen L, Wang T, Jiang X, Zhang H,
Li P, Lv B and Gao X: Ginsenoside Rg3 antagonizes
adriamycin-induced cardiotoxicity by improving endothelial
dysfunction from oxidative stress via upregulating the Nrf2-ARE
pathway through the activation of akt. Phytomedicine. 22:875–884.
2015. View Article : Google Scholar : PubMed/NCBI
|
|
64
|
Xu TM, Xin Y, Cui MH, Jiang X and Gu LP:
Inhibitory effect of ginsenoside Rg3 combined with cyclophosphamide
on growth and angiogenesis of ovarian cancer. Chin Med J (Engl).
120:584–588. 2007.
|
|
65
|
Zhang Q, Kang X and Zhao W: Antiangiogenic
effect of low-dose cyclophosphamide combined with ginsenoside Rg3
on Lewis lung carcinoma. Biochem Biophys Res Commun. 342:824–828.
2006. View Article : Google Scholar : PubMed/NCBI
|
|
66
|
Chang L, Huo B, Lv Y, Wang Y and Liu W:
Ginsenoside Rg3 enhances the inhibitory effects of chemotherapy on
esophageal squamous cell carcinoma in mice. Mol Clin Oncol.
2:1043–1046. 2014.PubMed/NCBI
|
|
67
|
Yang LQ, Wang B, Gan H, Fu ST, Zhu XX, Wu
ZN, Zhan DW, Gu RL, Dou GF and Meng ZY: Enhanced oral
bioavailability and anti-tumour effect of paclitaxel by
20(s)-ginsenoside Rg3 in vivo. Biopharm Drug Dispos. 33:425–436.
2012. View Article : Google Scholar : PubMed/NCBI
|
|
68
|
Kwon HY, Kim EH, Kim SW, Kim SN, Park JD
and Rhee DK: Selective toxicity of ginsenoside Rg3 on multidrug
resistant cells by membrane fluidity modulation. Arch Pharm Res.
31:171–177. 2008. View Article : Google Scholar : PubMed/NCBI
|
|
69
|
Park JD, Rhee DK and Lee YH: Biological
activities and chemistry of saponins from Panax ginseng C.A. Meyer.
Phytochem Rev. 4:159–175. 2005. View Article : Google Scholar
|
|
70
|
Kim SM, Lee SY, Cho JS, Son SM, Choi SS,
Yun YP, Yoo HS, Yoon DY, Oh KW, Han SB and Hong JT: Combination of
ginsenoside Rg3 with docetaxel enhances the susceptibility of
prostate cancer cells via inhibition of NF-kappaB. Eur J Pharmacol.
631:1–9. 2010. View Article : Google Scholar : PubMed/NCBI
|
|
71
|
Kim SM, Lee SY, Yuk DY, Moon DC, Choi SS,
Kim Y, Han SB, Oh KW and Hong JT: Inhibition of NF-kappaB by
ginsenoside Rg3 enhances the susceptibility of colon cancer cells
to docetaxel. Arch Pharm Res. 32:755–765. 2009. View Article : Google Scholar : PubMed/NCBI
|
|
72
|
Lee CK, Park KK, Chung AS and Chung WY:
Ginsenoside Rg3 enhances the chemosensitivity of tumors to
cisplatin by reducing the basal level of nuclear factor erythroid
2-related factor 2-mediated heme oxygenase-1/NAD(P)H quinone
oxidore-ductase-1 and prevents normal tissue damage by scavenging
cisplatin-induced intracellular reactive oxygen species. Food Chem
Toxicol. 50:2565–2574. 2012. View Article : Google Scholar : PubMed/NCBI
|
|
73
|
Lee JY, Jung KH, Morgan MJ, Kang YR, Lee
HS, Koo GB, Hong SS, Kwon SW and Kim YS: Sensitization of
TRAIL-induced cell death by 20(S)-ginsenoside Rg3 via CHOP-mediated
DR5 upregulation in human hepatocellular carcinoma cells. Mol
Cancer Ther. 12:274–285. 2013. View Article : Google Scholar
|
|
74
|
Kim DG, Jung KH, Lee DG, Yoon JH, Choi KS,
Kwon SW, Shen HM, Morgan MJ, Hong SS and Kim YS: 20(S)-Ginsenoside
Rg3 is a novel inhibitor of autophagy and sensitizes hepatocellular
carcinoma to doxorubicin. Oncotarget. 5:4438–4451. 2014. View Article : Google Scholar : PubMed/NCBI
|
|
75
|
Park D, Bae DK, Jeon JH, Lee J, Oh N, Yang
G, Yang YH, Kim TK, Song J, Lee SH, et al: Immunopotentiation and
antitumor effects of a ginsenoside Rg3-fortified red ginseng
preparation in mice bearing H460 lung cancer cells. Environ Toxicol
Pharmacol. 31:397–405. 2011. View Article : Google Scholar : PubMed/NCBI
|
|
76
|
Wu R, Ru Q, Chen L, Ma B and Li C:
Stereospecificity of ginsenoside Rg3 in the promotion of cellular
immunity in hepatoma H22-bearing mice. J Food Sci. 79:H1430–H1435.
2014. View Article : Google Scholar : PubMed/NCBI
|
|
77
|
Choi YJ, Kang LJ and Lee SG: Stimulation
of DDX3 expression by ginsenoside Rg3 through the Akt/p53 pathway
activates the innate immune response via TBK1/IKKε/IRF3 signalling.
Curr Med Chem. 21:1050–1060. 2014. View Article : Google Scholar
|
|
78
|
Cheng Y and Hua HQ: Clinical research
progress in anti-tumor effects of ginesenoside Rg3. Medical
recapitulate. 21:2938–2940. 2015.
|
|
79
|
Lu P, Su W, Miao ZH, Niu HR, Liu J and Hua
QL: Effect and mechanism of ginsenoside Rg3 on postoperative life
span of patients with non-small cell lung cancer. Chin J Integr
Med. 14:33–36. 2008. View Article : Google Scholar : PubMed/NCBI
|
|
80
|
Huang JY, Sun Y, Fan QX and Zhang YQ:
Efficacy of Shenyi capsule combined with gemcitabine plus cisplatin
in treatment of advanced esophageal cancer: a randomized controlled
trial. Zhong Xi Yi Jie He Xue Bao. 7:1047–1051. 2009.In Chinese.
View Article : Google Scholar : PubMed/NCBI
|
|
81
|
Wang XS, Wu Q and Liang L: Combined Shen
yi-Jiao nang and chemotherapy in treatment of breast cancer: a
systematic review. Pract J Clin Med. 9:192–195. 2012.
|
|
82
|
Coon JT and Ernst E: Panax ginseng: a
systematic review of adverse effects and drug interactions. Drug
Saf. 25:323–344. 2002. View Article : Google Scholar : PubMed/NCBI
|
|
83
|
Liu JP, Lu D, Nicholson RC, Li PY and Wang
F: Toxicity of a novel anti-tumor agent 20(S)-ginsenoside Rg3: a
26-week intramuscular repeated administration study in Beagle dogs.
Food Chem Toxicol. 49:1718–1727. 2011. View Article : Google Scholar : PubMed/NCBI
|
|
84
|
Liu JP, Lu D, Nicholson RC, Zhao WJ, Li PY
and Wang F: Toxicity of a novel anti-tumor agent 20(S)-ginsenoside
Rg3: a 26-week intramuscular repeated administration study in rats.
Food Chem Toxicol. 50:3388–3396. 2012. View Article : Google Scholar : PubMed/NCBI
|
|
85
|
Zhang YH, Li HD, Li B, Jiang SD and Jiang
LS: Ginsenoside Rg3 induces DNA damage in human osteosarcoma cells
and reduces MNNG-induced DNA damage and apoptosis in normal human
cells. Oncol Rep. 31:919–925. 2014.
|
|
86
|
Poon PY, Kwok HH, Yue PY, Yang MS, Mak NK,
Wong CK and Wong RN: Cytoprotective effect of 20S-Rg3 on benzo[a]
pyrene-induced DNA damage. Drug Metab Dispos. 40:120–129. 2012.
View Article : Google Scholar
|
|
87
|
Cheong JH, Kim H, Hong MJ, Yang MH, Kim
JW, Yoo H, Yang H, Park JH, Sung SH, Kim HP and Kim J:
Stereoisomer-specific anticancer activities of ginsenoside Rg3 and
Rh2 in HepG2 cells: disparity in cytotoxicity and
autophagy-inducing effects due to 20(S)-epimers. Biol Pharm Bull.
38:102–108. 2015. View Article : Google Scholar : PubMed/NCBI
|
|
88
|
Wang Y, Jin Y, Zhou C, Qu H and Cheng Y:
Discovering active compounds from mixture of natural products by
data mining approach. Med Biol Eng Comput. 46:605–611. 2008.
View Article : Google Scholar : PubMed/NCBI
|
|
89
|
Yang R, Chen D, Li M, Miao F, Liu P and
Tang Q: 20(s)-ginsenoside Rg3-loaded magnetic human serum albumin
nanospheres applied to HeLa cervical cancer cells in vitro. Biomed
Mater Eng. 24:1991–1998. 2014.PubMed/NCBI
|
|
90
|
Yu H and Teng L, Meng Q, Li Y, Sun X, Lu
J, J Lee R and Teng L: Development of liposomal ginsenoside Rg3:
formulation optimization and evaluation of its anticancer effects.
Int J Pharm. 450:250–258. 2013. View Article : Google Scholar : PubMed/NCBI
|
|
91
|
Li J, Liu T, Zhao L, Chen W, Hou H, Ye Z
and Li X: Ginsenoside 20(S) Rg3 inhibits the Warburg effect through
STAT3 pathways in ovarian cancer cells. Int J Oncol. 46:775–781.
2015.
|
