Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
International Journal of Molecular Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1107-3756 Online ISSN: 1791-244X
Journal Cover
June-2017 Volume 39 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
June-2017 Volume 39 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Suppressive role of diallyl trisulfide in the activated platelet-mediated hematogenous metastasis of MDA-MB-231 human breast cancer cells

  • Authors:
    • Yuping Liu
    • Yang Zhao
    • Yingyu Wang
    • Pingting Zhu
    • Zhonghong Wei
    • Siliang Wang
    • Li Tao
    • Zhaoguo Liu
    • Hongyan Wu
    • Xiaobo Sheng
    • Yin Lu
  • View Affiliations / Copyright

    Affiliations: Department of Pharmacology, College of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, Jiangsu 210023, P.R. China
  • Pages: 1516-1524
    |
    Published online on: April 19, 2017
       https://doi.org/10.3892/ijmm.2017.2953
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Accumulating evidence has indicated that garlic consumption may reduce the risk of developing several types of cancer, and extensive studies have revealed the effects of its bioactive component, diallyl trisulfide (DATS), on the proliferation and apoptosis of tumor cells. The present study was undertaken to examine whether DATS affects hematogenous metastasis. In view of the dynamic crosstalk interplayed by tumor cells and platelets in hematogenous metastasis, we attempted to demonstrate the role of DATS in the metastatic behavior of MDA-MB-231 human breast cancer cells, which were co-incubated with activated platelets. Indeed, our data indicated that DATS significantly blocked platelet activation and aggregation induced by platelet-activating factor (PAF), and decreased the production of thromboxane B2 (TXB2). It was also found that DATS suppressed the migration and invasion of MDA-MB-231 cells in the presence of platelets activated by PAF in vitro in a dose-dependent manner. Furthermore, our results revealed thaat the release of activated TGF-β1 in the platelet-tumor cell system was markedly attenuated by DATS. Therefore, our findings strongly suggest that the diverse pharmacological activities of DATS are at least partially reflected by the interruption of the activated platelets-mediated metastasis of breast cancer cells.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

View References

1 

Zhang XH: Why cancer cells metastasize? Med Hypotheses. 80:669–671. 2013. View Article : Google Scholar : PubMed/NCBI

2 

Labelle M and Hynes RO: The initial hours of metastasis: the importance of cooperative host-tumor cell interactions during hematogenous dissemination. Cancer Discov. 2:1091–1099. 2012. View Article : Google Scholar : PubMed/NCBI

3 

Mezouar S, Mege D, Darbousset R, Farge D, Debourdeau P, Dignat-George F, Panicot-Dubois L and Dubois C: Involvement of platelet-derived microparticles in tumor progression and thrombosis. Semin Oncol. 41:346–358. 2014. View Article : Google Scholar : PubMed/NCBI

4 

Stravodimou A and Voutsadakis IA: Pretreatment thrombocytosis as a prognostic factor in metastatic breast cancer. Int J Breast Cancer. 2013:2895632013. View Article : Google Scholar : PubMed/NCBI

5 

Wang PL, Cheng YB and Kuerban G: The clinical characteristic differences between thrombosis-related edema and lymphedema following radiotherapy or chemoradiotherapy for patients with cervical cancer. J Radiat Res (Tokyo). 53:125–129. 2012. View Article : Google Scholar

6 

Holmes CE, Levis JE and Ornstein DL: Activated platelets enhance ovarian cancer cell invasion in a cellular model of metastasis. Clin Exp Metastasis. 26:653–661. 2009. View Article : Google Scholar : PubMed/NCBI

7 

Zhu JF, Cai L, Zhang XW, Wen YS, Su XD, Rong TH and Zhang LJ: High plasma fibrinogen concentration and platelet count unfavorably impact survival in non-small cell lung cancer patients with brain metastases. Chin J Cancer. 33:96–104. 2014. View Article : Google Scholar :

8 

Gupta GP and Massagué J: Platelets and metastasis revisited: a novel fatty link. J Clin Invest. 114:1691–1693. 2004. View Article : Google Scholar : PubMed/NCBI

9 

Smith AL, Robin TP and Ford HL: Molecular pathways: targeting the TGF-β pathway for cancer therapy. Clin Cancer Res. 18:4514–4521. 2012. View Article : Google Scholar : PubMed/NCBI

10 

Perera M, Tsang CS, Distel RJ, Lacy JN, Ohno-Machado L, Ricchiuti V, Samaranayake LP, Smejkal GB, Smith MG, Trachtenberg AJ, et al: TGF-beta1 interactome: metastasis and beyond. Cancer Genomics Proteomics. 7:217–229. 2010.PubMed/NCBI

11 

Ma J, Gao HM, Hua X, Lu ZY and Gao HC: Role of TGF-β1 in human colorectal cancer and effects after cantharidinate intervention. Asian Pac J Cancer Prev. 15:4045–4048. 2014. View Article : Google Scholar

12 

Hyytiäinen M, Penttinen C and Keski-Oja J: Latent TGF-beta binding proteins: extracellular matrix association and roles in TGF-beta activation. Crit Rev Clin Lab Sci. 41:233–264. 2004. View Article : Google Scholar : PubMed/NCBI

13 

Meindl-Beinker NM, Matsuzaki K and Dooley S: TGF-β signaling in onset and progression of hepatocellular carcinoma. Dig Dis. 30:514–523. 2012. View Article : Google Scholar

14 

Bakkebø M, Huse K, Hilden VI, Smeland EB and Oksvold MP: TGF-β-induced growth inhibition in B-cell lymphoma correlates with Smad1/5 signalling and constitutively active p38 MAPK. BMC Immunol. 11:572010. View Article : Google Scholar

15 

Binker MG, Binker-Cosen AA, Gaisano HY, de Cosen RH and Cosen-Binker LI: TGF-β1 increases invasiveness of SW1990 cells through Rac1/ROS/NF-κB/IL-6/MMP-2. Biochem Biophys Res Commun. 405:140–145. 2011. View Article : Google Scholar : PubMed/NCBI

16 

Morita T, Mayanagi T and Sobue K: Dual roles of myocardin-related transcription factors in epithelial mesenchymal transition via slug induction and actin remodeling. J Cell Biol. 179:1027–1042. 2007. View Article : Google Scholar : PubMed/NCBI

17 

Wilkins-Port CE, Higgins SP, Higgins CE, Kobori-Hotchkiss I and Higgins PJ: Complex regulation of the pericellular proteolytic microenvironment during tumor progression and wound repair: functional interactions between the serine protease and matrix metalloproteinase cascades. Biochem Res Int. 2012:4543682012. View Article : Google Scholar : PubMed/NCBI

18 

Hawinkels LJ, Verspaget HW, van der Reijden JJ, van der Zon JM, Verheijen JH, Hommes DW, Lamers CB and Sier CF: Active TGF-beta1 correlates with myofibroblasts and malignancy in the colorectal adenoma-carcinoma sequence. Cancer Sci. 100:663–670. 2009. View Article : Google Scholar : PubMed/NCBI

19 

Donovan MJ and Cordon-Cardo C: Genomic analysis in active surveillance: predicting high-risk disease using tissue biomarkers. Curr Opin Urol. 24:303–310. 2014. View Article : Google Scholar : PubMed/NCBI

20 

Joseph JV, Balasubramaniyan V, Walenkamp A and Kruyt FA: TGF-β as a therapeutic target in high grade gliomas - promises and challenges. Biochem Pharmacol. 85:478–485. 2013. View Article : Google Scholar

21 

Han H, Cao FL, Wang BZ, Mu XR, Li GY and Wang XW: Expression of angiogenesis regulatory proteins and epithelial-mesenchymal transition factors in platelets of the breast cancer patients. ScientificWorldJournal. 2014:8782092014. View Article : Google Scholar : PubMed/NCBI

22 

Pak KH, Kim DH, Kim H, Lee do H and Cheong JH: Differences in TGF-β1 signaling and clinicopathologic characteristics of histologic subtypes of gastric cancer. BMC Cancer. 16:602016. View Article : Google Scholar

23 

Surh YJ and Ferguson LR: Dietary and medicinal antimutagens and anticarcinogens: molecular mechanisms and chemopreventive potential - highlights of a symposium. Mutat Res. 523–524:1–8. 2003. View Article : Google Scholar

24 

Mousa SA: Antithrombotic effects of naturally derived products on coagulation and platelet function. Methods Mol Biol. 663:229–240. 2010. View Article : Google Scholar : PubMed/NCBI

25 

Chan KC, Yin MC and Chao WJ: Effect of diallyl trisulfide-rich garlic oil on blood coagulation and plasma activity of anticoagulation factors in rats. Food Chem Toxicol. 45:502–507. 2007. View Article : Google Scholar

26 

Khatua TN, Adela R and Banerjee SK: Garlic and cardioprotection: insights into the molecular mechanisms. Can J Physiol Pharmacol. 91:448–458. 2013. View Article : Google Scholar : PubMed/NCBI

27 

Allison GL, Lowe GM and Rahman K: Aged garlic extract and its constituents inhibit platelet aggregation through multiple mechanisms. J Nutr. 136(Suppl 3): 782S–788S. 2006.PubMed/NCBI

28 

Rahman K and Billington D: Dietary supplementation with aged garlic extract inhibits ADP-induced platelet aggregation in humans. J Nutr. 130:2662–2665. 2000.PubMed/NCBI

29 

Trio PZ, You S, He X, He J, Sakao K and Hou DX: Chemo-preventive functions and molecular mechanisms of garlic organosulfur compounds. Food Funct. 5:833–844. 2014. View Article : Google Scholar : PubMed/NCBI

30 

Chandra-Kuntal K, Lee J and Singh SV: Critical role for reactive oxygen species in apoptosis induction and cell migration inhibition by diallyl trisulfide, a cancer chemopreventive component of garlic. Breast Cancer Res Treat. 138:69–79. 2013. View Article : Google Scholar : PubMed/NCBI

31 

Li Y, Zhang J, Zhang L, Si M, Yin H and Li J: Diallyl trisulfide inhibits proliferation, invasion and angiogenesis of osteosarcoma cells by switching on suppressor microRNAs and inactivating of Notch-1 signaling. Carcinogenesis. 34:1601–1610. 2013. View Article : Google Scholar : PubMed/NCBI

32 

Lai KC, Hsu SC, Kuo CL, Yang JS, Ma CY, Lu HF, Tang NY, Hsia TC, Ho HC and Chung JG: Diallyl sulfide, diallyl disulfide, and diallyl trisulfide inhibit migration and invasion in human colon cancer colo 205 cells through the inhibition of matrix metalloproteinase-2, -7, and -9 expressions. Environ Toxicol. 28:479–488. 2013. View Article : Google Scholar

33 

Singh SV, Powolny AA, Stan SD, Xiao D, Arlotti JA, Warin R, Hahm ER, Marynowski SW, Bommareddy A, Potter DM and Dhir R: Garlic constituent diallyl trisulfide prevents development of poorly differentiated prostate cancer and pulmonary metastasis multiplicity in TRAMP mice. Cancer Res. 68:9503–9511. 2008. View Article : Google Scholar : PubMed/NCBI

34 

Xiao D, Herman-Antosiewicz A, Antosiewicz J, Xiao H, Brisson M, Lazo JS and Singh SV: Diallyl trisulfide-induced G(2)-M phase cell cycle arrest in human prostate cancer cells is caused by reactive oxygen species-dependent destruction and hyperphosphorylation of Cdc 25 C. Oncogene. 24:6256–6268. 2005. View Article : Google Scholar : PubMed/NCBI

35 

Shankar S, Chen Q, Ganapathy S, Singh KP and Srivastava RK: Diallyl trisulfide increases the effectiveness of TRAIL and inhibits prostate cancer growth in an orthotopic model: molecular mechanisms. Mol Cancer Ther. 7:2328–2338. 2008. View Article : Google Scholar : PubMed/NCBI

36 

Powolny AA and Singh SV: Multitargeted prevention and therapy of cancer by diallyl trisulfide and related Allium vegetable-derived organosulfur compounds. Cancer Lett. 269:305–314. 2008. View Article : Google Scholar : PubMed/NCBI

37 

Ng KT, Guo DY, Cheng Q, Geng W, Ling CC, Li CX, Liu XB, Ma YY, Lo CM, Poon RT, et al: A garlic derivative, S-allylcysteine (SAC), suppresses proliferation and metastasis of hepatocellular carcinoma. PLoS One. 7:e316552012. View Article : Google Scholar : PubMed/NCBI

38 

Belloc C, Lu H, Soria C, Fridman R, Legrand Y and Menashi S: The effect of platelets on invasiveness and protease production of human mammary tumor cells. Int J Cancer. 60:413–417. 1995. View Article : Google Scholar : PubMed/NCBI

39 

Nierodzik ML, Plotkin A, Kajumo F and Karpatkin S: Thrombin stimulates tumor-platelet adhesion in vitro and metastasis in vivo. J Clin Invest. 87:229–236. 1991. View Article : Google Scholar : PubMed/NCBI

40 

Jurasz P, Alonso-Escolano D and Radomski MW: Platele-cancer interactions: mechanisms and pharmacology of tumour cell-induced platelet aggregation. Br J Pharmacol. 143:819–826. 2004. View Article : Google Scholar : PubMed/NCBI

41 

Qian YF and Wang XJ: Effects of blood-activating and stasis-resolving drugs on tumor formation and metastasis. J Tradit Chin Med. 29:301–310. 2009. View Article : Google Scholar

42 

Gil-Bernabé AM, Ferjancic S, Tlalka M, Zhao L, Allen PD, Im JH, Watson K, Hill SA, Amirkhosravi A, Francis JL, et al: Recruitment of monocytes/macrophages by tissue factor-mediated coagulation is essential for metastatic cell survival and premetastatic niche establishment in mice. Blood. 119:3164–3175. 2012. View Article : Google Scholar : PubMed/NCBI

43 

Im JH, Fu W, Wang H, Bhatia SK, Hammer DA, Kowalska MA and Muschel RJ: Coagulation facilitates tumor cell spreading in the pulmonary vasculature during early metastatic colony formation. Cancer Res. 64:8613–8619. 2004. View Article : Google Scholar : PubMed/NCBI

44 

McEachron TA, Pawlinski R, Richards KL, Church FC and Mackman N: Protease-activated receptors mediate crosstalk between coagulation and fibrinolysis. Blood. 116:5037–5044. 2010. View Article : Google Scholar : PubMed/NCBI

45 

Battinelli EM, Markens BA and Italiano JE Jr: Release of angiogenesis regulatory proteins from platelet alpha granules: modulation of physiologic and pathologic angiogenesis. Blood. 118:1359–1369. 2011. View Article : Google Scholar : PubMed/NCBI

46 

Hara T, Shimizu K, Ogawa F, Yanaba K, Iwata Y, Muroi E, Takenaka M, Komura K, Hasegawa M, Fujimoto M, et al: Platelets control leukocyte recruitment in a murine model of cutaneous arthus reaction. Am J Pathol. 176:259–269. 2010. View Article : Google Scholar :

47 

Xu L, Tong R, Cochran DM and Jain RK: Blocking platelet-derived growth factor-D/platelet-derived growth factor receptor beta signaling inhibits human renal cell carcinoma progression in an orthotopic mouse model. Cancer Res. 65:5711–5719. 2005. View Article : Google Scholar : PubMed/NCBI

48 

Fleischauer AT and Arab L: Garlic and cancer: a critical review of the epidemiologic literature. J Nutr. 131:1032S–1040S. 2001.PubMed/NCBI

49 

Ginter E and Simko V: Garlic (Allium sativum L.) and cardiovascular diseases. Bratisl Lek Listy. 111:452–456. 2010.PubMed/NCBI

50 

Allison GL, Lowe GM and Rahman K: Aged garlic extract inhibits platelet activation by increasing intracellular cAMP and reducing the interaction of GPIIb/IIIa receptor with fibrinogen. Life Sci. 91:1275–1280. 2012. View Article : Google Scholar : PubMed/NCBI

51 

Li W, Tian H, Li L, Li S, Yue W, Chen Z, Qi L, Hu W, Zhu Y, Hao B, et al: Diallyl trisulfide induces apoptosis and inhibits proliferation of A549 cells in vitro and in vivo. Acta Biochim Biophys Sin (Shanghai). 44:577–583. 2012. View Article : Google Scholar

52 

Watanabe K, Hosono T, Watanabe K, Hosono-Fukao T, Ariga T and Seki T: Diallyl trisulfide induces apoptosis in Jurkat cells by the modification of cysteine residues in thioredoxin. Biosci Biotechnol Biochem. 78:1418–1420. 2014. View Article : Google Scholar : PubMed/NCBI

53 

Ma HB, Huang S, Yin XR, Zhang Y and Di ZL: Apoptotic pathway induced by diallyl trisulfide in pancreatic cancer cells. World J Gastroenterol. 20:193–203. 2014. View Article : Google Scholar : PubMed/NCBI

54 

Sakamoto K, Lawson LD and Milner JA: Allyl sulfides from garlic suppress the in vitro proliferation of human A549 lung tumor cells. Nutr Cancer. 29:152–156. 1997. View Article : Google Scholar : PubMed/NCBI

55 

Li J, Liu W, Zhao K, Zhang Y, Li X, Yang Q, Li Z and Li J: Diallyl trisulfide reverses drug resistance and lowers the ratio of CD133+ cells in conjunction with methotrexate in a human osteosarcoma drug-resistant cell subline. Mol Med Rep. 2:245–252. 2009. View Article : Google Scholar : PubMed/NCBI

56 

Tsai CY, Wang CC, Lai TY, Tsu HN, Wang CH, Liang HY and Kuo WW: Antioxidant effects of diallyl trisulfide on high glucose-induced apoptosis are mediated by the PI3K/Akt-dependent activation of Nrf2 in cardiomyocytes. Int J Cardiol. 168:1286–1297. 2013. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Liu Y, Zhao Y, Wang Y, Zhu P, Wei Z, Wang S, Tao L, Liu Z, Wu H, Sheng X, Sheng X, et al: Suppressive role of diallyl trisulfide in the activated platelet-mediated hematogenous metastasis of MDA-MB-231 human breast cancer cells. Int J Mol Med 39: 1516-1524, 2017.
APA
Liu, Y., Zhao, Y., Wang, Y., Zhu, P., Wei, Z., Wang, S. ... Lu, Y. (2017). Suppressive role of diallyl trisulfide in the activated platelet-mediated hematogenous metastasis of MDA-MB-231 human breast cancer cells. International Journal of Molecular Medicine, 39, 1516-1524. https://doi.org/10.3892/ijmm.2017.2953
MLA
Liu, Y., Zhao, Y., Wang, Y., Zhu, P., Wei, Z., Wang, S., Tao, L., Liu, Z., Wu, H., Sheng, X., Lu, Y."Suppressive role of diallyl trisulfide in the activated platelet-mediated hematogenous metastasis of MDA-MB-231 human breast cancer cells". International Journal of Molecular Medicine 39.6 (2017): 1516-1524.
Chicago
Liu, Y., Zhao, Y., Wang, Y., Zhu, P., Wei, Z., Wang, S., Tao, L., Liu, Z., Wu, H., Sheng, X., Lu, Y."Suppressive role of diallyl trisulfide in the activated platelet-mediated hematogenous metastasis of MDA-MB-231 human breast cancer cells". International Journal of Molecular Medicine 39, no. 6 (2017): 1516-1524. https://doi.org/10.3892/ijmm.2017.2953
Copy and paste a formatted citation
x
Spandidos Publications style
Liu Y, Zhao Y, Wang Y, Zhu P, Wei Z, Wang S, Tao L, Liu Z, Wu H, Sheng X, Sheng X, et al: Suppressive role of diallyl trisulfide in the activated platelet-mediated hematogenous metastasis of MDA-MB-231 human breast cancer cells. Int J Mol Med 39: 1516-1524, 2017.
APA
Liu, Y., Zhao, Y., Wang, Y., Zhu, P., Wei, Z., Wang, S. ... Lu, Y. (2017). Suppressive role of diallyl trisulfide in the activated platelet-mediated hematogenous metastasis of MDA-MB-231 human breast cancer cells. International Journal of Molecular Medicine, 39, 1516-1524. https://doi.org/10.3892/ijmm.2017.2953
MLA
Liu, Y., Zhao, Y., Wang, Y., Zhu, P., Wei, Z., Wang, S., Tao, L., Liu, Z., Wu, H., Sheng, X., Lu, Y."Suppressive role of diallyl trisulfide in the activated platelet-mediated hematogenous metastasis of MDA-MB-231 human breast cancer cells". International Journal of Molecular Medicine 39.6 (2017): 1516-1524.
Chicago
Liu, Y., Zhao, Y., Wang, Y., Zhu, P., Wei, Z., Wang, S., Tao, L., Liu, Z., Wu, H., Sheng, X., Lu, Y."Suppressive role of diallyl trisulfide in the activated platelet-mediated hematogenous metastasis of MDA-MB-231 human breast cancer cells". International Journal of Molecular Medicine 39, no. 6 (2017): 1516-1524. https://doi.org/10.3892/ijmm.2017.2953
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team