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Article

Downregulation of miR-10b promotes osteoblast differentiation through targeting Bcl6

  • Authors:
    • Jizhou Yang
    • Shaojie Wang
    • Fengxian Wang
    • Xiaohong Mu
    • Yi Qu
    • Ziyi Zhao
    • Xing Yu
  • View Affiliations / Copyright

    Affiliations: Department of Orthopaedics, Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine, Beijing 100700, P.R. China, Department of Orthopaedics, Dongfang Hospital, Beijing University of Chinese Medicine, Beijing 100078, P.R. China
  • Pages: 1605-1612
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    Published online on: April 20, 2017
       https://doi.org/10.3892/ijmm.2017.2955
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Abstract

MicroRNAs (miRNAs or miRs) have been shown to play a critical role in osteoblast differentiation. miR-10b has been found to be downregulated during osteoblast differentiation; however, its precise effect on osteoblast differentiation remains unknown. In this study, we aimed to investigate the potential role of miR-10b and the potential underlying mechanism in regulating osteoblast differentiation. We found that miR-10b was downregulated during osteoblast differentiation. Overexpression of miR-10b inhibited osteoblast differentiation, whereas the suppression of miR-10b promoted osteoblast differentiation. Bioinformatics analysis and the dual-luciferase reporter assay demonstrated that miR-10b could target the 3'-untranslated regions of B cell lymphoma 6 (Bcl6) which is an important regulator of osteoblast differentiation. Real‑time quantitative polymerase chain reaction and western blot analysis showed that miR-10b directly regulated Bcl6 expression. Further experiments showed that the overexpression of miR-10b increased the expression of signal transducer and activator of transcription 1 (STAT1) and blocked Runt-related transcription factor 2 (Runx2) nuclear translocation, whereas miR-10b suppression showed an opposite effect. Moreover, the miR-10b suppression-induced effects were partially reversed by Bcl6 knockdown. Taken together, our study suggests that miR-10b contributes to osteoblast differentiation through targeting Bcl6, providing a novel insight into understanding the molecular mechanism underlying osteoblast differentiation and suggesting a potential target for inhibiting bone loss.
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View References

1 

Franceschi RT: The developmental control of osteoblast-specific gene expression: Role of specific transcription factors and the extracellular matrix environment. Crit Rev Oral Biol Med. 10:40–57. 1999. View Article : Google Scholar

2 

Park H, Noh AL, Kang JH, Sim JS, Lee DS and Yim M: Peroxiredoxin II negatively regulates lipopolysaccharide-induced osteoclast formation and bone loss via JNK and STAT3. Antioxid Redox Signal. 22:63–77. 2015. View Article : Google Scholar :

3 

Diddle AW and Smith IQ: Postmenopausal osteoporosis: The role of estrogens. South Med J. 77:868–874. 1984. View Article : Google Scholar : PubMed/NCBI

4 

Canalis E, Economides AN and Gazzerro E: Bone morphogenetic proteins, their antagonists, and the skeleton. Endocr Rev. 24:218–235. 2003. View Article : Google Scholar : PubMed/NCBI

5 

Huang C, Geng J and Jiang S: MicroRNAs in regulation of osteogenic differentiation of mesenchymal stem cells. Cell Tissue Res. Jul 18–2016.Epub ahead of print.

6 

Bartel DP: MicroRNAs: Genomics, biogenesis, mechanism, and function. Cell. 116:281–297. 2004. View Article : Google Scholar : PubMed/NCBI

7 

Ambros V: The functions of animal microRNAs. Nature. 431:350–355. 2004. View Article : Google Scholar : PubMed/NCBI

8 

Bartel DP: MicroRNAs: Target recognition and regulatory functions. Cell. 136:215–233. 2009. View Article : Google Scholar : PubMed/NCBI

9 

Vishal M, Vimalraj S, Ajeetha R, Gokulnath M, Keerthana R, He Z, Partridge NC and Selvamurugan N: MicroRNA-590-5p stabilizes Runx2 by targeting Smad7 during osteoblast differentiation. J Cell Physiol. 232:371–380. 2017. View Article : Google Scholar

10 

Yan J, Guo D, Yang S, Sun H, Wu B and Zhou D: Inhibition of miR-222-3p activity promoted osteogenic differentiation of hBMSCs by regulating Smad5-RUNX2 signal axis. Biochem Biophys Res Commun. 470:498–503. 2016. View Article : Google Scholar : PubMed/NCBI

11 

Hu Z, Wang Y, Sun Z, Wang H, Zhou H, Zhang L, Zhang S and Cao X: miRNA-132-3p inhibits osteoblast differentiation by targeting Ep300 in simulated microgravity. Sci Rep. 5:186552015. View Article : Google Scholar : PubMed/NCBI

12 

Fukuda T, Ochi H, Sunamura S, Haiden A, Bando W, Inose H, Okawa A, Asou Y and Takeda S: MicroRNA-145 regulates osteoblastic differentiation by targeting the transcription factor Cbfb. FEBS Lett. 589:3302–3308. 2015. View Article : Google Scholar : PubMed/NCBI

13 

Chen D, Zhao M and Mundy GR: Bone morphogenetic proteins. Growth Factors. 22:233–241. 2004. View Article : Google Scholar : PubMed/NCBI

14 

Komori T, Yagi H, Nomura S, Yamaguchi A, Sasaki K, Deguchi K, Shimizu Y, Bronson RT, Gao YH, Inada M, et al: Targeted disruption of Cbfa1 results in a complete lack of bone formation owing to maturational arrest of osteoblasts. Cell. 89:755–764. 1997. View Article : Google Scholar : PubMed/NCBI

15 

Ducy P, Zhang R, Geoffroy V, Ridall AL and Karsenty G: Osf2/Cbfa1: A transcriptional activator of osteoblast differentiation. Cell. 89:747–754. 1997. View Article : Google Scholar : PubMed/NCBI

16 

Nakashima K, Zhou X, Kunkel G, Zhang Z, Deng JM, Behringer RR and de Crombrugghe B: The novel zinc finger-containing transcription factor osterix is required for osteoblast differentiation and bone formation. Cell. 108:17–29. 2002. View Article : Google Scholar : PubMed/NCBI

17 

Takayanagi H, Kim S, Koga T and Taniguchi T: Stat1-mediated cytoplasmic attenuation in osteoimmunology. J Cell Biochem. 94:232–240. 2005. View Article : Google Scholar

18 

Kim S, Koga T, Isobe M, Kern BE, Yokochi T, Chin YE, Karsenty G, Taniguchi T and Takayanagi H: Stat1 functions as a cytoplasmic attenuator of Runx2 in the transcriptional program of osteoblast differentiation. Genes Dev. 17:1979–1991. 2003. View Article : Google Scholar : PubMed/NCBI

19 

Takayanagi H, Ogasawara K, Hida S, Chiba T, Murata S, Sato K, Takaoka A, Yokochi T, Oda H, Tanaka K, et al: T-cell-mediated regulation of osteoclastogenesis by signalling cross-talk between RANKL and IFN-gamma. Nature. 408:600–605. 2000. View Article : Google Scholar : PubMed/NCBI

20 

Takayanagi H, Kim S, Matsuo K, Suzuki H, Suzuki T, Sato K, Yokochi T, Oda H, Nakamura K, Ida N, et al: RANKL maintains bone homeostasis through c-Fos-dependent induction of interferon-beta. Nature. 416:744–749. 2002. View Article : Google Scholar : PubMed/NCBI

21 

Fujie A, Funayama A, Miyauchi Y, Sato Y, Kobayashi T, Kanagawa H, Katsuyama E, Hao W, Tando T, Watanabe R, et al: Bcl6 promotes osteoblastogenesis through Stat1 inhibition. Biochem Biophys Res Commun. 457:451–456. 2015. View Article : Google Scholar : PubMed/NCBI

22 

Chang CC, Ye BH, Chaganti RS and Dalla-Favera R: BCL-6, a POZ/zinc-finger protein, is a sequence-specific transcriptional repressor. Proc Natl Acad Sci USA. 93:6947–6952. 1996. View Article : Google Scholar : PubMed/NCBI

23 

Jardin F, Ruminy P, Bastard C and Tilly H: The BCL6 proto-oncogene: A leading role during germinal center development and lymphomagenesis. Pathol Biol (Paris). 55:73–83. 2007. View Article : Google Scholar

24 

Zou Q, Tan S, Yang Z, Wang J, Xian J, Zhang S, Jin H, Yang L, Wang L and Zhang L: The human nucleophosmin 1 mutation A inhibits myeloid differentiation of leukemia cells by modulating miR-10b. Oncotarget. 7:71477–71490. 2016.PubMed/NCBI

25 

Foley NH, Bray I, Watters KM, Das S, Bryan K, Bernas T, Prehn JH and Stallings RL: MicroRNAs 10a and 10b are potent inducers of neuroblastoma cell differentiation through targeting of nuclear receptor corepressor 2. Cell Death Differ. 18:1089–1098. 2011. View Article : Google Scholar : PubMed/NCBI

26 

Okamoto H, Matsumi Y, Hoshikawa Y, Takubo K, Ryoke K and Shiota G: Involvement of microRNAs in regulation of osteoblastic differentiation in mouse induced pluripotent stem cells. PLoS One. 7:e438002012. View Article : Google Scholar : PubMed/NCBI

27 

Hassan MQ, Maeda Y, Taipaleenmaki H, Zhang W, Jafferji M, Gordon JA, Li Z, Croce CM, van Wijnen AJ, Stein JL, et al: miR-218 directs a Wnt signaling circuit to promote differentiation of osteoblasts and osteomimicry of metastatic cancer cells. J Biol Chem. 287:42084–42092. 2012. View Article : Google Scholar : PubMed/NCBI

28 

Boyce BF, Rosenberg E, de Papp AE and Duong LT: The osteoclast, bone remodelling and treatment of metabolic bone disease. Eur J Clin Invest. 42:1332–1341. 2012. View Article : Google Scholar : PubMed/NCBI

29 

Wang J, Wang B, Chen LQ, Yang J, Gong ZQ, Zhao XL, Zhang CQ and Du KL: miR-10b promotes invasion by targeting KLF4 in osteosarcoma cells. Biomed Pharmacother. 84:947–953. 2016. View Article : Google Scholar : PubMed/NCBI

30 

Knirsh R, Ben-Dror I, Modai S, Shomron N and Vardimon L: MicroRNA 10b promotes abnormal expression of the proto-oncogene c-Jun in metastatic breast cancer cells. Oncotarget. 7:59932–59944. 2016.PubMed/NCBI

31 

Wang X, Ling CC, Li L, Qin Y, Qi J, Liu X, You B, Shi Y, Zhang J, Jiang Q, et al: MicroRNA-10a/10b represses a novel target gene mib1 to regulate angiogenesis. Cardiovasc Res. 110:140–150. 2016. View Article : Google Scholar : PubMed/NCBI

32 

Giusti J, Pinhal D, Moxon S, Campos CL, Münsterberg A and Martins C: MicroRNA-10 modulates Hox genes expression during Nile tilapia embryonic development. Mech Dev. 140:12–18. 2016. View Article : Google Scholar : PubMed/NCBI

33 

Duan S, Cermak L, Pagan JK, Rossi M, Martinengo C, di Celle PF, Chapuy B, Shipp M, Chiarle R and Pagano M: FBXO11 targets BCL6 for degradation and is inactivated in diffuse large B-cell lymphomas. Nature. 481:90–93. 2012. View Article : Google Scholar :

34 

Wu Q, Liu X, Yan H, He YH, Ye S, Cheng XW, Zhu GL, Wu WY, Wang XN, Kong XJ, et al: B-cell lymphoma 6 protein stimulates oncogenicity of human breast cancer cells. BMC Cancer. 14:4182014. View Article : Google Scholar : PubMed/NCBI

35 

Nance JP, Bélanger S, Johnston RJ, Hu JK, Takemori T and Crotty S: Bcl6 middle domain repressor function is required for T follicular helper cell differentiation and utilizes the corepressor MTA3. Proc Natl Acad Sci USA. 112:13324–13329. 2015. View Article : Google Scholar : PubMed/NCBI

36 

Liu X, Lu H, Chen T, Nallaparaju KC, Yan X, Tanaka S, Ichiyama K, Zhang X, Zhang L, Wen X, et al: Genome-wide analysis identifies Bcl6-controlled regulatory networks during T follicular helper cell differentiation. Cell Rep. 14:1735–1747. 2016. View Article : Google Scholar : PubMed/NCBI

37 

Hu G and Zhao K: Looping around Bcl6 in germinal center to sharpen B cell immunity. Immunity. 45:459–461. 2016. View Article : Google Scholar : PubMed/NCBI

38 

Ying Z, Mei M, Zhang P, Liu C, He H, Gao F and Bao S: Histone arginine methylation by PRMT7 controls germinal center formation via regulating Bcl6 transcription. J Immunol. 195:1538–1547. 2015. View Article : Google Scholar : PubMed/NCBI

39 

Miyauchi Y, Ninomiya K, Miyamoto H, Sakamoto A, Iwasaki R, Hoshi H, Miyamoto K, Hao W, Yoshida S, Morioka H, et al: The Blimp1-Bcl6 axis is critical to regulate osteoclast differentiation and bone homeostasis. J Exp Med. 207:751–762. 2010. View Article : Google Scholar : PubMed/NCBI

40 

Park-Min KH, Lee EY, Moskowitz NK, Lim E, Lee SK, Lorenzo JA, Huang C, Melnick AM, Purdue PE, Goldring SR, et al: Negative regulation of osteoclast precursor differentiation by CD11b and β2 integrin-B-cell lymphoma 6 signaling. J Bone Miner Res. 28:135–149. 2013. View Article : Google Scholar

41 

Swarnkar G, Shim K, Nasir AM, Seehra K, Chen HP, Mbalaviele G and Abu-Amer Y: Myeloid deletion of nemo causes osteopetrosis in mice owing to upregulation of transcriptional repressors. Sci Rep. 6:298962016. View Article : Google Scholar : PubMed/NCBI

42 

Morita M, Yoshida S, Iwasaki R, Yasui T, Sato Y, Kobayashi T, Watanabe R, Oike T, Miyamoto K, Takami M, et al: Smad4 is required to inhibit osteoclastogenesis and maintain bone mass. Sci Rep. 6:352212016. View Article : Google Scholar : PubMed/NCBI

43 

Li J, He X, Wei W and Zhou X: MicroRNA-194 promotes osteoblast differentiation via downregulating STAT1. Biochem Biophys Res Commun. 460:482–488. 2015. View Article : Google Scholar : PubMed/NCBI

44 

Xiao WZ, Gu XC, Hu B, Liu XW, Zi Y and Li M: Role of microRNA-129-5p in osteoblast differentiation from bone marrow mesenchymal stem cells. Cell Mol Biol (Noisy-le-grand). 62:95–99. 2016.

45 

Tajima K, Takaishi H, Takito J, Tohmonda T, Yoda M, Ota N, Kosaki N, Matsumoto M, Ikegami H, Nakamura T, et al: Inhibition of STAT1 accelerates bone fracture healing. J Orthop Res. 28:937–941. 2010.PubMed/NCBI

46 

Yoshida K, Okamura H, Amorim BR, Hinode D, Yoshida H and Haneji T: PKR-mediated degradation of STAT1 regulates osteoblast differentiation. Exp Cell Res. 315:2105–2114. 2009. View Article : Google Scholar : PubMed/NCBI

47 

Tryndyak VP, Ross SA, Beland FA and Pogribny IP: Downregulation of the microRNAs miR-34a, miR-127, and miR-200b in rat liver during hepatocarcinogenesis induced by a methyl-deficient diet. Mol Carcinog. 48:479–487. 2009. View Article : Google Scholar

48 

Martín-Pérez D, Vargiu P, Montes-Moreno S, León EA, Rodríguez-Pinilla SM, Lisio LD, Martínez N, Rodríguez R, Mollejo M, Castellvi J, et al: Epstein-Barr virus microRNAs repress BCL6 expression in diffuse large B-cell lymphoma. Leukemia. 26:180–183. 2012. View Article : Google Scholar

49 

Nazari-Jahantigh M, Wei Y, Noels H, Akhtar S, Zhou Z, Koenen RR, Heyll K, Gremse F, Kiessling F, Grommes J, et al: MicroRNA-155 promotes atherosclerosis by repressing Bcl6 in macrophages. J Clin Invest. 122:4190–4202. 2012. View Article : Google Scholar : PubMed/NCBI

50 

Chen J, Wang M, Guo M, Xie Y and Cong YS: miR-127 regulates cell proliferation and senescence by targeting BCL6. PLoS One. 8:e802662013. View Article : Google Scholar : PubMed/NCBI

51 

Sun C, Li S, Yang C, Xi Y, Wang L, Zhang F and Li D: MicroRNA-187-3p mitigates non-small cell lung cancer (NSCLC) development through Downregulation of BCL6. Biochem Biophys Res Commun. 471:82–88. 2016. View Article : Google Scholar : PubMed/NCBI

52 

Huang F, Jin Y and Wei Y: MicroRNA-187 induces diffuse large B-cell lymphoma cell apoptosis via targeting BCL6. Oncol Lett. 11:2845–2850. 2016.PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Yang J, Wang S, Wang F, Mu X, Qu Y, Zhao Z and Yu X: Downregulation of miR-10b promotes osteoblast differentiation through targeting Bcl6. Int J Mol Med 39: 1605-1612, 2017.
APA
Yang, J., Wang, S., Wang, F., Mu, X., Qu, Y., Zhao, Z., & Yu, X. (2017). Downregulation of miR-10b promotes osteoblast differentiation through targeting Bcl6. International Journal of Molecular Medicine, 39, 1605-1612. https://doi.org/10.3892/ijmm.2017.2955
MLA
Yang, J., Wang, S., Wang, F., Mu, X., Qu, Y., Zhao, Z., Yu, X."Downregulation of miR-10b promotes osteoblast differentiation through targeting Bcl6". International Journal of Molecular Medicine 39.6 (2017): 1605-1612.
Chicago
Yang, J., Wang, S., Wang, F., Mu, X., Qu, Y., Zhao, Z., Yu, X."Downregulation of miR-10b promotes osteoblast differentiation through targeting Bcl6". International Journal of Molecular Medicine 39, no. 6 (2017): 1605-1612. https://doi.org/10.3892/ijmm.2017.2955
Copy and paste a formatted citation
x
Spandidos Publications style
Yang J, Wang S, Wang F, Mu X, Qu Y, Zhao Z and Yu X: Downregulation of miR-10b promotes osteoblast differentiation through targeting Bcl6. Int J Mol Med 39: 1605-1612, 2017.
APA
Yang, J., Wang, S., Wang, F., Mu, X., Qu, Y., Zhao, Z., & Yu, X. (2017). Downregulation of miR-10b promotes osteoblast differentiation through targeting Bcl6. International Journal of Molecular Medicine, 39, 1605-1612. https://doi.org/10.3892/ijmm.2017.2955
MLA
Yang, J., Wang, S., Wang, F., Mu, X., Qu, Y., Zhao, Z., Yu, X."Downregulation of miR-10b promotes osteoblast differentiation through targeting Bcl6". International Journal of Molecular Medicine 39.6 (2017): 1605-1612.
Chicago
Yang, J., Wang, S., Wang, F., Mu, X., Qu, Y., Zhao, Z., Yu, X."Downregulation of miR-10b promotes osteoblast differentiation through targeting Bcl6". International Journal of Molecular Medicine 39, no. 6 (2017): 1605-1612. https://doi.org/10.3892/ijmm.2017.2955
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