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Review Open Access

Human osteopontin: Potential clinical applications in cancer (Review)

  • Authors:
    • Chengcheng Hao
    • Yuxin Cui
    • Sionen Owen
    • Wenbin Li
    • Shan Cheng
    • Wen G. Jiang
  • View Affiliations / Copyright

    Affiliations: Department of Biochemistry and Molecular Biology, Capital Medical University, Beijing 100069, P.R. China, Cardiff China Medical Research Collaborative, Cardiff University School of Medicine, Heath Park, Cardiff CF14 4XN, UK, Department of Oncology, Beijing Shijitan Hospital, Capital Medical University, Beijing 100038, P.R. China
    Copyright: © Hao et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY 4.0].
  • Pages: 1327-1337
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    Published online on: April 21, 2017
       https://doi.org/10.3892/ijmm.2017.2964
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Abstract

Human osteopontin (OPN) is a glycosylated phosphoprotein which is expressed in a variety of tissues in the body. In recent years, accumulating evidence has indicated that the aberrant expression of OPN is closely associated with tumourigensis, progression and most prominently with metastasis in several tumour types. In this review, we present the current knowledge on the expression profiles of OPN and its main splice variants in human cancers, as well as the potential implications in patient outcome. We also discuss its putative clinical application as a cancer biomarker and as a therapeutic target.
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Copy and paste a formatted citation
Spandidos Publications style
Hao C, Cui Y, Owen S, Li W, Cheng S and Jiang WG: Human osteopontin: Potential clinical applications in cancer (Review). Int J Mol Med 39: 1327-1337, 2017.
APA
Hao, C., Cui, Y., Owen, S., Li, W., Cheng, S., & Jiang, W.G. (2017). Human osteopontin: Potential clinical applications in cancer (Review). International Journal of Molecular Medicine, 39, 1327-1337. https://doi.org/10.3892/ijmm.2017.2964
MLA
Hao, C., Cui, Y., Owen, S., Li, W., Cheng, S., Jiang, W. G."Human osteopontin: Potential clinical applications in cancer (Review)". International Journal of Molecular Medicine 39.6 (2017): 1327-1337.
Chicago
Hao, C., Cui, Y., Owen, S., Li, W., Cheng, S., Jiang, W. G."Human osteopontin: Potential clinical applications in cancer (Review)". International Journal of Molecular Medicine 39, no. 6 (2017): 1327-1337. https://doi.org/10.3892/ijmm.2017.2964
Copy and paste a formatted citation
x
Spandidos Publications style
Hao C, Cui Y, Owen S, Li W, Cheng S and Jiang WG: Human osteopontin: Potential clinical applications in cancer (Review). Int J Mol Med 39: 1327-1337, 2017.
APA
Hao, C., Cui, Y., Owen, S., Li, W., Cheng, S., & Jiang, W.G. (2017). Human osteopontin: Potential clinical applications in cancer (Review). International Journal of Molecular Medicine, 39, 1327-1337. https://doi.org/10.3892/ijmm.2017.2964
MLA
Hao, C., Cui, Y., Owen, S., Li, W., Cheng, S., Jiang, W. G."Human osteopontin: Potential clinical applications in cancer (Review)". International Journal of Molecular Medicine 39.6 (2017): 1327-1337.
Chicago
Hao, C., Cui, Y., Owen, S., Li, W., Cheng, S., Jiang, W. G."Human osteopontin: Potential clinical applications in cancer (Review)". International Journal of Molecular Medicine 39, no. 6 (2017): 1327-1337. https://doi.org/10.3892/ijmm.2017.2964
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