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Article

Transfer of CD11c+ lamina propria mononuclear phagocytes from post-infectious irritable bowel syndrome causes mucosal barrier dysfunction and visceral hypersensitivity in recipient mice

  • Authors:
    • Ya‑Jun Ren
    • Lei Zhang
    • Tao Bai
    • Hong‑Lu Yu
    • Ying Li
    • Wei Qian
    • Si Jin
    • Zhi‑Fan Xiong
    • Huan Wang
    • Xiao‑Hua Hou
  • View Affiliations / Copyright

    Affiliations: Division of Gastroenterology, Liyuan Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430077, P.R. China, Division of Gastroenterology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430022, P.R. China, Department of Endocrinology, Institute of Geriatric Medicine, Liyuan Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430077, P.R. China
  • Pages: 1555-1563
    |
    Published online on: April 25, 2017
       https://doi.org/10.3892/ijmm.2017.2966
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Abstract

The role of low-grade inflammation in the development of post‑infectious irritable bowel syndrome (PI‑IBS) has attracted increasing attention. Abnormal CD11c+ mononuclear phagocytes, such as dendritic cells (DCs), macrophages, and monocytes, are involved in the disruption of immune tolerance in organisms, which can lead to the development of chronic inflammatory diseases. The present study tested the hypothesis that CD11c+ lamina propria mononuclear phagocytes (CD11c+ LPMPs) contribute to increased mucosal permeability and visceral hypersensitivity in a PI‑IBS mouse model. CD11c+ LPMPs were isolated and purified via the digestion of intestinal tissues and magnetic‑activated cell sorting. We detected increased mucosal permeability, visceral hypersensitivity and intestinal inflammation during both the acute and chronic stages of Trichinella infection. Following the transfer of CD11c+ LPMPs from PI‑IBS mice into normal mice, low‑grade inflammation was detected, as demonstrated by increased IL‑4 expression in the ileum, as well as enhanced mucosal permeability, as indicated by decreased transepithelial electrical resistance and the pre­sence of ultrastructural alterations. More importantly, the mice that underwent adoptive transfer of CD11c+ LPMPs from the PI‑IBS mice also exhibited increased abdominal withdrawal reflex scores and a decreased threshold. Our data demonstrated that the CD11c+ LPMPs from this PI‑IBS mouse model were not only able to transfer enteric inflammation to the normal mice but also caused abnormal intestinal function, characterized by epithelial barrier disruption and visceral hyperalgesia.
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1 

Shen L and Turner JR: Role of epithelial cells in initiation and propagation of intestinal inflammation. Eliminating the static: Tight junction dynamics exposed. Am J Physiol Gastrointest Liver Physiol. 290:G577–G582. 2006. View Article : Google Scholar : PubMed/NCBI

2 

Turner JR: Intestinal mucosal barrier function in health and disease. Nat Rev Immunol. 9:799–809. 2009. View Article : Google Scholar : PubMed/NCBI

3 

Martínez C, Lobo B, Pigrau M, Ramos L, González-Castro AM, Alonso C, Guilarte M, Guilá M, de Torres I, Azpiroz F, et al: Diarrhoea-predominant irritable bowel syndrome: An organic disorder with structural abnormalities in the jejunal epithelial barrier. Gut. 62:1160–1168. 2013. View Article : Google Scholar

4 

Keszthelyi D, Troost FJ, Jonkers DM, van Eijk HM, Lindsey PJ, Dekker J, Buurman WA and Masclee AA: Serotonergic reinforcement of intestinal barrier function is impaired in irritable bowel syndrome. Aliment Pharmacol Ther. 40:392–402. 2014. View Article : Google Scholar : PubMed/NCBI

5 

Cheng P, Yao J, Wang C, Zhang L and Kong W: Molecular and cellular mechanisms of tight junction dysfunction in the irritable bowel syndrome. Mol Med Rep. 12:3257–3264. 2015.PubMed/NCBI

6 

Barbara G: Mucosal barrier defects in irritable bowel syndrome. Who left the door open? Am J Gastroenterol. 101:1295–1298. 2006. View Article : Google Scholar : PubMed/NCBI

7 

Camilleri M and Gorman H: Intestinal permeability and irri table bowel syndrome. Neurogastroenterol Motil. 19:545–552. 2007. View Article : Google Scholar : PubMed/NCBI

8 

Dunlop SP, Hebden J, Campbell E, Naesdal J, Olbe L, Perkins AC and Spiller RC: Abnormal intestinal permeability in subgroups of diarrhea-predominant irritable bowel syndromes. Am J Gastroenterol. 101:1288–1294. 2006. View Article : Google Scholar : PubMed/NCBI

9 

Piche T, Barbara G, Aubert P, Bruley des Varannes S, Dainese R, Nano JL, Cremon C, Stanghellini V, De Giorgio R, Galmiche JP, et al: Impaired intestinal barrier integrity in the colon of patients with irritable bowel syndrome: Involvement of soluble mediators. Gut. 58:196–201. 2009. View Article : Google Scholar

10 

Thabane M and Marshall JK: Post-infectious irritable bowel syndrome. World J Gastroenterol. 15:3591–3596. 2009. View Article : Google Scholar : PubMed/NCBI

11 

Spiller RC, Jenkins D, Thornley JP, Hebden JM, Wright T, Skinner M and Neal KR: Increased rectal mucosal enteroendocrine cells, T lymphocytes, and increased gut permeability following acute Campylobacter enteritis and in post-dysenteric irritable bowel syndrome. Gut. 47:804–811. 2000. View Article : Google Scholar : PubMed/NCBI

12 

Guilarte M, Santos J, de Torres I, Alonso C, Vicario M, Ramos L, Martínez C, Casellas F, Saperas E and Malagelada JR: Diarrhoea-predominant IBS patients show mast cell activation and hyperplasia in the jejunum. Gut. 56:203–209. 2007. View Article : Google Scholar

13 

Walker MM, Talley NJ, Prabhakar M, Pennaneac'h CJ, Aro P, Ronkainen J, Storskrubb T, Harmsen WS, Zinsmeister AR and Agreus L: Duodenal mastocytosis, eosinophilia and intraepithelial lymphocytosis as possible disease markers in the irritable bowel syndrome and functional dyspepsia. Aliment Pharmacol Ther. 29:765–773. 2009. View Article : Google Scholar : PubMed/NCBI

14 

Ohman L and Simrén M: Pathogenesis of IBS: Role of inflammation, immunity and neuroimmune interactions. Nat Rev Gastroenterol Hepatol. 7:163–173. 2010. View Article : Google Scholar : PubMed/NCBI

15 

Sundin J, Rangel I, Kumawat AK, Hultgren-Hörnquist E and Brummer RJ: Aberrant mucosal lymphocyte number and subsets in the colon of post-infectious irritable bowel syndrome patients. Scand J Gastroenterol. 49:1068–1075. 2014. View Article : Google Scholar : PubMed/NCBI

16 

Bhuiyan MR, Majumder TK, Raihan AA, Roy PK, Farha N and Kamal M: Histopathological alterations in post-infectious irritable bowel syndrome in Bangladeshi population. Mymensingh Med J. 19:275–281. 2010.PubMed/NCBI

17 

Kirsch R and Riddell RH: Histopathological alterations in irritable bowel syndrome. Mod Pathol. 19:1638–1645. 2006. View Article : Google Scholar : PubMed/NCBI

18 

Gwee KA, Collins SM, Read NW, Rajnakova A, Deng Y, Graham JC, McKendrick MW and Moochhala SM: Increased rectal mucosal expression of interleukin 1beta in recently acquired post-infectious irritable bowel syndrome. Gut. 52:523–526. 2003. View Article : Google Scholar : PubMed/NCBI

19 

Chen J, Zhang Y and Deng Z: Imbalanced shift of cytokine expression between T helper 1 and T helper 2 (Th1/Th2) in intestinal mucosa of patients with post-infectious irritable bowel syndrome. BMC Gastroenterol. 12:912012. View Article : Google Scholar : PubMed/NCBI

20 

Feng B, La JH, Schwartz ES and Gebhart GF: Irritable bowel syndrome: Methods, mechanisms, and pathophysiology. Neural and neuro-immune mechanisms of visceral hypersensitivity in irritable bowel syndrome. Am J Physiol Gastrointest Liver Physiol. 302:G1085–G1098. 2012. View Article : Google Scholar : PubMed/NCBI

21 

Scott CL, Henri S and Guilliams M: Mononuclear phagocytes of the intestine, the skin, and the lung. Immunol Rev. 262:9–24. 2014. View Article : Google Scholar : PubMed/NCBI

22 

Huang H, Liu JQ, Yu Y, Mo LH, Ge RT, Zhang HP, Liu ZG, Zheng PY and Yang PC: Regulation of TWIK-related potassium channel-1 (Trek1) restitutes intestinal epithelial barrier function. Cell Mol Immunol. 13:110–118. 2016. View Article : Google Scholar :

23 

Arnold IC, Mathisen S, Schulthess J, Danne C, Hegazy AN and Powrie F: CD11c(+) monocyte/macrophages promote chronic Helicobacter hepaticus-induced intestinal inflammation through the production of IL-23. Mucosal Immunol. 9:352–363. 2016. View Article : Google Scholar

24 

Aychek T, Mildner A, Yona S, Kim KW, Lampl N, Reich-Zeliger S, Boon L, Yogev N, Waisman A, Cua DJ, et al: IL-23-mediated mononuclear phagocyte crosstalk protects mice from Citrobacter rodentium-induced colon immunopathology. Nat Commun. 6:65252015. View Article : Google Scholar : PubMed/NCBI

25 

Hart AL, Al-Hassi HO, Rigby RJ, Bell SJ, Emmanuel AV, Knight SC, Kamm MA and Stagg AJ: Characteristics of intestinal dendritic cells in inflammatory bowel diseases. Gastroenterology. 129:50–65. 2005. View Article : Google Scholar : PubMed/NCBI

26 

Silva MA, López CB, Riverin F, Oligny L, Menezes J and Seidman EG: Characterization and distribution of colonic dendritic cells in Crohn's disease. Inflamm Bowel Dis. 10:504–512. 2004. View Article : Google Scholar : PubMed/NCBI

27 

Krajina T, Leithäuser F, Möller P, Trobonjaca Z and Reimann J: Colonic lamina propria dendritic cells in mice with CD4+ T cell-induced colitis. Eur J Immunol. 33:1073–1083. 2003. View Article : Google Scholar : PubMed/NCBI

28 

Karlis J, Penttila I, Tran TB, Jones B, Nobbs S, Zola H and Flesch IE: Characterization of colonic and mesenteric lymph node dendritic cell subpopulations in a murine adoptive transfer model of inflammatory bowel disease. Inflamm Bowel Dis. 10:834–847. 2004. View Article : Google Scholar

29 

Long Y, Wang W, Wang H, Hao L, Qian W and Hou X: Characteristics of intestinal lamina propria dendritic cells in a mouse model of postinfectious irritable bowel syndrome. J Gastroenterol Hepatol. 27:935–944. 2012. View Article : Google Scholar

30 

Li M, Zhang L, Lu B, Chen Z, Chu L, Meng L and Fan Y: Role of dendritic cell-mediated abnormal immune response in visceral hypersensitivity. Int J Clin Exp Med. 8:13243–13250. 2015.PubMed/NCBI

31 

Jones RC III, Otsuka E, Wagstrom E, Jensen CS, Price MP and Gebhart GF: Short-term sensitization of colon mechanoreceptors is associated with long-term hypersensitivity to colon distention in the mouse. Gastroenterology. 133:184–194. 2007. View Article : Google Scholar : PubMed/NCBI

32 

Al-Chaer ED, Kawasaki M and Pasricha PJ: A new model of chronic visceral hypersensitivity in adult rats induced by colon irritation during postnatal development. Gastroenterology. 119:1276–1285. 2000. View Article : Google Scholar : PubMed/NCBI

33 

Velin AK, Ericson AC, Braaf Y, Wallon C and Söderholm JD: Increased antigen and bacterial uptake in follicle associated epithelium induced by chronic psychological stress in rats. Gut. 53:494–500. 2004. View Article : Google Scholar : PubMed/NCBI

34 

Keita AV, Söderholm JD and Ericson AC: Stress-induced barrier disruption of rat follicle-associated epithelium involves corticotropin-releasing hormone, acetylcholine, substance P, and mast cells. Neurogastroenterol Motil. 22:770–778. 2010. View Article : Google Scholar : PubMed/NCBI

35 

Overman EL, Rivier JE and Moeser AJ: CRF induces intestinal epithelial barrier injury via the release of mast cell proteases and TNF-α. PLoS One. 7:e399352012. View Article : Google Scholar

36 

Pozzo Miller LD and Landis DM: Cytoplasmic structure in organotypic cultures of rat hippocampus prepared by rapid freezing and freeze-substitution fixation. Synapse. 13:195–205. 1993. View Article : Google Scholar : PubMed/NCBI

37 

Siddiqui KR, Laffont S and Powrie F: E-cadherin marks a subset of inflammatory dendritic cells that promote T cell-mediated colitis. Immunity. 32:557–567. 2010. View Article : Google Scholar : PubMed/NCBI

38 

McDole JR, Wheeler LW, McDonald KG, Wang B, Konjufca V, Knoop KA, Newberry RD and Miller MJ: Goblet cells deliver luminal antigen to CD103+ dendritic cells in the small intestine. Nature. 483:345–349. 2012. View Article : Google Scholar : PubMed/NCBI

39 

Cascio JA, Haymaker CL, Divekar RD, Zaghouani S, Khairallah MT, Wan X, Rowland LM, Dhakal M, Chen W and Zaghouani H: Antigen-specific effector CD4 T lymphocytes school lamina propria dendritic cells to transfer innate tolerance. J Immunol. 190:6004–6014. 2013. View Article : Google Scholar : PubMed/NCBI

40 

Poritz LS, Garver KI, Tilberg AF and Koltun WA: Tumor necrosis factor alpha disrupts tight junction assembly. J Surg Res. 116:14–18. 2004. View Article : Google Scholar : PubMed/NCBI

41 

McDermott JR, Bartram RE, Knight PA, Miller HR, Garrod DR and Grencis RK: Mast cells disrupt epithelial barrier function during enteric nematode infection. Proc Natl Acad Sci USA. 100:7761–7766. 2003. View Article : Google Scholar : PubMed/NCBI

42 

Edelblum KL and Turner JR: The tight junction in inflammatory disease: Communication breakdown. Curr Opin Pharmacol. 9:715–720. 2009. View Article : Google Scholar : PubMed/NCBI

43 

Al-Sadi R, Ye D, Boivin M, Guo S, Hashimi M, Ereifej L and Ma TY: Interleukin-6 modulation of intestinal epithelial tight junction permeability is mediated by JNK pathway activation of claudin-2 gene. PLoS One. 9:e853452014. View Article : Google Scholar : PubMed/NCBI

44 

Al-Sadi R, Boivin M and Ma T: Mechanism of cytokine modulation of epithelial tight junction barrier. Front Biosci (Landmark Ed). 14:2765–2778. 2009. View Article : Google Scholar

45 

Bercík P, Wang L, Verdú EF, Mao YK, Blennerhassett P, Khan WI, Kean I, Tougas G and Collins SM: Visceral hyperalgesia and intestinal dysmotility in a mouse model of postinfective gut dysfunction. Gastroenterology. 127:179–187. 2004. View Article : Google Scholar : PubMed/NCBI

46 

Fu Y, Wang W, Tong J, Pan Q, Long Y, Qian W and Hou X: Th17 cells influence intestinal muscle contraction during Trichinella spiralis infection. J Huazhong Univ Sci Technolog Med Sci. 29:481–485. 2009. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Ren YJ, Zhang L, Bai T, Yu HL, Li Y, Qian W, Jin S, Xiong ZF, Wang H, Hou XH, Hou XH, et al: Transfer of CD11c+ lamina propria mononuclear phagocytes from post-infectious irritable bowel syndrome causes mucosal barrier dysfunction and visceral hypersensitivity in recipient mice. Int J Mol Med 39: 1555-1563, 2017.
APA
Ren, Y., Zhang, L., Bai, T., Yu, H., Li, Y., Qian, W. ... Hou, X. (2017). Transfer of CD11c+ lamina propria mononuclear phagocytes from post-infectious irritable bowel syndrome causes mucosal barrier dysfunction and visceral hypersensitivity in recipient mice. International Journal of Molecular Medicine, 39, 1555-1563. https://doi.org/10.3892/ijmm.2017.2966
MLA
Ren, Y., Zhang, L., Bai, T., Yu, H., Li, Y., Qian, W., Jin, S., Xiong, Z., Wang, H., Hou, X."Transfer of CD11c+ lamina propria mononuclear phagocytes from post-infectious irritable bowel syndrome causes mucosal barrier dysfunction and visceral hypersensitivity in recipient mice". International Journal of Molecular Medicine 39.6 (2017): 1555-1563.
Chicago
Ren, Y., Zhang, L., Bai, T., Yu, H., Li, Y., Qian, W., Jin, S., Xiong, Z., Wang, H., Hou, X."Transfer of CD11c+ lamina propria mononuclear phagocytes from post-infectious irritable bowel syndrome causes mucosal barrier dysfunction and visceral hypersensitivity in recipient mice". International Journal of Molecular Medicine 39, no. 6 (2017): 1555-1563. https://doi.org/10.3892/ijmm.2017.2966
Copy and paste a formatted citation
x
Spandidos Publications style
Ren YJ, Zhang L, Bai T, Yu HL, Li Y, Qian W, Jin S, Xiong ZF, Wang H, Hou XH, Hou XH, et al: Transfer of CD11c+ lamina propria mononuclear phagocytes from post-infectious irritable bowel syndrome causes mucosal barrier dysfunction and visceral hypersensitivity in recipient mice. Int J Mol Med 39: 1555-1563, 2017.
APA
Ren, Y., Zhang, L., Bai, T., Yu, H., Li, Y., Qian, W. ... Hou, X. (2017). Transfer of CD11c+ lamina propria mononuclear phagocytes from post-infectious irritable bowel syndrome causes mucosal barrier dysfunction and visceral hypersensitivity in recipient mice. International Journal of Molecular Medicine, 39, 1555-1563. https://doi.org/10.3892/ijmm.2017.2966
MLA
Ren, Y., Zhang, L., Bai, T., Yu, H., Li, Y., Qian, W., Jin, S., Xiong, Z., Wang, H., Hou, X."Transfer of CD11c+ lamina propria mononuclear phagocytes from post-infectious irritable bowel syndrome causes mucosal barrier dysfunction and visceral hypersensitivity in recipient mice". International Journal of Molecular Medicine 39.6 (2017): 1555-1563.
Chicago
Ren, Y., Zhang, L., Bai, T., Yu, H., Li, Y., Qian, W., Jin, S., Xiong, Z., Wang, H., Hou, X."Transfer of CD11c+ lamina propria mononuclear phagocytes from post-infectious irritable bowel syndrome causes mucosal barrier dysfunction and visceral hypersensitivity in recipient mice". International Journal of Molecular Medicine 39, no. 6 (2017): 1555-1563. https://doi.org/10.3892/ijmm.2017.2966
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