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Resveratrol protects against L-arginine-induced acute necrotizing pancreatitis in mice by enhancing SIRT1-mediated deacetylation of p53 and heat shock factor 1

  • Authors:
    • Nian Wang
    • Fen Zhang
    • Liu Yang
    • Jiang Zou
    • Hao Wang
    • Ke Liu
    • Meidong Liu
    • Huali Zhang
    • Xianzhong Xiao
    • Kangkai Wang
  • View Affiliations / Copyright

    Affiliations: Translational Medicine Center of Sepsis, Department of Pathophysiology, Xiangya School of Medicine, Central South University, Changsha, Hunan 410078, P.R. China
    Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 427-437
    |
    Published online on: June 6, 2017
       https://doi.org/10.3892/ijmm.2017.3012
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Abstract

Acute necrotizing pancreatitis (ANP) is a common severe critical illness with a high mortality rate. Resveratrol, a polyphenol compound derived from various plants such as grape skin, peanut, berry and veratrum, exhibits multiple biological activities, especially potent anti‑inflammatory activity, but its effect on ANP has not yet been fully elucidated. The present study aimed to investigate the effects of resveratrol on L-arginine-induced ANP and the possible mechanisms. A mouse model of ANP was established by 2 hourly intraperitoneal injections of 8% L-arginine (4 g/kg). Then the mice were treated by intragastric administration of resveratrol (80 mg/kg) every 12 h immediately after the second injection of L-arginine. Mice with ANP showed increased apoptosis of pancreatic acinar cells, pancreatic myeloperoxidase activity, serum lactate dehydrogenase activity, amylase, tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6) levels as well as decreased serum IL-10 level, pancreatic expression of heat shock factor 1 (HSF1), sirtuin 1 (SIRT1) and p53, but the ratio of acetylated HSF1 and p53 was markedly increased. Resveratrol enhanced the survival rate of mice with ANP from 47.8 to 71.4% and obviously restored the changes in mice with ANP as mentioned above. Additionally, interactions between SIRT1 and p53 and between SIRT1 and HSF1 in the pancreas of the mice were confirmed by co-immunoprecipitation. These data suggest that resveratrol protects against L-arginine-induced ANP, which may be related to the enhancement of SIRT1-mediated deacetylation of p53 and HSF1.
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View References

1 

Weitz G, Woitalla J, Wellhöner P, Schmidt K, Büning J and Fellermann K: Does etiology of acute pancreatitis matter? A review of 391 consecutive episodes. JOP. 16:171–175. 2015.PubMed/NCBI

2 

Agarwal S, George J, Padhan RK, Vadiraja PK, Behera S, Hasan A, Dhingra R, Shalimar and Garg PK: Reduction in mortality in severe acute pancreatitis: A time trend analysis over 16 years. Pancreatology. 16:194–199. 2016. View Article : Google Scholar : PubMed/NCBI

3 

Dellinger EP, Forsmark CE, Layer P, Lévy P, Maraví-Poma E, Petrov MS, Shimosegawa T, Siriwardena AK, Uomo G, Whitcomb DC, et al: Pancreatitis Across Nations Clinical Research and Education Alliance (PANCREA): Determinant-based classification of acute pancreatitis severity: An international multidisciplinary consultation. Ann Surg. 256:875–880. 2012. View Article : Google Scholar : PubMed/NCBI

4 

Sandakov PIa, Samartsev VA and Mineev DA: Surgical and therapeutic treatment of acute pancreatitis. Khirurgiia (Mosk). 10:56–63. 2014.In Russian.

5 

Hegyi P, Pandol S, Venglovecz V and Rakonczay Z Jr: The acinar-ductal tango in the pathogenesis of acute pancreatitis. Gut. 60:544–552. 2011. View Article : Google Scholar

6 

Bhatia M: Inflammatory response on the pancreatic acinar cell injury. Scand J Surg. 94:97–102. 2005.PubMed/NCBI

7 

Lv JC, Wang G, Pan SH, Bai XW and Sun B: Lycopene protects pancreatic acinar cells against severe acute pancreatitis by abating the oxidative stress through JNK pathway. Free Radic Res. 49:151–163. 2015. View Article : Google Scholar

8 

Carrasco C, Holguín-Arévalo MS, Martín-Partido G, Rodríguez AB and Pariente JA: Chemopreventive effects of resveratrol in a rat model of cerulein-induced acute pancreatitis. Mol Cell Biochem. 387:217–225. 2014. View Article : Google Scholar

9 

Sha H, Ma Q, Jha RK, Wu Z, Qingyuan Z, Wang Z, Ma Z, Luo X and Liu C: Resveratrol suppresses microcirculatory disturbance in a rat model of severe acute pancreatitis. Cell Biochem Biophys. 67:1059–1065. 2013. View Article : Google Scholar : PubMed/NCBI

10 

Ghemrawi R, Pooya S, Lorentz S, Gauchotte G, Arnold C, Gueant JL and Battaglia-Hsu SF: Decreased vitamin B12 availability induces ER stress through impaired SIRT1-deacetylation of HSF1. Cell Death Dis. 4:e5532013. View Article : Google Scholar : PubMed/NCBI

11 

Lee JT and Gu W: SIRT1: Regulator of p53 Deacetylation. Genes Cancer. 4:112–117. 2013. View Article : Google Scholar : PubMed/NCBI

12 

Sun C, Zhang F, Ge X, Yan T, Chen X, Shi X and Zhai Q: SIRT1 improves insulin sensitivity under insulin-resistant conditions by repressing PTP1B. Cell Metab. 6:307–319. 2007. View Article : Google Scholar : PubMed/NCBI

13 

Grewal HP, Mohey EDA, Gaber L, Kotb M and Gaber AO: Amelioration of the physiologic and biochemical changes of acute pancreatitis using an anti-TNF-alpha polyclonal antibody. Am J Surg. 167:214–219. 1994. View Article : Google Scholar : PubMed/NCBI

14 

Dawra R, Sharif R, Phillips P, Dudeja V, Dhaulakhandi D and Saluja AK: Development of a new mouse model of acute pancreatitis induced by administration of L-arginine. Am J Physiol Gastrointest Liver Physiol. 292:G1009–G1018. 2007. View Article : Google Scholar

15 

Kui B, Balla Z, Vasas B, Végh ET, Pallagi P, Kormányos ES, Venglovecz V, Iványi B, Takács T, Hegyi P, et al: New insights into the methodology of L-arginine-induced acute pancreatitis. PLoS One. 10:e01175882015. View Article : Google Scholar : PubMed/NCBI

16 

Hong W, Tatsuo S, Shou-Dong W, Qian Z, Jian-Feng H, Jue W, Chen J, Hai-Yan Q and Yue-Jin Y: Resveratrol Upregulates Cardiac SDF-1 in mice with acute myocardial infarction through the deacetylation of cardiac p53. PLoS One. 10:e01289782015. View Article : Google Scholar : PubMed/NCBI

17 

Kume S, Haneda M, Kanasaki K, Sugimoto T, Araki S, Isono M, Isshiki K, Uzu T, Kashiwagi A and Koya D: Silent information regulator 2 (SIRT1) attenuates oxidative stress-induced mesangial cell apoptosis via p53 deacetylation. Free Radic Biol Med. 40:2175–2182. 2006. View Article : Google Scholar : PubMed/NCBI

18 

Lankisch PG, Apte M and Banks PA: Acute pancreatitis. Lancet. 386:85–96. 2015. View Article : Google Scholar : PubMed/NCBI

19 

Mayer J, Rau B, Gansauge F and Beger HG: Inflammatory mediators in human acute pancreatitis: Clinical and pathophysiological implications. Gut. 47:546–552. 2000. View Article : Google Scholar : PubMed/NCBI

20 

Vandenabeele P, Galluzzi L, Vanden Berghe T and Kroemer G: Molecular mechanisms of necroptosis: An ordered cellular explosion. Nat Rev Mol Cell Biol. 11:700–714. 2010. View Article : Google Scholar : PubMed/NCBI

21 

Capurso G, Zerboni G, Signoretti M, Valente R, Stigliano S, Piciucchi M and Delle Fave G: Role of the gut barrier in acute pancreatitis. J Clin Gastroenterol. 46(Suppl): S46–S51. 2012. View Article : Google Scholar : PubMed/NCBI

22 

Tani S, Itoh H, Okabayashi Y, Nakamura T, Fujii M, Fujisawa T, Koide M and Otsuki M: New model of acute necrotizing pancreatitis induced by excessive doses of arginine in rats. Dig Dis Sci. 35:367–374. 1990. View Article : Google Scholar : PubMed/NCBI

23 

Chen J, Chen J, Wang X, Wang C, Cao W, Zhao Y, Zhang B, Cui M, Shi Q and Zhang G: Ligustrazine alleviates acute pancreatitis by accelerating acinar cell apoptosis at early phase via the suppression of p38 and Erk MAPK pathways. Biomed Pharmacother. 82:1–7. 2016. View Article : Google Scholar : PubMed/NCBI

24 

Nakamura Y, Do JH, Yuan J, Odinokova IV, Mareninova O, Gukovskaya AS and Pandol SJ: Inflammatory cells regulate p53 and caspases in acute pancreatitis. Am J Physiol Gastrointest Liver Physiol. 298:G92–G100. 2010. View Article : Google Scholar :

25 

Mareninova OA, Sung KF, Hong P, Lugea A, Pandol SJ, Gukovsky I and Gukovskaya AS: Cell death in pancreatitis: Caspases protect from necrotizing pancreatitis. J Biol Chem. 281:3370–3381. 2006. View Article : Google Scholar

26 

Liu Y, Yuan J, Tan T, Jia W, Lugea A, Mareninova O, Waldron RT and Pandol SJ: Genetic inhibition of protein kinase Cε attenuates necrosis in experimental pancreatitis. Am J Physiol Gastrointest Liver Physiol. 307:G550–G563. 2014. View Article : Google Scholar : PubMed/NCBI

27 

Gu J, Hu W and Zhang DD: Resveratrol, a polyphenol phytoalexin, protects against doxorubicin-induced cardiotoxicity. J Cell Mol Med. 19:2324–2328. 2015. View Article : Google Scholar : PubMed/NCBI

28 

Han G, Xia J, Gao J, Inagaki Y, Tang W and Kokudo N: Anti-tumor effects and cellular mechanisms of resveratrol. Drug Discov Ther. 9:1–12. 2015. View Article : Google Scholar : PubMed/NCBI

29 

Zhang H, Zhang L, Yu F, Liu Y, Liang Q, Deng G, Chen G, Liu M and Xiao X: HSF1 is a transcriptional activator of IL-10 gene expression in RAW264.7 macrophages. Inflammation. 35:1558–1566. 2012. View Article : Google Scholar : PubMed/NCBI

30 

Chen S, Zuo X, Yang M, Lu H, Wang N, Wang K, Tu Z, Chen G, Liu M, Liu K, et al: Severe multiple organ injury in HSF1 knockout mice induced by lipopolysaccharide is associated with an increase in neutrophil infiltration and surface expression of adhesion molecules. J Leukoc Biol. 92:851–857. 2012. View Article : Google Scholar : PubMed/NCBI

31 

Tong Z, Jiang B, Zhang L, Liu Y, Gao M, Jiang Y, Li Y, Lu Q, Yao Y and Xiao X: HSF-1 is involved in attenuating the release of inflammatory cytokines induced by LPS through regulating autophagy. Shock. 41:449–453. 2014. View Article : Google Scholar : PubMed/NCBI

32 

Raynes R, Pombier KM, Nguyen K, Brunquell J, Mendez JE and Westerheide SD: The SIRT1 modulators AROS and DBC1 regulate HSF1 activity and the heat shock response. PLoS One. 8:e543642013. View Article : Google Scholar : PubMed/NCBI

33 

Kim HN, Han L, Iyer S, de Cabo R, Zhao H, O'Brien CA, Manolagas SC and Almeida M: Sirtuin1 suppresses osteoclastogenesis by deacetylating FoxOs. Mol Endocrinol. 29:1498–1509. 2015. View Article : Google Scholar : PubMed/NCBI

34 

Shinozaki S, Chang K, Sakai M, Shimizu N, Yamada M, Tanaka T, Nakazawa H, Ichinose F, Yamada Y, Ishigami A, et al: Inflammatory stimuli induce inhibitory S-nitrosylation of the deacetylase SIRT1 to increase acetylation and activation of p53 and p65. Sci Signal. 7:ra1062014. View Article : Google Scholar : PubMed/NCBI

35 

Hu YY, Zhou CH, Dou WH, Tang W, Hu CY, Hu DM, Feng H, Wang JZ, Qian MJ, Cheng GL, et al: Improved autophagic flux is correlated with mTOR activation in the later recovery stage of experimental acute pancreatitis. Pancreatology. 15:470–477. 2015. View Article : Google Scholar : PubMed/NCBI

36 

Ji L, Li L, Qu F, Zhang G, Wang Y, Bai X, Pan S, Xue D, Wang G and Sun B: Hydrogen sulphide exacerbates acute pancreatitis by over-activating autophagy via AMPK/mTOR pathway. J Cell Mol Med. 20:2349–2361. 2016. View Article : Google Scholar : PubMed/NCBI

37 

Kwon HS and Ott M: The ups and downs of SIRT1. Trends Biochem Sci. 33:517–525. 2008. View Article : Google Scholar : PubMed/NCBI

38 

Ghosh HS, McBurney M and Robbins PD: SIRT1 negatively regulates the mammalian target of rapamycin. PLoS One. 5:e91992010. View Article : Google Scholar : PubMed/NCBI

39 

Zhou XL, Xu JJ, Ni YH, Chen XC, Zhang HX, Zhang XM, Liu WJ, Luo LL and Fu YC: SIRT1 activator (SRT1720) improves the follicle reserve and prolongs the ovarian lifespan of diet-induced obesity in female mice via activating SIRT1 and suppressing mTOR signaling. J Ovarian Res. 7:972014. View Article : Google Scholar : PubMed/NCBI

40 

Diaz-Gerevini GT, Repossi G, Dain A, Tarres MC, Das UN and Eynard AR: Beneficial action of resveratrol: How and why? Nutrition. 32:174–178. 2016. View Article : Google Scholar

41 

Jung MJ, Lee J, Shin NR, Kim MS, Hyun DW, Yun JH, Kim PS, Whon TW and Bae JW: Chronic repression of mTOR complex 2 induces changes in the gut microbiota of diet-induced obese mice. Sci Rep. 6:308872016. View Article : Google Scholar : PubMed/NCBI

42 

Alayev A, Berger SM and Holz MK: Resveratrol as a novel treatment for diseases with mTOR pathway hyperactivation. Ann NY Acad Sci. 1348:116–123. 2015. View Article : Google Scholar : PubMed/NCBI

43 

Gu J, Hu W, Song ZP, Chen YG, Zhang DD and Wang CQ: Resveratrol-induced autophagy promotes survival and attenuates doxorubicin-induced cardiotoxicity. Int Immunopharmacol. 32:1–7. 2016. View Article : Google Scholar : PubMed/NCBI

44 

Park D, Jeong H, Lee MN, Koh A, Kwon O, Yang YR, Noh J, Suh PG, Park H and Ryu SH: Resveratrol induces autophagy by directly inhibiting mTOR through ATP competition. Sci Rep. 6:217722016. View Article : Google Scholar : PubMed/NCBI

45 

Zhang Z, Chen N, Liu JB, Wu JB, Zhang J, Zhang Y and Jiang X: Protective effect of resveratrol against acute lung injury induced by lipopolysaccharide via inhibiting the myd88-dependent Toll-like receptor 4 signaling pathway. Mol Med Rep. 10:101–106. 2014.PubMed/NCBI

46 

Zhong K: Curcumin mediates a protective effect via TLR-4/NF-κB signaling pathway in rat model of severe acute pancreatitis. Cell Biochem Biophys. 73:175–180. 2015. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Wang N, Zhang F, Yang L, Zou J, Wang H, Liu K, Liu M, Zhang H, Xiao X, Wang K, Wang K, et al: Resveratrol protects against L-arginine-induced acute necrotizing pancreatitis in mice by enhancing SIRT1-mediated deacetylation of p53 and heat shock factor 1. Int J Mol Med 40: 427-437, 2017.
APA
Wang, N., Zhang, F., Yang, L., Zou, J., Wang, H., Liu, K. ... Wang, K. (2017). Resveratrol protects against L-arginine-induced acute necrotizing pancreatitis in mice by enhancing SIRT1-mediated deacetylation of p53 and heat shock factor 1. International Journal of Molecular Medicine, 40, 427-437. https://doi.org/10.3892/ijmm.2017.3012
MLA
Wang, N., Zhang, F., Yang, L., Zou, J., Wang, H., Liu, K., Liu, M., Zhang, H., Xiao, X., Wang, K."Resveratrol protects against L-arginine-induced acute necrotizing pancreatitis in mice by enhancing SIRT1-mediated deacetylation of p53 and heat shock factor 1". International Journal of Molecular Medicine 40.2 (2017): 427-437.
Chicago
Wang, N., Zhang, F., Yang, L., Zou, J., Wang, H., Liu, K., Liu, M., Zhang, H., Xiao, X., Wang, K."Resveratrol protects against L-arginine-induced acute necrotizing pancreatitis in mice by enhancing SIRT1-mediated deacetylation of p53 and heat shock factor 1". International Journal of Molecular Medicine 40, no. 2 (2017): 427-437. https://doi.org/10.3892/ijmm.2017.3012
Copy and paste a formatted citation
x
Spandidos Publications style
Wang N, Zhang F, Yang L, Zou J, Wang H, Liu K, Liu M, Zhang H, Xiao X, Wang K, Wang K, et al: Resveratrol protects against L-arginine-induced acute necrotizing pancreatitis in mice by enhancing SIRT1-mediated deacetylation of p53 and heat shock factor 1. Int J Mol Med 40: 427-437, 2017.
APA
Wang, N., Zhang, F., Yang, L., Zou, J., Wang, H., Liu, K. ... Wang, K. (2017). Resveratrol protects against L-arginine-induced acute necrotizing pancreatitis in mice by enhancing SIRT1-mediated deacetylation of p53 and heat shock factor 1. International Journal of Molecular Medicine, 40, 427-437. https://doi.org/10.3892/ijmm.2017.3012
MLA
Wang, N., Zhang, F., Yang, L., Zou, J., Wang, H., Liu, K., Liu, M., Zhang, H., Xiao, X., Wang, K."Resveratrol protects against L-arginine-induced acute necrotizing pancreatitis in mice by enhancing SIRT1-mediated deacetylation of p53 and heat shock factor 1". International Journal of Molecular Medicine 40.2 (2017): 427-437.
Chicago
Wang, N., Zhang, F., Yang, L., Zou, J., Wang, H., Liu, K., Liu, M., Zhang, H., Xiao, X., Wang, K."Resveratrol protects against L-arginine-induced acute necrotizing pancreatitis in mice by enhancing SIRT1-mediated deacetylation of p53 and heat shock factor 1". International Journal of Molecular Medicine 40, no. 2 (2017): 427-437. https://doi.org/10.3892/ijmm.2017.3012
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