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Article Open Access

Triptolide exerts protective effects against fibrosis following ileocolonic anastomosis by mechanisms involving the miR-16-1/HSP70 pathway in IL-10-deficient mice

  • Authors:
    • Hong‑Wei Hou
    • Jin‑Min Wang
    • Dong Wang
    • Rong Wu
    • Zhen‑Ling Ji
  • View Affiliations / Copyright

    Affiliations: Department of General Surgery, Southeast University Medical School, Nanjing, Jiangsu 210009, P.R. China
    Copyright: © Hou et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 337-346
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    Published online on: June 9, 2017
       https://doi.org/10.3892/ijmm.2017.3016
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Abstract

Surgeries, particularly ileocecal resection (ICR), are often required in the treatment of Crohn's disease (CD). However, recurrences are common for patients who undergo ICR, and anastomotic fibrosis is the main cause of re-operation. The present study aimed to investigate the therapeutic effects of triptolide (TPL) in ameliorating fibrosis following ileocolonic anastomosis. A model of IL‑10‑/‑ mice undergoing ICR was used to study postsurgical inflammation and fibrosis of anastomosis. For this purpsose, interleukin (IL)‑10‑/‑ mice were randomly divided into 3 groups as follows: the control group, the saline‑treated group subjected to ICR (ST‑ICR) and the TPL‑treated group subjected to ICR (TT‑ICR). Wild‑type (WT) mice of matching ages were assigned to the WT group. The effects of TPL treatment on ileocolonic anastomosis were determined by histopathological evaluation, western blot analysis and ELISA. The analysis of the effects of TPL treatment on microRNA‑16‑1 (miR‑16‑1) and heat shock protein 70 (HSP70) expression was carried out by RT‑qPCR and western blot analysis. Compared with the control group, significantly higher inflammation scores following anastomosis were observed in the ST‑ICR group (P<0.05), although reversion was observed in the TT‑ICR group, which was consistent with changes in the area of CD4+ cell infiltration. The elevated fibrosis scores and the overexpression of procollagen I and III in the ST‑ICR group were all inhibited by TPL. With an increase in the severity of inflammation and fibrosis, the levels of IL‑6, tumor necrosis factor‑α (TNF‑α) and transforming growth factor‑β1 (TGF‑β1) increased; however, a significant decrease in these levels was observed following treatment with TPL (P<0.05). The results of RT‑qPCR revealed that the upregulated miR‑16‑1 levels in the ST‑ICR group were significantly reduced by TPL. HSP70, which can be inhibited by miR-16-1, ameliorates anastomotic inflammation and fibrosis. Thus, the present study demonstrates that TPL exerts a protective effect against fibrosis following anastomosis in CD. The miR‑16‑1/HSP70 signaling pathway, which can be regulated by TPL, may thus represent a novel therapeutic option in CD that deserves further investigation.
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1 

Bernstein CN, Fried M, Krabshuis JH, Cohen H, Eliakim R, Fedail S, Gearry R, Goh KL, Hamid S, Khan AG, et al: World Gastroenterology Organization practice guidelines for the diagnosis and management of IBD in 2010. Inflamm Bowel Dis. 16:112–124. 2010. View Article : Google Scholar

2 

Carter MJ and Lobo AJ: Guidelines for the management of inflammatory bowel disease in adults. Gut. 53(Suppl 5): V1–V16. 2004. View Article : Google Scholar : PubMed/NCBI

3 

Ren J, Tao Q, Wang X, Wang Z and Li J: Efficacy of T2 in active Crohn's disease: A prospective study report. Dig Dis Sci. 52:1790–1797. 2007. View Article : Google Scholar : PubMed/NCBI

4 

Titov DV, Gilman B, He QL, Bhat S, Low WK, Dang Y, Smeaton M, Demain AL, Miller PS, Kugel JF, et al: XPB, a subunit of TFIIH, is a target of the natural product triptolide. Nat Chem Biol. 7:182–188. 2011. View Article : Google Scholar : PubMed/NCBI

5 

Yu C, Shan T, Feng A, Li Y, Zhu W, Xie Y, Li N and Li J: Triptolide ameliorates Crohn's colitis is associated with inhibition of TLRs/NF-κB signaling pathway. Fitoterapia. 82:709–715. 2011. View Article : Google Scholar : PubMed/NCBI

6 

Wei X, Gong J, Zhu J, Wang P, Li N, Zhu W and Li J: The suppressive effect of triptolide on chronic colitis and TNF-alpha/TNFR2 signal pathway in interleukin-10 deficient mice. Clin Immunol. 129:211–218. 2008. View Article : Google Scholar : PubMed/NCBI

7 

Rigby RJ, Hunt MR, Scull BP, Simmons JG, Speck KE, Helmrath MA and Lund PK: A new animal model of postsurgical bowel inflammation and fibrosis: The effect of commensal microflora. Gut. 58:1104–1112. 2009. View Article : Google Scholar : PubMed/NCBI

8 

Murthy SN, Cooper HS, Shim H, Shah RS, Ibrahim SA and Sedergran DJ: Treatment of dextran sulfate sodium-induced murine colitis by intracolonic cyclosporin. Dig Dis Sci. 38:1722–1734. 1993. View Article : Google Scholar : PubMed/NCBI

9 

Berg DJ, Davidson N, Kühn R, Müller W, Menon S, Holland G, Thompson-Snipes L, Leach MW and Rennick D: Enterocolitis and colon cancer in interleukin-10-deficient mice are associated with aberrant cytokine production and CD4(+) TH1-likeresponses. J Clin Invest. 98:1010–1020. 1996. View Article : Google Scholar : PubMed/NCBI

10 

Rath HC, Herfarth HH, Ikeda JS, Grenther WB, Hamm TE Jr, Balish E, Taurog JD, Hammer RE, Wilson KH and Sartor RB: Normal luminal bacteria, especially Bacteroides species, mediate chronic colitis, gastritis, and arthritis in HLA-B27/human beta2 microglobulin transgenic rats. J Clin Invest. 98:945–953. 1996. View Article : Google Scholar : PubMed/NCBI

11 

Eckes B, Zigrino P, Kessler D, Holtkötter O, Shephard P, Mauch C and Krieg T: Fibroblast-matrix interactions in wound healing and fibrosis. Matrix Biol. 19:325–332. 2000. View Article : Google Scholar : PubMed/NCBI

12 

Chou DH, Lee W and McCulloch CA: TNF-alpha inactivation of collagen receptors: Implications for fibroblast function and fibrosis. J Immunol. 156:4354–4362. 1996.PubMed/NCBI

13 

Morikawa M, Derynck R and Miyazono K: TGF-β and the TGF-β family: Context-dependent roles in cell and tissue physiology. Cold Spring Harb Perspect Biol. 8:82016. View Article : Google Scholar

14 

Lochhead P, Khalili H, Ananthakrishnan AN, Richter JM and Chan AT: Association between circulating levels of c-reactive protein and interleukin-6 and risk of inflammatory bowel disease. Clin Gastroenterol Hepatol. 14:818–824. 2016. View Article : Google Scholar : PubMed/NCBI

15 

Iborra M, Bernuzzi F, Correale C, Vetrano S, Fiorino G, Beltrán B, Marabita F, Locati M, Spinelli A, Nos P, et al: Identification of serum and tissue micro-RNA expression profiles in different stages of inflammatory bowel disease. Clin Exp Immunol. 173:250–258. 2013. View Article : Google Scholar : PubMed/NCBI

16 

Paraskevi A, Theodoropoulos G, Papaconstantinou I, Mantzaris G, Nikiteas N and Gazouli M: Circulating MicroRNA in inflammatory bowel disease. J Crohn's Colitis. 6:900–904. 2012. View Article : Google Scholar

17 

Meng HT, Zhu L, Ni WM, You LS, Jin J and Qian WB: Triptolide inhibits the proliferation of cells from lymphocytic leukemic celllines in association with downregulation of NF-κB activity and miR-16-1*. Acta Pharmacol Sin. 32:503–511. 2011. View Article : Google Scholar : PubMed/NCBI

18 

Bellaye PS, Burgy O, Causse S, Garrido C and Bonniaud P: Heat shock proteins in fibrosis and wound healing: Good or evil? Pharmacol Ther. 143:119–132. 2014. View Article : Google Scholar : PubMed/NCBI

19 

Hauet-Broere F, Wieten L, Guichelaar T, Berlo S, van der Zee R and Van Eden W: Heat shock proteins induce T cell regulation of chronic inflammation. Ann Rheum Dis. 65(Suppl 3): iii65–iii68. 2006. View Article : Google Scholar : PubMed/NCBI

20 

Zhang Z and Cheng Y: miR-16-1 promotes the aberrant α-synuclein accumulation in parkinson disease via targeting heat shock protein 70. Scientific World Journal. 2014:9383482014.

21 

Li C and Kuemmerle JF: Mechanisms that mediate the development of fibrosis in patients with Crohn's disease. Inflamm Bowel Dis. 20:1250–1258. 2014. View Article : Google Scholar : PubMed/NCBI

22 

Borowiec AM, Sydora BC, Doyle J, Guan LL, Churchill TA, Madsen K and Fedorak RN: Small bowel fibrosis and systemic inflammatory response after ileocolonic anastomosis in IL-10null mice. J Surg Res. 178:147–154. 2012. View Article : Google Scholar : PubMed/NCBI

23 

Kühn R, Löhler J, Rennick D, Rajewsky K and Müller W: Interleukin-10-deficient mice develop chronic enterocolitis. Cell. 75:263–274. 1993. View Article : Google Scholar : PubMed/NCBI

24 

Liu Y, Li J, Liu Y, Wang P and Jia H: Inhibition of zymosan-induced cytokine and chemokine expression in human corneal fibroblasts by triptolide. Int J Ophthalmol. 9:9–14. 2016.PubMed/NCBI

25 

Burger D, Rezzonico R, Li JM, Modoux C, Pierce RA, Welgus HG and Dayer JM: Imbalance between interstitial collagenase and tissue inhibitor of metalloproteinases 1 in synoviocytes and fibroblasts upon direct contact with stimulated T lymphocytes: Involvement of membrane-associated cytokines. Arthritis Rheum. 41:1748–1759. 1998. View Article : Google Scholar : PubMed/NCBI

26 

Lin N, Liu C, Xiao C, Jia H, Imada K, Wu H and Ito A: Triptolide, a diterpenoid triepoxide, suppresses inflammation and cartilage destruction in collagen-induced arthritis mice. Biochem Pharmacol. 73:136–146. 2007. View Article : Google Scholar

27 

Klawitter M, Quero L, Klasen J, Liebscher T, Nerlich A, Boos N and Wuertz K: Triptolide exhibits anti-inflammatory, anti-catabolic as well as anabolic effects and suppresses TLR expression and MAPK activity in IL-1β treated human intervertebral disc cells. Eur Spine J. 21(Suppl 6): S850–S859. 2012. View Article : Google Scholar

28 

Zhu B, Wang YJ, Zhu CF, Lin Y, Zhu XL, Wei S, Lu Y and Cheng XX: Triptolide inhibits extracellular matrix protein synthesis by suppressing the Smad2 but not the MAPK pathway in TGF-beta1-stimulated NRK-49F cells. Nephrol Dial Transplant. 25:3180–3191. 2010. View Article : Google Scholar : PubMed/NCBI

29 

Zhang Z, Qu X, Ni Y, Zhang K, Dong Z, Yan X, Qin J, Sun H, Ding Y, Zhao P, et al: Triptolide protects rat heart against pressure overload-induced cardiac fibrosis. Int J Cardiol. 168:2498–2505. 2013. View Article : Google Scholar : PubMed/NCBI

30 

Chen M, Lv Z, Huang L, Zhang W, Lin X, Shi J, Zhang W, Liang R and Jiang S: Triptolide inhibits TGF-β1-induced cell proliferation in rat airway smooth muscle cells by suppressing Smad signaling. Exp Cell Res. 331:362–368. 2015. View Article : Google Scholar

31 

Guo X, Xue M, Li CJ, Yang W, Wang S, Ma Z, Zhang X, Wang X, Zhao R, Chang B and Chen LM: Protective effects of triptolide on TLR4 mediated autoimmune and inflammatory response induced myocardial fibrosis in diabetic cardiomyopathy. J Ethnopharmacol. 193:333–344. 2016. View Article : Google Scholar : PubMed/NCBI

32 

Jiang CB, Wei MG, Tu Y, Zhu H, Li CQ, Jing WM and Sun W: Triptolide attenuates podocyte injury by regulating expression of miRNA-344b-3p and miRNA-30b-3p in rats with adriamycin-induced nephropathy. Evidence-based complementary and alternative medicine. eCAM. 2015:pp. 1078142015, https://doi.org/10.1155/2015/107814.

33 

Wu R, Li Y, Guo Z, Gong J, Zhu W, Li N and Li J: Triptolide ameliorates ileocolonic anastomosis inflammation in IL-10 deficient mice by mechanism involving suppression of miR-155/SHIP-1 signaling pathway. Mol Immunol. 56:340–346. 2013. View Article : Google Scholar : PubMed/NCBI

34 

Calin GA, Dumitru CD, Shimizu M, Bichi R, Zupo S, Noch E, Aldler H, Rattan S, Keating M, Rai K, et al: Frequent deletions and down-regulation of micro-RNA genes miR15 and miR16 at 13q14 in chronic lymphocytic leukemia. Proc Natl Acad Sci USA. 99:15524–15529. 2002. View Article : Google Scholar

35 

Li F, Xu Y, Deng S, Li Z, Zou D, Yi S, Sui W, Hao M and Qiu L: MicroRNA-15a/16-1 cluster located at chromosome 13q14 is downregulated but displays different expression pattern and prognostic significance in multiple myeloma. Oncotarget. 6:38270–38282. 2015.PubMed/NCBI

36 

Jia X, Li X, Shen Y, Miao J, Liu H, Li G and Wang Z: MiR-16 regulates mouse peritoneal macrophage polarization and affects T-cell activation. J Cell Mol Med. 20:1898–1907. 2016. View Article : Google Scholar : PubMed/NCBI

37 

Zhu B, Wei XX, Wang TB, Zhou YC, Liu AM and Zhang GW: Increased miR-16 expression induced by hepatitis C virus infection promotes liver fibrosis through downregulation of hepatocyte growth factor and Smad7. Arch Virol. 160:2043–2050. 2015. View Article : Google Scholar : PubMed/NCBI

38 

Shi L, Jackstadt R, Siemens H, Li H, Kirchner T and Hermeking H: p53-induced miR-15a/16-1 and AP4 form a double-negative feedback loop to regulate epithelial-mesenchymal transition and metastasis in colorectal cancer. Cancer Res. 74:532–542. 2014. View Article : Google Scholar

39 

Liu L, Walker EA, Kissane S, Khan I, Murray PI, Rauz S and Wallace GR: Gene expression and miR profiles of human corneal fibroblasts in response to dexamethasone. Invest Ophthalmol Vis Sci. 52:7282–7288. 2011. View Article : Google Scholar : PubMed/NCBI

40 

Marcais A, Blevins R, Graumann J, Feytout A, Dharmalingam G, Carroll T, Amado IF, Bruno L, Lee K, Walzer T, et al: microRNA-mediated regulation of mTOR complex components facilitates discrimination between activation and anergy in CD4T cells. J Exp Med. 211:2281–2295. 2014. View Article : Google Scholar : PubMed/NCBI

41 

Rouse M, Rao R, Nagarkatti M and Nagarkatti PS: 3,3′-diindolylmethane ameliorates experimental autoimmune encephalomyelitis by promoting cell cycle arrest and apoptosis in activated T cells through microRNA signaling pathways. J Pharmacol Exp Ther. 350:341–352. 2014. View Article : Google Scholar : PubMed/NCBI

42 

Van Molle W, Wielockx B, Mahieu T, Takada M, Taniguchi T, Sekikawa K and Libert C: HSP70 protects against TNF-induced lethal inflammatory shock. Immunity. 16:685–695. 2002. View Article : Google Scholar : PubMed/NCBI

43 

Meng K, Liu Q, Dou Y and Huang Q: Prior peritoneal lavage with hot 0.9% saline induces HSP70 expression and protects against cerulein-induced acute pancreatitis in rats. Mol Biol Rep. 40:1443–1449. 2013. View Article : Google Scholar

44 

Sherman MY and Gabai VL: Hsp70 in cancer: Back to the future. Oncogene. 34:4153–4161. 2015. View Article : Google Scholar :

45 

Murphy ME: The HSP70 family and cancer. Carcinogenesis. 34:1181–1188. 2013. View Article : Google Scholar : PubMed/NCBI

46 

Abou El Azm AR, Yousef M, Kobtan A, Awad A, Elkassas G and Elfert A: Colonic mucosal expression of heat-shock proteins may have a potential prognostic value in ulcerative colitis. Arab journal of gastroenterology: the official publication of the Pan-Arab Association of Gastroenterology. 16:pp. 20–24. 2015, https://doi.org/10.1016/j.ajg.2015.02.005. View Article : Google Scholar

47 

Zhou Y, Mao H, Li S, Cao S, Li Z, Zhuang S, Fan J, Dong X, Borkan SC, Wang Y, et al: HSP72 inhibits Smad3 activation and nuclear translocation in renal epithelial-to-mesenchymal transition. J Am Soc Nephrol. 21:598–609. 2010. View Article : Google Scholar : PubMed/NCBI

48 

Li Y, Kang X and Wang Q: HSP70 decreases receptor-dependent phosphorylation of Smad2 and blocks TGF-beta-induced epithelial-mesenchymal transition. Journal of genetics and genomics = Yi chuan xue bao. 38:111–116. 2011. View Article : Google Scholar

49 

Tao Y, Hart J, Lichtenstein L, Joseph LJ, Ciancio MJ, Hu S, Chang EB and Bissonnette M: Inducible heat shock protein 70 prevents multifocal flat dysplastic lesions and invasive tumors in an inflammatory model of colon cancer. Carcinogenesis. 30:175–182. 2009. View Article : Google Scholar :

50 

Mao H, Li Z, Zhou Y, Li Z, Zhuang S, An X, Zhang B, Chen W, Nie J, Wang Z, et al: HSP72 attenuates renal tubular cell apoptosis and interstitial fibrosis in obstructive nephropathy. Am J Physiol Renal Physiol. 295:F202–F214. 2008. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Hou HW, Wang JM, Wang D, Wu R and Ji ZL: Triptolide exerts protective effects against fibrosis following ileocolonic anastomosis by mechanisms involving the miR-16-1/HSP70 pathway in IL-10-deficient mice. Int J Mol Med 40: 337-346, 2017.
APA
Hou, H., Wang, J., Wang, D., Wu, R., & Ji, Z. (2017). Triptolide exerts protective effects against fibrosis following ileocolonic anastomosis by mechanisms involving the miR-16-1/HSP70 pathway in IL-10-deficient mice. International Journal of Molecular Medicine, 40, 337-346. https://doi.org/10.3892/ijmm.2017.3016
MLA
Hou, H., Wang, J., Wang, D., Wu, R., Ji, Z."Triptolide exerts protective effects against fibrosis following ileocolonic anastomosis by mechanisms involving the miR-16-1/HSP70 pathway in IL-10-deficient mice". International Journal of Molecular Medicine 40.2 (2017): 337-346.
Chicago
Hou, H., Wang, J., Wang, D., Wu, R., Ji, Z."Triptolide exerts protective effects against fibrosis following ileocolonic anastomosis by mechanisms involving the miR-16-1/HSP70 pathway in IL-10-deficient mice". International Journal of Molecular Medicine 40, no. 2 (2017): 337-346. https://doi.org/10.3892/ijmm.2017.3016
Copy and paste a formatted citation
x
Spandidos Publications style
Hou HW, Wang JM, Wang D, Wu R and Ji ZL: Triptolide exerts protective effects against fibrosis following ileocolonic anastomosis by mechanisms involving the miR-16-1/HSP70 pathway in IL-10-deficient mice. Int J Mol Med 40: 337-346, 2017.
APA
Hou, H., Wang, J., Wang, D., Wu, R., & Ji, Z. (2017). Triptolide exerts protective effects against fibrosis following ileocolonic anastomosis by mechanisms involving the miR-16-1/HSP70 pathway in IL-10-deficient mice. International Journal of Molecular Medicine, 40, 337-346. https://doi.org/10.3892/ijmm.2017.3016
MLA
Hou, H., Wang, J., Wang, D., Wu, R., Ji, Z."Triptolide exerts protective effects against fibrosis following ileocolonic anastomosis by mechanisms involving the miR-16-1/HSP70 pathway in IL-10-deficient mice". International Journal of Molecular Medicine 40.2 (2017): 337-346.
Chicago
Hou, H., Wang, J., Wang, D., Wu, R., Ji, Z."Triptolide exerts protective effects against fibrosis following ileocolonic anastomosis by mechanisms involving the miR-16-1/HSP70 pathway in IL-10-deficient mice". International Journal of Molecular Medicine 40, no. 2 (2017): 337-346. https://doi.org/10.3892/ijmm.2017.3016
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