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International Journal of Molecular Medicine
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August-2017 Volume 40 Issue 2

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Article

DTX3L is upregulated in glioma and is associated with glioma progression

  • Authors:
    • Peng Xu
    • Xuelei Tao
    • Chengjin Zhao
    • Qingfeng Huang
    • Hao Chang
    • Na Ban
    • Yuanqi Bei
    • Xiaojie Xia
    • Chaoyan Shen
    • Kun Wang
    • Li Xu
    • Peizhang Wu
    • Jianbing Ren
    • Donglin Wang
  • View Affiliations / Copyright

    Affiliations: Department of Pathology, Nantong University, Nantong, Jiangsu 226001, P.R. China, Jiangsu Province Key Laboratory for Inflammation and Molecular Drug Targets, Nantong University, Nantong, Jiangsu 226001, P.R. China, Department of Neurosurgery, The Affiliated Hospital of Nantong University, Nantong, Jiangsu 226001, P.R. China, Department of Neurosurgery, The Second People's Hospital of Nantong, Nantong, Jiangsu 226001, P.R. China
  • Pages: 491-498
    |
    Published online on: June 13, 2017
       https://doi.org/10.3892/ijmm.2017.3023
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Abstract

Gliomas are the most common primary brain tumors of the central nervous system (CNS). Due to the poor prognosis of glioma patients, it is urgent to develop more effective therapies. Deltex-3-like (DTX3L), also known as B-lymphoma and BAL-associated protein (BBAP), has been reported to play an important role in the progression of many tumors. This study aimed to investigate the clinical significance and biological function of DTX3L in human glioma. Clinically, the protein expression level of DTX3L is increased in glioma tissues compared with that observed in normal brain tissues. Immunohistochemical analysis demonstrated that DTX3L was highly expressed in the glioma tissues and its level was correlated with the grade of malignancy. Multivariate analysis revealed the association between high expression of DTX3L and the poor prognosis of glioma patients. In addition, knockdown of DTX3L by siRNA transfection increased glioma cell apoptosis. Moreover, suppression of DTX3L expression was shown to significantly inhibit the migration and invasion of glioma cells. These data indicate that DTX3L plays an important role in the pathogenic process of glioma, suggesting that DTX3L could be a potential prognostic biomarker for glioma.
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Copy and paste a formatted citation
Spandidos Publications style
Xu P, Tao X, Zhao C, Huang Q, Chang H, Ban N, Bei Y, Xia X, Shen C, Wang K, Wang K, et al: DTX3L is upregulated in glioma and is associated with glioma progression. Int J Mol Med 40: 491-498, 2017.
APA
Xu, P., Tao, X., Zhao, C., Huang, Q., Chang, H., Ban, N. ... Wang, D. (2017). DTX3L is upregulated in glioma and is associated with glioma progression. International Journal of Molecular Medicine, 40, 491-498. https://doi.org/10.3892/ijmm.2017.3023
MLA
Xu, P., Tao, X., Zhao, C., Huang, Q., Chang, H., Ban, N., Bei, Y., Xia, X., Shen, C., Wang, K., Xu, L., Wu, P., Ren, J., Wang, D."DTX3L is upregulated in glioma and is associated with glioma progression". International Journal of Molecular Medicine 40.2 (2017): 491-498.
Chicago
Xu, P., Tao, X., Zhao, C., Huang, Q., Chang, H., Ban, N., Bei, Y., Xia, X., Shen, C., Wang, K., Xu, L., Wu, P., Ren, J., Wang, D."DTX3L is upregulated in glioma and is associated with glioma progression". International Journal of Molecular Medicine 40, no. 2 (2017): 491-498. https://doi.org/10.3892/ijmm.2017.3023
Copy and paste a formatted citation
x
Spandidos Publications style
Xu P, Tao X, Zhao C, Huang Q, Chang H, Ban N, Bei Y, Xia X, Shen C, Wang K, Wang K, et al: DTX3L is upregulated in glioma and is associated with glioma progression. Int J Mol Med 40: 491-498, 2017.
APA
Xu, P., Tao, X., Zhao, C., Huang, Q., Chang, H., Ban, N. ... Wang, D. (2017). DTX3L is upregulated in glioma and is associated with glioma progression. International Journal of Molecular Medicine, 40, 491-498. https://doi.org/10.3892/ijmm.2017.3023
MLA
Xu, P., Tao, X., Zhao, C., Huang, Q., Chang, H., Ban, N., Bei, Y., Xia, X., Shen, C., Wang, K., Xu, L., Wu, P., Ren, J., Wang, D."DTX3L is upregulated in glioma and is associated with glioma progression". International Journal of Molecular Medicine 40.2 (2017): 491-498.
Chicago
Xu, P., Tao, X., Zhao, C., Huang, Q., Chang, H., Ban, N., Bei, Y., Xia, X., Shen, C., Wang, K., Xu, L., Wu, P., Ren, J., Wang, D."DTX3L is upregulated in glioma and is associated with glioma progression". International Journal of Molecular Medicine 40, no. 2 (2017): 491-498. https://doi.org/10.3892/ijmm.2017.3023
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