Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
International Journal of Molecular Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1107-3756 Online ISSN: 1791-244X
Journal Cover
August-2017 Volume 40 Issue 2

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
August-2017 Volume 40 Issue 2

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Meiotic defects and decreased expression of genes located around the chromosomal breakpoint in the testis of a patient with a novel 46,X,t(Y;1)(p11.3;p31) translocation

  • Authors:
    • Guangyuan Li
    • Furhan Iqbal
    • Liu Wang
    • Zhipeng Xu
    • Xiaoyan Che
    • Wen Yu
    • Liang Shi
    • Tonghang Guo
    • Guixiang Zhou
    • Xiaohua Jiang
    • Huan Zhang
    • Yuanwei Zhang
    • Dexin Yu
  • View Affiliations / Copyright

    Affiliations: Department of Urology, The Second Affiliated Hospital of Anhui Medical University, Hefei, Anhui 230032, P.R. China, Hefei National Laboratory for Physical Sciences at Microscale and School of Life Sciences, University of Science and Technology of China, Hefei, Anhui 230022, P.R. China, Reproductive Medicine Center, Drum Tower Hospital Affiliated to Nanjing University Medical College, Nanjing, Jiangsu 210008, P.R. China, Center for Reproductive Medicine, Department of Obstetrics and Gynecology, Anhui Provincial Hospital Affiliated to Anhui Medical University, Hefei, Anhui 230001, P.R. China
    Copyright: © Li et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 367-377
    |
    Published online on: June 14, 2017
       https://doi.org/10.3892/ijmm.2017.3029
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Balanced translocations are known to be associated with infertility, spontaneous abortions and birth defects in mammals. Spermatocyte spreading and immunostaining were applied to detect meiotic prophase I progression, homologous chromosome pairing, synapsis and recombination in an azoospermic reciprocal translocation 46,X,t(Y;1)(p11.3;p31) carrier. Histological examination of testicular sections revealed a severely reduced number of germ cells with no spermatids or sperm in the carrier. A significant reduction in XY recombination was observed in the patient. The number of MLH1 foci on autosomes that are not involved in the translocation per cell was also significantly decreased in our patient as compared to the controls, which indicates an inter-chromosomal effect (ICE) of the translocation on recombination. An increase in leptotene (P<0.001) and zygotene (P<0.001) and a decrease in pachytene spermatocytes (P<0.001) were observed in the carrier when compared with the controls, indicating disturbed meiotic progression in the patient. Increased RAD51 foci during pachytene (P=0.02) in the spermatocytes of the patient were noted. A decreased expression of the genes (USP1, INSL5, LEPR and MSH4) critical for meiosis/spermatogenesis and located around the breakpoint region of chromosome 1 was observed in the 46,X,t(Y;1) carrier, which may further exacerbate the meiotic failure such as reduced recombination on autosomes and ultimately cause spermatogenesis arrest. In summary, we report a series of events that may have caused infertility in our 46,X,t(Y;1) carrier. To the best of our knowledge, this is the first report shedding light on how, possibly, a reciprocal translocation affects meiosis at the molecular level in azoospermia patients.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

Figure 6

Figure 7

Figure 8

Figure 9

View References

1 

Alves C, Carvalho F, Cremades N, Sousa M and Barros A: Unique (Y;13) translocation in a male with oligozoospermia: Cytogenetic and molecular studies. Eur J Hum Genet. 10:467–474. 2002. View Article : Google Scholar : PubMed/NCBI

2 

Hsu LY: Phenotype/karyotype correlations of Y chromosome aneuploidy with emphasis on structural aberrations in postnatally diagnosed cases. Am J Med Genet. 53:108–140. 1994. View Article : Google Scholar : PubMed/NCBI

3 

Alitalo T, Tiihonen J, Hakola P and de la Chapelle A: Molecular characterization of a Y;15 translocation segregating in a family. Hum Genet. 79:29–35. 1988. View Article : Google Scholar : PubMed/NCBI

4 

Brisset S, Izard V, Misrahi M, Aboura A, Madoux S, Ferlicot S, Schoevaert D, Soufir JC, Frydman R and Tachdjian G: Cytogenetic, molecular and testicular tissue studies in an infertile 45, X male carrying an unbalanced (Y;22) translocation: Case report. Hum Reprod. 20:2168–2172. 2005. View Article : Google Scholar : PubMed/NCBI

5 

Gunel M, Cavkaytar S, Ceylaner G and Batioglu S: Azoospermia and cryptorchidism in a male with a de novo reciprocal t(Y;16) translocation. Genet Couns. 19:277–280. 2008.PubMed/NCBI

6 

Jiang YT, Zhang HG, Wang RX, Yu Y, Zhang ZH and Liu RZ: Novel Y chromosome breakpoint in an infertile male with a de novo translocation t(Y;16): A case report. J Assist Reprod Genet. 29:1427–1430. 2012. View Article : Google Scholar : PubMed/NCBI

7 

Conte RA, Kleyman SM, Klein V, Bialer MG and Verma RS: Characterization of a de novo t(Y;9) (q11.2;q22) by FISH technique. Ann Genet. 39:10–15. 1996.PubMed/NCBI

8 

Vásquez-Velásquez AI, Arnaud-López L, Figuera LE, Padilla-Gutiérrez JR, Rivas F and Rivera H: Ambiguous genitalia by p9 p deletion inherent to a dic(Y;9)(q12;p24). J Appl Genet. 46:415–418. 2005.

9 

Röpke A, Stratis Y, Dossow-Scheele D, Wieacker P, Kliesch S and Tüttelmann F: Mosaicism for an unbalanced Y;21 translocation in an infertile man: A case report. J Assist Reprod Genet. 30:1553–1558. 2013. View Article : Google Scholar : PubMed/NCBI

10 

Sun F, Oliver-Bonet M, Turek PJ, Ko E and Martin RH: Meiotic studies in an azoospermic human translocation (Y;1) carrier. Mol Hum Reprod. 11:361–364. 2005. View Article : Google Scholar : PubMed/NCBI

11 

Jiang H, Wang L, Cui Y, Xu Z, Guo T, Cheng D, Xu P, Yu W and Shi Q: Meiotic chromosome behavior in a human male t(8;15) carrier. J Genet Genomics. 41:177–185. 2014. View Article : Google Scholar : PubMed/NCBI

12 

Pan Z, Yang Q, Ye N, Wang L, Li J, Yu D, Cooke HJ and Shi Q: Complex relationship between meiotic recombination frequency and autosomal synaptonemal complex length per cell in normal human males. Am J Med Genet A. 158A:581–587. 2012. View Article : Google Scholar : PubMed/NCBI

13 

Xu B, Hua J, Zhang Y, Jiang X, Zhang H, Ma T, Zheng W, Sun R, Shen W, Sha J, et al: Proliferating cell nuclear antigen (PCNA) regulates primordial follicle assembly by promoting apoptosis of oocytes in fetal and neonatal mouse ovaries. PLoS One. 6:e160462011. View Article : Google Scholar : PubMed/NCBI

14 

Ashley T, Plug AW, Xu J, Solari AJ, Reddy G, Golub EI and Ward DC: Dynamic changes in Rad51 distribution on chromatin during meiosis in male and female vertebrates. Chromosoma. 104:19–28. 1995. View Article : Google Scholar : PubMed/NCBI

15 

Moens PB, Chen DJ, Shen Z, Kolas N, Tarsounas M, Heng HH and Spyropoulos B: Rad51 immunocytology in rat and mouse spermatocytes and oocytes. Chromosoma. 106:207–215. 1997. View Article : Google Scholar : PubMed/NCBI

16 

Gonsalves J, Sun F, Schlegel PN, Turek PJ, Hopps CV, Greene C, Martin RH and Pera RA: Defective recombination in infertile men. Hum Mol Genet. 13:2875–2883. 2004. View Article : Google Scholar : PubMed/NCBI

17 

Vidal F, Navarro J, Templado C, Marina S and Egozcue J: Development and behavior of synaptonemal complexes in human spermatocytes by light and electron microscopy. Hum Genet. 68:142–147. 1984. View Article : Google Scholar : PubMed/NCBI

18 

von Wettstein D, Rasmussen SW and Holm PB: The synaptonemal complex in genetic segregation. Annu Rev Genet. 18:331–413. 1984. View Article : Google Scholar : PubMed/NCBI

19 

Walpita D, Plug AW, Neff NF, German J and Ashley T: Bloom's syndrome protein, BLM, colocalizes with replication protein A in meiotic prophase nuclei of mammalian spermatocytes. Proc Natl Acad Sci. 96:5622–5627. 1999. View Article : Google Scholar : PubMed/NCBI

20 

Mahadevaiah SK, Turner JM, Baudat F, Rogakou EP, de Boer P, Blanco-Rodríguez J, Jasin M, Keeney S, Bonner WM and Burgoyne PS: Recombinational DNA double-strand breaks in mice precede synapsis. Nat Genet. 27:271–276. 2001. View Article : Google Scholar : PubMed/NCBI

21 

Turner JM, Aprelikova O, Xu X, Wang R, Kim S, Chandramouli GV, Barrett JC, Burgoyne PS and Deng CX: BRCA1, histone H2AX phosphorylation, and male meiotic sex chromosome inactivation. Curr Biol. 14:2135–2142. 2004. View Article : Google Scholar : PubMed/NCBI

22 

Perrin A, Douet-Guilbert N, Le Bris MJ, Keromnes G, Langlois ML, Barrière P, Amice J, Amice V, De Braekeleer M and Morel F: Segregation of chromosomes in sperm of a t(X;18) (q11;p11.1) carrier inherited from his mother: Case report. Hum Reprod. 23:227–230. 2008. View Article : Google Scholar

23 

Pinho MJ, Neves R, Costa P, Ferrás C, Sousa M, Alves C, Almeida C, Fernandes S, Silva J, Ferrás L, et al: Unique t(Y;1) (q12;q12) reciprocal translocation with loss of the hetero-chromatic region of chromosome 1 in a male with azoospermia due to meiotic arrest: A case report. Hum Reprod. 20:689–696. 2005. View Article : Google Scholar : PubMed/NCBI

24 

Ferguson KA, Chow V and Ma S: Silencing of unpaired meiotic chromosomes and altered recombination patterns in an azoospermic carrier of a t(8;13) reciprocal translocation. Hum Reprod. 23:988–995. 2008. View Article : Google Scholar : PubMed/NCBI

25 

Oliver-Bonet M, Ko E and Martin RH: Male infertility in reciprocal translocation carriers: The sex body affair. Cytogenet Genome Res. 111:343–346. 2005. View Article : Google Scholar : PubMed/NCBI

26 

Leng M, Li G, Zhong L, Hou H, Yu D and Shi Q: Abnormal synapses and recombination in an azoospermic male carrier of a reciprocal translocation t(1;21). Fertil Steril. 91:1293.e1217–1222. 2009. View Article : Google Scholar

27 

Turner JM: Meiotic sex chromosome inactivation. Development. 134:1823–1831. 2007. View Article : Google Scholar : PubMed/NCBI

28 

Turner JM, Mahadevaiah SK, Fernandez-Capetillo O, Nussenzweig A, Xu X, Deng CX and Burgoyne PS: Silencing of unsynapsed meiotic chromosomes in the mouse. Nat Genet. 37:41–47. 2005.

29 

Baarends WM, Wassenaar E, van der Laan R, Hoogerbrugge J, Sleddens-Linkels E, Hoeijmakers JH, de Boer P and Grootegoed JA: Silencing of unpaired chromatin and histone H2A ubiquitination in mammalian meiosis. Mol Cell Biol. 25:1041–1053. 2005. View Article : Google Scholar : PubMed/NCBI

30 

Schoenmakers S, Wassenaar E, van Cappellen WA, Derijck AA, de Boer P, Laven JS, Grootegoed JA and Baarends WM: Increased frequency of asynapsis and associated meiotic silencing of heterologous chromatin in the presence of irradiation-induced extra DNA double strand breaks. Dev Biol. 317:270–281. 2008. View Article : Google Scholar : PubMed/NCBI

31 

Forejt J: Hybrid sterility in the mouse. Trends Genet. 12:412–417. 1996. View Article : Google Scholar : PubMed/NCBI

32 

Homolka D, Jansa P and Forejt J: Genetically enhanced asynapsis of autosomal chromatin promotes transcriptional dysregulation and meiotic failure. Chromosoma. 121:91–104. 2012. View Article : Google Scholar :

33 

Burgoyne PS, Mahadevaiah SK and Turner JM: The consequences of asynapsis for mammalian meiosis. Nat Rev Genet. 10:207–216. 2009. View Article : Google Scholar : PubMed/NCBI

34 

Mahadevaiah SK, Bourc'his D, de Rooij DG, Bestor TH, Turner JM and Burgoyne PS: Extensive meiotic asynapsis in mice antagonises meiotic silencing of unsynapsed chromatin and consequently disrupts meiotic sex chromosome inactivation. J Cell Biol. 182:263–276. 2008. View Article : Google Scholar : PubMed/NCBI

35 

Manterola M, Page J, Vasco C, Berríos S, Parra MT, Viera A, Rufas JS, Zuccotti M, Garagna S and Fernández-Donoso R: A high incidence of meiotic silencing of unsynapsed chromatin is not associated with substantial pachytene loss in heterozygous male mice carrying multiple simple robertsonian translocations. PLoS Genet. 5:e10006252009. View Article : Google Scholar : PubMed/NCBI

36 

Mark M, Jacobs H, Oulad-Abdelghani M, Dennefeld C, Féret B, Vernet N, Codreanu CA, Chambon P and Ghyselinck NB: STRA8-deficient spermatocytes initiate, but fail to complete, meiosis and undergo premature chromosome condensation. J Cell Sci. 121:3233–3242. 2008. View Article : Google Scholar : PubMed/NCBI

37 

Zimmermann C, Romero Y, Warnefors M, Bilican A, Borel C, Smith LB, Kotaja N, Kaessmann H and Nef S: Germ cell-specific targeting of DICER or DGCR8 reveals a novel role for endo-siRNAs in the progression of mammalian spermatogenesis and male fertility. PLoS One. 9:e1070232014. View Article : Google Scholar : PubMed/NCBI

38 

Subramanian VV and Hochwagen A: The meiotic checkpoint network: Step-by-step through meiotic prophase. Cold Spring Harb Perspect Biol. 6:a0166752014. View Article : Google Scholar : PubMed/NCBI

39 

Harewood L, Schütz F, Boyle S, Perry P, Delorenzi M, Bickmore WA and Reymond A: The effect of translocation-induced nuclear reorganization on gene expression. Genome Res. 20:554–564. 2010. View Article : Google Scholar : PubMed/NCBI

40 

Kleinjan DA and van Heyningen V: Long-range control of gene expression: Emerging mechanisms and disruption in disease. Am J Hum Genet. 76:8–32. 2005. View Article : Google Scholar :

41 

Wang W: Emergence of a DNA-damage response network consisting of Fanconi anaemia and BRCA proteins. Nat Rev Genet. 8:735–748. 2007. View Article : Google Scholar : PubMed/NCBI

42 

Kim JM, Parmar K, Huang M, Weinstock DM, Ruit CA, Kutok JL and D'Andrea AD: Inactivation of murine Usp1 results in genomic instability and a Fanconi anemia phenotype. Dev Cell. 16:314–320. 2009. View Article : Google Scholar : PubMed/NCBI

43 

Burnicka-Turek O, Mohamed BA, Shirneshan K, Thanasupawat T, Hombach-Klonisch S, Klonisch T and Adham IM: INSL5-deficient mice display an alteration in glucose homeostasis and an impaired fertility. Endocrinology. 153:4655–4665. 2012. View Article : Google Scholar : PubMed/NCBI

44 

Tartaglia LA: The leptin receptor. J Biol Chem. 272:6093–6096. 1997. View Article : Google Scholar : PubMed/NCBI

45 

de Luca C, Kowalski TJ, Zhang Y, Elmquist JK, Lee C, Kilimann MW, Ludwig T, Liu SM and Chua SC Jr: Complete rescue of obesity, diabetes, and infertility in db/db mice by neuron-specific LEPR-B transgenes. J Clin Invest. 115:3484–3493. 2005. View Article : Google Scholar : PubMed/NCBI

46 

Paquis-Flucklinger V, Santucci-Darmanin S, Paul R, Saunières A, Turc-Carel C and Desnuelle C: Cloning and expression analysis of a meiosis-specific MutS homolog: The human MSH4 gene. Genomics. 44:188–194. 1997. View Article : Google Scholar : PubMed/NCBI

47 

Winand NJ, Panzer JA and Kolodner RD: Cloning and characterization of the human and Caenorhabditis elegans homologs of the Saccharomyces cerevisiae MSH5 gene. Genomics. 53:69–80. 1998. View Article : Google Scholar : PubMed/NCBI

48 

Kneitz B, Cohen PE, Avdievich E, Zhu L, Kane MF, Hou H Jr, Kolodner RD, Kucherlapati R, Pollard JW and Edelmann W: MutS homolog 4 localization to meiotic chromosomes is required for chromosome pairing during meiosis in male and female mice. Genes Dev. 14:1085–1097. 2000.PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Li G, Iqbal F, Wang L, Xu Z, Che X, Yu W, Shi L, Guo T, Zhou G, Jiang X, Jiang X, et al: Meiotic defects and decreased expression of genes located around the chromosomal breakpoint in the testis of a patient with a novel 46,X,t(Y;1)(p11.3;p31) translocation. Int J Mol Med 40: 367-377, 2017.
APA
Li, G., Iqbal, F., Wang, L., Xu, Z., Che, X., Yu, W. ... Yu, D. (2017). Meiotic defects and decreased expression of genes located around the chromosomal breakpoint in the testis of a patient with a novel 46,X,t(Y;1)(p11.3;p31) translocation. International Journal of Molecular Medicine, 40, 367-377. https://doi.org/10.3892/ijmm.2017.3029
MLA
Li, G., Iqbal, F., Wang, L., Xu, Z., Che, X., Yu, W., Shi, L., Guo, T., Zhou, G., Jiang, X., Zhang, H., Zhang, Y., Yu, D."Meiotic defects and decreased expression of genes located around the chromosomal breakpoint in the testis of a patient with a novel 46,X,t(Y;1)(p11.3;p31) translocation". International Journal of Molecular Medicine 40.2 (2017): 367-377.
Chicago
Li, G., Iqbal, F., Wang, L., Xu, Z., Che, X., Yu, W., Shi, L., Guo, T., Zhou, G., Jiang, X., Zhang, H., Zhang, Y., Yu, D."Meiotic defects and decreased expression of genes located around the chromosomal breakpoint in the testis of a patient with a novel 46,X,t(Y;1)(p11.3;p31) translocation". International Journal of Molecular Medicine 40, no. 2 (2017): 367-377. https://doi.org/10.3892/ijmm.2017.3029
Copy and paste a formatted citation
x
Spandidos Publications style
Li G, Iqbal F, Wang L, Xu Z, Che X, Yu W, Shi L, Guo T, Zhou G, Jiang X, Jiang X, et al: Meiotic defects and decreased expression of genes located around the chromosomal breakpoint in the testis of a patient with a novel 46,X,t(Y;1)(p11.3;p31) translocation. Int J Mol Med 40: 367-377, 2017.
APA
Li, G., Iqbal, F., Wang, L., Xu, Z., Che, X., Yu, W. ... Yu, D. (2017). Meiotic defects and decreased expression of genes located around the chromosomal breakpoint in the testis of a patient with a novel 46,X,t(Y;1)(p11.3;p31) translocation. International Journal of Molecular Medicine, 40, 367-377. https://doi.org/10.3892/ijmm.2017.3029
MLA
Li, G., Iqbal, F., Wang, L., Xu, Z., Che, X., Yu, W., Shi, L., Guo, T., Zhou, G., Jiang, X., Zhang, H., Zhang, Y., Yu, D."Meiotic defects and decreased expression of genes located around the chromosomal breakpoint in the testis of a patient with a novel 46,X,t(Y;1)(p11.3;p31) translocation". International Journal of Molecular Medicine 40.2 (2017): 367-377.
Chicago
Li, G., Iqbal, F., Wang, L., Xu, Z., Che, X., Yu, W., Shi, L., Guo, T., Zhou, G., Jiang, X., Zhang, H., Zhang, Y., Yu, D."Meiotic defects and decreased expression of genes located around the chromosomal breakpoint in the testis of a patient with a novel 46,X,t(Y;1)(p11.3;p31) translocation". International Journal of Molecular Medicine 40, no. 2 (2017): 367-377. https://doi.org/10.3892/ijmm.2017.3029
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team