Open Access

Anti-obesity effects of yellow catfish protein hydrolysate on mice fed a 45% kcal high-fat diet

  • Authors:
    • Mi-Ryung Kim
    • Joo-Wan Kim
    • Jeong Been Park
    • Yong-Ki Hong
    • Sae Kwang Ku
    • Jae-Suk Choi
  • View Affiliations

  • Published online on: July 10, 2017     https://doi.org/10.3892/ijmm.2017.3063
  • Pages:784-800
0

Abstract

Obesity contributes to the etiologies of a variety of comorbid conditions, such as type 2 diabetes, hypertension and cardiovascular disease. In the present study, the anti-obesity effects of yellow catfish protein hydrolysate (YPh) were observed in mice fed a 45% kcal high-fat diet (HFD) compared with those of mice treated with simvastatin. The HFD-fed control mice exhibited noticeable increase in body weight, and whole-body and abdominal fat densities, periovarian and abdominal wall-deposited fat pad weight, as well as in the levels of triglycerides (TG), blood total cholesterol (TC), low-density lipoprotein, alanine aminotransferase, aspartate aminotransferase, creatinine, blood urea nitrogen, and in the fecal TG and TC contents. However, they exhibited a decrease in serum high-density lipoprotein levels. In addition, an increase was detected in periovarian and dorsal abdominally deposited fat pad thickness, adipocyte hypertrophy, the number of steatohepatitis regions, hepatocyte hypertrophy and lipid droplet deposition-related renal tubular vacuolation degenerative lesions, along with increased hepatic lipid peroxidation and a deteriorated endogenous antioxidant defense system (glutathione, catalase and superoxide dismutase). However, all the above-mentioned obesity-related complications were dose-dependently and significantly inhibited after 84 days of thye consecutive oral administration of 125, 250 and 500 mg/kg YPh. In addition, YPh dose-dependently depleted the liver endogenous antioxidant defense system and inhibited hepatic lipid peroxidation. Overall, the effects of 250 mg/kg YPh on HFD-induced obesity and related complications were similar or more potent than those of 10 mg/kg simvastatin. These results indicate that YPh is a promising new potent medicinal ingredient for possible use in the treatment of obesity and related complications.

Related Articles

Journal Cover

September 2017
Volume 40 Issue 3

Print ISSN: 1107-3756
Online ISSN:1791-244X

2016 Impact Factor: 2.341
Ranked #21/128 Medicine Research and Experimental
(total number of cites)

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
APA
Kim, M., Kim, J., Park, J.B., Hong, Y., Ku, S.K., & Choi, J. (2017). Anti-obesity effects of yellow catfish protein hydrolysate on mice fed a 45% kcal high-fat diet. International Journal of Molecular Medicine, 40, 784-800. https://doi.org/10.3892/ijmm.2017.3063
MLA
Kim, M., Kim, J., Park, J. B., Hong, Y., Ku, S. K., Choi, J."Anti-obesity effects of yellow catfish protein hydrolysate on mice fed a 45% kcal high-fat diet". International Journal of Molecular Medicine 40.3 (2017): 784-800.
Chicago
Kim, M., Kim, J., Park, J. B., Hong, Y., Ku, S. K., Choi, J."Anti-obesity effects of yellow catfish protein hydrolysate on mice fed a 45% kcal high-fat diet". International Journal of Molecular Medicine 40, no. 3 (2017): 784-800. https://doi.org/10.3892/ijmm.2017.3063