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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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International Journal of Molecular Medicine

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Journal Cover
September-2017 Volume 40 Issue 3

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Journal Metrics

Impact Factor: 5.8

CiteScore: 13.2

CiteScore Rank: Q1: #23/348 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 1.28

SCImago Journal Rank (SJR): 1.381

Review Open Access

Molecular genetics and targeted therapy of WNT-related human diseases (Review)

Masuko Katoh, Masaru Katoh
Pages: 587-606
Published online on: 19 July 2017

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Review Open Access

Dietary fiber in irritable bowel syndrome (Review)

Magdy El-Salhy, Synne Otterasen Ystad, Tarek Mazzawi, Doris Gundersen
Pages: 607-613
Published online on: 19 July 2017

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Article Open Access

Establishment and characterization of cell lines derived from complete hydatidiform mole

Eiko Yamamoto, Kaoru Niimi, Tohru Kiyono, Toshimichi Yamamoto, Kimihiro Nishino, Kenichi Nakamura, Tomomi Kotani, Hiroaki Kajiyama, Kiyosumi Shibata, Fumitaka Kikkawa
Pages: 614-622
Published online on: 14 July 2017

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Article Open Access

Bisphosphonate inhibits the expression of cyclin A2 at the transcriptional level in normal human oral keratinocytes

Rachel S. Lee, Suhjin Sohn, Ki-Hyuk Shin, Mo K. Kang, No-Hee Park, Reuben H. Kim
Pages: 623-630
Published online on: 12 July 2017

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Article Open Access

Soyasaponin Ag inhibits α‑MSH‑induced melanogenesis in B16F10 melanoma cells via the downregulation of TRP‑2

Seung Hwan Yang, Aristides M. Tsatsakis, George Tzanakakis, Hong‑Suk Kim, Bao Le, Maria Sifaki, Demetrios A. Spandidos, Chigen Tsukamoto, Kirill S. Golokhvast, Boris N. Izotov, Gyuhwa Chung
Pages: 631-636
Published online on: 10 July 2017

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Article Open Access

Visfatin induces the apoptosis of endothelial progenitor cells via the induction of pro-inflammatory mediators through the NF-κB pathway

Lina Sun, Shuchun Chen, Haina Gao, Luping Ren, Guangyao Song
Pages: 637-646
Published online on: 03 July 2017

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Article Open Access

Comparison of gene expression profiles between dental pulp and periodontal ligament tissues in humans

Ai-Xiu Gong, Jing-Han Zhang, Jing Li, Jun Wu, Lin Wang, Deng-Shun Miao
Pages: 647-660
Published online on: 12 July 2017

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Article Open Access

Regulation of retinoic acid synthetic enzymes by WT1 and HDAC inhibitors in 293 cells

Yifan Li, Lei Wang, Weipeng Ai, Nianhui He, Lin Zhang, Jihui Du, Yong Wang, Xingjian Mao, Junqi Ren, Dan Xu, Bei Zhou, Rong Li, Liwen Mai
Pages: 661-672
Published online on: 03 July 2017

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Article Open Access

Inactivation of MSH3 by promoter methylation correlates with primary tumor stage in nasopharyngeal carcinoma

Haifeng Ni, Bo Jiang, Zhen Zhou, Xiaoyang Yuan, Xiaolin Cao, Guangwu Huang, Yong Li
Pages: 673-678
Published online on: 27 June 2017

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Article Open Access

Designer D-form self-assembling peptide scaffolds promote the proliferation and migration of rat bone marrow-derived mesenchymal stem cells

Shuo Chen, Ao Zhou, Bin He, Weikang Zhao, Xiaojun Chen, Dianming Jiang
Pages: 679-688
Published online on: 05 July 2017

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Article Open Access

Systematic analysis of lncRNAs, miRNAs and mRNAs for the identification of biomarkers for osteoporosis in the mandible of ovariectomized mice

Lingyu Hao, Jiayao Fu, Yawen Tian, Junhua Wu
Pages: 689-702
Published online on: 10 July 2017

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Article Open Access

Assessment of the antioxidant activity of an olive oil total polyphenolic fraction and hydroxytyrosol from a Greek Olea europea variety in endothelial cells and myoblasts

Paraskevi Kouka, Alexandros Priftis, Dimitrios Stagos, Apostolis Angelis, Panagiotis Stathopoulos, Nikos Xinos, Alexios‑Léandros Skaltsounis, Charalampos Mamoulakis, Aristides M. Tsatsakis, Demetrios A. Spandidos, Demetrios Kouretas
Pages: 703-712
Published online on: 20 July 2017

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Article Open Access

Botulinum toxin A improves adipose tissue engraftment by promoting cell proliferation, adipogenesis and angiogenesis

Qi Tang, Chang Chen, Xiaqi Wang, Wei Li, Yan Zhang, Muyao Wang, Wei Jing, Hang Wang, Weihua Guo, Weidong Tian
Pages: 713-720
Published online on: 19 July 2017

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Article Open Access

Multi-glycoside of Tripterygium wilfordii Hook. f. attenuates glomerulosclerosis in a rat model of diabetic nephropathy by exerting anti-microinflammatory effects without affecting hyperglycemia

Wei Wu, Jing-Jing Yang, Hai-Ming Yang, Meng-Meng Huang, Qi-Jun Fang, Ge Shi, Zhi-Min Mao, Wen-Bei Han, Shan-Mei Shen, Yi-Gang Wan
Pages: 721-730
Published online on: 17 July 2017

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Article Open Access

Overexpression of non‑SMC condensin I complex subunit G serves as a promising prognostic marker and therapeutic target for hepatocellular carcinoma

Wanwei Liu, Bo Liang, Hongliang Liu, Yong Huang, Xiangbao Yin, Fan Zhou, Xin Yu, Qian Feng, Enliang Li, Zhenhong Zou, Linquan Wu
Pages: 731-738
Published online on: 24 July 2017

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Valproic acid enforces the priming effect of sphingosine-1 phosphate on human mesenchymal stem cells

Jisun Lim, Seungun Lee, Hyein Ju, Yonghwan Kim, Jinbeom Heo, Hye-Yeon Lee, Kyung-Chul Choi, Jaekyoung Son, Yeon-Mok Oh, In-Gyu Kim, Dong-Myung Shin
Pages: 739-747
Published online on: 03 July 2017

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Article Open Access

Glutathione peroxidase 3 is a protective factor against acetaminophen‑induced hepatotoxicity in vivo and in vitro

Syu-Ichi Kanno, Ayako Tomizawa, Shin Yomogida, Akiyoshi Hara
Pages: 748-754
Published online on: 03 July 2017

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Article Open Access

Progesterone suppresses triple-negative breast cancer growth and metastasis to the brain via membrane progesterone receptor α

Li Zhou, Wei Zhou, Hongwei Zhang, Yan Hu, Lei Yu, Yufei Zhang, Yanli Zhang, Shuang Wang, Peng Wang, Wei Xia
Pages: 755-761
Published online on: 07 July 2017

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Article Open Access

Simvastatin ameliorates ionizing radiation-induced apoptosis in the thymus by activating the AKT/sirtuin 1 pathway in mice

Hong Yang, Fei Huang, Yulong Tao, Xinbin Zhao, Lina Liao, Xia Tao
Pages: 762-770
Published online on: 03 July 2017

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Article Open Access

Transcriptome profiling of the subventricular zone and dentate gyrus in an animal model of Parkinson's disease

Xin-Jie Bao, Geng-Chao Wang, Fu-Xing Zuo, Xue-Yuan Li, Jun Wu, Guo Chen, Wan‑Chen Dou, Yi Guo, Qin Shen, Ren-Zhi Wang
Pages: 771-783
Published online on: 03 July 2017

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Article Open Access

Anti-obesity effects of yellow catfish protein hydrolysate on mice fed a 45% kcal high-fat diet

Mi-Ryung Kim, Joo-Wan Kim, Jeong Been Park, Yong-Ki Hong, Sae Kwang Ku, Jae-Suk Choi
Pages: 784-800
Published online on: 10 July 2017

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Article Open Access

An optimized gene transfection system in WERI-Rb1 cells

Ying Liu, Zhigang Fan, Kang Li, Fei Deng, Yunfan Xiong, Meixin Liang, Jian Ge
Pages: 801-813
Published online on: 06 July 2017

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Article Open Access

miR‑146b‑5p promotes the neural conversion of pluripotent stem cells by targeting Smad4

Nianping Zhang, Ying Lyu, Xuebing Pan, Liping Xu, Aiguo Xuan, Xiaosong He, Wandan Huang, Dahong Long
Pages: 814-824
Published online on: 11 July 2017

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Article Open Access

Paeoniflorin exerts neuroprotective effects against glutamate‑induced PC12 cellular cytotoxicity by inhibiting apoptosis

Ahong Chen, Hongyun Wang, Yuqin Zhang, Xiaoying Wang, Lishuang Yu, Wen Xu, Wei Xu, Yu Lin
Pages: 825-833
Published online on: 20 July 2017

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Article Open Access

Comparison of isolation methods of exosomes and exosomal RNA from cell culture medium and serum

Yue-Ting Tang, Yi-Yao Huang, Lei Zheng, Si-Hua Qin, Xu-Ping Xu, Tai-Xue An, Yong Xu, Ying-Song Wu, Xiu-Mei Hu, Bao-Hong Ping, Qian Wang
Pages: 834-844
Published online on: 24 July 2017

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Article Open Access

Piezo1 protein induces the apoptosis of human osteoarthritis-derived chondrocytes by activating caspase-12, the signaling marker of ER stress Retraction in /10.3892/ijmm.2018.3918

Xiao-Fei Li, Zhao Zhang, Zhu-Ke Chen, Zhao-Wei Cui, Hai-Ning Zhang
Pages: 845-853
Published online on: 19 July 2017

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Article

α2-antiplasmin modulates bone formation by negatively regulating osteoblast differentiation and function

Yosuke Kanno, Akira Ishisaki, Hiromi Kuretake, Chihiro Maruyama, Ayaka Matsuda, Osamu Matsuo
Pages: 854-858
Published online on: 05 July 2017

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Article

Inhibition of pre-B cell colony-enhancing factor attenuates inflammation induced by hyperoxia in EA.hy926 cells

Jia Yu He, Huan Jin Cui, Li Jun Tang, Jinwen Chen, Wei Min Huang
Pages: 859-866
Published online on: 29 June 2017

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Article

MicroRNA-582 promotes tumorigenesis by targeting phosphatase and tensin homologue in colorectal cancer

Bin Song, Yanbin Long, Dong Liu, Wen Zhang, Chang Liu
Pages: 867-874
Published online on: 06 July 2017

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Article

Roles of electro-acupuncture in glucose metabolism as assessed by 18F-FDG/PET imaging and AMPKα phosphorylation in rats with ischemic stroke

Jingsong Wu, Bingbing Lin, Weilin Liu, Jia Huang, Guanhao Shang, Yunjiao Lin, Lulu Wang, Lidian Chen, Jing Tao
Pages: 875-882
Published online on: 06 July 2017

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Article

Aberrant expression of RSK4 in breast cancer and its role in the regulation of tumorigenicity

Yi Jiang, Xinqing Ye, Yinan Ji, Xiao Zhou, Huawei Yang, Wei Wei, Qiuyun Li
Pages: 883-890
Published online on: 17 July 2017

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Article

MicroRNA-492 overexpression exerts suppressive effects on the progression of osteosarcoma by targeting PAK7

Xuanhe Song, Yaoping Xie, Yang Liu, Ming Shao, Weiliang Yang
Pages: 891-897
Published online on: 29 June 2017

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Article

NLRC3 promotes host resistance against Pseudomonas aeruginosa-induced keratitis by promoting the degradation of IRAK1

Litao Guo, Qingzhu Kong, Zhijun Dong, Weili Dong, Xiaoxiao Fu, Leqi Su, Xiaobo Tan
Pages: 898-906
Published online on: 20 July 2017

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Article

Sulforaphane inhibits the interferon-γ-induced expression of MIG, IP-10 and I-TAC in INS‑1 pancreatic β-cells through the downregulation of IRF-1, STAT-1 and PKB

Yu-Kyoung Park, Mahesh Ramalingam, Shin Kim, Byeong-Churl Jang, Jong Wook Park
Pages: 907-912
Published online on: 03 July 2017

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Article

Mulberry granules protect against diabetic cardiomyopathy through the AMPK/Nrf2 pathway

Yang Liu, Yan-Bo Zhao, Si-Wang Wang, Yu Zhou, Zhi-Shu Tang, Feng Li
Pages: 913-921
Published online on: 03 July 2017

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Article

Protective role of Pollen Typhae total flavone against the palmitic acid-induced impairment of glucose-stimulated insulin secretion involving GPR40 signaling in INS-1 cells

Xiao-Tao Feng, Hui-Ming Duan, Shuang-Lei Li
Pages: 922-930
Published online on: 18 July 2017

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Article

Irrelevance of anti‑nAChR cytoplasmic loop antibody in the degree of myasthenia gravis

Ye Lin, Chen Song, Jiang Xu, Yongxiang Yang, Hang Qin, Cong Zhao, Jiaji Lin, Rui Liu, Zhuyi Li
Pages: 931-939
Published online on: 19 July 2017

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Journal Cover
February-2026 Volume 57 Issue 2

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Journal Metrics

Impact Factor: 5.8

CiteScore: 13.2

CiteScore Rank: Q1: #23/348 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 1.28

SCImago Journal Rank (SJR): 1.381

Review Open Access

miR‑205: A dual regulator of angiogenesis in health and disease (Review)

Maria Oltra, Miriam Martínez‑Santos, Maria Ybarra, Maria Pires, Chiara Ceresoni, Clara Gomis‑Coloma, Cristina Medina‑Trillo, Javier Sancho, Jorge Barcia
Article Number: 51
Published online on: 29 December 2025

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Astragaloside IV: A multipotent phytochemical for treating fibrotic diseases (Review)

Mingyu Wu, Ke Li, Jiabin Wu, Qiuyu Zhang, Xiaotong Ma, Wei Dai, Haoyang Gao, Xianyi Ding, Wenhong Wang, Weihua Xiao
Article Number: 50
Published online on: 24 December 2025

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Activating transcription factors: Orchestrators of macrophage biology in pathological settings (Review)

Yue-Chen Liu, Jia-Wei Zhao, Xiong-Tao Yue, Qi-Jie Chen, Shan-Jie Rong, Shi-Wei Liu, Fei Sun, Chun-Liang Yang, Cong-Yi Wang
Article Number: 49
Published online on: 24 December 2025

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Role of SIRT3 in digestive system diseases and therapeutic prospects (Review)

Jiajia Li, Qian Liu, Shun Yao, Xin Li, Li Zhang, Yongfeng Wang, Guorong Wen, Jiaxing An, Hai Jin, Biguang Tuo
Article Number: 48
Published online on: 22 December 2025

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Recombinant ADAMTS‑1 promotes muscle regeneration accompanied by downregulation of Notch signaling

Jin-Hwa Kim, Sang-Hyup Lee, Sang-Yoon Kim, Jeong-Won Kim, Ji-Soo Jeong, Eun-Hye Chung, Su-Ha Lee, Chang-Yeop Kim, Bong-Keun Choi, Je-Won Ko, Tae-Won Kim
Article Number: 47
Published online on: 22 December 2025

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A comprehensive review on pain: Model, target, therapy, and prospect (Review)

Chenyu Chang, Xutao Wu, Kejia Liu, Lei Wang, Mozili Adu, Qingyuan Lin, Huilian Huang, Qinge Ma, Rongrui Wei, Xiaoyun Wang, Wenmin Liu
Article Number: 46
Published online on: 17 December 2025

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[Retracted] Curculigoside attenuates myocardial ischemia‑reperfusion injury by inhibiting the opening of the mitochondrial permeability transition pore

Yanbing Zhao, Yuxuan Guo, Yuqiong Chen, Shuang Liu, Nan Wu, Dalin Jia
Article Number: 45
Published online on: 15 December 2025

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Nanomaterials and exercise interventions: A synergistic approach for atherosclerosis therapy (Review)

Quanquan Zhou, Ge‑Lin Zhang, Weitong Sun, Jiayi Cai, Li-Hua Yu
Article Number: 44
Published online on: 10 December 2025

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Selective autophagic degradation of glycolytic activator PFKFB3 contributes to maintaining intestinal epithelial barrier in inflammatory bowel disease

Yiyang Pan, Feng Yang, Liucan Wang, Tianshu Yang, Guangsheng Du, Cong Xu, Hua Yang, Min Yu, Weidong Xiao
Article Number: 43
Published online on: 10 December 2025

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Lactylation‑mediated ferroptosis: A novel mechanism and therapeutic prospects in human diseases (Review)

Zhengjun Lin, Yugang Zou, Songzhu Zou, Kunming Wen
Article Number: 42
Published online on: 08 December 2025

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Dual role of lactate in ferroptosis: Mechanisms, pathophysiology and therapeutic opportunities (Review)

Qian Yu, Yu Kuang, Jie He, Li Yang, Xinjie Li, Hao Yu
Article Number: 41
Published online on: 08 December 2025

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Retraction Open Access

[Retracted] MicroRNA‑493‑5p promotes apoptosis and suppresses proliferation and invasion in liver cancer cells by targeting VAMP2

Guannan Wang, Xiaosan Fang, Meng Han, Xiaoming Wang, Qiang Huang
Article Number: 40
Published online on: 08 December 2025

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FGF4 alleviates the lung cell damage caused by high glucose via AMPK‑PGC‑1 signaling axis in vitro and in vivo

Qiujuan Fu, Yongfang Ou, Qin Wu, Jue Gong, Feixia Li, Tuxing Wang, Zhitai Lin, Kejie Huang, Jianlong Xie
Article Number: 39
Published online on: 05 December 2025

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STOML2 interacts with PHB to activate the MEK/ERK signaling pathway and mediates autophagy‑related proteins in the progression of hepatocellular carcinoma

Haoyang Hu, Haozhe Zhang, Shuai Han, Jianli Chen, Ying Xie
Article Number: 38
Published online on: 04 December 2025

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HMGB1 mediates low-dose ionizing radiation-induced Wnt/β-catenin activation in SRA01/04 cells: Mechanistic clues to early cataractogenesis

Ping Wang, Chunnan Piao, Dong Yan, Yingxue He, Yaru Li, Li Fan, Mei Tian
Article Number: 37
Published online on: 04 December 2025

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FBXO22 promotes hepatocellular carcinoma progression via paracrine myo‑inositol‑induced M2‑type polarization of macrophages

Liangliang Bai, Jing Xiong, Sihai Chen, Jiahao Hu, Meixia Zhang, Bimin Li, Jing Hu, Mingyan He
Article Number: 36
Published online on: 02 December 2025

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Branched‑chain amino acid metabolism and bone metabolism: Implications for osteoporosis pathogenesis and therapeutic strategies (Review)

Qi Xiao, Haimin Zeng, Ruhui Yang, Yuxin Zhan, Fangzhen Lin, Bofan Chen, Xiang Chen
Article Number: 35
Published online on: 02 December 2025

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Mitochondria-associated endoplasmic reticulum membranes: Emerging regulators of cardiac microvascular ischemia/reperfusion injury (Review)

Yan Wang, Baowei Feng, Yanting Wu, Zongle Sun, Hao Yuan, Wei Chen, Chang Zhao, Zhi Liu
Article Number: 34
Published online on: 02 December 2025

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Role of matrix metalloproteinases in the invasion of glioblastoma and drug interventions (Review)

Bohao Zheng, Ying Han, Haiying Zhang
Article Number: 33
Published online on: 01 December 2025

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Review

Bridging bench to bedside: Exosome‑based strategies for endometriosis diagnosis and treatment (Review)

Wanmeng Chen, Yujiu Ma, Xudong Zhang, Siwen Zhang, Shanshan Wu, Yimeng Lu, Jichun Tan
Article Number: 32
Published online on: 01 December 2025

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Retraction Open Access

[Retracted] miR‑381 functions as a tumor suppressor by targeting ETS1 in pancreatic cancer

Guanen Qiao, Jing Li, Jun Wang, Zhaoyang Wang, Wei Bian
Article Number: 31
Published online on: 01 December 2025

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March-2026 Volume 57 Issue 3

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Impact Factor: 5.8

CiteScore: 13.2

CiteScore Rank: Q1: #23/348 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 1.28

SCImago Journal Rank (SJR): 1.381

Review Open Access

Environmental exposure to air pollution and climate: Intersecting the impact on ear and nose health and chemosensory function (Review)

Yu-Chen Zhang, Lei Zhang, Ping-Ting Zhou, Zi-Hui Xie, Wen-Jie Zhang, Min Fan, Yan-Xun Han, Ye-Hai Liu, Yu-Chen Liu
Article Number: 55
Published online on: 31 December 2025

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Review Open Access

Role and mechanisms of ferroptosis in cognitive impairment: From molecular pathways to therapeutic targets (Review)

Shenghui Ge, Deyue Kong, Shuyue Fan, Yi Luo, Xiao Yin, Zehua Jin, Wenqing Xia, Jianhua Ma
Article Number: 54
Published online on: 30 December 2025

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Review Open Access

The GPR124‑Wnt‑PPARγ regulatory axis: Molecular mechanisms and therapeutic implications in chronic inflammatory diseases (Review)

Ming-Wang Cui, Si-Yu Tao, Tao Wen, Zhu-Ling Guo
Article Number: 53
Published online on: 30 December 2025

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Review Open Access

Advances in RPGR gene therapy for X‑linked retinitis pigmentosa: From preclinical insights to clinical application (Review)

Yushan Long, Jia Qi, Wenliang Zhang, Huan Qin, Kai Yao
Article Number: 52
Published online on: 30 December 2025

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