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Transcription factors Nrf2 and NF-κB contribute to inflammation and apoptosis induced by intestinal ischemia-reperfusion in mice

  • Authors:
    • Qing-Tao Meng
    • Rong Chen
    • Cheng Chen
    • Ke Su
    • Wei Li
    • Ling-Hua Tang
    • Hui-Min Liu
    • Rui Xue
    • Qian Sun
    • Yan Leng
    • Jia-Bao Hou
    • Yang Wu
    • Zhong-Yuan Xia
  • View Affiliations / Copyright

    Affiliations: Department of Anesthesiology, Renmin Hospital of Wuhan University, Wuhan, Hubei 430060, P.R. China, Department of Nephrology, Renmin Hospital of Wuhan University, Wuhan, Hubei 430060, P.R. China, Department of Anesthesiology, Renmin Hospital of Shiyan City, Hubei University of Medicine, Shiyan, Hubei 442000, P.R. China
    Copyright: © Meng et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 1731-1740
    |
    Published online on: October 2, 2017
       https://doi.org/10.3892/ijmm.2017.3170
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Abstract

Intestinal ischemia/reperfusion (IIR) is a common pathological event associated with intestinal injury and apoptosis with high mortality. Nuclear factor (NF)-E2-related factor-2 (Nrf2) is a key transcription factor that interacts with NF-κB and has a vital anti-inflammatory effect. However, whether Nrf2 has a role in IIR-induced apoptosis and the possible underlining mechanisms, such as modulation of the inflammation regulation pathway, have remained to be fully elucidated. In the present study, IIR was identified to cause significant intestinal injury and apoptosis, with high expression levels of inflammatory cytokines, as well as the apoptotic proteins B-cell lymphoma 2 (Bcl-2)-associated X protein (Bax) and caspase-3, while simultaneously decreasing the protein levels of Bcl-2. The effect was more pronounced after pretreatment of the animals with all-trans retinoic acid or brusatol, potent inhibitors of Nrf2. t-Butylhydroquinone, an Nrf2 activator, significantly attenuated IIR-induced intestinal injury and apoptosis, with inhibition of the overexpression of the inflammatory cytokines, Bax and caspase-3 protein and partial restoration of Bcl-2 protein expression. Taken together, these results indicated that increased Nrf2 expression reduced IIR-induced intestinal apoptosis and that the protective function of Nrf2 may be based on its anti-inflammatory effects through the inhibition of the NF-κB pathway.
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1 

Huang CY, Hsiao JK, Lu YZ, Lee TC and Yu LC: Anti-apoptotic PI3K/Akt signaling by sodium/glucose transporter 1 reduces epithelial barrier damage and bacterial translocation in intestinal ischemia. Lab Invest. 91:294–309. 2011. View Article : Google Scholar

2 

Gerlach UA, Atanasov G, Wallenta L, Polenz D, Reutzel-Selke A, Kloepfel M, Jurisch A, Marksteiner M, Loddenkemper C, Neuhaus P, et al: Short-term TNF-alpha inhibition reduces short-term and long-term inflammatory changes post-ischemia/reperfusion in rat intestinal transplantation. Transplantation. 97:732–739. 2014. View Article : Google Scholar : PubMed/NCBI

3 

Kim M, Park SW, Kim M, D'Agati VD and Lee HT: Isoflurane post-conditioning protects against intestinal ischemia-reperfusion injury and multiorgan dysfunction via transforming growth factor-β1 generation. Ann Surg. 255:492–503. 2012. View Article : Google Scholar : PubMed/NCBI

4 

Crafts TD, Hunsberger EB, Jensen AR, Rescorla FJ, Yoder MC and Markel TA: Direct peritoneal resuscitation improves survival and decreases inflammation after intestinal ischemia and reperfusion injury. J Surg Res. 199:428–434. 2015. View Article : Google Scholar : PubMed/NCBI

5 

Tian S, Guo R, Wei S, Kong Y, Wei X, Wang W, Shi X and Jiang H: Curcumin protects against the intestinal ischemia-reperfusion injury: Involvement of the tight junction protein ZO-1 and TNF-α related mechanism. Korean J Physiol Pharmacol. 20:147–152. 2016. View Article : Google Scholar : PubMed/NCBI

6 

Komaravelli N, Tian B, Ivanciuc T, Mautemps N, Brasier AR, Garofalo RP and Casola A: Respiratory syncytial virus infection down-regulates antioxidant enzyme expression by triggering deacetylation-proteasomal degradation of Nrf2. Free Radic Biol Med. 88:391–403. 2015. View Article : Google Scholar : PubMed/NCBI

7 

Gallorini M, Petzel C, Bolay C, Hiller KA, Cataldi A, Buchalla W, Krifka S and Schweikl H: Activation of the Nrf2-regulated antioxidant cell response inhibits HEMA-induced oxidative stress and supports cell viability. Biomaterials. 56:114–128. 2015. View Article : Google Scholar : PubMed/NCBI

8 

Boyanapalli SS, Paredes-Gonzalez X, Fuentes F, Zhang C, Guo Y, Pung D, Saw CL and Kong AN: Nrf2 knockout attenuates the anti-inflammatory effects of phenethyl isothiocyanate and curcumin. Chem Res Toxicol. 27:2036–2043. 2014. View Article : Google Scholar : PubMed/NCBI

9 

Park JH, Choi JW, Ju EJ, Pae AN and Park KD: Antioxidant and anti-inflammatory activities of a natural compound, shizukahenriol, through Nrf2 activation. Molecules. 20:15989–16003. 2015. View Article : Google Scholar : PubMed/NCBI

10 

Zhao W, Sun Z, Wang S, Li Z and Zheng L: Wnt1 participates in inflammation induced by lipopolysaccharide through upregulating scavenger receptor A and NF-κB. Inflammation. 38:1700–1706. 2015. View Article : Google Scholar : PubMed/NCBI

11 

Wardyn JD, Ponsford AH and Sanderson CM: Dissecting molecular cross-talk between Nrf2 and NF-κB response pathways. Biochem Soc Trans. 43:621–626. 2015. View Article : Google Scholar : PubMed/NCBI

12 

Meng QT, Cao C, Wu Y, Liu HM, Li W, Sun Q, Chen R, Xiao YG, Tang LH, Jiang Y, et al: Ischemic post-conditioning attenuates acute lung injury induced by intestinal ischemia-reperfusion in mice: Role of Nrf2. Lab Invest. 96:1087–1104. 2016. View Article : Google Scholar : PubMed/NCBI

13 

Wang XJ, Hayes JD, Henderson CJ and Wolf CR: Identification of retinoic acid as an inhibitor of transcription factor Nrf2 through activation of retinoic acid receptor alpha. Proc Natl Acad Sci USA. 104:19589–19594. 2007. View Article : Google Scholar : PubMed/NCBI

14 

Ren D, Villeneuve NF, Jiang T, Wu T, Lau A, Toppin HA and Zhang DD: Brusatol enhances the efficacy of chemotherapy by inhibiting the Nrf2-mediated defense mechanism. Proc Natl Acad Sci USA. 108:1433–1438. 2011. View Article : Google Scholar : PubMed/NCBI

15 

Chiu CJ, McArdle AH, Brown R, Scott HJ and Gurd FN: Intestinal mucosal lesion in low-flow states. I. A morphological, hemodynamic, and metabolic reappraisal. Arch Surg. 101:478–483. 1970. View Article : Google Scholar : PubMed/NCBI

16 

Sun Z, Wang X, Deng X, Lasson A, Wallén R, Hallberg E and Andersson R: The influence of intestinal ischemia and reperfusion on bidirectional intestinal barrier permeability, cellular membrane integrity, proteinase inhibitors, and cell death in rats. Shock. 10:203–212. 1998. View Article : Google Scholar : PubMed/NCBI

17 

Marques GMN, Rasslan R, Belon AR, Carvalho JG, Felice Neto R, Rasslan S, Utiyama EM and Montero EF: Pentoxifylline associated to hypertonic saline solution attenuates inflammatory process and apoptosis after intestinal ischemia/reperfusion in rats. Acta Cir Bras. 29:735–741. 2014. View Article : Google Scholar : PubMed/NCBI

18 

Yang X, Bai H, Wang Y, Li J, Zhou Q, Cai W, Han J, Zhu X, Dong M and Hu D: Deletion of regulatory T cells supports the development of intestinal ischemia-reperfusion injuries. J Surg Res. 184:832–837. 2013. View Article : Google Scholar : PubMed/NCBI

19 

Jiang Y, Zhou Z, Meng QT, Sun Q, Su W, Lei S, Xia Z and Xia ZY: Ginsenoside Rb1 treatment attenuates pulmonary inflammatory cytokine release and tissue injury following intestinal ischemia reperfusion injury in mice. Oxid Med Cell Longev. 2015:8437212015. View Article : Google Scholar : PubMed/NCBI

20 

Schneider KM, Bieghs V, Heymann F, Hu W, Dreymueller D, Liao L, Frissen M, Ludwig A, Gassler N, Pabst O, et al: CX3CR1 is a gatekeeper for intestinal barrier integrity in mice: Limiting steatohepatitis by maintaining intestinal homeostasis. Hepatology. 62:1405–1416. 2015. View Article : Google Scholar : PubMed/NCBI

21 

Sheedy JR, Wettenhall RE, Scanlon D, Gooley PR, Lewis DP, McGregor N, Stapleton DI, Butt HL and DE Meirleir KL: Increased d-lactic Acid intestinal bacteria in patients with chronic fatigue syndrome. In Vivo. 23:621–628. 2009.PubMed/NCBI

22 

Khadaroo RG, Fortis S, Salim SY, Streutker C, Churchill TA and Zhang H: I-FABP as biomarker for the early diagnosis of acute mesenteric ischemia and resultant lung injury. PLoS One. 9:e1152422014. View Article : Google Scholar : PubMed/NCBI

23 

Diebel ME, Diebel LN, Manke CW, Liberati DM and Whittaker JR: Early tranexamic acid administration: A protective effect on gut barrier function following ischemia/reperfusion injury. J Trauma Acute Care Surg. 79:1015–1022. 2015. View Article : Google Scholar : PubMed/NCBI

24 

Santamaría B, Ucero AC, Benito-Martin A, Vicent MJ, Orzáez M, Celdrán A, Selgas R, Ruíz-Ortega M and Ortiz A: Biocompatibility reduces inflammation-induced apoptosis in mesothelial cells exposed to peritoneal dialysis fluid. Blood Purif. 39:200–209. 2015. View Article : Google Scholar : PubMed/NCBI

25 

Ahmad SF, Attia SM, Bakheet SA, Zoheir KM, Ansari MA, Korashy HM, Abdel-Hamied HE, Ashour AE and Abd-Allah AR: Naringin attenuates the development of carrageenan-induced acute lung inflammation through inhibition of NF-κB, STAT3 and pro-inflammatory mediators and enhancement of IκBα and anti-inflammatory cytokines. Inflammation. 38:846–857. 2015. View Article : Google Scholar

26 

Fan B, Dun SH, Gu JQ, Guo Y and Ikuyama S: Pycnogenol attenuates the release of proinflammatory cytokines and expression of perilipin 2 in lipopolysaccharide-stimulated microglia in part via inhibition of NF-κB and AP-1 activation. PLoS One. 10:e01378372015. View Article : Google Scholar

27 

Wang Y, Wang B, Du F, Su X, Sun G, Zhou G, Bian X and Liu N: Epigallocatechin-3-gallate attenuates oxidative stress and inflammation in obstructive nephropathy via NF-κB and Nrf2/HO-1 signalling pathway regulation. Basic Clin Pharmacol Toxicol. 117:164–172. 2015. View Article : Google Scholar : PubMed/NCBI

28 

Li L, Dong H, Song E, Xu X, Liu L and Song Y: Nrf2/ARE pathway activation, HO-1 and NQO1 induction by polychlorinated biphenyl quinone is associated with reactive oxygen species and PI3K/AKT signaling. Chem Biol Interact. 209:56–67. 2014. View Article : Google Scholar

29 

Park SY, Kim YH and Park G: Cucurbitacins attenuate microglial activation and protect from neuroinflammatory injury through Nrf2/ARE activation and STAT/NF-κB inhibition. Neurosci Lett. 609:129–136. 2015. View Article : Google Scholar : PubMed/NCBI

30 

Keleku-Lukwete N, Suzuki M, Otsuki A, Tsuchida K, Katayama S, Hayashi M, Naganuma E, Moriguchi T, Tanabe O, Engel JD, et al: Amelioration of inflammation and tissue damage in sickle cell model mice by Nrf2 activation. Proc Natl Acad Sci USA. 112:12169–12174. 2015. View Article : Google Scholar : PubMed/NCBI

31 

Qin S, Du R, Yin S, Liu X, Xu G and Cao W: Nrf2 is essential for the anti-inflammatory effect of carbon monoxide in LPS-induced inflammation. Inflamm Res. 64:537–548. 2015. View Article : Google Scholar : PubMed/NCBI

32 

Pan H, Wang H, Wang X, Zhu L and Mao L: The absence of Nrf2 enhances NF-κB-dependent inflammation following scratch injury in mouse primary cultured astrocytes. Mediators Inflamm. 2012:2175802012. View Article : Google Scholar

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Copy and paste a formatted citation
Spandidos Publications style
Meng Q, Chen R, Chen C, Su K, Li W, Tang L, Liu H, Xue R, Sun Q, Leng Y, Leng Y, et al: Transcription factors Nrf2 and NF-κB contribute to inflammation and apoptosis induced by intestinal ischemia-reperfusion in mice. Int J Mol Med 40: 1731-1740, 2017.
APA
Meng, Q., Chen, R., Chen, C., Su, K., Li, W., Tang, L. ... Xia, Z. (2017). Transcription factors Nrf2 and NF-κB contribute to inflammation and apoptosis induced by intestinal ischemia-reperfusion in mice. International Journal of Molecular Medicine, 40, 1731-1740. https://doi.org/10.3892/ijmm.2017.3170
MLA
Meng, Q., Chen, R., Chen, C., Su, K., Li, W., Tang, L., Liu, H., Xue, R., Sun, Q., Leng, Y., Hou, J., Wu, Y., Xia, Z."Transcription factors Nrf2 and NF-κB contribute to inflammation and apoptosis induced by intestinal ischemia-reperfusion in mice". International Journal of Molecular Medicine 40.6 (2017): 1731-1740.
Chicago
Meng, Q., Chen, R., Chen, C., Su, K., Li, W., Tang, L., Liu, H., Xue, R., Sun, Q., Leng, Y., Hou, J., Wu, Y., Xia, Z."Transcription factors Nrf2 and NF-κB contribute to inflammation and apoptosis induced by intestinal ischemia-reperfusion in mice". International Journal of Molecular Medicine 40, no. 6 (2017): 1731-1740. https://doi.org/10.3892/ijmm.2017.3170
Copy and paste a formatted citation
x
Spandidos Publications style
Meng Q, Chen R, Chen C, Su K, Li W, Tang L, Liu H, Xue R, Sun Q, Leng Y, Leng Y, et al: Transcription factors Nrf2 and NF-κB contribute to inflammation and apoptosis induced by intestinal ischemia-reperfusion in mice. Int J Mol Med 40: 1731-1740, 2017.
APA
Meng, Q., Chen, R., Chen, C., Su, K., Li, W., Tang, L. ... Xia, Z. (2017). Transcription factors Nrf2 and NF-κB contribute to inflammation and apoptosis induced by intestinal ischemia-reperfusion in mice. International Journal of Molecular Medicine, 40, 1731-1740. https://doi.org/10.3892/ijmm.2017.3170
MLA
Meng, Q., Chen, R., Chen, C., Su, K., Li, W., Tang, L., Liu, H., Xue, R., Sun, Q., Leng, Y., Hou, J., Wu, Y., Xia, Z."Transcription factors Nrf2 and NF-κB contribute to inflammation and apoptosis induced by intestinal ischemia-reperfusion in mice". International Journal of Molecular Medicine 40.6 (2017): 1731-1740.
Chicago
Meng, Q., Chen, R., Chen, C., Su, K., Li, W., Tang, L., Liu, H., Xue, R., Sun, Q., Leng, Y., Hou, J., Wu, Y., Xia, Z."Transcription factors Nrf2 and NF-κB contribute to inflammation and apoptosis induced by intestinal ischemia-reperfusion in mice". International Journal of Molecular Medicine 40, no. 6 (2017): 1731-1740. https://doi.org/10.3892/ijmm.2017.3170
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