Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
International Journal of Molecular Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1107-3756 Online ISSN: 1791-244X
Journal Cover
December-2017 Volume 40 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
December-2017 Volume 40 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Essential role of microRNA-650 in the regulation of B-cell CLL/lymphoma 11B gene expression following transplantation: A novel mechanism behind the acute rejection of renal allografts

  • Authors:
    • Peng Jin
    • Hongxi Chen
    • Jinliang Xie
    • Cheng Zhou
    • Xiangrong Zhu
  • View Affiliations / Copyright

    Affiliations: Centre of Organ Transplantation, Xiangya Hospital, Central South University, Changsha, Hunan 410008, P.R. China, Department of General Surgery, Xiangya Hospital, Central South University, Changsha, Hunan 410008, P.R. China
    Copyright: © Jin et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 1840-1850
    |
    Published online on: October 17, 2017
       https://doi.org/10.3892/ijmm.2017.3194
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Kidney transplantation is an effective final therapeutic procedure for patients with end-stage kidney failure. Although advanced immunosuppressive therapy is administered following transplantation, certain patients still suffer from acute allograft rejection. MicroRNAs (miRs) have a potential diagnostic and therapeutic value for acute renal allograft rejection; however, their underlying mechanism of action is largely unknown. In the present study, an increased level of miR-650 was identified to be associated with the downregulation of B-cell CLL/lymphoma 11B (BCL11B) expression in acute renal allograft rejection. Furthermore, in vitro study using human renal glomerular endothelial cells (HRGECs) transfected with a miR-650 mimic revealed that key characteristics of acute renal allograft rejection were observed, including apoptosis, the release of cytokines and the chemotaxis of macrophages, while the effects were reduced in HRGECs transfected with a miR-650 inhibitor. The existence of a conserved miR-650 binding site on the 3'-untranslated region of BCL11B mRNA was predicted by computational algorithms and confirmed by a luciferase reporter assay. Knockdown of BCL11B with small interfering RNA (siRNA) significantly increased the apoptotic rate and significantly decreased the proliferation ability of HRGECs compared with the negative control group. HRGECs transfected with a combination of BCL11B siRNA and the miR-650 mimic demonstrated a significant increase in the rate of apoptosis compared with the control. These results suggest that the upregulation of miR-650 contributes to the development of acute renal allograft rejection by suppression of BCL11B, which leads to apoptosis and inflammatory responses. Thus, miR-650 and BCL11B may represent potential therapeutic targets for the prevention of acute renal allograft rejection.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

Figure 6

Figure 7

Figure 8

Figure 9

View References

1 

Mas VR, Le TH and Maluf DG: Epigenetics in kidney transplantation: Current evidence, predictions, and future research directions. Transplantation. 100:23–38. 2016. View Article : Google Scholar

2 

Li PK, Burdmann EA and Mehta RL; World Kidney Day Steering Committee 2013: Acute kidney injury: Global health alert. Transplantation. 95:653–657. 2013. View Article : Google Scholar : PubMed/NCBI

3 

Van Sandwijk MS, Ten Berge IJ, Majoie CB, Caan MW, De Sonneville LM, Van Gool WA and Bemelman FJ: Cognitive changes in chronic kidney disease and after transplantation. Transplantation. 100:734–742. 2016. View Article : Google Scholar

4 

Hakenberg O: Kidney transplantation. Urologe. 54:13552015.In German. View Article : Google Scholar

5 

Verhave J, Boucher A, Dandavino R, Collette S, Senécal L, Hebert MJ, Girardin C and Cardinal H: The incidence, management, and evolution of rapamycin-related side effects in kidney transplant recipients. Clin Transplant. 28:616–622. 2014. View Article : Google Scholar : PubMed/NCBI

6 

El Ters M, Grande JP, Keddis MT, Rodrigo E, Chopra B, Dean PG, Stegall MD and Cosio FG: Kidney allograft survival after acute rejection, the value of follow-up biopsies. Am J Transplant. 13:2334–2341. 2013. View Article : Google Scholar : PubMed/NCBI

7 

Vlachopanos G and Georgalis A: On the value and pitfalls of follow-up biopsies after acute rejection. Am J Transplant. 14:2372014. View Article : Google Scholar

8 

Goldberg RJ, Weng FL and Kandula P: Acute and chronic allograft dysfunction in kidney transplant recipients. Med Clin North Am. 100:487–503. 2016. View Article : Google Scholar : PubMed/NCBI

9 

Becker LE, Morath C and Suesal C: Immune mechanisms of acute and chronic rejection. Clin Biochem. 49:320–323. 2016. View Article : Google Scholar : PubMed/NCBI

10 

Hammond SM: An overview of microRNAs. Adv Drug Deliv Rev. 87:3–14. 2015. View Article : Google Scholar : PubMed/NCBI

11 

Iwakawa HO and Tomari Y: The Functions of MicroRNAs: mRNA decay and translational repression. Trends Cell Biol. 25:651–665. 2015. View Article : Google Scholar : PubMed/NCBI

12 

Ambros V: The functions of animal microRNAs. Nature. 431:350–355. 2004. View Article : Google Scholar : PubMed/NCBI

13 

Small EM and Olson EN: Pervasive roles of microRNAs in cardiovascular biology. Nature. 469:336–342. 2011. View Article : Google Scholar : PubMed/NCBI

14 

Fan PC, Chen CC, Chen YC, Chang YS and Chu PH: MicroRNAs in acute kidney injury. Hum Genomics. 10:292016. View Article : Google Scholar : PubMed/NCBI

15 

Lujambio A and Lowe SW: The microcosmos of cancer. Nature. 482:347–355. 2012. View Article : Google Scholar : PubMed/NCBI

16 

Kim JK, Kim TS, Basu J and Jo EK: MicroRNA in innate immunity and autophagy during mycobacterial infection. Cell Microbiol. 19:e126872017. View Article : Google Scholar

17 

Zawada AM, Zhang L, Emrich IE, Rogacev KS, Krezdorn N, Rotter B, Fliser D, Devaux Y, et al: MicroRNA profiling of human intermediate monocytes. Immunobiology. 222:587–596. 2017. View Article : Google Scholar

18 

Oda H, Ikeguchi R, Yurie H, Kaizawa Y, Ohta S, Yamamoto K, Aoyama T and Matsuda S: Plasma microRNAs are potential biomarkers of acute rejection after hindlimb transplantation in rats. Transplantation Direct. 2:e1082016. View Article : Google Scholar : PubMed/NCBI

19 

Fujino M, Zhu P, Cai S, Nishio Y, Zhuang J and Li XK: MicroRNAs involved in acute rejection and tolerance in murine cardiac allografts. Exp Clin Transplant. 14:424–430. 2016.PubMed/NCBI

20 

Soltaninejad E, Nicknam MH, Nafar M, Ahmadpoor P, Pourrezagholi F, Sharbafi MH, Hosseinzadeh M, Foroughi F, Yekaninejad MS, Bahrami T, et al: Differential expression of microRNAs in renal transplant patients with acute T-cell mediated rejection. Transpl Immunol. 33:1–6. 2015. View Article : Google Scholar : PubMed/NCBI

21 

Wilflingseder J, Reindl-Schwaighofer R, Sunzenauer J, Kainz A, Heinzel A, Mayer B and Oberbauer R: MicroRNAs in kidney transplantation. Nephrol Dial Transplant. 30:910–917. 2015. View Article : Google Scholar :

22 

Zhang X, Zhu W, Zhang J, Huo S, Zhou L, Gu Z and Zhang M: MicroRNA-650 targets ING4 to promote gastric cancer tumorigenicity. Biochem Biophys Res Commun. 395:275–280. 2010. View Article : Google Scholar : PubMed/NCBI

23 

Huang JY, Cui SY, Chen YT, Song HZ, Huang GC, Feng B, Sun M, De W, Wang R and Chen LB: MicroRNA-650 was a prognostic factor in human lung adenocarcinoma and confers the docetaxel chemoresistance of lung adenocarcinoma cells via regulating Bcl-2/Bax expression. PLoS One. 8:e726152013. View Article : Google Scholar : PubMed/NCBI

24 

Feng L, Xie Y, Zhang H and Wu Y: Down-regulation of NDRG2 gene expression in human colorectal cancer involves promoter methylation and microRNA-650. Biochem Biophys Res Commun. 406:534–538. 2011. View Article : Google Scholar : PubMed/NCBI

25 

Zuo ZH, Yu YP, Ding Y, Liu S, Martin A, Tseng G and Luo JH: Oncogenic activity of miR-650 in prostate cancer is mediated by suppression of CSR1 expression. Am J Pathol. 185:1991–1999. 2015. View Article : Google Scholar : PubMed/NCBI

26 

Chien WW, Domenech C, Catallo R, Kaddar T, Magaud JP, Salles G and Ffrench M: Cyclin-dependent kinase 1 expression is inhibited by p16(INK4a) at the post-transcriptional level through the microRNA pathway. Oncogene. 30:1880–1891. 2011. View Article : Google Scholar

27 

Mengel M, Sis B and Halloran PF: SWOT analysis of Banff: Strengths, weaknesses, opportunities and threats of the international Banff consensus process and classification system for renal allograft pathology. Am J Transplant. 7:2221–2226. 2007. View Article : Google Scholar : PubMed/NCBI

28 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(−Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar

29 

Farooqi AA, Qureshi MZ, Coskunpinar E, Naqvi SK, Yaylim I and Ismail M: MiR-421, miR-155 and miR-650: Emerging trends of regulation of cancer and apoptosis. Asian Pac J Cancer Prev. 15:1909–1912. 2014. View Article : Google Scholar : PubMed/NCBI

30 

Aktaş A: Transplanted kidney function evaluation. Semin Nucl Med. 44:129–145. 2014. View Article : Google Scholar

31 

Montero N, Pérez-Sáez MJ, Pascual J, Abramowicz D, Budde K, Dudley C, Hazzan M, Klinger M, Maggiore U, Oberbauer R, et al; DESCARTES Working Group. DESCARTES ERA-EDTA Board: Immunosuppression in the elderly renal allograft recipient: A systematic review. Transplant Rev (Orlando). 30:144–153. 2016. View Article : Google Scholar

32 

O'Leary JG, Samaniego M, Barrio MC, Potena L, Zeevi A, Djamali A and Cozzi E: The influence of immunosuppressive agents on the risk of de novo donor-specific HLA antibody production in solid organ transplant recipients. Transplantation. 100:39–53. 2016. View Article : Google Scholar

33 

Watson CJ and Dark JH: Organ transplantation: Historical perspective and current practice. Br J Anaesth. 108(Suppl 1): i29–i42. 2012. View Article : Google Scholar : PubMed/NCBI

34 

Xu Z, Yang W, Steward N, Sweet SC, Danziger-Isakov L, Heeger PS and Mohanakumar T: Role of circulating microRNAs in the immunopathogenesis of rejection following pediatric lung transplantation. Transplantation. 101:2461–2468. 2017. View Article : Google Scholar

35 

Matz M, Lorkowski C, Fabritius K, Durek P, Wu K, Rudolph B, Neumayer HH, Mashreghi MF and Budde K: Free microRNA levels in plasma distinguish T-cell mediated rejection from stable graft function after kidney transplantation. Transpl Immunol. 39:52–59. 2016. View Article : Google Scholar : PubMed/NCBI

36 

Schmuck RB, Reutzel-Selke A, Raschzok N, Morgul HM, Struecker B, Lippert S, de Carvalho Fischer C, Schmelzle M, Boas-Knoop S, Bahra M, et al: Bile: miRNA pattern and protein-based biomarkers may predict acute cellular rejection after liver transplantation. Biomarkers. 22:19–27. 2017. View Article : Google Scholar

37 

Patnaik S, Mallick R, Kannisto E, Sharma R, Bshara W, Yendamuri S and Dhillon SS: MiR-205 and MiR-375 microRNA assays to distinguish squamous cell carcinoma from adenocarcinoma in lung cancer biopsies. J Thorac Oncol. 10:446–453. 2015. View Article : Google Scholar : PubMed/NCBI

38 

Wen J, Luo K, Liu H, Liu S, Lin G, Hu Y, Zhang X, Wang G, Chen Y, Chen Z, et al: MiRNA expression analysis of pretreatment biopsies predicts the pathological response of esophageal squamous cell carcinomas to neoadjuvant chemoradiotherapy. Ann Surg. 263:942–948. 2016. View Article : Google Scholar

39 

Gharib SA, Edelman JD, Ge L and Chen P: Acute cellular rejection elicits distinct microRNA signatures in airway epithelium of lung transplant patients. Transplant Direct. 1:e442015. View Article : Google Scholar

40 

Merhi B, Bayliss G and Gohh RY: Role for urinary biomarkers in diagnosis of acute rejection in the transplanted kidney. World J Transplant. 5:251–260. 2015. View Article : Google Scholar

41 

Iwasaki K, Yamamoto T, Inanaga Y, Hiramitsu T, Miwa Y, Murotani K, Narumi S, Watarai Y, Katayama A, Uchida K, et al: MiR-142-5p and miR-486-5p as biomarkers for early detection of chronic antibody-mediated rejection in kidney transplantation. Biomarkers. 22:45–54. 2017. View Article : Google Scholar

42 

Anglicheau D, Sharma VK, Ding R, Hummel A, Snopkowski C, Dadhania D, Seshan SV and Suthanthiran M: MicroRNA expression profiles predictive of human renal allograft status. Proc Natl Acad Sci USA. 106:5330–5335. 2009. View Article : Google Scholar : PubMed/NCBI

43 

Wei Q, Mi QS and Dong Z: The regulation and function of microRNAs in kidney diseases. IUBMB Life. 65:602–614. 2013. View Article : Google Scholar : PubMed/NCBI

44 

Ulbing M, Kirsch AH, Leber B, Lemesch S, Münzker J, Schweighofer N, Hofer D, Trummer O, Rosenkranz AR, Müller H, et al: MicroRNAs 223-3p and 93-5p in patients with chronic kidney disease before and after renal transplantation. Bone. 95:115–123. 2017. View Article : Google Scholar

45 

Lorenzen JM, Volkmann I, Fiedler J, Schmidt M, Scheffner I, Haller H, Gwinner W and Thum T: Urinary miR-210 as a mediator of acute T-cell mediated rejection in renal allograft recipients. Am J Transplant. 11:2221–2227. 2011. View Article : Google Scholar : PubMed/NCBI

46 

Yang IP, Tsai HL, Miao ZF, Huang CW, Kuo CH, Wu JY, Wang WM, Juo SH and Wang JY: Development of a deregulating microRNA panel for the detection of early relapse in postoperative colorectal cancer patients. J Transl Med. 14:1082016. View Article : Google Scholar : PubMed/NCBI

47 

Zeng ZL, Li FJ, Gao F, Sun DS and Yao L: Upregulation of miR-650 is correlated with down-regulation of ING4 and progression of hepatocellular carcinoma. J Surg Oncol. 107:105–110. 2013. View Article : Google Scholar

48 

Kominami R: Role of the transcription factor Bcl11b in development and lymphomagenesis. Proc Jpn Acad Ser B Phys Biol Sci. 88:72–87. 2012. View Article : Google Scholar : PubMed/NCBI

49 

Uddin MN, Zhang Y, Harton JA, MacNamara KC and Avram D: TNF-alpha-dependent hematopoiesis following Bcl11b deletion in T cells restricts metastatic melanoma. J Immunol. 192:1946–1953. 2014. View Article : Google Scholar : PubMed/NCBI

50 

Mahapatra S, Klee EW, Young CY, Sun Z, Jimenez RE, Klee GG, Tindall DJ and Donkena KV: Global methylation profiling for risk prediction of prostate cancer. Clin Cancer Res. 18:2882–2895. 2012. View Article : Google Scholar : PubMed/NCBI

51 

Li Z, Chen G, Yang Y, Guo W and Tian W: Bcl11b regulates enamel matrix protein expression and dental epithelial cell differentiation during rat tooth development. Mol Med Rep. 15:297–304. 2017. View Article : Google Scholar

52 

Huang X, Chen S, Shen Q, Chen S, Yang L, Grabarczyk P, Przybylski GK, Schmidt CA and Li Y: Down regulation of BCL11B expression inhibits proliferation and induces apoptosis in malignant T cells by BCL11B-935-siRNA. Hematology. 16:236–242. 2011. View Article : Google Scholar : PubMed/NCBI

53 

Hirose S, Touma M, Go R, Katsuragi Y, Sakuraba Y, Gondo Y, Abe M, Sakimura K, Mishima Y and Kominami R: Bcl11b prevents the intrathymic development of innate CD8 T cells in a cell intrinsic manner. Int Immunol. 27:205–215. 2015. View Article : Google Scholar

54 

Huang X, Du X and Li Y: The role of BCL11B in hematological malignancy. Exp Hematol Oncol. 1:222012. View Article : Google Scholar : PubMed/NCBI

55 

Wang Z, Zhang LJ, Guha G, Li S, Kyrylkova K, Kioussi C, Leid M, Ganguli-Indra G and Indra AK: Selective ablation of Ctip2/Bcl11b in epidermal keratinocytes triggers atopic dermatitis-like skin inflammatory responses in adult mice. PLoS One. 7:e512622012. View Article : Google Scholar

56 

Cherrier T, Le Douce V, Eilebrecht S, Riclet R, Marban C, Dequiedt F, Goumon Y, Paillart JC, Mericskay M, Parlakian A, et al: CTIP2 is a negative regulator of P-TEFb. Proc Natl Acad Sci USA. 110:12655–12660. 2013. View Article : Google Scholar : PubMed/NCBI

57 

Cismasiu VB, Paskaleva E, Suman Daya S, Canki M, Duus K and Avram D: BCL11B is a general transcriptional repressor of the HIV-1 long terminal repeat in T lymphocytes through recruitment of the NuRD complex. Virology. 380:173–181. 2008. View Article : Google Scholar : PubMed/NCBI

58 

Takachi T, Takahashi M, Takahashi-Yoshita M, Higuchi M, Obata M, Mishima Y, Okuda S, Tanaka Y, Matsuoka M, Saitoh A, et al: Human T-cell leukemia virus type 1 Tax oncoprotein represses the expression of the BCL11B tumor suppressor in T-cells. Cancer Sci. 106:461–465. 2015. View Article : Google Scholar : PubMed/NCBI

59 

Li L, Zhang JA, Dose M, Kueh HY, Mosadeghi R, Gounari F and Rothenberg EV: A far downstream enhancer for murine Bcl11b controls its T-cell specific expression. Blood. 122:902–911. 2013. View Article : Google Scholar : PubMed/NCBI

60 

Liu P, Li P and Burke S: Critical roles of Bcl11b in T-cell development and maintenance of T-cell identity. Immunol Rev. 238:138–149. 2010. View Article : Google Scholar : PubMed/NCBI

61 

Kinsey GR and Okusa MD: Expanding role of T cells in acute kidney injury. Curr Opin Nephrol Hypertens. 23:9–16. 2014. View Article : Google Scholar :

62 

Yu Y, Wang C, Clare S, Wang J, Lee SC, Brandt C, Burke S, Lu L, He D, Jenkins NA, et al: The transcription factor Bcl11b is specifically expressed in group 2 innate lymphoid cells and is essential for their development. J Exp Med. 212:865–874. 2015. View Article : Google Scholar : PubMed/NCBI

63 

Gutierrez A, Kentsis A, Sanda T, Holmfeldt L, Chen SC, Zhang J, Protopopov A, Chin L, Dahlberg SE, Neuberg DS, et al: The BCL11B tumor suppressor is mutated across the major molecular subtypes of T-cell acute lymphoblastic leukemia. Blood. 118:4169–4173. 2011. View Article : Google Scholar : PubMed/NCBI

64 

Zhong C and Zhu J: Bcl11b drives the birth of ILC2 innate lymphocytes. J Exp Med. 212:8282015. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Jin P, Chen H, Xie J, Zhou C and Zhu X: Essential role of microRNA-650 in the regulation of B-cell CLL/lymphoma 11B gene expression following transplantation: A novel mechanism behind the acute rejection of renal allografts. Int J Mol Med 40: 1840-1850, 2017.
APA
Jin, P., Chen, H., Xie, J., Zhou, C., & Zhu, X. (2017). Essential role of microRNA-650 in the regulation of B-cell CLL/lymphoma 11B gene expression following transplantation: A novel mechanism behind the acute rejection of renal allografts. International Journal of Molecular Medicine, 40, 1840-1850. https://doi.org/10.3892/ijmm.2017.3194
MLA
Jin, P., Chen, H., Xie, J., Zhou, C., Zhu, X."Essential role of microRNA-650 in the regulation of B-cell CLL/lymphoma 11B gene expression following transplantation: A novel mechanism behind the acute rejection of renal allografts". International Journal of Molecular Medicine 40.6 (2017): 1840-1850.
Chicago
Jin, P., Chen, H., Xie, J., Zhou, C., Zhu, X."Essential role of microRNA-650 in the regulation of B-cell CLL/lymphoma 11B gene expression following transplantation: A novel mechanism behind the acute rejection of renal allografts". International Journal of Molecular Medicine 40, no. 6 (2017): 1840-1850. https://doi.org/10.3892/ijmm.2017.3194
Copy and paste a formatted citation
x
Spandidos Publications style
Jin P, Chen H, Xie J, Zhou C and Zhu X: Essential role of microRNA-650 in the regulation of B-cell CLL/lymphoma 11B gene expression following transplantation: A novel mechanism behind the acute rejection of renal allografts. Int J Mol Med 40: 1840-1850, 2017.
APA
Jin, P., Chen, H., Xie, J., Zhou, C., & Zhu, X. (2017). Essential role of microRNA-650 in the regulation of B-cell CLL/lymphoma 11B gene expression following transplantation: A novel mechanism behind the acute rejection of renal allografts. International Journal of Molecular Medicine, 40, 1840-1850. https://doi.org/10.3892/ijmm.2017.3194
MLA
Jin, P., Chen, H., Xie, J., Zhou, C., Zhu, X."Essential role of microRNA-650 in the regulation of B-cell CLL/lymphoma 11B gene expression following transplantation: A novel mechanism behind the acute rejection of renal allografts". International Journal of Molecular Medicine 40.6 (2017): 1840-1850.
Chicago
Jin, P., Chen, H., Xie, J., Zhou, C., Zhu, X."Essential role of microRNA-650 in the regulation of B-cell CLL/lymphoma 11B gene expression following transplantation: A novel mechanism behind the acute rejection of renal allografts". International Journal of Molecular Medicine 40, no. 6 (2017): 1840-1850. https://doi.org/10.3892/ijmm.2017.3194
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team