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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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May-2019 Volume 43 Issue 5

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

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International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

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Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

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Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

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Article

Upregulation of microRNA‑590 in rheumatoid arthritis promotes apoptosis of bone cells through transforming growth factor‑β1/phosphoinositide 3‑kinase/Akt signaling

  • Authors:
    • Jun Yang
    • Yunxiang Zhuang
    • Jianghua Liu
  • View Affiliations / Copyright

    Affiliations: Department of Orthopedics and Traumatology, Yuxi Municipal Hospital of Traditional Chinese Medicine, Yuxi, Yunnan 653100, P.R. China
  • Pages: 2212-2220
    |
    Published online on: February 28, 2019
       https://doi.org/10.3892/ijmm.2019.4116
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Abstract

The aim of the present study was to further define the role of microRNA (miR)‑590 in osteoarthritis (OA) and to investigate the underlying mechanism. In brief, reverse transcription‑quantitative polymerase chain reaction was used to analyze miR‑590 expression in bone tissue samples from rats with OA. Results indicated the expression of miR‑590 was increased. miR‑590 upregulation induced apoptosis in bone cells, whereas miR‑590 downregulation reduced apoptosis of bone cells. Furthermore, miR‑590 upregulation suppressed the protein expression levels of transforming growth factor (TGF)‑β1, phosphoinositide 3‑kinase (PI3K) and phosphorylated (p)‑Akt in bone cells. However, downregulation of miR‑590 induced the protein expression levels of TGF‑β1, PI3K and p‑Akt in bone cells. In addition, TGF‑β1 attenuated the effects of miR‑590 upregulation on bone cell apoptosis and the inactivation of PI3K inhibited the effects of miR‑590 downregulation on bone cell apoptosis. Taken together, the present data suggested that miR‑590 promoted apoptosis in bone cells from rats with OA by regulating the TGF‑β1/PI3K signaling pathway.
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Copy and paste a formatted citation
Spandidos Publications style
Yang J, Zhuang Y and Liu J: Upregulation of microRNA‑590 in rheumatoid arthritis promotes apoptosis of bone cells through transforming growth factor‑β1/phosphoinositide 3‑kinase/Akt signaling. Int J Mol Med 43: 2212-2220, 2019.
APA
Yang, J., Zhuang, Y., & Liu, J. (2019). Upregulation of microRNA‑590 in rheumatoid arthritis promotes apoptosis of bone cells through transforming growth factor‑β1/phosphoinositide 3‑kinase/Akt signaling. International Journal of Molecular Medicine, 43, 2212-2220. https://doi.org/10.3892/ijmm.2019.4116
MLA
Yang, J., Zhuang, Y., Liu, J."Upregulation of microRNA‑590 in rheumatoid arthritis promotes apoptosis of bone cells through transforming growth factor‑β1/phosphoinositide 3‑kinase/Akt signaling". International Journal of Molecular Medicine 43.5 (2019): 2212-2220.
Chicago
Yang, J., Zhuang, Y., Liu, J."Upregulation of microRNA‑590 in rheumatoid arthritis promotes apoptosis of bone cells through transforming growth factor‑β1/phosphoinositide 3‑kinase/Akt signaling". International Journal of Molecular Medicine 43, no. 5 (2019): 2212-2220. https://doi.org/10.3892/ijmm.2019.4116
Copy and paste a formatted citation
x
Spandidos Publications style
Yang J, Zhuang Y and Liu J: Upregulation of microRNA‑590 in rheumatoid arthritis promotes apoptosis of bone cells through transforming growth factor‑β1/phosphoinositide 3‑kinase/Akt signaling. Int J Mol Med 43: 2212-2220, 2019.
APA
Yang, J., Zhuang, Y., & Liu, J. (2019). Upregulation of microRNA‑590 in rheumatoid arthritis promotes apoptosis of bone cells through transforming growth factor‑β1/phosphoinositide 3‑kinase/Akt signaling. International Journal of Molecular Medicine, 43, 2212-2220. https://doi.org/10.3892/ijmm.2019.4116
MLA
Yang, J., Zhuang, Y., Liu, J."Upregulation of microRNA‑590 in rheumatoid arthritis promotes apoptosis of bone cells through transforming growth factor‑β1/phosphoinositide 3‑kinase/Akt signaling". International Journal of Molecular Medicine 43.5 (2019): 2212-2220.
Chicago
Yang, J., Zhuang, Y., Liu, J."Upregulation of microRNA‑590 in rheumatoid arthritis promotes apoptosis of bone cells through transforming growth factor‑β1/phosphoinositide 3‑kinase/Akt signaling". International Journal of Molecular Medicine 43, no. 5 (2019): 2212-2220. https://doi.org/10.3892/ijmm.2019.4116
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