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Protective effects of CXCR3/HO‑1 gene‑modified BMMSCs on damaged intestinal epithelial cells: Role of the p38‑MAPK signaling pathway

  • Authors:
    • Mingli Yin
    • Zhongyang Shen
    • Liu Yang
    • Weiping Zheng
    • Hongli Song
  • View Affiliations / Copyright

    Affiliations: Tianjin First Central Hospital Clinic Institute, Tianjin Medical University, Tianjin 300070, P.R. China, Department of Organ Transplantation, Tianjin First Central Hospital, Tianjin 300192, P.R. China
    Copyright: © Yin et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 2086-2102
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    Published online on: March 4, 2019
       https://doi.org/10.3892/ijmm.2019.4120
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Abstract

The purpose of the present study was to investigate whether bone marrow mesenchymal stem cells (BMMSCs) modified by CXC‑chemokine receptor type 3 (CXCR3) and heme oxygenase‑1 (HO‑1) genes can repair damaged intestinal epithelial cells in vitro, and the role of the p38 mitogen‑activated protein kinase (p38‑MAPK) pathway in this process. A model of intestinal epithelial crypt cell line‑6 (IEC‑6) damage was created, and BMMSCs were transfected with either the CXCR3 and/or HO‑1 gene in vitro. There were nine experimental groups in which the damaged IEC‑6 cells were co‑cultured with differentially‑treated BMMSCs and lymphocytes for 24 h. Reverse transcription‑quantitative polymerase chain reaction analysis, immunohistochemistry and a western blot analysis were performed to detect stem cell transfection, the repair of damaged intestinal epithelial cells and the expression of related molecules in the P38‑MAPK pathway, respectively. Crystal violet staining and live cell imaging were used to detect the chemotaxis of BMMSCs. Flow cytometry was used to detect T lymphocyte activity and the surface markers expressed on BMMSCs. An ELISA was used to quantify cytokine production. The adenovirus (Ad)‑CXCR3/MSCs exhibited the characteristics of stem cells and exhibited chemotaxis. The Ad‑CXCR3/MSCs and Ad‑(CXCR3 + HO)/MSCs exhibited increased expression of tight junction protein zonula occludens‑1 (ZO‑1) and anti‑proliferating cell nuclear antigen in the damaged IEC‑6 cells, and apoptosis of the damaged IEC‑6 cells was decreased. BMMSCs inhibited the phosphorylation of p38, in addition to downstream molecules of the p38MAPK signaling pathway. The Ad‑CXCR3/MSCs and Ad‑(CXCR3 + HO)/MSCs exhibited significantly decreased expression levels of downstream molecules, including phosphorylated (p)‑p38, p‑activated transcription factor 2, p‑C/EBP homologous protein‑10, and p‑myocyte enhancer factor 2C, and target molecules (e.g., apoptotic bodies). The effects of Ad‑(CXCR3 + HO)/MSCs on the repair of the damaged intestinal tract and inhibition of the p38‑MAPK pathway was more marked than those in other groups on day 7 post‑surgery in the rejection model for small bowel transplantation. BMMSCs modified by the CXCR3 and HO‑1 genes exhibited superior ability to repair damaged intestinal epithelial cells and served this role via the p38‑MAPK pathway.
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1 

Ruiz P, Kato T and Tzakis A: Current status of transplantation of the small intestine. Transplantation. 83:1–6. 2007. View Article : Google Scholar : PubMed/NCBI

2 

Koo J, Dawson DW, Dry S, French SW, Naini BV and Wang HL: Allograft biopsy findings in patients with small bowel transplantation. Clin Transplant. 30:1433–1439. 2016. View Article : Google Scholar : PubMed/NCBI

3 

Libby P and Pober JS: Chronic rejection. Immunity. 14:387–397. 2001. View Article : Google Scholar : PubMed/NCBI

4 

Yang Y, Song HL, Zhang W, Wu BJ, Fu NN, Dong C and Shen ZY: Hemeoxygenase-1-transduced bone marrow mesenchymal stem cells in reducing acute rejection and improving small bowel transplantation outcomes in rats. Stem Cell Res Ther. 7:1642016. View Article : Google Scholar

5 

Wu B, Song HL, Yang Y, Yin ML, Zhang BY, Cao Y, Dong C and Shen ZY: Improvement of liver transplantation outcome by heme oxygenase-1-transduced bone marrow mesenchymal stem cells in rats. Stem Cells Int. 2016:92350732016. View Article : Google Scholar : PubMed/NCBI

6 

Schu S, Nosov M, O'Flynn L, Shaw G, Treacy O, Barry F, Murphy M, O'Brien T and Ritter T: Immunogenicity of allogeneic mesenchymal stem cells. J Cell Mol Med. 16:2094–2103. 2012. View Article : Google Scholar

7 

De Miguel MP, Fuentes-Julian S, Blazquez-Martinez A, Pascual CY, Aller MA, Arias J and Arnalich-Montiel F: Immunosuppressive properties of mesenchymal stem cells: Advances and applications. Curr Mol Med. 12:574–591. 2012. View Article : Google Scholar : PubMed/NCBI

8 

Barry FP and Murphy JM: Mesenchymal stem cells: Clinical applications and biological characterization. Int J Biochem Cell Biol. 36:568–584. 2004. View Article : Google Scholar : PubMed/NCBI

9 

Yang Y, Song HL, Zhang W, Wu BJ, Fu NN, Zheng WP, Dong C and Shen ZY: Reduction of acute rejection by bone marrow mesenchymal stem cells during rat small bowel transplantation. Plos One. 9:e1145282014. View Article : Google Scholar : PubMed/NCBI

10 

Hodgkinson CP, Gomez JA, Mirotsou M and Dzau VJ: Genetic engineering of mesenchymal stem cells and its application in human disease therapy. Hum Gene Ther. 21:1513–1526. 2010. View Article : Google Scholar : PubMed/NCBI

11 

Freyman T, Polin G, Osman H, Crary J, Lu M, Cheng L, Palasis M and Wilensky RL: A quantitative, randomized study evaluating three methods of mesenchymal stem cell delivery following myocardial infarction. Eur Heart J. 27:1114–1122. 2006. View Article : Google Scholar : PubMed/NCBI

12 

Yamashita K, Ollinger R, McDaid J, Sakahama H, Wang H, Tyagi S, Csizmadia E, Smith NR, Soares MP and Bach FH: Heme oxygenase-1 is essential for and promotes tolerance to transplanted organs. FASEB J. 20:776–778. 2006. View Article : Google Scholar : PubMed/NCBI

13 

Vanella L, Kim DH, Asprinio D, Peterson SJ, Barbagallo I, Vanella A, Goldstein D, Ikehara S, Kappas A and Abraham NG: HO-1 expression increases mesenchymal stem cell-derived osteoblasts but decreases adipocyte lineage. Bone. 46:236–243. 2010. View Article : Google Scholar

14 

Zeng B, Lin G, Ren X, Zhang Y and Chen H: Overexpression of HO-1 on mesenchymal stem cells promotes angiogenesis and improves myocardial function in infarcted myocardium. J Biomed Sci. 17:802010. View Article : Google Scholar

15 

Jenh CH, Cox MA, Cui L, Reich EP, Sullivan L, Chen SC, Kinsley D, Qian S, Kim SH, Rosenblum S, et al: A selective and potent CXCR3 antagonist SCH 546738 attenuates the development of autoimmune diseases and delays graft rejection. BMC Immunol. 13:22012. View Article : Google Scholar : PubMed/NCBI

16 

Agostini C, Calabrese F, Rea F, Facco M, Tosoni A, Loy M, Binotto G, Valente M, Trentin L and Semenzato G: CXCR3 and its ligand CXCL10 are expressed by inflammatory cells infiltrating lung allografts and mediate chemotaxis of T cells at sites of rejection. Am J Pathol. 158:1703–1711. 2001. View Article : Google Scholar : PubMed/NCBI

17 

Hancock WW, Wang L, Ye Q, Han R and Lee I: Chemokines and their receptors as markers of allograft rejection and targets for immunosuppression. Curr Opin Immunol. 15:479–486. 2003. View Article : Google Scholar : PubMed/NCBI

18 

Yin ML, Song HL, Yang Y, Zheng WP, Liu T and Shen ZY: Effect of CXCR3/HO-1 genes modified bone marrow mesenchymal stem cells on small bowel transplant rejection. World J Gastroenterol. 23:4016–4038. 2017. View Article : Google Scholar : PubMed/NCBI

19 

Chu W, Li M, Li F, Hu R, Chen Z, Lin J and Feng H: Immediate splenectomy down-regulates the MAPK-NF-κB signaling pathway in rat brain after severe traumatic brain injury. J Trauma Acute Care Surg. 74:1446–1453. 2013. View Article : Google Scholar : PubMed/NCBI

20 

Wu H, Wang G, Li S, Zhang M, Li H and Wang K: TNF-α- mediated-p38-dependent signaling pathway contributes to myocyte apoptosis in rats subjected to surgical trauma. Cell Physiol Biochem. 35:1454–1466. 2015. View Article : Google Scholar

21 

Dai J, Gu L, Su Y, Wang Q, Zhao Y, Chen X, Deng H, Li W, Wang G and Li K: Inhibition of curcumin on influenza A virus infection and influenzal pneumonia via oxidative stress, TLR2/4, p38/JNK MAPK and NF-κB pathways. Int Immunopharmacol. 54:177–187. 2017. View Article : Google Scholar

22 

Khan SI, Malhotra RK, Rani N, Sahu AK, Tomar A, Garg S, Nag TC, Ray R, Ojha S, Arya DS and Bhatia J: Febuxostat modulates MAPK/NF-κBp65/TNF-α signaling in cardiac ischemia-reperfusion injury. Oxid Med Cell Longev. 2017:80958252017. View Article : Google Scholar

23 

Cuadrado A and Nebreda AR: Mechanisms and functions of p38 MAPK signalling. Biochem J. 429:403–417. 2010. View Article : Google Scholar : PubMed/NCBI

24 

Gao JH, Guo LJ, Huang ZY, Rao JN and Tang CW: Roles of cellular polyamines in mucosal healing in the gastrointestinal tract. J Physiol Pharmacol. 64:681–693. 2013.

25 

Liu T, Fu NN, Song HL, Wang YL, Wu BJ and Shen ZY: Suppression of microRNA-203 improves survival of rat bone marrow mesenchymal stem cells through enhancing PI3K-induced cellular activation. IUBMB Life. 66:220–227. 2014. View Article : Google Scholar : PubMed/NCBI

26 

Cao Y, Wu BJ, Zheng WP, Yin ML, Liu T and Song HL: Effect of heme oxygenase-1 transduced bone marrow mesenchymal stem cells on damaged intestinal epithelial cells in vitro. Cell Biol Int. 41:726–738. 2017. View Article : Google Scholar : PubMed/NCBI

27 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar

28 

Ho MS, Mei SH and Stewart DJ: The immunomodulatory and therapeutic effects of mesenchymal stromal cells for acute lung Injury and sepsis. J Cell Physiol. 230:2606–2617. 2015. View Article : Google Scholar : PubMed/NCBI

29 

Chen J, Li C and Chen L: The role of microvesicles derived from mesenchymal stem cells in lung diseases. Biomed Res Int. 2015:9858142015.PubMed/NCBI

30 

English K: Mechanisms of mesenchymal stromal cell immunomodulation. Immunol Cell Biol. 91:19–26. 2013. View Article : Google Scholar

31 

Le Blanc K and Mougiakakos D: Multipotent mesenchymal stromal cells and the innate immune system. Nat Rev Immunol. 12:383–396. 2012. View Article : Google Scholar : PubMed/NCBI

32 

Singh AK, Arya RK, Trivedi AK, Sanyal S, Baral R, Dormond O, Briscoe DM and Datta D: Chemokine receptor trio: CXCR3, CXCR4 and CXCR7 crosstalk via CXCL11 and CXCL12. Cytokine Growth Factor Rev. 24:41–49. 2013. View Article : Google Scholar

33 

Billottet C, Quemener C and Bikfalvi A: CXCR3, a double-edged sword in tumor progression and angiogenesis. Biochim Biophys Acta. 1836:287–295. 2013.PubMed/NCBI

34 

Morikawa S, Mabuchi Y, Kubota Y, Nagai Y, Niibe K, Hiratsu E, Suzuki S, Miyauchi-Hara C, Nagoshi N, Sunabori T, et al: Prospective identification, isolation, and systemic transplantation of multipotent mesenchymal stem cells in murine bone marrow. J Exp Med. 206:2483–2496. 2009. View Article : Google Scholar : PubMed/NCBI

35 

Song K, Huang M, Shi Q, Du T and Cao Y: Cultivation and identification of rat bone marrow-derived mesenchymal stem cells. Mol Med Rep. 10:755–760. 2014. View Article : Google Scholar : PubMed/NCBI

36 

Zheng XK, Liu CX, Zhai YY, Li LL, Wang XL and Feng WS: Protection effect of amentoflavone in selaginella tamariscina against TNF-alpha-induced vascular injury of endothelial cells. Yao Xue Xue Bao. 48:1503–1509. 2013.In Chinese. PubMed/NCBI

37 

Le Blanc K, Rasmusson I, Götherström C, Seidel C, Sundberg B, Sundin M, Rosendahl K, Tammik C and Ringdén O: Mesenchymal stem cells inhibit the expression of CD25 (interleukin-2 receptor) and CD38 on phytohaemagglutinin-activated lymphocytes. Scand J Immunol. 60:307–315. 2004. View Article : Google Scholar : PubMed/NCBI

38 

Shipkova M and Wieland E: Surface markers of lymphocyte activation and markers of cell proliferation. Clin Chim Acta. 413:1338–1349. 2012. View Article : Google Scholar

39 

Daniels TR, Delgado T, Rodriguez JA, Helguera G and Penichet ML: The transferrin receptor part I: Biology and targeting with cytotoxic antibodies for the treatment of cancer. Clin Immunol. 121:144–158. 2006. View Article : Google Scholar : PubMed/NCBI

40 

Elhaik Goldman S, Dotan S, Talias A, Lilo A, Azriel S, Malka I, Portnoi M, Ohayon A, Kafka D, Ellis R, et al: Streptococcus pneumoniae fructose-1,6-bisphosphate aldolase, a protein vaccine candidate, elicits Th1/Th2/Th17-type cytokine responses in mice. Int J Mol Med. 37:1127–1138. 2016. View Article : Google Scholar : PubMed/NCBI

41 

Xiang RL, Mei M, Su YC, Li L, Wang JY and Wu LL: Visfatin protects rat pancreatic β-cells against IFN-γ-Induced apoptosis through AMPK and ERK1/2 signaling pathways. Biomed Environ Sci. 28:169–177. 2015.PubMed/NCBI

42 

Duarte S, Shen XD, Fondevila C, Busuttil RW and Coito AJ: Fibronectin-α4β1 interactions in hepatic cold ischemia and reperfusion injury: Regulation of MMP-9 and MT1-MMP via the p38 MAPK pathway. Am J Transplant. 12:2689–2699. 2012. View Article : Google Scholar : PubMed/NCBI

43 

Peng S, Hang N, Liu W, Guo W, Jiang C, Yang X, Xu Q and Sun Y: Andrographolide sulfonate ameliorates lipopolysaccharide-induced acute lung injury in mice by down-regulating MAPK and NF-κB pathways. Acta Pharm Sin B. 6:205–211. 2016. View Article : Google Scholar : PubMed/NCBI

44 

Lopez-Bergami P, Lau E and Ronai Z: Emerging roles of ATF2 and the dynamic AP1 network in cancer. Nat Rev Cancer. 10:65–76. 2010. View Article : Google Scholar :

45 

Lau E and Ronai ZA: ATF2 - at the crossroad of nuclear and cytosolic functions. J Cell Sci. 125:2815–2824. 2012. View Article : Google Scholar : PubMed/NCBI

46 

Todd DJ, Lee AH and Glimcher LH: The endoplasmic reticulum stress response in immunity and autoimmunity. Nat Rev Immunol. 8:663–674. 2008. View Article : Google Scholar : PubMed/NCBI

47 

Li Y, Guo Y, Tang J, Jiang J and Chen Z: New insights into the roles of CHOP-induced apoptosis in ER stress. Acta Biochim Biophys Sin (Shanghai). 47:146–147. 2015. View Article : Google Scholar

48 

He J, Wang C, Sun Y, Lu B, Cui J, Dong N, Zhang M, Liu Y and Yu B: Exendin-4 protects bone marrow-derived mesenchymal stem cells against oxygen/glucose and serum deprivation-induced apoptosis through the activation of the cAMP/PKA signaling pathway and the attenuation of ER stress. Int J Mol Med. 37:889–900. 2016. View Article : Google Scholar : PubMed/NCBI

49 

Shi GX, Han J and Andres DA: Rin GTPase couples nerve growth factor signaling to p38 and b-Raf/ERK pathways to promote neuronal differentiation. J Biol Chem. 280:37599–37609. 2005. View Article : Google Scholar : PubMed/NCBI

50 

Wu J, Kubota J, Hirayama J, Nagai Y, Nishina S, Yokoi T, Asaoka Y, Seo J, Shimizu N, Kajiho H, et al: P38 mitogen-activated protein kinase controls a switch between cardiomyocyte and neuronal commitment of murine embryonic stem cells by activating myocyte enhancer factor 2C-dependent bone morphogenetic protein 2 transcription. Stem Cells Dev. 19:1723–1734. 2010. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Yin M, Shen Z, Yang L, Zheng W and Song H: Protective effects of CXCR3/HO‑1 gene‑modified BMMSCs on damaged intestinal epithelial cells: Role of the p38‑MAPK signaling pathway. Int J Mol Med 43: 2086-2102, 2019.
APA
Yin, M., Shen, Z., Yang, L., Zheng, W., & Song, H. (2019). Protective effects of CXCR3/HO‑1 gene‑modified BMMSCs on damaged intestinal epithelial cells: Role of the p38‑MAPK signaling pathway. International Journal of Molecular Medicine, 43, 2086-2102. https://doi.org/10.3892/ijmm.2019.4120
MLA
Yin, M., Shen, Z., Yang, L., Zheng, W., Song, H."Protective effects of CXCR3/HO‑1 gene‑modified BMMSCs on damaged intestinal epithelial cells: Role of the p38‑MAPK signaling pathway". International Journal of Molecular Medicine 43.5 (2019): 2086-2102.
Chicago
Yin, M., Shen, Z., Yang, L., Zheng, W., Song, H."Protective effects of CXCR3/HO‑1 gene‑modified BMMSCs on damaged intestinal epithelial cells: Role of the p38‑MAPK signaling pathway". International Journal of Molecular Medicine 43, no. 5 (2019): 2086-2102. https://doi.org/10.3892/ijmm.2019.4120
Copy and paste a formatted citation
x
Spandidos Publications style
Yin M, Shen Z, Yang L, Zheng W and Song H: Protective effects of CXCR3/HO‑1 gene‑modified BMMSCs on damaged intestinal epithelial cells: Role of the p38‑MAPK signaling pathway. Int J Mol Med 43: 2086-2102, 2019.
APA
Yin, M., Shen, Z., Yang, L., Zheng, W., & Song, H. (2019). Protective effects of CXCR3/HO‑1 gene‑modified BMMSCs on damaged intestinal epithelial cells: Role of the p38‑MAPK signaling pathway. International Journal of Molecular Medicine, 43, 2086-2102. https://doi.org/10.3892/ijmm.2019.4120
MLA
Yin, M., Shen, Z., Yang, L., Zheng, W., Song, H."Protective effects of CXCR3/HO‑1 gene‑modified BMMSCs on damaged intestinal epithelial cells: Role of the p38‑MAPK signaling pathway". International Journal of Molecular Medicine 43.5 (2019): 2086-2102.
Chicago
Yin, M., Shen, Z., Yang, L., Zheng, W., Song, H."Protective effects of CXCR3/HO‑1 gene‑modified BMMSCs on damaged intestinal epithelial cells: Role of the p38‑MAPK signaling pathway". International Journal of Molecular Medicine 43, no. 5 (2019): 2086-2102. https://doi.org/10.3892/ijmm.2019.4120
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